{"id":"https://openalex.org/W1568197909","doi":null,"title":"The Use of Response Surface Methodology in Optimization of Lactic Acid Production: Focus on Medium Supplementation, Temperature and pH Control","display_name":"The Use of Response Surface Methodology in Optimization of Lactic Acid Production: Focus on Medium Supplementation, Temperature and pH Control","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1568197909","mag":"1568197909"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.unesp.br:11449/225981","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/225981","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/225981","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049059999","display_name":"Cristian Jacques Bolner de Lima","orcid":"https://orcid.org/0000-0002-9518-3588","observed_orcids":["https://orcid.org/0000-0002-9518-3588"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"de Lima, Cristian J. B.","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050939330","display_name":"Luciana Fontes Coelho","orcid":"https://orcid.org/0000-0001-5474-3465","observed_orcids":["https://orcid.org/0000-0001-5474-3465"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Coelho, Luciana F.","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061249772","display_name":"Jonas Contiero","orcid":"https://orcid.org/0000-0003-1215-6400","observed_orcids":["https://orcid.org/0000-0003-1215-6400"]},"institutions":[{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Contiero, Jonas","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Institute of Biological Sciences, S\u00e3o Paulo State University, Av. 24-A, 1515 Bela Vista, 13506-900 Rio Claro, SP, Brazil","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I879563668"],"apc_list":null,"apc_paid":null,"fwci":6.0034,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.95548767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.31029999256134033,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.2484000027179718,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.996999979019165},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8629999756813049},{"id":"https://openalex.org/keywords/whey","display_name":"whey","score":0.7789999842643738},{"id":"https://openalex.org/keywords/corn-steep-liquor","display_name":"corn steep liquor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ammonium-sulfate","display_name":"ammonium sulfate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nitrogen-source","display_name":"nitrogen source","score":0.578000009059906},{"id":"https://openalex.org/keywords/fermentation-medium-optimization","display_name":"fermentation medium optimization","score":0.7459999918937683},{"id":"https://openalex.org/keywords/fermentation-temperature","display_name":"fermentation temperature","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ph-control","display_name":"pH control","score":0.9729999899864197},{"id":"https://openalex.org/keywords/d-lactate","display_name":"D-lactate","score":0.7620000243186951},{"id":"https://openalex.org/keywords/lactose-conversion","display_name":"lactose conversion","score":0.5619999766349792},{"id":"https://openalex.org/keywords/yeast-extract-replacement","display_name":"yeast extract replacement","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.9221616983413696},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.7883506417274475},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.7731441259384155},{"id":"https://openalex.org/C2778724459","wikidata":"https://www.wikidata.org/wiki/Q127900","display_name":"Lactose","level":2,"score":0.7479077577590942},{"id":"https://openalex.org/C2779078344","wikidata":"https://www.wikidata.org/wiki/Q5171066","display_name":"Corn steep liquor","level":3,"score":0.6996996402740479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6542829871177673},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.6508173942565918},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.64959317445755},{"id":"https://openalex.org/C145890019","wikidata":"https://www.wikidata.org/wiki/Q1593672","display_name":"Yeast extract","level":3,"score":0.611063539981842},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.42551523447036743},{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.4170319437980652},{"id":"https://openalex.org/C2776382133","wikidata":"https://www.wikidata.org/wiki/Q4087","display_name":"Ammonia","level":2,"score":0.41344964504241943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31360143423080444},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25582072138786316},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15675529837608337},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.152574360370636},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13097497820854187},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:repositorio.unesp.br:11449/225981","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/225981","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:hrcak.srce.hr:53626","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/53626","pdf_url":"http://hrcak.srce.hr/53626","source":{"id":"https://openalex.org/S4306400071","display_name":"University of Zagreb University Computing Centre (SRCE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I181343428","host_organization_name":"University of Zagreb","host_organization_lineage":["https://openalex.org/I181343428"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Technology