{"id":"https://openalex.org/W1570137200","doi":null,"title":"The Role of Adaptive Stress Responses in HIV Replication and Macrophage-Mediated Neurotoxicity","display_name":"The Role of Adaptive Stress Responses in HIV Replication and Macrophage-Mediated Neurotoxicity","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1570137200","mag":"1570137200"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1579","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/967","pdf_url":"https://repository.upenn.edu/edissertations/967","source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/edissertations/967","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111456147","display_name":"Stephanie A. Cross","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephanie A. Cross","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111456147"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hiv-associated-neurocognitive-disorders","display_name":"HIV-associated neurocognitive disorders","score":0.8849999904632568},{"id":"https://openalex.org/keywords/adaptive-stress-response","display_name":"adaptive stress response","score":0.8009999990463257},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.8190000057220459},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9750000238418579},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hiv-replication","display_name":"HIV replication","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neurotoxins","display_name":"neurotoxins","score":0.6840000152587891},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bip","display_name":"BiP","score":0.9279999732971191},{"id":"https://openalex.org/keywords/monocyte-derived-macrophages","display_name":"monocyte-derived macrophages","score":0.8970000147819519},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6430000066757202},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hiv-associated-neuroinflammation","display_name":"HIV-associated neuroinflammation","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7519821524620056},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6239252686500549},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.5847223401069641},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5534541606903076},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.431243360042572},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41471344232559204},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4007079005241394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3559650778770447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3555978834629059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2623908817768097},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22469544410705566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14846399426460266},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1381036937236786},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09608858823776245},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-1579","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/967","pdf_url":"https://repository.upenn.edu/edissertations/967","source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/32757","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/32757","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-10697","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3497972","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:1570137200","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=10697&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1579","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/967","pdf_url":"https://repository.upenn.edu/edissertations/967","source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1570137200.pdf","grobid_xml":"https://content.openalex.org/works/W1570137200.grobid-xml"},"referenced_works_count":444,"referenced_works":["https://openalex.org/W42114648","https://openalex.org/W44613858","https://openalex.org/W94371219","https://openalex.org/W115591739","https://openalex.org/W233645389","https://openalex.org/W1042014336","https://openalex.org/W1499200045","https://openalex.org/W1500808920","https://openalex.org/W1502937057","https://openalex.org/W1505517942","https://openalex.org/W1522763255","https://openalex.org/W1522823711","https://openalex.org/W1538178082","https://openalex.org/W1538245603","https://openalex.org/W1539290896","https://openalex.org/W1546139069","https://openalex.org/W1549188961","https://openalex.org/W1568529372","https://openalex.org/W