{"id":"https://openalex.org/W1570167331","doi":"https://doi.org/10.1002/jbt.21585","title":"Swainsonine Induces Caprine Luteal Cells Apoptosis via Mitochondrial\u2010Mediated Caspase\u2010Dependent Pathway","display_name":"Swainsonine Induces Caprine Luteal Cells Apoptosis via Mitochondrial\u2010Mediated Caspase\u2010Dependent Pathway","publication_year":2014,"publication_date":"2014-06-30","ids":{"openalex":"https://openalex.org/W1570167331","doi":"https://doi.org/10.1002/jbt.21585","mag":"1570167331","pmid":"https://pubmed.ncbi.nlm.nih.gov/24977789"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.21585","doi":"https://doi.org/10.1002/jbt.21585","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.21585","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","College of Veterinary Medicine , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"College of Veterinary Medicine , Northwest A&F University , Yangling , Shaanxi 712100 , People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012447055","display_name":"Yong Huang","orcid":"https://orcid.org/0000-0001-7444-5182","observed_orcids":["https://orcid.org/0000-0001-7444-5182"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017605990","display_name":"Xiaomin Zhao","orcid":"https://orcid.org/0000-0002-1814-8586","observed_orcids":["https://orcid.org/0000-0002-1814-8586"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaomin Zhao","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453341","display_name":"Wenlong Zhang","orcid":"https://orcid.org/0000-0001-7929-0730","observed_orcids":["https://orcid.org/0000-0001-7929-0730"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlong Zhang","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Dong","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101514226","display_name":"Qian Du","orcid":"https://orcid.org/0000-0002-5228-1508","observed_orcids":["https://orcid.org/0000-0002-5228-1508"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Du","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068129831","display_name":"Dewen Tong","orcid":"https://orcid.org/0000-0003-2069-8306","observed_orcids":["https://orcid.org/0000-0003-2069-8306"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dewen Tong","raw_affiliation_strings":["College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 People's Republic of China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068129831"],"corresponding_institution_ids":["https://openalex.org/I89652312"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.1258,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.43409728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"28","issue":"10","first_page":"456","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/swainsonine","display_name":"swainsonine","score":1.0},{"id":"https://openalex.org/keywords/luteal-cells","display_name":"luteal cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bax-bcl-2-ratio","display_name":"Bax/Bcl-2 ratio","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9390000104904175},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase-cleavage","display_name":"poly(ADP-ribose) polymerase cleavage","score":0.9120000004768372},{"id":"https://openalex.org/keywords/indolizidine-alkaloids","display_name":"indolizidine alkaloids","score":0.7879999876022339},{"id":"https://openalex.org/keywords/goats","display_name":"goats","score":0.5149999856948853},{"id":"https://openalex.org/keywords/progesterone-synthesis","display_name":"progesterone secretion","score":0.800000011920929},{"id":"https://openalex.org/keywords/fas-fas-ligand","display_name":"Fas/Fas ligand","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.785741925239563},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.7034358978271484},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.6300360560417175},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5840362310409546},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5639314651489258},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.546605110168457},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5226783156394958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5044175386428833},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.5025391578674316},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4685462713241577},{"id":"https://openalex.org/C2775998712","wikidata":"https://www.wikidata.org/wiki/Q14907714","display_name":"Caspase-9","level":5,"score":0.446489542722702},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.43749701976776123},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4155203700065613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