{"id":"https://openalex.org/W156904301","doi":"https://doi.org/10.1182/blood.v62.5.1070.1070","title":"The mechanism of action of the antiinflammatory agents dexamethasone and Auranofin in human polymorphonuclear leukocytes","display_name":"The mechanism of action of the antiinflammatory agents dexamethasone and Auranofin in human polymorphonuclear leukocytes","publication_year":1983,"publication_date":"1983-11-01","ids":{"openalex":"https://openalex.org/W156904301","doi":"https://doi.org/10.1182/blood.v62.5.1070.1070","mag":"156904301","pmid":"https://pubmed.ncbi.nlm.nih.gov/6313097"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v62.5.1070.1070","doi":"https://doi.org/10.1182/blood.v62.5.1070.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v62.5.1070.1070","pdf_url":"https://ashpublications.org/blood/article-pdf/62/5/1070/589190/1070.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/62/5/1070/589190/1070.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077729374","display_name":"Thomas D. Coates","orcid":"https://orcid.org/0000-0001-9878-6029","observed_orcids":["https://orcid.org/0000-0001-9878-6029"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"TD Coates","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084526103","display_name":"B Wolach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Wolach","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109197367","display_name":"Diana Y. Tzeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DY Tzeng","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020609932","display_name":"Coleen Higgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Higgins","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111733578","display_name":"Robert L. Baehner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RL Baehner","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112178228","display_name":"LA Boxer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LA Boxer","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology, University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University Medical Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.3852,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.80587802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"62","issue":"5","first_page":"1070","last_page":"1077"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/auranofin","display_name":"auranofin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neutrophil-degranulation","display_name":"neutrophil degranulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.7239999771118164},{"id":"https://openalex.org/keywords/fmlp-receptor","display_name":"fMLP receptor","score":0.6579999923706055},{"id":"https://openalex.org/keywords/chlortetracycline","display_name":"chlortetracycline","score":0.800000011920929},{"id":"https://openalex.org/keywords/electrophoretic-mobility","display_name":"electrophoretic mobility","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cell-surface-charge","display_name":"cell surface charge","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2776243873","wikidata":"https://www.wikidata.org/wiki/Q421230","display_name":"Auranofin","level":3,"score":0.9874093532562256},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6963436007499695},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.6299508810043335},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.605973482131958},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5582317113876343},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5412371754646301},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.4549242854118347},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43121644854545593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34308376908302307},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32271814346313477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.246323823928833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23029181361198425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2264632284641266},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12091642618179321},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001310","descriptor_name":"Auranofin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002751","descriptor_name":"Chlortetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006046","descriptor_name":"Gold","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006051","descriptor_name":"Aurothioglucose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006051","descriptor_name":"Aurothioglucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v62.5.1070.1070","doi":"https://doi.org/10.1182/blood.v62.5.1070.