1570888466","https://openalex.org/W1571153387","https://openalex.org/W1576120369","https://openalex.org/W1580068662","https://openalex.org/W1581513547","https://openalex.org/W1590241149","https://openalex.org/W1600863966","https://openalex.org/W1613383360","https://openalex.org/W1614954929","https://openalex.org/W1622439358","https://openalex.org/W1656832641","https://openalex.org/W1660178166","https://openalex.org/W1748465268","https://openalex.org/W1758390239","https://openalex.org/W1762774688","https://openalex.org/W1773656017","https://openalex.org/W1782287000","https://openalex.org/W1789490659","https://openalex.org/W1812789667","https://openalex.org/W1826650183","https://openalex.org/W1833727709","https://openalex.org/W1855124553","https://openalex.org/W1892809027","https://openalex.org/W1912782418","https://openalex.org/W1913367972","https://openalex.org/W1932355166","https://openalex.org/W1934602558","https://openalex.org/W1936351921","https://openalex.org/W1937757791","https://openalex.org/W1963609057","https://openalex.org/W1965740674","https://openalex.org/W1965901600","https://openalex.org/W1966156553","https://openalex.org/W1968567971","https://openalex.org/W1969311653","https://openalex.org/W1969443674","https://openalex.org/W1969670719","https://openalex.org/W1970006967","https://openalex.org/W1970090817","https://openalex.org/W1970848662","https://openalex.org/W1972441677","https://openalex.org/W1972635588","https://openalex.org/W1973558008","https://openalex.org/W1973852185","https://openalex.org/W1974399512","https://openalex.org/W1975104247","https://openalex.org/W1975447710","https://openalex.org/W1975492163","https://openalex.org/W1975803523","https://openalex.org/W1976434061","https://openalex.org/W1978094617","https://openalex.org/W1979190471","https://openalex.org/W1979218462","https://openalex.org/W1979733074","https://openalex.org/W1979989842","https://openalex.org/W1981199036","https://openalex.org/W1982377759","https://openalex.org/W1982628675","https://openalex.org/W1984178163","https://openalex.org/W1984423498","https://openalex.org/W1984547206","https://openalex.org/W1984672567","https://openalex.org/W1984811742","https://openalex.org/W1985031521","https://openalex.org/W1985065986","https://openalex.org/W1986173197","https://openalex.org/W1986600046","https://openalex.org/W1987547165","https://openalex.org/W1988165884","https://openalex.org/W1988482079","https://openalex.org/W1988582914","https://openalex.org/W1989463753","https://openalex.org/W1990771642","https://openalex.org/W1991163088","https://openalex.org/W1991556620","https://openalex.org/W1991884672","https://openalex.org/W1991999080","https://openalex.org/W1992442770","https://openalex.org/W1992644506","https://openalex.org/W1993054214","https://openalex.org/W1993182734","https://openalex.org/W1993812737","https://openalex.org/W1994600662","https://openalex.org/W1994662730","https://openalex.org/W1995254193","https://openalex.org/W1995546110","https://openalex.org/W1995746794","https://openalex.org/W1995924099","https://openalex.org/W1997415476","https://openalex.org/W1997677784","https://openalex.org/W1998529637","https://openalex.org/W1999523285","https://openalex.org/W1999528934","https://openalex.org/W2000366874","https://openalex.org/W2000388934","https://openalex.org/W2000673488","https://openalex.org/W2001819303","https://openalex.org/W2001911176","https://openalex.org/W2002819675","https://openalex.org/W2003661425","https://openalex.org/W2006283502","https://openalex.org/W2008373701","https://openalex.org/W2008669330","https://openalex.org/W2008734149","https://openalex.org/W2009318275","https://openalex.org/W2009630307","https://openalex.org/W2009948376","https://openalex.org/W2010097112","https://openalex.org/W2010301693","https://openalex.org/W2010494349","https://openalex.org/W2010581370","https://openalex.org/W2010630698","https://openalex.org/W2010946709","https://openalex.org/W2012143024","https://openalex.org/W2013663529","https://openalex.org/W2013810114","https://openalex.org/W2014439767","https://openalex.org/W2014495235","https://openalex.org/W2015407678","https://openalex.org/W2015697428","https://openalex.org/W2016148096","https://openalex.org/W2016522925","https://openalex.org/W2017151728","https://openalex.org/W2018051115","https://openalex.org/W2018073475","https://openalex.org/W2018685714","https://openalex.org/W2020554336","https://openalex.org/W2020665900","https://openalex.org/W2020750577","https://openalex.org/W2021911222","https://openalex.org/W2022317515","https