4090003967285156},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3350526988506317},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29977118968963623},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.12258562445640564},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10626175999641418},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006041","descriptor_name":"Goats","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008184","descriptor_name":"Luteal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008184","descriptor_name":"Luteal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017026","descriptor_name":"Swainsonine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jbt.21585","doi":"https://doi.org/10.1002/jbt.21585","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbt.21585","pdf_url":null,"source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:24977789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24977789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6886287572","display_name":null,"funder_award_id":"31072108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W119944315","https://openalex.org/W193587149","https://openalex.org/W243428056","https://openalex.org/W1500271849","https://openalex.org/W1512463999","https://openalex.org/W1527815822","https://openalex.org/W1966612160","https://openalex.org/W1976308669","https://openalex.org/W1976609606","https://openalex.org/W1981058689","https://openalex.org/W1986452122","https://openalex.org/W1989429068","https://openalex.org/W1993855694","https://openalex.org/W1995670082","https://openalex.org/W2000576721","https://openalex.org/W2005206971","https://openalex.org/W2011997987","https://openalex.org/W2018231751","https://openalex.org/W2034246810","https://openalex.org/W2044676964","https://openalex.org/W2050758335","https://openalex.org/W2068345687","https://openalex.org/W2073474576","https://openalex.org/W2073665583","https://openalex.org/W2099818615","https://openalex.org/W2100185604","https://openalex.org/W2101143476","https://openalex.org/W2107277218","https://openalex.org/W2121853087","https://openalex.org/W2128016549","https://openalex.org/W2136800439","https://openalex.org/W2136949042","https://openalex.org/W2162653594","https://openalex.org/W2164742140","https://openalex.org/W2186559937"],"related_works":["https://openalex.org/W2126168209","https://openalex.org/W2055976037","https://openalex.org/W2127566937","https://openalex.org/W7152085229","https://openalex.org/W865379900","https://openalex.org/W3099664566","https://openalex.org/W1974763625","https://openalex.org/W1452991878","https://openalex.org/W2996919380","https://openalex.org/W2068345687"],"abstract_inverted_index":{"Swainsonine":[0],"(SW)":[1],"is":[2],"an":[3],"indolizidine":[4],"alkaloid":[5],"isolated":[6],"from":[7,82,94,131],"a":[8,149],"number":[9],"of":[10,36,91],"poisonous":[11],"plants.":[12],"We":[13],"have":[14],"previously":[15],"reported":[16],"that":[17,62,118,142],"SW":[18,63,73,143],"inhibited":[19],"luteal":[20,27,45,145],"cell":[21,28],"progesterone":[22],"production":[23],"by":[24],"inducing":[25],"caprine":[26],"apoptosis":[29,48,147],"in":[30,76],"vitro;":[31],"however,":[32],"the":[33,83,89,97,129],"molecular":[34],"mechanism":[35],"this":[37,42],"phenomenon":[38],"remains":[39],"unclear.":[40],"In":[41],"study,":[43],"SW-treated":[44],"cells":[46,130,146],"showed":[47,61,117],"characteristics,":[49],"including":[50],"nuclear":[51],"fragmentation,":[52],"DNA":[53],"ladder":[54],"formation,":[55],"and":[56,66,87,101],"phosphatidylserine":[57],"externalization.":[58],"Further":[59],"studies":[60],"activated":[64],"caspase-9":[65,121],"caspase-3,":[67],"which":[68],"subsequently":[69],"cleaved":[70],"poly(ADP-ribose)":[71],"polymerase.":[72],"also":[74,116],"increased":[75],"Bax/BcL-2":[77],"ratios,":[78],"promoted":[79],"Bax":[80],"translocation":[81],"cytosol":[84],"to":[85],"mitochondria,":[86],"triggered":[88],"release":[90],"cytochrome":[92],"c":[93],"mitochondria":[95],"into":[96],"cytoplasm.":[98],"However,":[99],"Fas":[100,102],"ligand":[103],"induction":[104],"or":[105,123],"caspase-8":[106,136],"activity":[107],"did":[108],"not":[109,135],"appear":[110],"any":[111],"significant":[112],"changes.":[113],"Additional":[114],"analysis":[115],"pan-caspase":[119],"inhibitor,":[120,122],"caspase-3":[124],"inhibitor":[125],"almost":[126],"completely":[127],"protected":[128],"SW-induced":[132],"apoptosis,":[133],"but":[134],"inhibitor.":[137],"Overall,":[138],"these":[139],"data":[140],"demonstrated":[141],"induced":[144],"through":[148],"mitochondrial-mediated":[150],"caspase-dependent":[151],"pathway.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}