{"id":"https://openalex.org/W1568967795","doi":null,"title":"Control of the master virulence regulatory gene atxA in Bacillus anthracis","display_name":"Control of the master virulence regulatory gene atxA in Bacillus anthracis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1568967795","mag":"1568967795"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1276","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/259","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1276&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1276&context=utgsbs_dissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039342325","display_name":"Jennifer L. Dale","orcid":"https://orcid.org/0000-0001-7575-1958","observed_orcids":["https://orcid.org/0000-0001-7575-1958"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer L. Dale","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7575-1958","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039342325"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-anthracis","display_name":"Bacillus anthracis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/atxa","display_name":"AtxA","score":0.7459999918937683},{"id":"https://openalex.org/keywords/virulence-regulation","display_name":"virulence regulation","score":0.5149999856948853},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/abrb","display_name":"AbrB","score":0.9279999732971191},{"id":"https://openalex.org/keywords/up-element","display_name":"UP element","score":0.5709999799728394},{"id":"https://openalex.org/keywords/anthrax-toxin","display_name":"anthrax toxin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/capsule-biosynthesis","display_name":"capsule biosynthesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/pxo1","display_name":"pXO1","score":0.7879999876022339},{"id":"https://openalex.org/keywords/pxo2","display_name":"pXO2","score":0.878000020980835},{"id":"https://openalex.org/keywords/sporulation","display_name":"sporulation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/virulence-plasmid","display_name":"virulence plasmid","score":0.824999988079071},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2780239966","wikidata":"https://www.wikidata.org/wiki/Q614156","display_name":"Bacillus anthracis","level":3,"score":0.8947634100914001},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7077981233596802},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.51088947057724},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.5001857280731201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4895528256893158},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.4458518624305725},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4334816336631775},{"id":"https://openalex.org/C41810244","wikidata":"https://www.wikidata.org/wiki/Q1935986","display_name":"Anthrax toxin","level":5,"score":0.4268670082092285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3590651750564575},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2470153570175171},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.23781025409698486},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1276","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/259","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1276&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:1568967795","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1276&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1276","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/259","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1276&context=utgsbs_dissertations","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1568967795.pdf","grobid_xml":"https://content.openalex.org/works/W1568967795.grobid-xml"},"referenced_works_count":177,"referenced_works":["https://openalex.org/W18397646","https://openalex.org/W58436318","https://openalex.org/W999207133","https://openalex.org/W1420454241","https