://openalex.org/W2022879400","https://openalex.org/W2022905263","https://openalex.org/W2023150076","https://openalex.org/W2023596852","https://openalex.org/W2023876571","https://openalex.org/W2025518316","https://openalex.org/W2026435727","https://openalex.org/W2026726892","https://openalex.org/W2026995847","https://openalex.org/W2027459737","https://openalex.org/W2027580727","https://openalex.org/W2028168243","https://openalex.org/W2028279477","https://openalex.org/W2028762442","https://openalex.org/W2029097526","https://openalex.org/W2029642537","https://openalex.org/W2029752274","https://openalex.org/W2030692398","https://openalex.org/W2031094596","https://openalex.org/W2031256822","https://openalex.org/W2032618901","https://openalex.org/W2034213169","https://openalex.org/W2034399323","https://openalex.org/W2035126438","https://openalex.org/W2035421145","https://openalex.org/W2035807473","https://openalex.org/W2036738390","https://openalex.org/W2037472543","https://openalex.org/W2037696254","https://openalex.org/W2037928479","https://openalex.org/W2038418972","https://openalex.org/W2038968007","https://openalex.org/W2039271176","https://openalex.org/W2039285894","https://openalex.org/W2039631987","https://openalex.org/W2042418839","https://openalex.org/W2043281805","https://openalex.org/W2043541788","https://openalex.org/W2044164721","https://openalex.org/W2044177663","https://openalex.org/W2044360533","https://openalex.org/W2044975828","https://openalex.org/W2045301606","https://openalex.org/W2045694632","https://openalex.org/W2045939131","https://openalex.org/W2046019763","https://openalex.org/W2047044941","https://openalex.org/W2047126558","https://openalex.org/W2047385013","https://openalex.org/W2048158801","https://openalex.org/W2048400917","https://openalex.org/W2048551040","https://openalex.org/W2048699193","https://openalex.org/W2048731469","https://openalex.org/W2048970001","https://openalex.org/W2049147024","https://openalex.org/W2049659704","https://openalex.org/W2049675290","https://openalex.org/W2049761557","https://openalex.org/W2049791475","https://openalex.org/W2050055755","https://openalex.org/W2051471929","https://openalex.org/W2052305221","https://openalex.org/W2052763560","https://openalex.org/W2052769426","https://openalex.org/W2053584325","https://openalex.org/W2054655809","https://openalex.org/W2054735547","https://openalex.org/W2054874422","https://openalex.org/W2054973971","https://openalex.org/W2055217426","https://openalex.org/W2055345597","https://openalex.org/W2056632599","https://openalex.org/W2058322866","https://openalex.org/W2058511356","https://openalex.org/W2058886900","https://openalex.org/W2059475414","https://openalex.org/W2062152625","https://openalex.org/W2062643827","https://openalex.org/W2064018971","https://openalex.org/W2064981396","https://openalex.org/W2065111916","https://openalex.org/W2066480236","https://openalex.org/W2066538173","https://openalex.org/W2068607362","https://openalex.org/W2069201165","https://openalex.org/W2069561875","https://openalex.org/W2069924169","https://openalex.org/W2070772192","https://openalex.org/W2070867389","https://openalex.org/W2070939832","https://openalex.org/W2071125722","https://openalex.org/W2071273959","https://openalex.org/W2071832924","https://openalex.org/W2072787765","https://openalex.org/W2074274825","https://openalex.org/W2074425801","https://openalex.org/W2075319928","https://openalex.org/W2075643855","https://openalex.org/W2076249077","https://openalex.org/W2077012020","https://openalex.org/W2077784911","https://openalex.org/W2078627026","https://openalex.org/W2079721673","https://openalex.org/W2080290248","https://openalex.org/W2080901528","https://openalex.org/W2081151377","https://openalex.org/W2081626616","https://openalex.org/W2082249109","https://openalex.org/W2082618741","https://openalex.org/W2083891382","https://openalex.org/W2084284910","https://openalex.org/W2084354056","https://openalex.org/W2084355781","https://openalex.org/W2084714153","https://openalex.org/W2085122076","https://openalex.org/W2086004607","https://openalex.org/W2086419987","https://openalex.org/W2087416436","https://openalex.org/W2087423729","https://openalex.org/W2087736278","https://openalex.org/W2088258820","https://openalex.org/W2088362013","https://openalex.org/W2088493593","https://openalex.org/W2088746151","https://openalex.org/W2088788596","https://openalex.org/W2088840314","https://openalex.org/W2089198803","https://openalex.org/W2089674731","https://openalex.org/W2089701069","https://openalex.org