{"id":"https://openalex.org/W1566434220","doi":"https://doi.org/10.1016/s0021-9258(18)86917-4","title":"Stage-specific glycosphingolipids from amastigote forms of Leishmania (L.) amazonensis. Immunogenicity and role in parasite binding and invasion of macrophages","display_name":"Stage-specific glycosphingolipids from amastigote forms of Leishmania (L.) amazonensis. Immunogenicity and role in parasite binding and invasion of macrophages","publication_year":1993,"publication_date":"1993-06-01","ids":{"openalex":"https://openalex.org/W1566434220","doi":"https://doi.org/10.1016/s0021-9258(18)86917-4","mag":"1566434220","pmid":"https://pubmed.ncbi.nlm.nih.gov/8514804"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)86917-4","doi":"https://doi.org/10.1016/s0021-9258(18)86917-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)86917-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)86917-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109872705","display_name":"A. H. Straus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.H. Straus","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005032064","display_name":"Steven B. Levery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.B. Levery","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009905050","display_name":"Miriam Galvonas Jasiulionis","orcid":"https://orcid.org/0000-0002-4135-0440","observed_orcids":["https://orcid.org/0000-0002-4135-0440"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.G. Jasiulionis","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021992614","display_name":"Mary Ellen K. Salyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.E. Salyan","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S.J. Steele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.J. Steele","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074953319","display_name":"Luiz Rodolpho Travassos","orcid":"https://orcid.org/0000-0002-7692-2795","observed_orcids":["https://orcid.org/0000-0002-7692-2795"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.R. Travassos","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070398233","display_name":"Sen\u2010itiroh Hakomori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Hakomori","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085757072","display_name":"Helio Kiyoshi Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.K. Takahashi","raw_affiliation_strings":["Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","University of Washington, Seattle, Washington 98195","\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and the Well Biology Division, Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Caixa Postal 20372, Siio Paulo, S. P. 04023-062, Brazil,","institution_ids":[]},{"raw_affiliation_string":"University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"\u00a7The Biomembrane Institute, Seattle, Washington 98119, and the Department of Pathobiology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":7.8793,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.97400384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"268","issue":"18","first_page":"13723","last_page":"13730"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania-amazonensis","display_name":"Leishmania amazonensis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/amastigotes","display_name":"amastigotes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neutral-glycosphingolipids","display_name":"neutral glycosphingolipids","score":0.921999990940094},{"id":"https://openalex.org/keywords/globoside","display_name":"globoside","score":0.5950000286102295},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/promastigotes","display_name":"promastigotes","score":0.8489999771118164},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9150000214576721},{"id":"https://openalex.org/keywords/glycan-epitopes","display_name":"carbohydrate epitopes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/galactosylceramide","display_name":"galactosylceramide","score":0.6449999809265137},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.5879999995231628},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C98319499","wikidata":"https://www.wikidata.org/wiki/Q455445","display_name":"Amastigote","level":4,"score":0.9552977085113525},{"id":"https://openalex.org/C13426554","wikidata":"https://www.wikidata.org/wiki/Q416019","display_name":"Glycoconjugate","level":2,"score":0.6947287917137146},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6710772514343262},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6613299250602722},{"id":"https://openalex.org/C2781371782","wikidata":"https://www.wikidata.org/wiki/Q2493771","display_name":"Leishmania mexicana","level":4,"score":0.6587846279144287},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6371015310287476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6233327388763428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5497817993164062},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5232235789299011},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.43250855803489685},{"id":"https://openalex.org/C2779546828","wikidata":"https://www.wikidata.org/wiki/Q6556736","display_name":"Lipophosphoglycan","level":5,"score":0.4224146008491516},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41947564482688904},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.39845216274261475},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.36527734994888306},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.35624873638153076},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3018385171890259},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23932141065597534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10813122987747192},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000953","descriptor_name":"Antigens, Protozoan","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002855","descriptor_name":"Chromatography, Thin Layer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006028","descriptor_name":"Glycosphingolipids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006028","descriptor_name":"Glycosphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007894","descriptor_name":"Leishmania