://openalex.org/W1480746437","https://openalex.org/W1496264315","https://openalex.org/W1508801011","https://openalex.org/W1515163878","https://openalex.org/W1521268454","https://openalex.org/W1533665911","https://openalex.org/W1536607091","https://openalex.org/W1546783991","https://openalex.org/W1548638618","https://openalex.org/W1559668074","https://openalex.org/W1580404795","https://openalex.org/W1590105680","https://openalex.org/W1601063816","https://openalex.org/W1624615484","https://openalex.org/W1664136833","https://openalex.org/W1674478883","https://openalex.org/W1765888134","https://openalex.org/W1771926894","https://openalex.org/W1840588602","https://openalex.org/W1849620684","https://openalex.org/W1870131243","https://openalex.org/W1888642611","https://openalex.org/W1902591105","https://openalex.org/W1904656084","https://openalex.org/W1932746288","https://openalex.org/W1942644614","https://openalex.org/W1946539893","https://openalex.org/W1947263708","https://openalex.org/W1951398891","https://openalex.org/W1957227160","https://openalex.org/W1957462594","https://openalex.org/W1966849007","https://openalex.org/W1967025437","https://openalex.org/W1967912874","https://openalex.org/W1968670929","https://openalex.org/W1969206674","https://openalex.org/W1974816594","https://openalex.org/W1974917488","https://openalex.org/W1975412992","https://openalex.org/W1979583889","https://openalex.org/W1981563187","https://openalex.org/W1984260496","https://openalex.org/W1988885874","https://openalex.org/W1992108973","https://openalex.org/W1997196594","https://openalex.org/W1998591058","https://openalex.org/W1999980020","https://openalex.org/W2000601745","https://openalex.org/W2004519006","https://openalex.org/W2005585895","https://openalex.org/W2008183439","https://openalex.org/W2010094925","https://openalex.org/W2010273018","https://openalex.org/W2012470011","https://openalex.org/W2012684708","https://openalex.org/W2014917430","https://openalex.org/W2016792086","https://openalex.org/W2019456366","https://openalex.org/W2019763194","https://openalex.org/W2020657021","https://openalex.org/W2022381548","https://openalex.org/W2025771032","https://openalex.org/W2028268916","https://openalex.org/W2028790693","https://openalex.org/W2029344760","https://openalex.org/W2029347323","https://openalex.org/W2030924818","https://openalex.org/W2035699290","https://openalex.org/W2037321950","https://openalex.org/W2038679047","https://openalex.org/W2039401254","https://openalex.org/W2046254945","https://openalex.org/W2046677615","https://openalex.org/W2047005829","https://openalex.org/W2047064510","https://openalex.org/W2047595880","https://openalex.org/W2049236196","https://openalex.org/W2050039810","https://openalex.org/W2052205534","https://openalex.org/W2052543350","https://openalex.org/W2054027422","https://openalex.org/W2055016234","https://openalex.org/W2055422081","https://openalex.org/W2057576561","https://openalex.org/W2058185440","https://openalex.org/W2060010240","https://openalex.org/W2060775017","https://openalex.org/W2065152402","https://openalex.org/W2067729346","https://openalex.org/W2069068356","https://openalex.org/W2079746411","https://openalex.org/W2081933429","https://openalex.org/W2082440258","https://openalex.org/W2083604712","https://openalex.org/W2087232840","https://openalex.org/W2088835913","https://openalex.org/W2091017889","https://openalex.org/W2091643608","https://openalex.org/W2093784289","https://openalex.org/W2095192370","https://openalex.org/W2096324489","https://openalex.org/W2097492854","https://openalex.org/W2097611238","https://openalex.org/W2098299293","https://openalex.org/W2099471869","https://openalex.org/W2100938352","https://openalex.org/W2101047480","https://openalex.org/W2101355256","https://openalex.org/W2102355366","https://openalex.org/W2105077075","https://openalex.org/W2105141333","https://openalex.org/W2106229825","https://openalex.org/W2106387893","