/W2090381977","https://openalex.org/W2090458882","https://openalex.org/W2090498230","https://openalex.org/W2091012005","https://openalex.org/W2091720736","https://openalex.org/W2093043725","https://openalex.org/W2093106975","https://openalex.org/W2093352510","https://openalex.org/W2093412414","https://openalex.org/W2093575507","https://openalex.org/W2093611886","https://openalex.org/W2093635022","https://openalex.org/W2093693943","https://openalex.org/W2094474932","https://openalex.org/W2094716188","https://openalex.org/W2095547757","https://openalex.org/W2096030919","https://openalex.org/W2096330567","https://openalex.org/W2096482886","https://openalex.org/W2096790092","https://openalex.org/W2097433834","https://openalex.org/W2097477483","https://openalex.org/W2097972613","https://openalex.org/W2099141302","https://openalex.org/W2099411992","https://openalex.org/W2100042702","https://openalex.org/W2100123567","https://openalex.org/W2100347985","https://openalex.org/W2100772840","https://openalex.org/W2101060023","https://openalex.org/W2101748704","https://openalex.org/W2101947529","https://openalex.org/W2102013643","https://openalex.org/W2103097492","https://openalex.org/W2103255214","https://openalex.org/W2103553111","https://openalex.org/W2104085655","https://openalex.org/W2104164035","https://openalex.org/W2104873390","https://openalex.org/W2105122728","https://openalex.org/W2105548401","https://openalex.org/W2106314483","https://openalex.org/W2108394487","https://openalex.org/W2109624357","https://openalex.org/W2110420807","https://openalex.org/W2111374555","https://openalex.org/W2112181653","https://openalex.org/W2112822581","https://openalex.org/W2112826148","https://openalex.org/W2113107925","https://openalex.org/W2113839963","https://openalex.org/W2114079476","https://openalex.org/W2114279859","https://openalex.org/W2114994968","https://openalex.org/W2115056738","https://openalex.org/W2115118763","https://openalex.org/W2115205812","https://openalex.org/W2115264344","https://openalex.org/W2115338196","https://openalex.org/W2115583464","https://openalex.org/W2116484687","https://openalex.org/W2116988757","https://openalex.org/W2117576623","https://openalex.org/W2117687785","https://openalex.org/W2117787345","https://openalex.org/W2119003997","https://openalex.org/W2119480459","https://openalex.org/W2120519926","https://openalex.org/W2120736516","https://openalex.org/W2122483069","https://openalex.org/W2122711892","https://openalex.org/W2123461383","https://openalex.org/W2123738327","https://openalex.org/W2123823922","https://openalex.org/W2124268946","https://openalex.org/W2124347712","https://openalex.org/W2125546678","https://openalex.org/W2127639686","https://openalex.org/W2127848114","https://openalex.org/W2127906377","https://openalex.org/W2128913090","https://openalex.org/W2129181401","https://openalex.org/W2130537821","https://openalex.org/W2131632095","https://openalex.org/W2134297336","https://openalex.org/W2134741050","https://openalex.org/W2134765536","https://openalex.org/W2135364357","https://openalex.org/W2135664183","https://openalex.org/W2136012004","https://openalex.org/W2136439668","https://openalex.org/W2137012634","https://openalex.org/W2137230586","https://openalex.org/W2137368432","https://openalex.org/W2137681991","https://openalex.org/W2137873654","https://openalex.org/W2138485536","https://openalex.org/W2138884788","https://openalex.org/W2138902434","https://openalex.org/W2139575177","https://openalex.org/W2139631964","https://openalex.org/W2140675537","https://openalex.org/W2141400607","https://openalex.org/W2141636174","https://openalex.org/W2142102457","https://openalex.org/W2142853998","https://openalex.org/W2143310289","https://openalex.org/W2143681653","https://openalex.org/W2144414931","https://openalex.org/W2144643842","https://openalex.org/W2146061835","https://openalex.org/W2147098723","https://openalex.org/W2148052797","https://openalex.org/W2148457862","https://openalex.org/W2148535109","https://openalex.org/W2149250090","https://openalex.org/W2149352351","https://openalex.org/W2150701587","https://openalex.org/W2151283331","https://openalex.org/W2152126682","https://openalex.org/W2152364824","https://openalex.org/W2153335144","https://openalex.org/W2153613497","https://openalex.org/W2154993634","https://openalex.org/W2155884826","https://openalex.org/W2156746491","https://openalex.org/W2157482683","https://openalex.org/W2158550197","https://openalex.org/W2158752186","https://openalex.org/W2161017525","https://openalex.org/W2162076197","