and Biotechnology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:acervodigital.unesp.br:11449/20152","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/20152","pdf_url":null,"source":{"id":"https://openalex.org/S4306400256","display_name":"Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115194","host_organization_name":"Funda\u00e7\u00e3o para o Desenvolvimento da UNESP","host_organization_lineage":["https://openalex.org/I4210115194"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"outro"},{"id":"pmh:oai:doaj.org/article:38f736d17d5745adb3cd13d2e6835a20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/38f736d17d5745adb3cd13d2e6835a20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Food Technology and Biotechnology, Vol 48, Iss 2, Pp 175-181 (2010)","raw_type":"article"},{"id":"pmh:oai:repositorio.unesp.br:11449/20152","doi":null,"is_oa":true,"landing_page_url":"http://www.ftb.com.hr/48/48-175.html","pdf_url":null,"source":{"id":"https://openalex.org/S4377196277","display_name":"UNESP Institutional Repository (S\u00e3o Paulo State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I879563668","host_organization_name":"Universidade Estadual Paulista (Unesp)","host_organization_lineage":["https://openalex.org/I879563668"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"pmh:oai:repositorio.unesp.br:11449/225981","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/225981","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1568197909.pdf","grobid_xml":"https://content.openalex.org/works/W1568197909.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W210538755","https://openalex.org/W1538311265","https://openalex.org/W1554579077","https://openalex.org/W1647712532","https://openalex.org/W1965667013","https://openalex.org/W1971613296","https://openalex.org/W1972097962","https://openalex.org/W1992019322","https://openalex.org/W2009982995","https://openalex.org/W2017955296","https://openalex.org/W2029949115","https://openalex.org/W2036098137","https://openalex.org/W2037322546","https://openalex.org/W2041322713","https://openalex.org/W2049455213","https://openalex.org/W2057094160","https://openalex.org/W2069453975","https://openalex.org/W2070354803","https://openalex.org/W2072183133","https://openalex.org/W2076835608","https://openalex.org/W2091308361","https://openalex.org/W2092554234","https://openalex.org/W2109729067","https://openalex.org/W2142740316","https://openalex.org/W2146814389","https://openalex.org/W2154442861","https://openalex.org/W2158642845","https://openalex.org/W4230443690"],"related_works":["https://openalex.org/W2147617759","https://openalex.org/W7220604499","https://openalex.org/W2082273677","https://openalex.org/W2084049603","https://openalex.org/W6996222780","https://openalex.org/W1593614084","https://openalex.org/W2144791852","https://openalex.org/W2733970057","https://openalex.org/W2139589601","https://openalex.org/W4380881726"],"abstract_inverted_index":{"Two":[0],"response":[1],"surface":[2],"methodologies":[3],"involving":[4],"central":[5,42,111],"composite":[6,43,112],"designs":[7],"have":[8],"been":[9],"successfully":[10],"applied":[11],"to":[12,62,116,120],"evaluate":[13],"the":[14,40,90,93,101,118,126,131,135,144,156,167,196],"effect":[15],"of":[16,76,80,87,133,149,179,185,191,195,218],"cheese":[17],"whey,":[18],"corn":[19,45,81],"steep":[20,46,82],"liquor,":[21],"ammonium":[22,49,88],"sulphate,":[23],"temperature":[24,122,158],"and":[25,48,84,123,159,164],"pH":[26,124,160],"control":[27],"on":[28],"lactic":[29,94,106,127,146,168,200,220],"acid":[30,95,107,128,147,169,201,214,221],"fermentation":[31,136],"by":[32,206],"Lactobacillus":[33,207],"sp.LMI8":[34,208],"isolated":[35],"from":[36,203],"cassava":[37],"flour":[38],"wastewater.In":[39],"first":[41],"design,":[44],"liquor":[47,83],"sulphate":[50],"were":[51,71,161],"investigated":[52],"as":[53],"low-cost":[54],"nitrogen":[55],"sources":[56],"in":[57,171],"combination":[58],"with":[59,73,130,187],"other":[60],"components":[61],"substitute":[63],"yeast":[64],"extract":[65],"for":[66,105],"economical":[67],"production.The":[68],"best":[69],"results":[70],"obtained":[72,154],"55":[74],"g/L":[75,79,86,151],"lactose,":[77],"15":[78],"5.625":[85],"sulphate.At":[89],"maximum":[91,145],"point,":[92],"concentration":[96],"reached":[97],"18.68":[98],"g/L.After":[99],"defining":[100],"optimal":[102],"nutritional":[103],"conditions":[104],"production,":[108],"a":[109,188],"second":[110],"design":[113],"was":[114,176,209],"performed":[115],"determine":[117],"extent":[119],"which":[121],"influence":[125],"production":[129,148,170],"aim":[132],"improving":[134],"process.The":[137],"second-order":[138],"polynomial":[139],"regression":[140],"model":[141],"determined":[142],"that":[143],"52.37":[150],"would":[152],"be":[153],"when":[155],"optimum":[157],"39.6":[162],"\u00b0C":[163],"5.9,":[165],"respectively.Comparing":[166],"shake":[172],"flask":[173],"fermentation,":[174],"there":[175],"an":[177],"increase":[178],"180":[180],"%":[181,194,217],"after":[182],"30":[183],"h":[184],"processing,":[186],"conversion":[189],"efficiency":[190],"about":[192],"86.12":[193],"initial":[197],"lactose.In":[198],"addition,":[199],"produced":[202],"whey":[204],"lactose":[205],"optically":[210],"almost":[211],"pure":[212],"D-lactic":[213],"(over":[215],"98":[216],"total":[219],"produced).":[222]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}