{"id":"https://openalex.org/W156985409","doi":"https://doi.org/10.1080/00039896.1975.10666786","title":"Tritiated Methylmercury in the Brain of Squirrel Monkeys","display_name":"Tritiated Methylmercury in the Brain of Squirrel Monkeys","publication_year":1975,"publication_date":"1975-12-01","ids":{"openalex":"https://openalex.org/W156985409","doi":"https://doi.org/10.1080/00039896.1975.10666786","mag":"156985409","pmid":"https://pubmed.ncbi.nlm.nih.gov/812429"},"language":"en","primary_location":{"id":"doi:10.1080/00039896.1975.10666786","doi":"https://doi.org/10.1080/00039896.1975.10666786","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00039896.1975.10666786","pdf_url":null,"source":{"id":"https://openalex.org/S13479866","display_name":"Archives of Environmental Health An International Journal","issn_l":"0003-9896","issn":["0003-9896","2331-4303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320374","host_organization_name":"Heldref Publications","host_organization_lineage":["https://openalex.org/P4310320374","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Heldref Publications","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Environmental Health: An International Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110336499","display_name":"Maths Berlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Maths Berlin","raw_affiliation_strings":["Department of Environmental Health, University of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health, University of Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073985767","display_name":"Christian Blomstrand","orcid":"https://orcid.org/0000-0003-3503-860X","observed_orcids":["https://orcid.org/0000-0003-3503-860X"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christian Blomstrand","raw_affiliation_strings":["Institute of Neurobiology, University of Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113605479","display_name":"C. A. Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Crawford A. Grant","raw_affiliation_strings":["The Department of Pathology, Karolinska Hospital, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Pathology, Karolinska Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072899776","display_name":"Anders Hamberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Hamberger","raw_affiliation_strings":["Institute of Neurobiology, University of Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology, University of Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063015736","display_name":"Jan Trofast","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Trofast","raw_affiliation_strings":["Chemical Center, University of Lund, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Center, University of Lund, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.02,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.82822478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"30","issue":"12","first_page":"591","last_page":"597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10819","display_name":"Mercury impact and mitigation studies","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylmercury","display_name":"methylmercury","score":0.9520000219345093},{"id":"https://openalex.org/keywords/squirrel-monkey","display_name":"squirrel monkey","score":0.6850000023841858},{"id":"https://openalex.org/keywords/brain-distribution","display_name":"brain distribution","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.781000018119812},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.609000027179718},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neuropil","display_name":"neuropil","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cortex","display_name":"cortex","score":0.5260000228881836},{"id":"https://openalex.org/keywords/subcellular-fractionation","display_name":"subcellular fractionation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/microautoradiography","display_name":"microautoradiography","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2780373914","wikidata":"https://www.wikidata.org/wiki/Q414075","display_name":"Methylmercury","level":3,"score":0.8420562148094177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6900138854980469},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.547842800617218},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.5432002544403076},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.5130304098129272},{"id":"https://openalex.org/C3017894987","wikidata":"https://www.wikidata.org/wiki/Q1087035","display_name":"Stomach tube","level":2,"score":0.5116227269172668},{"id":"https://openalex.org/C2780000105","wikidata":"https://www.wikidata.org/wiki/Q424236","display_name":"Tritiated water","level":3,"score":0.4456683099269867},{"id":"https://openalex.org/C62538594","wikidata":"https://www.wikidata.org/wiki/Q54389","display_name":"Tritium","level":2,"score":0.41554445028305054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38277190923690796},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.27761662006378174},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21344664692878723},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.202184796333313},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19411900639533997},{"id":"https://openalex.org/C71572567","wikidata":"https://www.wikidata.org/wiki/Q864231","display_name":"Bioaccumulation","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008630","descriptor_name":"Mercury Poisoning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008630","descriptor_name":"Mercury Poisoning","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008767","descriptor_name":"Methylmercury Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008767","descriptor_name":"Methylmercury Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012453","descriptor_name":"Saimiri","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/00039896.1975.10666786","doi":"https://doi.org/10.1080/00039896.1975.10666786","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00039896.1975.10666786","pdf_url":null,"source":{"id":"https://openalex.org/S13479866","display_name":"Archives of Environmental Health An International Journal","issn_l":"0003-9896","issn":["0003-9896","2331-4303"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320374","host_organization_name":"Heldref Publications","host_organization_lineage":["https://openalex.org/P4310320374","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Heldref Publications","Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Environmental Health: An International Journal","raw_type":"journal-article"},{"id":"pmid:812429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/812429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of environmental health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W74306928","https://openalex.org/W1479673206","https://openalex.org/W1546300015","https://openalex.org/W1775749144","https://openalex.org/W1971739206","https://openalex.org/W1978125168","https://openalex.org/W1983226630","https://openalex.org/W1991371630","https://openalex.org/W1998159930","https://openalex.org/W2003655092","https://openalex.org/W2019887385","https://openalex.org/W2029281382","https://openalex.org/W2030823419","https://openalex.org/W2051308399","https://openalex.org/W2082827598"],"related_works":["https://openalex.org/W2069147340","https://openalex.org/W2087343884","https://openalex.org/W2056023787","https://openalex.org/W2085465359","https://openalex.org/W2012827184","https://openalex.org/W2031298547","https://openalex.org/W2035691201","https://openalex.org/W2040844725","https://openalex.org/W2417558393","https://openalex.org/W418571854"],"abstract_inverted_index":{"Tritiated":[0,26],"methylmercuty":[1],"hydroxide":[2],"(MeHgOH)":[3],"with":[4,21],"a":[5,14,22,85],"specific":[6],"activity":[7],"of":[8,24,39,54,68,77,96,126],"306":[9],"curies/mol":[10],"was":[11,28,60,89,107,144],"synthesized":[12],"by":[13,33,63,66],"Grignard":[15],"reagent":[16],"from":[17],"tritiated":[18],"methyl":[19],"iodide":[20],"yield":[23],"70%.":[25],"MeHg":[27,79,127],"given":[29],"to":[30,138],"squirrel":[31],"monkeys":[32],"stomach":[34],"tube":[35],"in":[36,57,80,84,93,109,114,134,147,152],"weekly":[37],"doses":[38,101],"0.8":[40],"mg/kg.":[41],"The":[42,52],"animals":[43],"were":[44],"killed":[45],"after":[46],"one":[47],"dose":[48,120,140],"or":[49],"six":[50],"doses.":[51],"distribution":[53],"the":[55,58,78,81,94,97,110,115,123,135],"substance":[56],"brain":[59,69,82],"then":[61],"studied":[62],"microautoradiography":[64],"and":[65,73],"fractionation":[67],"tissue":[70],"into":[71],"cellular":[72],"subcellular":[74],"fractions.":[75],"Part":[76],"is":[83],"water-soluble":[86],"form.":[87],"Methylmercuty":[88],"found":[90,108],"autoradiographically":[91,146],"mainly":[92],"neuropile":[95],"cortex.":[98],"At":[99,118],"subtoxic":[100],"(one":[102,141],"dose),":[103],"more":[104],"protein-bound":[105,124],"radioactivity":[106],"glial":[111],"fraction":[112,125],"than":[113,132],"neuronal":[116],"fraction.":[117],"toxic":[119],"(six":[121],"doses),":[122],"increased":[128],"significantly":[129],"(P":[130],"less":[131],".02)":[133],"neurons":[136,149],"relative":[137],"nontoxic":[139],"dose).":[142],"Methylmercury":[143],"demonstrated":[145],"damaged":[148],"but":[150],"not":[151],"undamaged":[153],"neurons.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}