https://openalex.org/W2162166621","https://openalex.org/W2162723667","https://openalex.org/W2163312598","https://openalex.org/W2163487275","https://openalex.org/W2163568031","https://openalex.org/W2165092386","https://openalex.org/W2165101346","https://openalex.org/W2165594846","https://openalex.org/W2165679784","https://openalex.org/W2166780324","https://openalex.org/W2166781237","https://openalex.org/W2167813790","https://openalex.org/W2167871776","https://openalex.org/W2168073523","https://openalex.org/W2168646690","https://openalex.org/W2169241566","https://openalex.org/W2169753949","https://openalex.org/W2170951382","https://openalex.org/W2177855681","https://openalex.org/W2188271172","https://openalex.org/W2246583043","https://openalex.org/W2261081340","https://openalex.org/W2312778470","https://openalex.org/W2323859250","https://openalex.org/W2324194497","https://openalex.org/W2331268788","https://openalex.org/W2337869677","https://openalex.org/W2346945285","https://openalex.org/W2415112129","https://openalex.org/W2419640859","https://openalex.org/W2424788494","https://openalex.org/W2735705544","https://openalex.org/W4294309387","https://openalex.org/W4320578718"],"related_works":["https://openalex.org/W2096790092","https://openalex.org/W2069309234","https://openalex.org/W2168459313","https://openalex.org/W2026430918","https://openalex.org/W2344044967","https://openalex.org/W2115168263","https://openalex.org/W2413308048","https://openalex.org/W2341023075","https://openalex.org/W1600883564","https://openalex.org/W4384033965"],"abstract_inverted_index":{"Despite":[0],"antiretroviral":[1],"therapy":[2],"(ART),":[3],"HIV":[4,66,77,93,110,126,137,156,166,221,248],"infection":[5,78,138,167,222],"promotes":[6],"cognitive":[7],"dysfunction":[8],"and":[9,14,23,33,39,87,112,142,155,181,212,227],"neurodegeneration":[10],"through":[11],"persistent":[12],"inflammation":[13],"neurotoxin":[15,119,210,228],"release":[16,71,120],"from":[17,121],"infected":[18,67,94],"and/or":[19],"activated":[20],"macrophages.":[21],"Inflammation":[22],"immune":[24],"activation":[25],"within":[26],"both":[27],"the":[28,84,88,106,133,147,169,191,204,232,244],"central":[29],"nervous":[30],"system":[31,180],"(CNS)":[32],"periphery":[34],"correlate":[35],"with":[36,124],"disease":[37,157],"progression":[38],"morbidity":[40],"in":[41,58,64,99,159,171,176,178,184,206,231],"ART-treated":[42,160],"individuals.":[43,161],"Accordingly,":[44],"drugs":[45],"targeting":[46],"these":[47],"pathological":[48,215],"processes":[49,201,216],"are":[50],"needed":[51],"for":[52,243],"effective,":[53],"adjunctive":[54,153,241],"therapy.":[55],"Using":[56],"our":[57,177,236],"vitro":[59,179],"model":[60],"of":[61,105,114,132,146,190,247],"HIV-mediated":[62],"neurotoxicity,":[63],"which":[65,193],"monocyte-derived":[68],"macrophages":[69,95,207],"(HIV/MDM)":[70],"excitatory":[72],"neurotoxins,":[73],"we":[74,163],"demonstrate":[75],"that":[76,130,143,165,202],"dysregulates":[79],"adaptive":[80,224],"stress":[81,225],"responses,":[82],"including":[83],"antioxidant":[85,107,134,148],"response":[86,91,108,135,149],"unfolded":[89],"protein":[90],"(UPR).":[92],"have":[96],"dramatic":[97],"reductions":[98],"heme":[100],"oxygenase-1":[101],"(HO-1)":[102],"levels.":[103],"Activation":[104],"attenuates":[109,194],"replication":[111],"restoration":[113],"HO-1":[115],"expression,":[116],"specifically,":[117],"reduces":[118],"HIV/MDM,":[122],"even":[123],"robust":[125],"replication.":[127],"We":[128],"propose":[129],"dysregulation":[131],"during":[136],"drives":[139],"macrophage-mediated":[140,198],"neurotoxicity":[141],"pharmacological":[144],"inducers":[145],"could":[150],"serve":[151],"as":[152],"neuroprotectants":[154],"modifiers":[158],"Additionally,":[162],"found":[164],"activates":[168],"UPR":[170,205],"macrophages,":[172],"increasing":[173],"phosphorylated":[174],"eIF2\u03b1":[175],"macrophagic":[182],"BiP":[183],"HAND":[185],"frontal":[186],"cortex.":[187],"Pharmacological":[188],"induction":[189],"UPR,":[192],"viral":[195],"replication,":[196],"enhances":[197],"neurotoxicity.":[199],"Therefore,":[200],"induce":[203],"may":[208],"enhance":[209],"production":[211,229],"contribute":[213],"to":[214,238],"underlying":[217],"HAND.":[218],"Understanding":[219],"how":[220],"affects":[223],"responses":[226],"pathways":[230],"macrophage":[233],"will":[234],"improve":[235],"ability":[237],"develop":[239],"effective":[240],"therapies":[242],"neurological":[245],"consequences":[246],"infection.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}