{"id":"https://openalex.org/W1567320710","doi":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","title":"Genetic mapping in the human malaria parasite Plasmodium falciparum","display_name":"Genetic mapping in the human malaria parasite Plasmodium falciparum","publication_year":2004,"publication_date":"2004-08-12","ids":{"openalex":"https://openalex.org/W1567320710","doi":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","mag":"1567320710","pmid":"https://pubmed.ncbi.nlm.nih.gov/15341640"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2958.2004.04270.x","doi":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075824166","display_name":"Xin\u2010zhuan Su","orcid":"https://orcid.org/0000-0003-3246-3248","observed_orcids":["https://orcid.org/0000-0003-3246-3248"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xin\u2010zhuan Su","raw_affiliation_strings":["Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 3E-24B, 12735 Twinbrook Parkway, Rockville, MD 20850, USA. xsu@niaid.nih.gov","Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 3E\u201024B, 12735 Twinbrook Parkway, Rockville, MD 20850, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 3E-24B, 12735 Twinbrook Parkway, Rockville, MD 20850, USA. xsu@niaid.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 3E\u201024B, 12735 Twinbrook Parkway, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110276911","display_name":"John C. Wootton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Wootton","raw_affiliation_strings":["Computational Biology Branch, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894\u20136075, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Branch, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894\u20136075, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075824166"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.5212,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.46582734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"53","issue":"6","first_page":"1573","last_page":"1582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":1.0},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.9179999828338623},{"id":"https://openalex.org/keywords/linkage-analysis","display_name":"linkage analysis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9190000295639038},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.7429999709129333},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.8700000047683716},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.3840000033378601},{"id":"https://openalex.org/keywords/population-genetics","display_name":"population genetics","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"gene knockout","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9312953948974609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6683393120765686},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6660728454589844},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6534148454666138},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.6480938196182251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5470210313796997},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5313755869865417},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.49755361676216125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46777358651161194},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44559597969055176},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3837366998195648},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.312671422958374},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.12357491254806519},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2958.2004.04270.x","doi":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2004.04270.x","pdf_url":null,"source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:15341640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15341640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1542836032","https://openalex.org/W1694215848","https://openalex.org/W1889531862","https://openalex.org/W1922669960","https://openalex.org/W1966069891","https://openalex.org/W1966124517","https://openalex.org/W1966882987","https://openalex.org/W1970568865","https://openalex.org/W1971446667","https://openalex.org/W1972177048","https://openalex.org/W1980752431","https://openalex.org/W1986794325","https://openalex.org/W1987120118","https://openalex.org/W1987311633","https://openalex.org/W1988408916","https://openalex.org/W1989290058","https://openalex.org/W1990805655","https://openalex.org/W1994981343","https://openalex.org/W1998770998","https://openalex.org/W1999417874","https://openalex.org/W2001102860","https://openalex.org/W2019851585","https://openalex.org/W2026791163","https://openalex.org/W2035054548","https://openalex.org/W2037542225","https://openalex.org/W2050052884","https://openalex.org/W2050767064","https://openalex.org/W2061649602","https://openalex.org/W2069881609","https://openalex.org/W2075152545","https://openalex.org/W2076050649","https://openalex.org/W2079451231","https://openalex.org/W2081729133","https://openalex.org/W2086910880","https://openalex.org/W2087000723","https://openalex.org/W2091457715","https://openalex.org/W2094331166","https://openalex.org/W2100255856","https://openalex.org/W2109405741","https://openalex.org/W2121826111","https://openalex.org/W2123447603","https://openalex.org/W2126296380","https://openalex.org/W2129174519","https://openalex.org/W2129965217","https://openalex.org/W2131867921","https://openalex.org/W2132923209","https://openalex.org/W2137764200","https://openalex.org/W2142999550","https://openalex.org/W2148835173","https://openalex.org/W2165672288","https://openalex.org/W2168421760","https://openalex.org/W2170342462","https://openalex.org/W2170874271","https://openalex.org/W2172061924","https://openalex.org/W2333050857","https://openalex.org/W4302606334"],"related_works":["https://openalex.org/W2008045938","https://openalex.org/W1968372099","https://openalex.org/W2037542225","https://openalex.org/W2164946423","https://openalex.org/W2075152545","https://openalex.org/W2056639403","https://openalex.org/W2018732951","https://openalex.org/W2091457715","https://openalex.org/W2026791163","https://openalex.org/W7095342244"],"abstract_inverted_index":{"The":[0],"Plasmodium":[1],"falciparum":[2,36,141],"genome":[3],"sequence":[4],"has":[5],"boosted":[6],"hopes":[7],"for":[8,16,79],"a":[9],"new":[10],"era":[11],"of":[12,19,32,49,149],"malaria":[13],"research":[14],"and":[15,44,59,96,106,147],"the":[17,33,145],"application":[18],"comprehensive":[20],"molecular":[21],"knowledge":[22],"to":[23,57,103,161],"disease":[24],"control,":[25],"but":[26],"formidable":[27],"obstacles":[28],"remain:":[29],"approximately":[30],"60%":[31],"predicted":[34],"P.":[35,140],"proteins":[37],"have":[38,132],"no":[39],"known":[40],"functions":[41],"or":[42,72],"homologues,":[43],"most":[45],"life":[46],"cycle":[47],"stages":[48],"this":[50],"haploid":[51],"eukaryotic":[52],"parasite":[53,85],"are":[54,100,107],"relatively":[55,138],"intractable":[56],"cultivation":[58],"biochemical":[60],"manipulation.":[61],"Genetic":[62],"mapping":[63,118,153],"based":[64],"on":[65],"high-resolution":[66],"maps":[67],"saturated":[68],"with":[69],"single-nucleotide":[70],"polymorphisms":[71],"microsatellites":[73],"is":[74,122],"now":[75,101],"providing":[76],"effective":[77],"strategies":[78],"discovering":[80],"candidate":[81,110],"genes":[82,111,131],"determining":[83],"important":[84],"phenotypes.":[86],"Here":[87],"we":[88],"review":[89],"classical":[90],"linkage":[91,120],"studies":[92],"using":[93],"laboratory":[94],"crosses":[95],"population":[97],"associations":[98],"that":[99],"amenable":[102],"genome-wide":[104],"approaches":[105],"revealing":[108],"multiple":[109],"involved":[112],"in":[113,124,135],"complex":[114],"drug":[115],"responses.":[116],"Moreover,":[117],"by":[119],"disequilibrium":[121],"practicable":[123],"cases":[125],"where":[126],"chromosomal":[127],"segments":[128],"flanking":[129],"drug-selected":[130],"been":[133],"preserved":[134],"populations":[136],"during":[137],"recent":[139],"evolution.":[142],"We":[143],"discuss":[144],"advantages":[146],"limitations":[148],"these":[150],"various":[151],"genetic":[152],"strategies,":[154],"results":[155],"from":[156,164],"which":[157],"offer":[158],"complementary":[159],"insights":[160],"those":[162],"emerging":[163],"gene":[165],"knockout":[166],"experiments":[167],"and/or":[168],"high-throughput":[169],"genomic":[170],"technologies.":[171]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}