{"id":"https://openalex.org/W1566436591","doi":null,"title":"Targeted therapy and outcome in chronic lymphocytic leukemia","display_name":"Targeted therapy and outcome in chronic lymphocytic leukemia","publication_year":2014,"publication_date":"2014-11-03","ids":{"openalex":"https://openalex.org/W1566436591","mag":"1566436591"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26895766","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Targeted_therapy_and_outcome_in_chronic_lymphocytic_leukemia/26895766","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/42175","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090781165","display_name":"Sandra Eketorp Sylvan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sandra Eketorp Sylvan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090781165"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fludarabine-refractory-disease","display_name":"fludarabine-refractory disease","score":0.8190000057220459},{"id":"https://openalex.org/keywords/alemtuzumab","display_name":"alemtuzumab","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5329999923706055},{"id":"https://openalex.org/keywords/treatment-response-rate","display_name":"treatment response rate","score":0.574999988079071},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7099999785423279},{"id":"https://openalex.org/keywords/lenalidomide-resistance","display_name":"lenalidomide resistance","score":0.5220000147819519},{"id":"https://openalex.org/keywords/relapsed-refractory-cll","display_name":"relapsed/refractory CLL","score":0.6589999794960022},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.5299999713897705},{"id":"https://openalex.org/keywords/cumulative-dose","display_name":"cumulative dose","score":0.32100000977516174},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7618716955184937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5534185171127319},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.49493950605392456},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46675944328308105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4160900115966797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3423337936401367},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3410627841949463},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144237770","wikidata":"https://www.wikidata.org/wiki/Q747534","display_name":"Mathematical economics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26895766","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Targeted_therapy_and_outcome_in_chronic_lymphocytic_leukemia/26895766","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/42175","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1566436591","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/42175/1/Thesis_Sandra_Eketorp_Sylvan.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/42175","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/42175","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W60865865","https://openalex.org/W83807906","https://openalex.org/W142412262","https://openalex.org/W262475294","https://openalex.org/W868725347","https://openalex.org/W981207258","https://openalex.org/W1525326448","https://openalex.org/W1545944104","https://openalex.org/W1549691519","https://openalex.org/W1571259813","https://openalex.org/W1719336338","https://openalex.org/W1833241997","https://openalex.org/W1863976964","https://openalex.org/W1957256977","https://openalex.org/W1960354891","https://openalex.org/W1965159977","https://openalex.org/W1966016310","https://openalex.org/W1968730538","https://openalex.org/W1969953749","https://openalex.org/W1970685635","https://openalex.org/W1973913746","https://openalex.org/W1976058906","https://openalex.org/W1976402300","https://openalex.org/W1976792933","https://openalex.org/W1977271544","https://openalex.org/W1977342543","https://openalex.org/W1980059696","https://openalex.org/W1980260104","https://openalex.org/W1981574853","https://openalex.org/W1982158899","https://openalex.org/W1983546578","https://openalex.org/W1984111648","https://openalex.org/W1987282310","https://openalex.org/W1987531974","https://openalex.org/W1987819921","https://openalex.org/W1989929255","https://openalex.org/W1991644988","https://openalex.org/W1992857313","https://openalex.org/W1993775026","https://openalex.org/W1994709165","https://openalex.org/W1995337370","https://openalex.org/W1998627443","https://openalex.org/W2004512786","https://openalex.org/W2004719848