https://openalex.org/W2107114762","https://openalex.org/W2108148906","https://openalex.org/W2108486617","https://openalex.org/W2113153814","https://openalex.org/W2113777669","https://openalex.org/W2114126023","https://openalex.org/W2114286698","https://openalex.org/W2115322619","https://openalex.org/W2115738596","https://openalex.org/W2116372830","https://openalex.org/W2117817642","https://openalex.org/W2118080685","https://openalex.org/W2120266240","https://openalex.org/W2121972255","https://openalex.org/W2123284949","https://openalex.org/W2123641345","https://openalex.org/W2124611161","https://openalex.org/W2124919081","https://openalex.org/W2125850446","https://openalex.org/W2127220978","https://openalex.org/W2130641564","https://openalex.org/W2134362529","https://openalex.org/W2136093063","https://openalex.org/W2139899202","https://openalex.org/W2141883257","https://openalex.org/W2142237413","https://openalex.org/W2142719872","https://openalex.org/W2144645983","https://openalex.org/W2145684092","https://openalex.org/W2147334835","https://openalex.org/W2148531602","https://openalex.org/W2148556915","https://openalex.org/W2148922163","https://openalex.org/W2148979040","https://openalex.org/W2149750189","https://openalex.org/W2149948630","https://openalex.org/W2150422350","https://openalex.org/W2150577180","https://openalex.org/W2151751905","https://openalex.org/W2153738223","https://openalex.org/W2154215109","https://openalex.org/W2154619570","https://openalex.org/W2156826116","https://openalex.org/W2158191471","https://openalex.org/W2158447179","https://openalex.org/W2158521027","https://openalex.org/W2164578725","https://openalex.org/W2165559682","https://openalex.org/W2166374078","https://openalex.org/W2166383488","https://openalex.org/W2166602148","https://openalex.org/W2167207107","https://openalex.org/W2167606638","https://openalex.org/W2168420558","https://openalex.org/W2170117367","https://openalex.org/W2301235020","https://openalex.org/W2304574966","https://openalex.org/W2396761555","https://openalex.org/W2400266213","https://openalex.org/W2608773137"],"related_works":["https://openalex.org/W2167268416","https://openalex.org/W3183484449","https://openalex.org/W1988885874","https://openalex.org/W1979583889","https://openalex.org/W1972823046","https://openalex.org/W58436318","https://openalex.org/W4293755499","https://openalex.org/W2050039810","https://openalex.org/W2093784289","https://openalex.org/W2939060314"],"abstract_inverted_index":{"Transcription":[0],"of":[1,32,67,83,141,226,229,234,258,270,288,298,324,362,375,411,426,453,463,489,505,540],"the":[2,8,30,61,79,90,102,132,169,181,198,230,235,259,271,278,289,321,339,373,376,412,472,490,503,510,520,533],"Bacillus":[3],"anthracis":[4,40,145,285,365,551],"structural":[5],"genes":[6],"for":[7,15,49,72,180,192,303,484,500,547],"anthrax":[9,247,387,405,464,501],"toxin":[10,74,248,388,406],"proteins":[11],"and":[12,60,63,75,128,135,153,186,238,246,253,296,315,329,381,386,396,404,438,460,542],"biosynthetic":[13],"operon":[14],"capsule":[16,76],"are":[17,415,422],"positively":[18],"regulated":[19],"by":[20,344],"AtxA,":[21],"a":[22,38,46,177,202,217,241,251,307,354,360,391,436,451,481,497],"transcription":[23,167,211],"regulator":[24,93],"with":[25,29,101,268],"unique":[26],"properties.":[27],"Consistent":[28],"role":[31,546],"atxA":[33,57,68,84,103,142,166,210,221,384,491,541],"in":[34,45,139,143,240,244,250,294,300,369,390,424,435,442,466,478,480,496,525,549],"virulence":[35,150,356,479,488],"factor":[36,184,522],"expression,":[37],"B.":[39,144,284,364,550],"atxA-null":[41],"mutant":[42,432,474,493],"is":[43,70,174,312,318,330,351,372,458,518],"avirulent":[44],"murine":[47,482,498],"model":[48,483,499],"anthrax.":[50,485],"In":[51,196,470,486],"batch":[52],"culture,":[53],"multiple":[54],"signals":[55],"impact":[56,374],"transcript":[58],"levels,":[59,456],"timing":[62],"steady":[64],"state":[65,92],"level":[66],"expression