{"id":"https://openalex.org/W156890127","doi":null,"title":"The function of mammalian COPII components Sec23a and Sec23b","display_name":"The function of mammalian COPII components Sec23a and Sec23b","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W156890127","mag":"156890127"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97814","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/97814/1/mpv_1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017551101","display_name":"Matthew P. Vasievich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew P. Vasievich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017551101"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12604","display_name":"Glycogen Storage Diseases and Myoclonus","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sec23a","display_name":"SEC23A","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sec23b","display_name":"SEC23B","score":1.0},{"id":"https://openalex.org/keywords/copii-vesicles","display_name":"COPII vesicles","score":0.9100000262260437},{"id":"https://openalex.org/keywords/er-to-golgi-transport","display_name":"ER-Golgi transport","score":0.8140000104904175},{"id":"https://openalex.org/keywords/congenital-dyserythropoietic-anemia-type-ii","display_name":"congenital dyserythropoietic anemia type II","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-trap-mice","display_name":"gene trap mice","score":0.699999988079071},{"id":"https://openalex.org/keywords/chimeric-mice","display_name":"chimeric mice","score":0.8690000176429749},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tissue-specific-function","display_name":"tissue-specific function","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C46617944","wikidata":"https://www.wikidata.org/wiki/Q410907","display_name":"COPII","level":5,"score":0.8785150051116943},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5448283553123474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3761405348777771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24905750155448914},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.0},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/97814","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/97814/1/mpv_1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:156890127","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/97814","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W167382485","https://openalex.org/W1531818302","https://openalex.org/W1540423321","https://openalex.org/W1554520293","https://openalex.org/W1608369370","https://openalex.org/W1820507099","https://openalex.org/W1963051938","https://openalex.org/W1963573377","https://openalex.org/W1966398753","https://openalex.org/W1969201628","https://openalex.org/W1969421148","https://openalex.org/W1969963064","https://openalex.org/W1970339026","https://openalex.org/W1974973994","https://openalex.org/W1976010436","https://openalex.org/W1979216961","https://openalex.org/W1979318888","https://openalex.org/W1986429697","https://openalex.org/W1989166164","https://openalex.org/W1991736711","https://openalex.org/W1992848590","https://openalex.org/W1994157173","https://openalex.org/W1995958002","https://openalex.org/W1998611493","https://openalex.org/W2007605191","https://openalex.org/W2008149441","https://openalex.org/W2011170563","https://openalex.org/W2013080121","https://openalex.org/W2017616199","https://openalex.org/W2019999162","https://openalex.org/W2021427342","https://openalex.org/W2029152767","https://openalex.org/W2029983725","https://openalex.org/W2030772679","https://openalex.org/W2035941767","https://openalex.org/W2040252009","https://openalex.org/W2040439630","https://openalex.org/W2041144268","https://openalex.org/W2041674095","https://openalex.org/W2042018563","https://openalex.org/W2045571454","https://openalex.org/W2048253222","https://openalex.org/W2049237667","https://openalex.org/W2050940330","https://openalex.org/W2059775037","https://openalex.org/W2059823229","https://openalex.org/W2067656182","https://openalex.org/W2082103548","https://openalex.org/W2085006382","https://openalex.org/W2085581069","https://openalex.org/W2101117598","https://openalex.org/W2101349818","https://openalex.org/W2106770740","https://openalex.org/W2107913200","https://openalex.org/W2109975639","https://openalex.org/W2112791998","https://openalex.org/W2123263958","https://openalex.org/W2125599080","https://openalex.org/W2126382616","https://openalex.org/W2129224672","https://openalex.org/W2129913763","https://openalex.org/W2134245600","https://openalex.org/W2136179119","https://openalex.org/W2138213290","https://openalex.org/W2140167060","https://openalex.org/W2144796443","https://openalex.org/W2147541221","https://openalex.org/W2150956621","https://openalex.org/W2156627876","https://openalex.org/W2157271565","https://openalex.org/W2165885405","https://openalex.org/W2169337490","https://openalex.org/W2170699469","https://openalex.org/W2213003028","https://openalex.org/W2325037197","https://openalex.org/W2414638865","https://openalex.org/W2793216206"],"related_works":["https://openalex.org/W2978908454","https://openalex.org/W2979667943","https://openalex.org/W2169337490","https://openalex.org/W2101186663","https://openalex.org/W3140298617","https://openalex.org/W2138213290","https://openalex.org/W2443142075","https://openalex.org/W2019490793","https://openalex.org/W2559304930","https://openalex.org/W2027605269"],"abstract_inverted_index":{"In":[0,48],"all":[1],"eukaryotic":[2],"cells,":[3],"cargo":[4],"proteins":[5,183],"are":[6,210,265],"transported":[7],"from":[8,28,173],"the":[9,14,32,44,53,61,94,105,109,223,237,241,256,320,323],"endoplasmic":[10],"reticulum":[11],"(ER)":[12],"to":[13,82,88,91,117,189],"Golgi":[15],"apparatus":[16],"in":[17,31,93,104,197,208,236,285,308,326],"COPII-coated":[18],"vesicles.":[19],"Human":[20],"diseases":[21],"have":[22,300,312],"recently":[23,86],"been":[24],"described":[25],"that":[26,184,302],"result":[27],"inherited":[29],"mutations":[30,92,207,307],"paralagous":[33],"genes":[34],"SEC23A":[35,209,295],"and":[36,66,85,122,203,226,248,259,267,296,304,310,329,342],"SEC23B,":[37],"which":[38,216],"encode":[39],"a":[40,100,125,177,232],"key":[41],"component":[42],"of":[43,55,108,127,132,142,155,167,222,240,250,322,334],"COPII":[45,324],"vesicle":[46],"coat.":[47],"this":[49],"thesis,":[50],"I":[51],"explore":[52],"phenotypes":[54],"gene":[56,101,112,233,243],"targeted":[57],"mice":[58,138,151,175,202,278,305],"deficient":[59],"for":[60,99,254],"mouse":[62,110],"SEC23":[63],"orthologs":[64],"Sec23a":[65,242,257,275,288,309],"Sec23b.":[67],"Congenital":[68],"dyserythropoietic":[69],"anemia":[70,133],"type":[71,150],"II":[72],"(CDAII)":[73],"is":[74,217],"an":[75,281],"autosomal":[76],"recessive":[77],"disorder":[78],"characterized":[79,218],"by":[80,140,219],"mild":[81,227],"severe":[83],"anemia,":[84],"reported":[87],"be":[89],"due":[90],"SEC23B":[95,199],"gene.":[96],"Mice":[97,230,252],"homozygous":[98],"trap":[102,234],"insertion":[103,235],"last":[106],"intron":[107,239],"Sec23b":[111,143,168,260,311],"(Sec23b":[113],"gt/gt)":[114],"were":[115,185],"demonstrated":[116,152],"exhibit":[118],"massive":[119],"pancreatic":[120],"degeneration":[121],"die":[123,244,279],"within":[124],"day":[126,246],"birth,":[128],"with":[129,206,212,231,269,306],"no":[130,182,270],"evidence":[131],"on":[134],"blood":[135,161],"analysis.":[136],"Chimeric":[137],"generated":[139],"transplantation":[141],"gt/gt":[144,169,276,289],"hematopoietic":[145],"precursor":[146],"cells":[147],"into":[148],"wild":[149],"full":[153],"reconstitution":[154],"erythropoiesis,":[156],"as":[157,159],"well":[158],"other":[160],"cell":[162],"lineages.":[163],"Mass":[164],"spectrometry":[165],"analysis":[166],"RBC":[170,191],"ghosts":[171],"prepared":[172],"chimeric":[174],"using":[176],"comparative":[178],"SILAC":[179],"approach":[180],"detected":[181],"quantitatively":[186],"decreased":[187],"compared":[188],"control":[190],"ghosts.":[192],"These":[193,298],"results":[194],"suggest":[195,331],"divergence":[196,333],"tissue-specific":[198],"function":[200],"between":[201,245,294,340],"humans.":[204],"Humans":[205],"affected":[211],"Cranio-Lenticulo-Sutural":[213],"Dysplasia":[214],"(CLSD),":[215],"late":[220],"closure":[221],"cranial":[224],"fontanelles":[225],"mental":[228],"retardation.":[229],"second":[238],"10.5":[247],"11.5":[249],"embryogenesis.":[251],"heterozygous":[253],"both":[255],"gt":[258,261],"alleles":[262],"(Sec23a+/gt":[263],"Sec23b+/gt)":[264],"viable":[266],"fertile":[268],"apparent":[271],"pathologic":[272],"phenotype.":[273],"However,":[274],"Sec23b+/gt":[277],"at":[280],"earlier":[282],"time":[283,339],"point":[284],"embryogenesis":[286],"than":[287],"mice,":[290],"suggesting":[291],"functional":[292,332],"overlap":[293],"SEC23B.":[297],"studies":[299],"shown":[301],"humans":[303],"disparate":[313],"but":[314],"tissue":[315],"specific":[316],"phenotypes.":[317],"This":[318],"demonstrates":[319],"importance":[321],"pathway":[325],"human":[327,341],"disease":[328],"could":[330],"these":[335],"isoforms":[336],"over":[337],"evolutionary":[338],"mouse.":[343]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}