","https://openalex.org/W2007064144","https://openalex.org/W2008650271","https://openalex.org/W2009276795","https://openalex.org/W2010881716","https://openalex.org/W2012234169","https://openalex.org/W2012630504","https://openalex.org/W2012721290","https://openalex.org/W2014246201","https://openalex.org/W2015345028","https://openalex.org/W2015638920","https://openalex.org/W2015856099","https://openalex.org/W2015969861","https://openalex.org/W2016561362","https://openalex.org/W2016973656","https://openalex.org/W2017723771","https://openalex.org/W2017898416","https://openalex.org/W2020586896","https://openalex.org/W2021588881","https://openalex.org/W2025707347","https://openalex.org/W2025741975","https://openalex.org/W2025786205","https://openalex.org/W2026805676","https://openalex.org/W2027971058","https://openalex.org/W2028959659","https://openalex.org/W2029215138","https://openalex.org/W2031192472","https://openalex.org/W2032423071","https://openalex.org/W2039640090","https://openalex.org/W2041925366","https://openalex.org/W2041997366","https://openalex.org/W2044421331","https://openalex.org/W2047415399","https://openalex.org/W2049353008","https://openalex.org/W2057432590","https://openalex.org/W2058370462","https://openalex.org/W2060508679","https://openalex.org/W2060916625","https://openalex.org/W2063994372","https://openalex.org/W2065338378","https://openalex.org/W2066373927","https://openalex.org/W2066564017","https://openalex.org/W2066815159","https://openalex.org/W2067064694","https://openalex.org/W2068283826","https://openalex.org/W2070433411","https://openalex.org/W2071549499","https://openalex.org/W2073938584","https://openalex.org/W2074584895","https://openalex.org/W2075247906","https://openalex.org/W2075875145","https://openalex.org/W2077650095","https://openalex.org/W2080646778","https://openalex.org/W2080951919","https://openalex.org/W2082312121","https://openalex.org/W2083175653","https://openalex.org/W2084803623","https://openalex.org/W2084870802","https://openalex.org/W2084952484","https://openalex.org/W2085648789","https://openalex.org/W2086296392","https://openalex.org/W2087894192","https://openalex.org/W2089082314","https://openalex.org/W2089103836","https://openalex.org/W2095119858","https://openalex.org/W2095491662","https://openalex.org/W2095969626","https://openalex.org/W2096082426","https://openalex.org/W2098701065","https://openalex.org/W2099145932","https://openalex.org/W2099308699","https://openalex.org/W2100207540","https://openalex.org/W2101653483","https://openalex.org/W2102552995","https://openalex.org/W2103857518","https://openalex.org/W2105172500","https://openalex.org/W2108206643","https://openalex.org/W2110624435","https://openalex.org/W2113278680","https://openalex.org/W2115637430","https://openalex.org/W2117648265","https://openalex.org/W2119261541","https://openalex.org/W2120319857","https://openalex.org/W2124513722","https://openalex.org/W2124575836","https://openalex.org/W2129650489","https://openalex.org/W2130011407","https://openalex.org/W2131826846","https://openalex.org/W2132191173","https://openalex.org/W2133111714","https://openalex.org/W2133545780","https://openalex.org/W2134103116","https://openalex.org/W2135215267","https://openalex.org/W2136107817","https://openalex.org/W2136242714","https://openalex.org/W2136597718","https://openalex.org/W2139793858","https://openalex.org/W2140395974","https://openalex.org/W2142881547","https://openalex.org/W2142963736","https://openalex.org/W2143749371","https://openalex.org/W2144617723","https://openalex.org/W2145796979","https://openalex.org/W2149515595","https://openalex.org/W2150044749","https://openalex.org/W2150439521","https://openalex.org/W2150487985","https://openalex.org/W2151177887","https://openalex.org/W2151694080","https://openalex.org/W2157799317","https://openalex.org/W2158313081","https://openalex.org/W2159428875","https://openalex.org/W2159853837","https://openalex.org/W2159880472","https://openalex.org/W2159982252","https://openalex.org/W2160457008","https://openalex.org/W2163348695","https://openalex.org/W2164090407","https://openalex.org/W2165912411","https://openalex.org/W2167550136","https://openalex.org/W2169167811","https://openalex.org/W2169269721","https://openalex.org/W2171443164","https://openalex.org/W2171771895","https://openalex.org/W2171924323","https://openalex.org/W2241277596","https://openalex.org/W2263883462","https://openalex.org/W2272554863","https://openalex.org/W2276310429","https://openalex.org/W2303421618","https