{"id":"https://openalex.org/W1568303755","doi":"https://doi.org/10.3233/jad-2010-100120","title":"A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration","display_name":"A NH2 Tau Fragment Targets Neuronal Mitochondria at AD Synapses: Possible Implications for Neurodegeneration","publication_year":2010,"publication_date":"2010-08-11","ids":{"openalex":"https://openalex.org/W1568303755","doi":"https://doi.org/10.3233/jad-2010-100120","mag":"1568303755","pmid":"https://pubmed.ncbi.nlm.nih.gov/20571215"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2010-100120","doi":"https://doi.org/10.3233/jad-2010-100120","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2010-100120","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042666528","display_name":"Giuseppina Amadoro","orcid":"https://orcid.org/0000-0003-2080-2951","observed_orcids":["https://orcid.org/0000-0003-2080-2951"]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppina Amadoro","raw_affiliation_strings":["Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081590385","display_name":"Veronica Corsetti","orcid":"https://orcid.org/0000-0001-6862-2998","observed_orcids":["https://orcid.org/0000-0001-6862-2998"]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Corsetti","raw_affiliation_strings":["Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050833052","display_name":"Annarita Stringaro","orcid":"https://orcid.org/0000-0002-0143-2978","observed_orcids":["https://orcid.org/0000-0002-0143-2978"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annarita Stringaro","raw_affiliation_strings":["Istituto Superiore di Sanit\u00e0 (ISS), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Superiore di Sanit\u00e0 (ISS), Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051018155","display_name":"Marisa Colone","orcid":"https://orcid.org/0000-0002-7522-7483","observed_orcids":["https://orcid.org/0000-0002-7522-7483"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marisa Colone","raw_affiliation_strings":["Istituto Superiore di Sanit\u00e0 (ISS), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Superiore di Sanit\u00e0 (ISS), Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070564127","display_name":"Simona D\u2019Aguanno","orcid":"https://orcid.org/0000-0002-1224-4454","observed_orcids":["https://orcid.org/0000-0002-1224-4454"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona D'Aguanno","raw_affiliation_strings":["IRCSS Fondazione Santa Lucia, Rome, Italy","Policlinico di Tor Vergata, Universit\u00e0 degli Studi di Roma Facolt\u00e0 di Medicina, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"Policlinico di Tor Vergata, Universit\u00e0 degli Studi di Roma Facolt\u00e0 di Medicina, Rome, Italy","institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070054021","display_name":"Giovanni Meli","orcid":"https://orcid.org/0000-0002-4633-364X","observed_orcids":["https://orcid.org/0000-0002-4633-364X"]},"institutions":[{"id":"https://openalex.org/I157210198","display_name":"Scuola Normale Superiore","ror":"https://ror.org/03aydme10","country_code":"IT","type":"education","lineage":["https://openalex.org/I157210198"]},{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Meli","raw_affiliation_strings":["European Brain Research Institute (EBRI), Rome Italy","Scuola Normale Superiore di Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute (EBRI), Rome Italy","institution_ids":["https://openalex.org/I4210142264"]},{"raw_affiliation_string":"Scuola Normale Superiore di Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I157210198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111444866","display_name":"M. T. Ciotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MariaTeresa Ciotti","raw_affiliation_strings":["Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029553123","display_name":"Giuseppe Sancesario","orcid":"https://orcid.org/0000-0002-1772-9012","observed_orcids":["https://orcid.org/0000-0002-1772-9012"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Sancesario","raw_affiliation_strings":["Policlinico di Tor Vergata, Universit\u00e0 degli Studi di Roma Facolt\u00e0 di Medicina, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Policlinico di Tor Vergata, Universit\u00e0 degli Studi di Roma Facolt\u00e0 di Medicina, Rome, Italy","institution_ids":["https://openalex.org/I116067653","https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020786321","display_name":"Antonino Cattaneo","orcid":"https://orcid.org/0000-0002-6975-8923","observed_orcids":["https://orcid.org/0000-0002-6975-8923"]},"institutions":[{"id":"https://openalex.org/I157210198","display_name":"Scuola Normale Superiore","ror":"https://ror.org/03aydme10","country_code":"IT","type":"education","lineage":["https://openalex.org/I157210198"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonino Cattaneo","raw_affiliation_strings":["Scuola Normale Superiore di Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scuola Normale Superiore di Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I157210198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044812537","display_name":"Rossana Bussani","orcid":"https://orcid.org/0000-0001-8241-9726","observed_orcids":["https://orcid.org/0000-0001-8241-9726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rossana Bussani","raw_affiliation_strings":["UCO Anatomia e Istologia Patologica, Trieste Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCO Anatomia e Istologia Patologica, Trieste Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079024473","display_name":"Delio Mercanti","orcid":"https://orcid.org/0000-0001-8301-2098","observed_orcids":["https://orcid.org/0000-0001-8301-2098"]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Delio Mercanti","raw_affiliation_strings":["Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059406139","display_name":"Pietro Calissano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141171","display_name":"Institute of Neurobiology and Molecular