{"id":"https://openalex.org/W1566973004","doi":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","title":"85-kDa cytosolic phospholipase A2 group IV\u03b1 gene promoter polymorphisms in patients with severe asthma: a gene expression and case\u2013control study","display_name":"85-kDa cytosolic phospholipase A2 group IV\u03b1 gene promoter polymorphisms in patients with severe asthma: a gene expression and case\u2013control study","publication_year":2007,"publication_date":"2007-08-02","ids":{"openalex":"https://openalex.org/W1566973004","doi":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","mag":"1566973004","pmid":"https://pubmed.ncbi.nlm.nih.gov/17672871","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2219277"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2007.03459.x","doi":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2219277","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022751958","display_name":"Milena Soko\u0142owska","orcid":"https://orcid.org/0000-0001-9710-6685","observed_orcids":["https://orcid.org/0000-0001-9710-6685"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Sokolowska","raw_affiliation_strings":["Department of Immunopathology, Chair of Immunology, Medical University of Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Chair of Immunology, Medical University of Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081894965","display_name":"Maciej Borowiec","orcid":"https://orcid.org/0000-0003-2812-5676","observed_orcids":["https://orcid.org/0000-0003-2812-5676"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Borowiec","raw_affiliation_strings":["Joslin Diabetes Center, Harvard University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joslin Diabetes Center, Harvard University, Boston, MA, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055163993","display_name":"Anetta Ptasinska","orcid":"https://orcid.org/0000-0002-5001-3294","observed_orcids":["https://orcid.org/0000-0002-5001-3294"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Ptasinska","raw_affiliation_strings":["Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA","Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA, and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002069586","display_name":"M Cie\u015blak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M Cieslak","raw_affiliation_strings":["Department of Immunology, Rheumatology and Allergy, Chair of Immunology, Medical University of Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Rheumatology and Allergy, Chair of Immunology, Medical University of Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108085040","display_name":"James H. Shelhamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Shelhamer","raw_affiliation_strings":["Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA","Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA, and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108073042","display_name":"M. L. Kowalski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"M L Kowalski","raw_affiliation_strings":["Department of Immunology, Rheumatology and Allergy, Chair of Immunology, Medical University of Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Rheumatology and Allergy, Chair of Immunology, Medical University of Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069697575","display_name":"Rafa\u0142 Pawliczak","orcid":"https://orcid.org/0000-0001-6784-453X","observed_orcids":["https://orcid.org/0000-0001-6784-453X"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"R Pawliczak","raw_affiliation_strings":["Department of Immunopathology, Chair of Immunology, Medical University of Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Chair of Immunology, Medical University of Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":1.0558,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75296438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"150","issue":"1","first_page":"124","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/promoter-polymorphism","display_name":"promoter polymorphism","score":0.9549999833106995},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ca-repeats","display_name":"CA repeats","score":0.6800000071525574},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9509999752044678},{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8289999961853027},{"id":"https://openalex.org/keywords/asthma-pathogenesis","display_name":"asthma pathogenesis","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7046970129013062},{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.6643620729446411},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.583239734172821},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5830999612808228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5787913799285889},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5752119421958923},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4995691776275635},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4353538155555725},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4343889057636261},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4257512092590332},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3733118772506714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2825121581554413},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2470921277999878},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19337084889411926},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09370782971382141}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054513","descriptor_name":"Group IV Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.2007.03459.x","doi":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2007.03459.