{"id":"https://openalex.org/W1569322902","doi":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","title":"GFR \u03b1\u20101 receptor expression in the aging nigrostriatal and mesoaccumbens pathways","display_name":"GFR \u03b1\u20101 receptor expression in the aging nigrostriatal and mesoaccumbens pathways","publication_year":2010,"publication_date":"2010-08-24","ids":{"openalex":"https://openalex.org/W1569322902","doi":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","mag":"1569322902","pmid":"https://pubmed.ncbi.nlm.nih.gov/20731758"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.2010.06963.x","doi":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087301022","display_name":"Brandon Scott Pruett","orcid":"https://orcid.org/0000-0001-9760-1635","observed_orcids":["https://orcid.org/0000-0001-9760-1635"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brandon S. Pruett","raw_affiliation_strings":["Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. bpruet@lsuhsc.edu","Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. bpruet@lsuhsc.edu","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114377100","display_name":"Michael F. Salvatore","orcid":"https://orcid.org/0000-0003-0217-5093","observed_orcids":["https://orcid.org/0000-0003-0217-5093"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael F. Salvatore","raw_affiliation_strings":["Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA","Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Toxicology, & Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA","institution_ids":["https://openalex.org/I81020160"]},{"raw_affiliation_string":"Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA","institution_ids":["https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087301022"],"corresponding_institution_ids":["https://openalex.org/I81020160"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.9056,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.84871569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"115","issue":"3","first_page":"707","last_page":"715"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7020999789237976,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.1598999947309494,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.972000002861023},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.8489999771118164},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9470000267028809},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.753000020980835},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bradykinesia","display_name":"bradykinesia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7781959772109985},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7647887468338013},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7305407524108887},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7101607322692871},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.6625875234603882},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.6421831250190735},{"id":"https://openalex.org/C2776355744","wikidata":"https://www.wikidata.org/wiki/Q4318555","display_name":"Nigrostriatal pathway","level":5,"score":0.5570049285888672},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5386355519294739},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5313193202018738},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.49686673283576965},{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.4764416813850403},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45594322681427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44369763135910034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34420016407966614},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.29294681549072266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24790650606155396},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050506","descriptor_name":"Mutant Chimeric Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050506","descriptor_name":"Mutant Chimeric Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051097","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor Receptors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051097","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.2010.06963.x","doi":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.2010.06963.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:20731758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20731758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306228","display_name":"American Federation for Aging Research","ror":"https://ror.org/000r61a05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1583740060","https://openalex.org/W1588182583","https://openalex.org/W1589264845","https://openalex.org/W1711374700","https://openalex.org/W1965451855","https://openalex.org/W1967070205","https://openalex.org/W1971258758","https://openalex.org/W1971282703","https://openalex.org/W1978306829","https://openalex.org/W1981229547","https://openalex.org/W1996001296","https://openalex.org/W1997129506","https://openalex.org/W1997769836","https://openalex.org/W1999363641","https://openalex.org/W2000712109","https://openalex.org/W2009259931","https://openalex.org/W2011351971","https://openalex.org/W2011590971","https://openalex.org/W2014078232","https://openalex.org/W2015167814","https://openalex.org/W2018798878","https://openalex.org/W2020949259","https://openalex.org/W2021145564","https://openalex.org/W2023638441","https://openalex.org/W2028093783","https://openalex.org/W2029098021","https://openalex.org/W2032554568","https://openalex.org/W2040317782","https://openalex.org/W2055078063","https://openalex.org/W2055206384","https://openalex.org/W2081127925","https://openalex.org/W2087772784","https://openalex.org/W2093575561","https://openalex.org/W2103899142","https://openalex.org/W2111031574","https://openalex.org/W2118428015","https://openalex.org/W2124386542","https://openalex.org/W2133470805","https://openalex.org/W2144258071","https://openalex.org/W2151738397","https://openalex.org/W2153669485","https://openalex.org/W2157405146","https://openalex.org/W2164920322","https://openalex.org/W2165583726","https://openalex.org/W2170416930","https://openalex.org/W2325514588","https://openalex.org/W2772934464","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2051000399","https://openalex.org/W2164920322","https://openalex.org/W1489006546","https://openalex.org/W2974490762","https://openalex.org/W2023130781","https://openalex.org/W2111031574","https://openalex.org/W2059415739","https://openalex.org/W2095953376","https://openalex.org/W2035475884","https://openalex.org/W4413981051"],"abstract_inverted_index":{"We":[0],"recently":[1],"reported":[2],"that":[3,33,169,218],"age-related":[4,183],"bradykinesia":[5,194],"was":[6],"associated":[7],"with":[8,136,155],"reduced":[9,38,120],"dopamine":[10],"(DA)":[11],"tissue":[12,215],"content,":[13],"ser31":[14],"tyrosine":[15],"hydroxylase":[16],"(TH)":[17],"phosphorylation,":[18],"and":[19,69,74,85,95,122,142,162,197,210,213],"total":[20,123],"TH":[21,137],"levels":[22,49,108,130],"in":[23,50,63,126,139,147,180,185,189,195,200],"substantia":[24],"nigra":[25],"(SN)":[26],"only.":[27],"In":[28],"this":[29],"study,":[30],"we":[31,167],"propose":[32],"these":[34,160,226],"decreases":[35,184],"result":[36],"from":[37,72,164],"glial":[39,219],"cell":[40,220],"line-derived":[41,221],"neurotrophic":[42,222],"factor":[43],"family":[44],"receptor":[45,61,173],"\u03b1-1":[46,60,113,125,133,152,172,188,205],"(GFR":[47],"\u03b1-1)":[48],"the":[51,110,115,127,148,165,203,208],"aged":[52],"(30-month-old)":[53],"cohort":[54],"of":[55,58,98,109,131,202],"rats.":[56],"Analysis":[57],"GFR":[59,99,112,124,132,151,171,187,204],"protein":[62,138],"SN,":[64,140],"striatum,":[65,141],"ventral":[66],"tegmental":[67],"area,":[68],"nucleus":[70,143],"accumbens":[71],"12-":[73],"30-month-old":[75],"Brown-Norway/Fischer":[76],"344":[77],"F(1)":[78],"hybrid":[79],"rats":[80],"revealed":[81],"immunoreactivity":[82],"at":[83],"\u223c48":[84],"52":[86],"kDa,":[87],"bands":[88],"previously":[89],"characterized":[90],"to":[91,93,193],"correspond":[92],"soluble":[94,111,121,186],"glycosyl-phosphatidylinositol-linked":[96],"forms":[97,206],"\u03b1-1,":[100],"respectively.":[101],"The":[102,129],"nigrostriatal":[103,209],"pathway":[104],"had":[105],"significantly":[106,119,134,153],"greater":[107],"than":[114],"mesoaccumbens":[116,211],"pathway.":[117],"Aging":[118],"SN.":[128],"correlated":[135],"accumbens,":[144],"but":[145],"only":[146],"SN":[149,190],"did":[150],"correlate":[154],"DA":[156,178,227],"levels.":[157],"Based":[158],"on":[159],"observations":[161],"findings":[163],"literature,":[166],"speculate":[168],"(i)":[170],"expression":[174,201],"may":[175,191,216],"regulate":[176],"nigral":[177],"bioavailability":[179],"vivo,":[181],"(ii)":[182],"contribute":[192],"aging,":[196],"(iii)":[198],"differences":[199],"between":[207,225],"pathways":[212],"allied":[214],"indicate":[217],"factor-signaling":[223],"differs":[224],"pathways.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}