{"id":"https://openalex.org/W1568306217","doi":"https://doi.org/10.1128/jvi.66.1.317-324.1992","title":"Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells","display_name":"Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W1568306217","doi":"https://doi.org/10.1128/jvi.66.1.317-324.1992","mag":"1568306217","pmid":"https://pubmed.ncbi.nlm.nih.gov/1370086","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/238290"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.66.1.317-324.1992","doi":"https://doi.org/10.1128/jvi.66.1.317-324.1992","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.66.1.317-324.1992","pdf_url":"https://jvi.asm.org/content/jvi/66/1/317.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/66/1/317.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060684492","display_name":"Lynne A. Hunter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Hunter","raw_affiliation_strings":["Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066559646","display_name":"R. Jude Samulski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J Samulski","raw_affiliation_strings":["Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":1.0133,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.71937947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"66","issue":"1","first_page":"317","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12849","display_name":"Parvovirus B19 Infection Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":1.0},{"id":"https://openalex.org/keywords/rep-protein","display_name":"Rep protein","score":0.7770000100135803},{"id":"https://openalex.org/keywords/rep78","display_name":"Rep78","score":0.7649999856948853},{"id":"https://openalex.org/keywords/rep68","display_name":"Rep68","score":0.9670000076293945},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protein-colocalization","display_name":"protein colocalization","score":0.921999990940094},{"id":"https://openalex.org/keywords/viral-replication-centers","display_name":"viral replication centers","score":0.7960000038146973},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8479999899864197},{"id":"https://openalex.org/keywords/indirect-immunofluorescence","display_name":"indirect immunofluorescence","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8065391778945923},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.7974212765693665},{"id":"https://openalex.org/C40209533","wikidata":"https://www.wikidata.org/wiki/Q5147828","display_name":"Colocalization","level":2,"score":0.7762248516082764},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.7038998007774353},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6188958287239075},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.5790113210678101},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5778001546859741},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.5711845755577087},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5132017135620117},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4600943922996521},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4522245526313782},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.30392181873321533},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.20266008377075195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10879865288734436},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07998815178871155},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.66.1.317-324.1992","doi":"https://doi.org/10.1128/jvi.66.1.317-324.1992","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.66.1.317-324.1992","pdf_url":"https://jvi.asm.org/content/jvi/66/1/317.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:238290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/238290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:1370086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1370086","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"mag:2607308970","doi":null,"is_oa":false,"landing_page_url":"https://jvi.asm.org/content/66/1/317.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1128/jvi.66.1.317-324.1992","doi":"https://doi.org/10.1128/jvi.66.1.317-324.1992","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.66.1.317-324.1992","pdf_url":"https://jvi.asm.org/content/jvi/66/1/317.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6853876213","display_name":"AAV-SPECIFIC INTEGRATION AND RESCUE IN HUMAN CELLS","funder_award_id":"R29AI025530","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7856188963","display_name":null,"funder_award_id":"AI 25530-03","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1568306217.pdf"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1484444210","https://openalex.org/W1496294057","https://openalex.org/W1505243819","https://openalex.org/W1507467441","https://openalex.org/W1515990833","https://openalex.org/W1521627295","https://openalex.org/W1545115691","https://openalex.org/W1581528859","https://openalex.org/W1585072946","https://openalex.org/W1601086837","https://openalex.org/W1645009826","https://openalex.org/W1665866727","https://openalex.org/W1686256874","https://openalex.org/W1711082173","https://openalex.org/W1809622386","https://openalex.org/W1873683136","https://openalex.org/W1879335341","https://openalex.org/W1901315342","https://openalex.org/W1901834903","https://openalex.org/W1948819130","https://openalex.org/W1951335634","https://openalex.org/W1968382713","https://openalex.org/W1975993749","https://openalex.org/W1993599538","https://openalex.org/W2018289835","https://openalex.org/W2020916241","https://openalex.org/W2025177940","https://openalex.org/W2028043537","https://openalex.org/W2040072356","https://openalex.org/W2050273056","https://openalex.org/W2053734797","https://openalex.org/W2060262597","https://openalex.org/W2068518785","https://openalex.org/W2070106664","https://openalex.org/W2087396336","https://openalex.org/W2101108802","https://openalex.org/W2121944814","https://openalex.org/W2144634347"],"related_works":["https://openalex.org/W2171960436","https://openalex.org/W2107307536","https://openalex.org/W2115185064","https://openalex.org/W2070106664","https://openalex.org/W2079538454","https://openalex.org/W1686256874","https://openalex.org/W2169557917","https://openalex.org/W2131134586","https://openalex.org/W3207835387","https://openalex.org/W7098186345"],"abstract_inverted_index":{"The":[0],"mechanism":[1,155],"of":[2,92,124,153,156],"adeno-associated":[3],"virus":[4],"(AAV)":[5],"DNA":[6],"replication":[7,131,158],"was":[8],"characterized":[9],"both":[10,68],"genetically":[11],"and":[12,20,29,31,34,62,71,113,117],"biochemically.":[13],"In":[14,75],"this":[15],"study,":[16],"we":[17,49],"used":[18],"monoclonal":[19,51,63],"polyclonal":[21],"antibodies":[22],"to":[23,134],"examine":[24],"the":[25,58,69,81,109,115,122,154],"AAV":[26,93,105,157],"p5":[27,59,70],"(Rep78":[28],"Rep68)":[30],"p19":[32,72],"(Rep52":[33],"Rep40)":[35],"proteins":[36,84,94,107,119],"in":[37,46,87,121,159],"infected":[38,125],"cells.":[39,126],"By":[40],"overexpressing":[41],"a":[42,147],"truncated":[43],"Rep78":[44],"protein":[45],"Escherichia":[47],"coli,":[48],"obtained":[50],"antibody":[52,64],"anti-78/68,":[53],"which":[54,66],"is":[55],"specific":[56],"for":[57,141,150],"Rep":[60,73,83,106,116],"proteins,":[61],"anti-52/40,":[65],"recognized":[67],"proteins.":[74],"single-fluorochrome":[76],"indirect":[77,97],"immunofluorescence":[78,98],"labeling":[79],"experiments,":[80],"viral":[82],"were":[85],"localized":[86],"distinct":[88],"intranuclear":[89,111],"foci.":[90],"Analysis":[91],"by":[95,137],"double-fluorochrome":[96],"experiments":[99],"demonstrated":[100],"that":[101,130],"(i)":[102],"all":[103],"four":[104],"occupied":[108],"same":[110],"compartments":[112],"(ii)":[114],"capsid":[118],"colocalized":[120],"nuclei":[123],"These":[127,143],"results":[128],"suggest":[129],"centers":[132],"similar":[133],"those":[135],"established":[136],"other":[138],"viruses":[139],"exist":[140],"AAV.":[142],"reagents":[144],"should":[145],"provide":[146],"useful":[148],"tool":[149],"further":[151],"delineation":[152],"vitro.":[160]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