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v62.5.1070.1070","pdf_url":"https://ashpublications.org/blood/article-pdf/62/5/1070/589190/1070.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v62.5.1070.bloodjournal6251070","doi":"https://doi.org/10.1182/blood.v62.5.1070.bloodjournal6251070","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v62.5.1070.bloodjournal6251070","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:6313097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6313097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v62.5.1070.1070","doi":"https://doi.org/10.1182/blood.v62.5.1070.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v62.5.1070.1070","pdf_url":"https://ashpublications.org/blood/article-pdf/62/5/1070/589190/1070.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W156904301.pdf","grobid_xml":"https://content.openalex.org/works/W156904301.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W7149148","https://openalex.org/W18146110","https://openalex.org/W153397760","https://openalex.org/W1482960314","https://openalex.org/W1504003021","https://openalex.org/W1510733163","https://openalex.org/W1514051340","https://openalex.org/W1518315072","https://openalex.org/W1561237132","https://openalex.org/W1804324355","https://openalex.org/W1987350788","https://openalex.org/W1987884928","https://openalex.org/W1990308369","https://openalex.org/W1997080236","https://openalex.org/W1999056723","https://openalex.org/W2008566974","https://openalex.org/W2026144498","https://openalex.org/W2027472039","https://openalex.org/W2028244101","https://openalex.org/W2031871624","https://openalex.org/W2035766093","https://openalex.org/W2057700297","https://openalex.org/W2065172995","https://openalex.org/W2068371198","https://openalex.org/W2081412243","https://openalex.org/W2089582175","https://openalex.org/W2090326611","https://openalex.org/W2091273324","https://openalex.org/W2119278977","https://openalex.org/W2124428466","https://openalex.org/W2141881478","https://openalex.org/W2150781890","https://openalex.org/W2154967631","https://openalex.org/W2166083878","https://openalex.org/W2307752279","https://openalex.org/W2315608135","https://openalex.org/W2333946890","https://openalex.org/W2340199679","https://openalex.org/W2400849189","https://openalex.org/W2411635405","https://openalex.org/W2413498067","https://openalex.org/W2417965259","https://openalex.org/W2468119228","https://openalex.org/W3154367256"],"related_works":["https://openalex.org/W2093763580","https://openalex.org/W2155201334","https://openalex.org/W1899058291","https://openalex.org/W2307752279","https://openalex.org/W2024185063","https://openalex.org/W2065231862","https://openalex.org/W169425564","https://openalex.org/W1973013701","https://openalex.org/W2144609345","https://openalex.org/W1985156522"],"abstract_inverted_index":{"Human":[0],"polymorphonuclear":[1],"neutrophils":[2],"(PMN)":[3],"were":[4,28,36],"treated":[5,14],"with":[6,15,30,153],"the":[7,40,53,70,73,79,90,103,120],"antiinflammatory":[8],"agents":[9,35,66,127],"dexamethasone":[10,16],"or":[11,24],"Auranofin.":[12],"PMN":[13],"in":[17,48,55,69],"a":[18,49],"dose":[19],"range":[20],"of":[21,43,72,81,102,115,122],"0.25-1":[22],"microM":[23],"Auranofin,":[25],"5-15":[26],"mM,":[27],"stimulated":[29],"10(-7)M":[31],"N-formyl-methionyl-leucyl-phenylalanine":[32],"(FMLP).":[33],"These":[34],"shown":[37,109,137],"to":[38,88,110,130,138],"inhibit":[39,89],"functional":[41],"responses":[42],"degranulation":[44],"and":[45],"superoxide":[46],"production":[47],"dose-dependent":[50],"manner.":[51],"Similarly,":[52],"change":[54,68],"electrophoretic":[56],"mobility,":[57],"reflecting":[58],"cell":[59],"surface":[60],"charge,":[61],"was":[62,83,107],"blocked.":[63],"While":[64],"both":[65],"inhibited":[67,99],"fluorescence":[71],"calcium":[74,144],"chelate":[75],"probe":[76],"chlorotetracycline":[77],"(CTC),":[78],"pattern":[80],"inhibition":[82],"significantly":[84,111],"different.":[85],"Dexamethasone":[86,135],"appeared":[87],"CTC":[91,104],"response":[92],"during":[93],"its":[94],"latter":[95],"phases,":[96],"while":[97,150],"Auranofin":[98,106,151],"all":[100],"aspects":[101],"response.":[105],"additionally":[108],"decrease":[112],"specific":[113],"binding":[114],"FMLP,":[116],"as":[117,119,146],"well":[118],"number":[121],"FMLP":[123],"receptors.":[124],"The":[125],"two":[126],"thus":[128],"appear":[129],"act":[131],"by":[132,148],"different":[133],"mechanisms.":[134],"is":[136],"have":[139],"an":[140],"effect":[141],"on":[142],"membrane-bound":[143],"release":[145],"measured":[147],"CTC,":[149],"interferes":[152],"receptor":[154],"binding.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}