":[69,385,539],"critical":[71],"optimal":[73],"synthesis.":[77],"Despite":[78],"apparent":[80],"complex":[81,534],"control":[82,114,425],"transcription,":[85],"only":[86,156,353,429,521],"one":[87,157],"trans-acting":[88,136,203,236,260,279],"protein,":[89],"transition":[91],"AbrB,":[94,379],"has":[95,108],"been":[96,109,118],"demonstrated":[97,368],"to":[98,216,306,320,332],"directly":[99],"interact":[100],"promoter.":[104],"The":[105,256,428],"AbrB-binding":[106],"site":[107,172,274,292],"described,":[110],"but":[111,358],"additional":[112,545],"cis-acting":[113,133],"sequences":[115,223],"have":[116,275],"not":[117,352,519],"defined.":[119],"Using":[120],"transcriptional":[121],"lacZ":[122],"fusions,":[123],"electrophoretic":[124],"mobility":[125],"shift":[126],"assays,":[127],"Western":[129],"blot":[130],"analysis,":[131],"elements":[134],"factors":[137,419],"involved":[138,423],"regulation":[140],"strains":[146],"containing":[147],"either":[148],"both":[149,313],"plasmids,":[151],"pXO1":[152],"pXO2,":[154],"or":[155],"plasmid,":[158],"pXO1,":[159],"were":[160],"studied.":[161],"This":[162],"work":[163,371,531],"demonstrates":[164],"that":[165,201,277,311,349,418,433,516,537],"from":[168,338,409],"major":[170],"start":[171],"P1":[173],"dependent":[175],"upon":[176],"consensus":[178],"sequence":[179],"housekeeping":[182],"sigma":[183],"SigA,":[185],"an":[187,334,447,467,476,526,544],"A+T-rich":[188],"upstream":[189],"element":[190],"(UP-element)":[191],"RNA":[193],"polymerase":[194],"(RNAP).":[195],"addition,":[197,471],"data":[199],"show":[200],"protein(s)":[204,237,262,281],"other":[205],"than":[206,509],"AbrB":[207],"negatively":[208],"impacts":[209],"when":[212,342],"it":[213],"binds":[214],"specifically":[215],"9-bp":[218],"palindrome":[219,231],"within":[220],"promoter":[222,492],"located":[224],"downstream":[225],"P1.":[227],"Mutation":[228,287],"prevents":[232],"binding":[233,273,291],"results":[239,293,347,514],"corresponding":[242],"increase":[243,441,477],"AtxA":[245,299,350,403,443,455,508,517,548],"production":[249,389,407,462,504],"strain-":[252],"culture-dependent":[254],"manner.":[255],"identity":[257],"repressor":[261,272,280,290],"remains":[263],"elusive;":[264],"however,":[265],"phenotypes":[266],"associated":[267],"mutation":[269],"revealed":[276],"indirectly":[282],"controls":[283],"development.":[286,366,552],"misregulation":[295],"overexpression":[297],"conditions":[301],"conducive":[302],"development,":[304],"leading":[305],"marked":[308],"sporulation":[309,325,340],"defect":[310],"atxA-":[314],"pXO2-61-dependent.":[316],"pXO2-61":[317],"homologous":[319],"sensor":[322,326],"domain":[323],"histidine":[327],"kinases":[328],"proposed":[331],"titrate":[333],"activating":[335],"signal":[336],"away":[337],"phosphorelay":[341],"overexpressed":[343],"AtxA.":[345],"These":[346,513],"indicate":[348],"master":[355],"regulator,":[357],"also":[359],"modulator":[361],"proper":[363],"Also":[367],"this":[370,530],"developmental":[377,413,430],"regulators":[378,414],"Spo0A,":[380],"SigH":[382],"on":[383,420],"genetically":[392,397],"incomplete":[393],"(pXO1+,":[394,399],"pXO2-)":[395],"complete":[398],"pXO2+)":[400],"strain":[401],"background.":[402],"resulting":[408],"deletion":[410,431],"strain-dependent":[416],"suggesting":[417],"pXO2":[421],"atxA.":[427],"resulted":[434],"prominent":[437],"consistent":[439],"strain-independent":[440],"protein":[444],"levels":[445],"was":[446,494],"abrB-null":[448,468,473,511,527],"mutant.":[449,469,512,528],"As":[450],"result":[452],"increased":[454,461],"there":[457],"early":[459],"toxins":[465],"exhibited":[475],"contrast,":[487],"unaffected":[495],"despite":[502],"5-fold":[506],"more":[507],"imply":[515],"impacting":[523],"pathogenesis":[524],"Overall,":[529],"highlights":[532],"regulatory":[535],"network":[536],"governs":[538],"provides":[543]},"counts_by_year":[],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}