://openalex.org/W2315242605","https://openalex.org/W2375706089","https://openalex.org/W2411017239","https://openalex.org/W2411959550","https://openalex.org/W2412672575","https://openalex.org/W2524625584","https://openalex.org/W2555601066","https://openalex.org/W2555940313","https://openalex.org/W2559574963","https://openalex.org/W2582681737","https://openalex.org/W2602916029","https://openalex.org/W2979637638","https://openalex.org/W2997258551"],"related_works":["https://openalex.org/W1481098219","https://openalex.org/W2045741361","https://openalex.org/W2523232626","https://openalex.org/W2093289553","https://openalex.org/W1530681279","https://openalex.org/W2366724976","https://openalex.org/W2321401161","https://openalex.org/W2199025621","https://openalex.org/W2015856099","https://openalex.org/W2087348053"],"abstract_inverted_index":{"Despite":[0],"major":[1],"advances,":[2],"chronic":[3,651,695,740,772],"lymphocytic":[4,652,696,741,773],"leukemia":[5,697,774],"(CLL)":[6,654,698,775],"is":[7,24,35,61],"still":[8],"considered":[9],"incurable.":[10],"Fludarabine":[11],"refractory":[12,113,121,257,590,739],"patients":[13,70,101,156,180,215,228,243,385,398,524,593,648,692],"and":[14,74,108,115,119,141,203,252,268,280,332,345,356,371,387,538,577,591,594,736],"those":[15,109],"with":[16,71,103,110,286,296,362,419,525,566,600,649,693],"TP53disruptions":[17],"have":[18],"a":[19,91,221,281,304,367,444,490,501,533,607,660,700],"particularly":[20],"poor":[21],"prognosis.":[22],"Alemtuzumab":[23,684],"an":[25,64,411,420,463,481,514,782],"established":[26],"treatment":[27,146,348],"option":[28],"for":[29,462,624],"these":[30],"patients.":[31,160,324,438,706],"However,":[32],"its":[33],"use":[34],"complicated":[36],"by":[37],"immunosuppressive":[38],"side":[39],"effects.":[40],"New":[41],"drugs":[42,193,472,620],"targeting":[43],"cellular":[44],"pathways":[45],"are":[46,51],"currently":[47],"developed":[48],"but":[49,399],"there":[50,400],"few":[52],"manufacturer-independent":[53],"comparative":[54,785],"experiments.":[55],"The":[56,134,259,276,408,551],"aim":[57],"of":[58,69,87,188,205,263,271,309,339,342,358,375,404,424,447,471,497,503,544,621,629,647,708,734,751,771],"this":[59,469],"thesis":[60],"to":[62,75,136,145,500,553,610,618,777],"gain":[63],"insight":[65],"into":[66],"the":[67,81,84,131,142,198,201,231,253,297,351,354,373,460,485,539],"outcome":[68],"advanced":[72,88],"CLL":[73,89,104,123,384,498,521],"explore":[76],"new":[77],"emerging":[78,504],"drugs.":[79],"In":[80,197,350,484],"first":[82],"study,":[83,200,353,487],"natural":[85],"history":[86],"in":[90,154,158,169,174,181,194,209,213,220,246,320,337,360,366,378,382,396,436,532,540,589,598,603,612,691,738,783],"well-defined":[92,661],"region":[93,233,702],"without":[94],"external":[95],"referrals":[96,129],"was":[97,139,148,164,224,265,273,278,284,292,364,390,401,430,451,564,586,595],"retrospectively":[98,237],"investigated.":[99],"All":[100],"diagnosed":[102,229],"1991-2010":[105],"were":[106,124,127,236,244,249,530,549],"screened":[107],"bulky":[111],"fludarabine":[112,118,256],"(BFR)":[114],"double":[116],"(i.e.":[117],"alemtuzumab)":[120],"(DR)":[122],"identified.":[125],"Subjects":[126],"primary":[128,535],"within":[130,230],"Stockholm":[132,232],"region.":[133,663],"ORR":[135,277],"salvage":[137],"therapy":[138,272,344,690],"20%":[140],"median":[143,260,269],"time":[144],"failure":[147],"6":[149],"months,":[150,432],"both":[151],"significantly":[152,596],"lower":[153],"BFR/DR":[155],"than":[157],"non-BFR/DR":[159],"Median":[161,290,426],"overall-survival":[162],"(OS)":[163],"18":[165],"months;":[166],"29":[167],"months":[168,173,435],"BFR":[170],"vs":[171],"13":[172],"DR.":[175],"Our":[176,325,457,614],"results":[177,298,326,458,615],"on":[178,191,453,468,478,495,513,704],"consecutive":[179,323,705],"routine":[182,210],"clinical":[183,417,626],"practice":[184],"may":[185,335,616],"facilitate":[186],"interpretation":[187],"non-randomized":[189],"trials":[190],"novel":[192],"advanced-stage":[195,383],"CLL.":[196],"second":[199],"safety":[202,355],"efficacy":[204,357],"alemtuzumab,":[206],"when":[207],"used":[208],"health":[211],"care":[212],"relapsed/refractory":[214,694],"at":[216],"experienced":[217],"medical":[218],"centres":[219],"defined":[222],"region,":[223],"evaluated.":[225,391],"Records":[226],"from":[227,240,299,523,659],"year":[234],"2000-2010":[235],"screened.":[238],"Files":[239],"alemtuzumab":[241,264,363,389,737],"treated":[242],"analysed":[245],"detail.":[247],"