{"id":"https://openalex.org/W1569806478","doi":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","title":"Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification","display_name":"Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W1569806478","doi":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","mag":"1569806478","pmid":"https://pubmed.ncbi.nlm.nih.gov/2335817","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/249463"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.64.6.2819-2824.1990","doi":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/6/2819.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/64/6/2819.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108188026","display_name":"Jesse W. Summers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Summers","raw_affiliation_strings":["Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043795275","display_name":"P M Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Smith","raw_affiliation_strings":["Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034561133","display_name":"Arthur L. Horwich","orcid":"https://orcid.org/0000-0001-9561-8839","observed_orcids":["https://orcid.org/0000-0001-9561-8839"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A L Horwich","raw_affiliation_strings":["Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of New Mexico, School of Medicine, Albuquerque 87131","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I169521973"],"apc_list":null,"apc_paid":null,"fwci":9.3334,"has_fulltext":false,"cited_by_count":326,"citation_normalized_percentile":{"value":0.98314476,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"64","issue":"6","first_page":"2819","last_page":"2824"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.7860000133514404},{"id":"https://openalex.org/keywords/duck-hepatitis-b-virus","display_name":"duck hepatitis B virus","score":0.8140000104904175},{"id":"https://openalex.org/keywords/viral-envelope-proteins","display_name":"viral envelope proteins","score":0.8700000047683716},{"id":"https://openalex.org/keywords/covalently-closed-circular-dna","display_name":"covalently closed circular DNA","score":0.9929999709129333},{"id":"https://openalex.org/keywords/viral-dna-replication","display_name":"viral DNA replication","score":0.7239999771118164},{"id":"https://openalex.org/keywords/persistent-infection","display_name":"persistent infection","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C189490182","wikidata":"https://www.wikidata.org/wiki/Q1052153","display_name":"cccDNA","level":5,"score":0.9763111472129822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8933246731758118},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.594615638256073},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5828103423118591},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5705430507659912},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.5403684973716736},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5120849609375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47058334946632385},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.4520844519138336},{"id":"https://openalex.org/C42625924","wikidata":"https://www.wikidata.org/wiki/Q2819111","display_name":"Circular DNA","level":4,"score":0.45135247707366943},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.45057186484336853},{"id":"https://openalex.org/C2777666129","wikidata":"https://www.wikidata.org/wiki/Q3503198","display_name":"Duck hepatitis B virus","level":5,"score":0.4165256917476654},{"id":"https://openalex.org/C2780617729","wikidata":"https://www.wikidata.org/wiki/Q1356878","display_name":"Hepadnaviridae","level":4,"score":0.19641342759132385},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10654404759407043},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10326161980628967},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.06552043557167053},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004372","descriptor_name":"Ducks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014759","descriptor_name":"Viral Envelope Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015613","descriptor_name":"Hepadnaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.64.6.2819-2824.1990","doi":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/6/2819.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:249463","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/249463","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:2335817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2335817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.64.6.2819-2824.1990","doi":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.64.6.2819-2824.1990","pdf_url":"https://jvi.asm.org/content/jvi/64/6/2819.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1400372781","display_name":null,"funder_award_id":"CA-42542","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1481019489","display_name":"PERSISTENT INFECTIONS BY HEPADNAVIRUSES","funder_award_id":"5r35ca042542-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4996811721","display_name":"DIGESTIVE DISEASES RESEARCH CORE CENTER","funder_award_id":"5p30am034989-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1569806478.pdf"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1487733209","https://openalex.org/W1574463005","https://openalex.org/W1808899511","https://openalex.org/W1845079004","https://openalex.org/W1931669582","https://openalex.org/W1958302458","https://openalex.org/W1971403557","https://openalex.org/W1989940717","https://openalex.org/W2007902841","https://openalex.org/W2048797939","https://openalex.org/W2056399135","https://openalex.org/W2104286731","https://openalex.org/W2129923672"],"related_works":["https://openalex.org/W2002563557","https://openalex.org/W1600467152","https://openalex.org/W7095514507","https://openalex.org/W2210436847","https://openalex.org/W1893522896","https://openalex.org/W2007902841","https://openalex.org/W2108226840","https://openalex.org/W1514441235","https://openalex.org/W1952314774","https://openalex.org/W2911063796"],"abstract_inverted_index":{"Primary":[0],"duck":[1,8],"hepatocytes":[2],"were":[3],"infected":[4,23,39,70],"with":[5,66],"a":[6,53,81,89],"mutant":[7,26],"hepatitis":[9],"B":[10],"virus":[11,77],"defective":[12],"in":[13,84,113],"envelope":[14,98],"protein":[15],"but":[16],"competent":[17],"for":[18,102,108],"viral":[19,31,97],"DNA":[20,35],"synthesis.":[21],"Cells":[22],"by":[24,40,68,71],"this":[25],"accumulated":[27],"higher":[28],"levels":[29,47],"of":[30,45,48,55,88,104,110],"covalently":[32],"closed,":[33],"circular":[34],"(cccDNA)":[36],"than":[37],"those":[38],"wild-type":[41],"virus.":[42],"The":[43,75],"accumulation":[44],"high":[46],"cccDNA":[49,63,105],"was":[50],"due":[51],"to":[52,59,79],"failure":[54],"the":[56,72],"mutant-infected":[57],"cells":[58,69],"suppress":[60],"de":[61],"novo":[62],"synthesis":[64,106],"compared":[65],"suppression":[67],"wild":[73],"type.":[74],"envelope-defective":[76],"failed":[78],"establish":[80],"persistent":[82,111],"infection":[83,112],"vitro,":[85],"possibly":[86],"because":[87],"virus-mediated":[90],"cell":[91],"death.":[92],"Therefore,":[93],"one":[94],"or":[95],"both":[96],"proteins":[99],"are":[100],"required":[101],"regulation":[103],"and":[107],"maintenance":[109],"vitro.":[114]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
