{"id":"https://openalex.org/W1567035010","doi":"https://doi.org/10.1158/1538-7445.am2014-4306","title":"Abstract 4306: Bioconjugation of near infrared dyes by PEGylation improves pharmacokinetics and allows for better labeling and imaging of human gastrointestinal cancers","display_name":"Abstract 4306: Bioconjugation of near infrared dyes by PEGylation improves pharmacokinetics and allows for better labeling and imaging of human gastrointestinal cancers","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1567035010","doi":"https://doi.org/10.1158/1538-7445.am2014-4306","mag":"1567035010"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-4306","doi":"https://doi.org/10.1158/1538-7445.am2014-4306","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4306","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025597945","display_name":"Ali A. Maawy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali A. Maawy","raw_affiliation_strings":["1University of California, San Diego; San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego; San Diego, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113917299","display_name":"Yukihiko Hiroshima","orcid":"https://orcid.org/0009-0005-7384-3513","observed_orcids":["https://orcid.org/0009-0005-7384-3513"]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiko Hiroshima","raw_affiliation_strings":["2Yokohama City University and AntiCancer, Inc, Yokohama City, Japan and San Diego, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Yokohama City University and AntiCancer, Inc, Yokohama City, Japan and San Diego, Japan;","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010474061","display_name":"George A. Luiken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George A. Luiken","raw_affiliation_strings":["3OncoFluor, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3OncoFluor, Inc., San Diego, CA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419770","display_name":"Yong Zhang","orcid":"https://orcid.org/0000-0002-1303-0458","observed_orcids":["https://orcid.org/0000-0002-1303-0458","https://orcid.org/0000-0002-9916-3832","https://orcid.org/0000-0001-6577-5235"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["4AntiCancer, Inc., San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4AntiCancer, Inc., San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["5AntiCancer, Inc., and University of California San Diego, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5AntiCancer, Inc., and University of California San Diego, San Diego, CA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210121314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009960666","display_name":"Michael Bouvet","orcid":"https://orcid.org/0000-0002-0086-2159","observed_orcids":["https://orcid.org/0000-0002-0086-2159"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bouvet","raw_affiliation_strings":["1University of California, San Diego; San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of California, San Diego; San Diego, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"4306","last_page":"4306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.10130000114440918,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegylation","display_name":"PEGylation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/near-infrared-dyes","display_name":"near-infrared dyes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bioconjugation","display_name":"bioconjugation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-cea-antibody","display_name":"anti-CEA antibody","score":0.9240000247955322},{"id":"https://openalex.org/keywords/colon-cancer-liver-metastasis","display_name":"colon cancer liver metastasis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/pancreatic-tumors","display_name":"pancreatic tumors","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tissue-penetration","display_name":"tissue penetration","score":0.3580000102519989},{"id":"https://openalex.org/keywords/photostability","display_name":"photostability","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hydrophilicity","display_name":"hydrophilicity","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2779149719","wikidata":"https://www.wikidata.org/wiki/Q682252","display_name":"PEGylation","level":3,"score":0.9466836452484131},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.8022910952568054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7459261417388916},{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.6549388766288757},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6340358257293701},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.6196874976158142},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5760992765426636},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.554166316986084},{"id":"https://openalex.org/C179687394","wikidata":"https://www.wikidata.org/wiki/Q4826281","display_name":"Autofluorescence","level":3,"score":0.5530315041542053},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.5024638175964355},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.42