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2219277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2219277","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:17672871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17672871","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2219277","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2219277","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323344","display_name":"Uniwersytet \u0141\u00f3dzki","ror":"https://ror.org/05cq64r17"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W387031605","https://openalex.org/W1530740124","https://openalex.org/W1544502281","https://openalex.org/W1596534657","https://openalex.org/W1812585379","https://openalex.org/W1966167948","https://openalex.org/W1966323838","https://openalex.org/W1970565982","https://openalex.org/W2011781801","https://openalex.org/W2019774786","https://openalex.org/W2024176341","https://openalex.org/W2029523161","https://openalex.org/W2043795001","https://openalex.org/W2047897365","https://openalex.org/W2060016314","https://openalex.org/W2086658365","https://openalex.org/W2092305488","https://openalex.org/W2114722789","https://openalex.org/W2118520335","https://openalex.org/W2140794817","https://openalex.org/W2156831614","https://openalex.org/W2282024633"],"related_works":["https://openalex.org/W2058999194","https://openalex.org/W2161425360","https://openalex.org/W1503447004","https://openalex.org/W2024061782","https://openalex.org/W2081091272","https://openalex.org/W3014006139","https://openalex.org/W2088591122","https://openalex.org/W7045422841","https://openalex.org/W6982410360","https://openalex.org/W1985130301"],"abstract_inverted_index":{"Cytosolic":[0],"phospholipase":[1],"A(2)":[2],"(cPLA(2))":[3],"group":[4,158,175],"IValpha":[5],"is":[6],"a":[7,97,127,262],"critical":[8],"enzyme":[9],"involved":[10],"in":[11,47,63,70,139,193,203,264],"the":[12,39,48,54,104,163,174,228],"liberation":[13],"of":[14,31,38,90,99,146,159,162,176,179,223],"arachidonic":[15],"acid":[16],"from":[17,85],"cellular":[18],"membranes.":[19],"cPLA(2)(-/-)":[20],"mice":[21],"have":[22,253],"reduced":[23],"allergen-induced":[24],"bronchoconstriction":[25],"and":[26,41,44,60,69,93,106,111,121,134,173,217,237,249],"bronchial":[27],"hyperresponsiveness.":[28],"The":[29,157],"goal":[30],"this":[32],"study":[33],"was":[34],"to":[35],"investigate":[36],"polymorphisms":[37],"(CA)(n)":[40,59,105,164,248],"(T)(n)":[42,61,107,180,250],"microsatellites":[43],"surrounding":[45],"regions":[46,57,108],"cPLA(2)alpha":[49],"gene":[50,141],"promoter.":[51],"We":[52,101,198],"analysed":[53],"cPLA(2)":[55,153,257],"promoter":[56,154],"containing":[58],"repeats":[62,118,123,150,181,251],"87":[64],"patients":[65,194],"with":[66,87,96,114,195,227],"severe":[67,196,229,265],"asthma":[68,230,266],"48":[71],"control":[72],"subjects":[73,86],"by":[74],"bidirectional":[75],"sequencing.":[76],"Functional":[77],"studies":[78],"were":[79,225],"performed":[80],"utilizing":[81],"reporter":[82,140],"genes":[83],"derived":[84],"varying":[88],"numbers":[89],"these":[91],"repeats,":[92],"on":[94,256],"constructs":[95,113],"series":[98],"deletions.":[100],"found":[102,200],"that":[103,112,247],"are":[109],"polymorphic":[110],"CA":[115,120,147],"or":[116,119,148],"T":[117,122,149,214],"deleted":[124],"revealed,":[125],"respectively,":[126],"41.8":[128],"+/-":[129,132,136],"7%,":[130],"22.3":[131],"5%":[133],"100":[135],"20%":[137],"increase":[138],"activity.":[142,156],"A":[143,210,219,239],"lower":[144],"number":[145],"caused":[151],"higher":[152],"luciferase":[155],"shorter":[160,177],"alleles":[161,178],"microsatellite":[165],"region":[166,182],"(n":[167,183],"=":[168,171,184,187,235,242],"12-18)":[169],"(P(cor)":[170,186,234,241],"0.00006),":[172],"17-38)":[185],"0.0039)":[188],"occurred":[189],"significantly":[190],"more":[191],"often":[192],"asthma.":[197],"also":[199],"novel":[201],"SNPs":[202],"positions":[204],"-292":[205],"C":[206,216],">":[207,211,215,220],"G,":[208],"-185":[209,238],"C,":[212],"-180":[213],"-165":[218],"C.":[221],"Two":[222],"them":[224],"associated":[226],"phenotype:":[231],"-180T":[232],"allele":[233,240],"0.03996)":[236],"0.03966).":[243],"These":[244],"results":[245],"demonstrate":[246],"may":[252],"an":[254],"influence":[255],"transcription":[258],"which":[259],"might":[260],"play":[261],"role":[263],"pathogenesis.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}