Patients":[248],"heavily":[250],"pretreated":[251],"majority":[254],"had":[255],"disease.":[258],"cumulative":[261,306],"dose":[262,283,455],"930":[266],"mg":[267],"duration":[270,308],"12":[274,434],"weeks.":[275],"43%":[279],"higher":[282,287,305,312,597],"associated":[285],"response":[288,313,422],"rate.":[289],"OS":[291],"22.5":[293],"months.":[294],"Compared":[295],"previous":[300],"reports,":[301],"we":[302,488],"observed":[303,565],"dose/longer":[307],"therapy,":[310],"numerically":[311],"rates":[314],"as":[315,317,414,416,441,443,473,475,480,688],"well":[316,415,442,474],"longer":[318],"survival":[319,429],"our":[321],"regional,":[322],"suggest":[327],"that":[328,611],"optimal":[329],"patient":[330,333],"management":[331],"identification":[334],"result":[336],"avoidance":[338],"early":[340],"discontinuation":[341],"planned":[343],"possibly":[346],"better":[347],"outcomes.":[349],"third":[352],"lenalidomide":[359,377,479,735],"combination":[361,409,470],"explored":[365],"phase":[368,465],"I":[369,732],"study":[370,658,733],"additionally,":[372],"capacity":[374,585],"low-dose":[376],"maintaining":[379,743],"immune":[380,744],"functions":[381,745],"prior":[386],"during":[388,746],"Tumor":[392],"flare":[393],"reaction":[394],"occurred":[395],"some":[397],"no":[402],"evidence":[403],"tumor":[405],"lysis":[406],"syndrome.":[407],"showed":[410,556,606],"acceptable":[412],"safetyprofile":[413],"activity":[418],"overall":[421],"rate":[423],"42%.":[425],"progression":[427],"free":[428],"5":[431],"exceeding":[433],"3":[437],"T-cell":[439],"stimulation":[440],"decreased":[445],"number":[446],"regulatory":[448],"T":[449],"cells":[450,499,522,599,776],"evident":[452],"low":[454],"lenalidomide.":[456],"provide":[459,489],"basis":[461],"extended":[464],"2":[466,571],"trial":[467],"further":[476,625],"studies":[477],"immune-enhancing":[482],"agent.":[483],"fourth":[486],"manufacturer":[491],"independent,":[492],"head-to-head":[493],"comparison":[494],"sensitivity":[496,552],"panel":[502],"small":[505,546,778],"targeted":[506,779],"therapeutic":[507,547,780],"molecules":[508,548],"using":[509],"highthroughput":[510],"screening":[511],"based":[512],"automated":[515],"fluorescence":[516],"digital":[517],"scanning":[518],"system.":[519],"Fresh":[520],"indolent":[526],"or":[527],"progressive":[528],"disease":[529],"cultured":[531],"unique":[534],"cell-culture":[536],"medium":[537],"vitro":[541,784],"anti-tumor":[542],"effects":[543],"31":[545],"compared.":[550],"each":[554],"drug":[555],"considerable":[557],"inter-patient":[558],"variability.":[559],"Highest":[560],"mean":[561],"direct":[562],"killing":[563,584],"one":[567,578],"survivin":[568],"inhibitor":[569,581],"(YM-155),":[570],"BCL-2":[572],"inhibitors":[573],"(ABT-199,":[574],"ABT":[575],"737)":[576],"selective":[579],"CDK":[580],"(dinaciclib).":[582],"Their":[583],"similarly":[587],"high":[588,608],"untreated":[592],"TP53disruptions.":[601],"Sensitivity":[602,770],"bone":[604],"marrow":[605],"correlation":[609],"blood.":[613],"help":[617],"identify":[619],"particular":[622],"interest":[623],"development.":[627],"List":[628],"scientific":[630],"papers":[631],"I.":[632],"Eketorp":[633,671,714,757],"Sylvan":[634,672,715,758],"S,":[635,641,673,716,759,763],"Hansson":[636,682,725],"L,":[637,726],"Karlsson":[638,680,723],"C,":[639,681,724],"Norin":[640,762],"Lundin":[642,674,727],"J,":[643,675,728],"\u00d6sterborg":[644,729,766],"A.":[645,730],"Outcomes":[646],"fludarabine-refractory":[650],"leukaemia":[653],"\u2013":[655,699],"A":[656],"population-based":[657],"geographic":[662],"Leukemia":[664],"&":[665],"Lymphoma.":[666],"55(8):1774-80,":[667],"2014.":[668,711],"https://doi.org/10.3109/10428194.2013.827786":[669],"II.":[670],"Ipek":[676],"M,":[677,679],"Palma":[678],"L.":[683,769],"(anti-CD52":[685],"monoclonal":[686],"antibody)":[687],"single-agent":[689],"single":[701],"experience":[703],"Annals":[707],"Hematology.":[709],"93(10):1725-1733,":[710],"https://doi.org/10.1007/s00277-014-2105-1":[712],"III.":[713],"Rossmann":[717],"E,":[718],"Mozaffari":[719],"F,":[720],"Porwit":[721],"A,":[722,767],"Phase":[731],"leukemia:":[742],"therapy-induced":[747],"immunosuppression.":[748],"British":[749],"Journal":[750],"Haematology.":[752],"159(5):599-613,":[753],"2012.":[754],"https://doi.org/10.1111/bjh.12077":[755],"IV.":[756],"Skribek":[760],"H,":[761],"Muhari":[764],"O,":[765],"Szekely":[768],"molecules:":[781],"study.":[786],"[Manuscript]":[787]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