521312832832336},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4249385893344879},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40292084217071533},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.323647677898407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29632288217544556},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2458549439907074},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17950525879859924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11701002717018127},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-4306","doi":"https://doi.org/10.1158/1538-7445.am2014-4306","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-4306","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2074904127","https://openalex.org/W2004583224","https://openalex.org/W1980625759","https://openalex.org/W1972584598","https://openalex.org/W7147689701","https://openalex.org/W2034986338","https://openalex.org/W3189499345","https://openalex.org/W1984590186","https://openalex.org/W2898493805","https://openalex.org/W1192613975"],"abstract_inverted_index":{"Abstract":[0],"NIR":[1,60,250],"dyes":[2,48,83,127,135,141,149,173,203,213,232,251,318],"are":[3,23],"becoming":[4],"increasingly":[5],"popular":[6],"due":[7],"to":[8,18,37,39,66,86,106,181,210,286],"their":[9,258],"good":[10,240],"tissue":[11,14,117,121,238,269],"penetration,":[12],"low":[13],"autofluorescence":[15],"and":[16,29,32,64,74,77,81,91,110,119,142,165,174,197,244,254,260,271,323,328],"resistance":[17],"hemoglobin":[19,290],"quenching.":[20],"However,":[21],"they":[22],"still":[24],"limited":[25],"by":[26,43,49,116,319],"lower":[27,152],"hydrophilicity":[28],"poor":[30],"chemical":[31],"photo-stability":[33],"in-vivo.":[34],"We":[35,56],"aimed":[36],"try":[38],"improve":[40],"these":[41,47],"properties":[42],"covalent":[44],"modification":[45],"of":[46,51,228,236,248,283,315,330,337,342],"addition":[50],"polyethylene":[52],"glycol":[53],"(PEG)":[54],"chains.":[55],"studied":[57],"2":[58],"commercially-available":[59],"dyes,":[61],"DyLight":[62,79,252],"650":[63,80,140,158,172,217,253],"750,":[65],"evaluate":[67],"how":[68],"PEGylation":[69,247,320],"affects":[70],"the":[71,139,145,157,162,171,177,211,216,249,295,338,343],"pharmacokinetics,":[72],"biodistribution":[73],"imaging.":[75],"PEGylated":[76,126,148,202,231],"non-PEGylated":[78,134,182,212],"750":[82,146,163,178,221,255],"were":[84,92,100,192],"conjugated":[85],"a":[87,224],"chimeric":[88],"anti-CEA":[89],"antibody":[90],"injected":[93],"intravenously":[94],"into":[95,189],"nude":[96,190],"mice.":[97],"Serum":[98],"samples":[99],"collected":[101],"at":[102],"various":[103],"time":[104],"points":[105],"determine":[107],"serum":[108,131,264],"concentrations":[109,132,154,168],"clearance":[111],"kinetics.":[112],"Biodistribution":[113],"was":[114],"determined":[115],"sonication":[118],"analyzing":[120],"concentration":[122],"profiles":[123],"over":[124],"time.":[125],"had":[128,150],"significantly":[129,151,206,256],"higher":[130,166,263],"than":[133],"with":[136,194,201,239],"p=0.005":[137],"for":[138,144,156,161,170,176,215,220,279,325,346],"p<0.001":[143,175],"dyes.":[147,183],"liver":[153,225],"(p=0.03":[155],"dyes;":[159,218],"p=0.002":[160],"dyes)":[164,179],"renal":[167],"(p=0.003":[169],"compared":[180,209],"Human":[184],"pancreatic":[185],"tumors":[186,208],"subcutaneously":[187],"implanted":[188],"mice":[191],"labeled":[193],"antibody-dye":[195],"conjugates":[196],"serially":[198],"imaged.":[199],"Labeling":[200],"resulted":[204],"in":[205,274],"brighter":[207,268],"(p<0.001":[214],"p=0.01":[219],"dyes).":[222],"In":[223],"metastasis":[226],"model":[227],"colon":[229],"cancer,":[230],"showed":[233],"bright":[234],"labeling":[235,270,327],"metastatic":[237,284],"contrast":[241],"between":[242],"normal":[243],"malignant":[245],"tissue.":[246],"changes":[257],"pharmacokinetics":[259,322],"biodistribution,":[261],"allowing":[262],"concentrations,":[265],"longer":[266],"half-life,":[267],"decreased":[272],"accumulation":[273],"lymphoid":[275,288],"organs.":[276],"This":[277],"allows":[278,324],"high":[280],"fidelity":[281],"imaging":[282,329],"disease":[285],"any":[287],"or":[289],"dense":[291],"organ":[292],"such":[293],"as":[294],"liver.":[296],"Citation":[297],"Format:":[298],"Ali":[299],"A.":[300,305],"Maawy,":[301],"Yukihiko":[302],"Hiroshima,":[303],"George":[304],"Luiken,":[306],"Yong":[307],"Zhang,":[308],"Robert":[309],"M.":[310],"Hoffman,":[311],"Michael":[312],"Bouvet.":[313],"Bioconjugation":[314],"near":[316],"infrared":[317],"improves":[321],"better":[326],"human":[331],"gastrointestinal":[332],"cancers.":[333],"[abstract].":[334],"In:":[335],"Proceedings":[336],"105th":[339],"Annual":[340],"Meeting":[341],"American":[344],"Association":[345],"Cancer":[347,358],"Research;":[348],"2014":[349],"Apr":[350],"5-9;":[351],"San":[352],"Diego,":[353],"CA.":[354],"Philadelphia":[355],"(PA):":[356],"AACR;":[357],"Res":[359],"2014;74(19":[360],"Suppl):Abstract":[361],"nr":[362],"4306.":[363],"doi:10.1158/1538-7445.AM2014-4306":[364]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