Medicine","ror":"https://ror.org/04smrs866","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210141171","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210142264","display_name":"European Brain Research Institute","ror":"https://ror.org/03ay27p09","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210142264"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pietro Calissano","raw_affiliation_strings":["European Brain Research Institute (EBRI), Rome Italy","Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Brain Research Institute (EBRI), Rome Italy","institution_ids":["https://openalex.org/I4210142264"]},{"raw_affiliation_string":"Institute of Neurobiology and Molecular Medicine-CNR, IRCSS Fondazione Santa Lucia, Rome, Italy","institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5042666528"],"corresponding_institution_ids":["https://openalex.org/I4210141171","https://openalex.org/I4210150112"],"apc_list":null,"apc_paid":null,"fwci":1.8974,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.83378236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"21","issue":"2","first_page":"445","last_page":"470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.8948410749435425},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7108131647109985},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.6327720284461975},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5151344537734985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38313719630241394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20170998573303223},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1716964840888977},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13915914297103882},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13007792830467224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10561951994895935},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3233/jad-2010-100120","doi":"https://doi.org/10.3233/jad-2010-100120","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2010-100120","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:20571215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/10833","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/10833","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arts.units.it:11368/2690955","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11368/2690955","pdf_url":null,"source":{"id":"https://openalex.org/S4306400480","display_name":"ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142444530","host_organization_name":"University of Trieste","host_organization_lineage":["https://openalex.org/I142444530"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.sns.it:11384/5846","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11384/5846","pdf_url":null,"source":{"id":"https://openalex.org/S7407050981","display_name":"Scuola Normale Superiore di Pisa","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326076","display_name":"Regione Lazio","ror":"https://ror.org/008hssd09"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035298175","https://openalex.org/W2142796354","https://openalex.org/W2110862168","https://openalex.org/W2081522223","https://openalex.org/W2093405284","https://openalex.org/W3208739658","https://openalex.org/W2890398446","https://openalex.org/W3028471102","https://openalex.org/W2808708775","https://openalex.org/W4233102730"],"abstract_inverted_index":{"Synapses":[0],"are":[1,39],"ultrastructural":[2],"sites":[3],"for":[4,41,215],"memory":[5],"storage":[6],"in":[7,20,74,92,105,127,135,162,170,175,196,203],"brain,":[8],"and":[9,30,68,77,101,114,144,174,200],"synaptic":[10,112],"damage":[11],"is":[12,51,57,89,124,138],"the":[13,61,69,75,110,116,157,161,184,192,202],"best":[14],"pathologic":[15],"correlate":[16],"of":[17,32,45,63,71,98,165],"cognitive":[18],"decline":[19],"Alzheimer's":[21],"disease":[22],"(AD).":[23],"Post-translational":[24],"hyperphosphorylation,":[25],"enzyme-mediated":[26],"truncation,":[27],"conformational":[28],"modifications,":[29],"aggregation":[31],"tau":[33,87,122,187,206],"protein":[34],"into":[35],"neurofibrillary":[36],"tangles":[37],"(NFTs)":[38],"hallmarks":[40],"a":[42,52,83],"heterogeneous":[43],"group":[44],"neurodegenerative":[46],"disorders,":[47],"so-called":[48],"tauopathies.":[49],"AD":[50,99,136,216],"secondary":[53],"tauopathy":[54],"since":[55],"it":[56],"pathologically":[58],"distinguished":[59],"by":[60,160],"presence":[62,70,134],"amyloid-beta":[64],"(Abeta)-containing":[65],"senile":[66],"plaques":[67],"tau-positive":[72],"NFTs":[73],"neocortex":[76],"hippocampus.":[78],"Here,":[79],"we":[80],"report":[81],"that":[82,102,183],"20-22":[84,166],"kDa":[85,167],"NH2-truncated":[86,121],"fragment":[88],"largely":[90],"enriched":[91],"human":[93,172],"mitochondria":[94],"from":[95],"cryopreserved":[96],"synaptosomes":[97],"brains":[100],"its":[103,133],"amount":[104],"terminal":[106],"fields":[107],"correlates":[108],"with":[109,115],"pathological":[111],"changes":[113],"organelle":[117],"functional":[118],"impairment.":[119],"This":[120],"form":[123],"also":[125],"found":[126],"other":[128],"human,":[129],"not":[130],"AD-tauopathies,":[131],"while":[132],"patients":[137],"linked":[139],"to":[140,146],"Abeta":[141,152],"multimeric":[142],"species":[143],"likely":[145,155],"pathology":[147],"severity.":[148],"Finally":[149],"native,":[150],"patient-derived,":[151],"oligomers-enriched":[153],"extracts":[154],"impair":[156],"mitochondrial":[158,185],"function":[159],"vitro":[163],"production":[164],"NH2-tau":[168],"fragments":[169],"mature":[171],"SY5Y":[173],"rat":[176],"hippocampal":[177],"neurons.":[178],"Thus":[179],"our":[180],"findings":[181],"suggest":[182],"NH2-derived":[186],"peptide":[188],"distribution":[189],"may":[190],"exacerbate":[191],"synapse":[193],"degeneration":[194],"occurring":[195],"tauopathies,":[197],"including":[198],"AD,":[199],"sustain":[201],"vivo":[204],"NH-2":[205],"cleavage":[207],"inhibitors":[208],"as":[209],"an":[210],"alternative":[211],"drug":[212],"discovery":[213],"strategies":[214],"therapy.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}