mexicana","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007894","descriptor_name":"Leishmania mexicana","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007894","descriptor_name":"Leishmania mexicana","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016339","descriptor_name":"Spectrometry, Mass, Fast Atom Bombardment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0021-9258(18)86917-4","doi":"https://doi.org/10.1016/s0021-9258(18)86917-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)86917-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:8514804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8514804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3197852","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3197852","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unifesp.br:11600/44199","doi":null,"is_oa":true,"landing_page_url":"http://www.jbc.org/content/268/18/13723.abstract","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)86917-4","doi":"https://doi.org/10.1016/s0021-9258(18)86917-4","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)86917-4","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G401348875","display_name":"GLYCOLIPIDS--CELL INTERACTION/PROLIFERATION/ONCOGENESIS","funder_award_id":"R35CA042505","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G464026059","display_name":null,"funder_award_id":"CA-42 505","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W24722359","https://openalex.org/W958441418","https://openalex.org/W980612985","https://openalex.org/W1237693602","https://openalex.org/W1485814238","https://openalex.org/W1501733677","https://openalex.org/W1522819451","https://openalex.org/W1549150856","https://openalex.org/W1549845633","https://openalex.org/W1567893015","https://openalex.org/W1569852946","https://openalex.org/W1570068227","https://openalex.org/W1608212624","https://openalex.org/W1619975851","https://openalex.org/W1625171252","https://openalex.org/W1671003146","https://openalex.org/W1681037495","https://openalex.org/W1741609474","https://openalex.org/W1927133128","https://openalex.org/W1959117053","https://openalex.org/W1963105351","https://openalex.org/W1971731473","https://openalex.org/W1981274610","https://openalex.org/W1998900417","https://openalex.org/W2009055218","https://openalex.org/W2012314875","https://openalex.org/W2013054067","https://openalex.org/W2018836902","https://openalex.org/W2024905666","https://openalex.org/W2029202131","https://openalex.org/W2037761102","https://openalex.org/W2048535029","https://openalex.org/W2057007315","https://openalex.org/W2064123559","https://openalex.org/W2064995530","https://openalex.org/W2069945861","https://openalex.org/W2071703000","https://openalex.org/W2072461239","https://openalex.org/W2074443036","https://openalex.org/W2085147606","https://openalex.org/W2094775957","https://openalex.org/W2128635872","https://openalex.org/W2142771538","https://openalex.org/W2144999511","https://openalex.org/W2151192612","https://openalex.org/W2162136447","https://openalex.org/W2163221943","https://openalex.org/W2198778513","https://openalex.org/W2344198552"],"related_works":["https://openalex.org/W2119087650","https://openalex.org/W1982756818","https://openalex.org/W2131346025","https://openalex.org/W6982044837","https://openalex.org/W1981274610","https://openalex.org/W2611750964","https://openalex.org/W7096760561","https://openalex.org/W7120746860","https://openalex.org/W7075613682","https://openalex.org/W2125575889"],"abstract_inverted_index":{"Neutral":[0],"glycosphingolipids":[1],"(GSLs)":[2],"from":[3,43,242],"amastigote":[4,36,243,268],"forms":[5,244,269],"of":[6,35,45,61,69,81,88,127,144,148,182,212,216,240,245,263],"Leishmania":[7],"(L.)":[8],"amazonensis":[9],"were":[10,18,27,39,64,98,133],"isolated,":[11],"and":[12,15,41,66,72,86,123,170,189,225,276],"their":[13,67],"structures":[14],"biological":[16],"properties":[17],"characterized.":[19],"Based":[20],"on":[21,112,116],"various":[22],"immunochemical":[23],"methods,":[24],"these":[25,62,166],"GSLs":[26,38,63,93,241,265],"shown":[28],"to":[29],"be":[30],"expressed":[31],"at":[32],"certain":[33],"stages":[34],"development.":[37],"extracted":[40],"purified":[42],"amastigotes":[44,85,101,131,153],"hamster":[46],"foot":[47],"lesions":[48],"by":[49,84,90,130,140,152,165],"established":[50],"procedures.":[51],"Three":[52],"mouse":[53,150],"monoclonal":[54],"antibodies":[55],"(MoAbs)":[56],"specific":[57],"for":[58],"carbohydrate":[59,250],"epitopes":[60],"established,":[65],"inhibition":[68],"parasite":[70],"binding":[71,275],"macrophage":[73,82,128,138],"invasion":[74,83,129,139,147],"was":[75,168],"analyzed.":[76],"MoAb":[77,96],"ST-3":[78,97,106,145],"inhibited":[79,125,146],"80%":[80],"60%":[87],"that":[89],"promastigotes.":[91,141],"Since":[92],"reacting":[94],"with":[95,108,160,187,237,248],"found":[99],"in":[100,104,136,210,274],"but":[102,132],"not":[103,134],"promastigotes,":[105],"reactivity":[107],"promastigotes":[109,156,273],"presumably":[110],"depends":[111],"an":[113,117],"epitope":[114],"present":[115],"unidentified":[118],"promastigote":[119],"glycoconjugate.":[120],"MoAbs":[121,167,234],"ST-4":[122],"ST-5":[124],"60-80%":[126],"effective":[135,271],"preventing":[137],"Fab":[142],"fragments":[143],"cultured":[149],"macrophages":[151],"(80%)":[154],"or":[155],"(60%).":[157],"The":[158,218,233],"GSL":[159],"the":[161,183,193,213,229,282],"simplest":[162],"structure":[163,196],"recognized":[164],"isolated":[169],"characterized":[171],"(by":[172],"negative":[173],"ion":[174],"fast":[175],"atom":[176],"bombardment-mass":[177],"spectrometry,":[178],"gas":[179],"chromatography-mass":[180],"spectrometry":[181],"permethylated":[184],"compound,":[185],"degradation":[186],"exoglycosidases,":[188],"1H":[190],"NMR)":[191],"as":[192,228],"novel":[194],"globoseries":[195],"Gal":[197,257],"beta":[198,202,204,208,214,258],"1-->3Gal":[199,209,259],"alpha":[200,260],"1-->4Gal":[201],"1-->4Glc":[203],"1-->Cer,":[205],"which":[206],"has":[207],"place":[211],"1-->3GalNAc":[215],"globoside.":[217],"ceramide":[219],"contains":[220],"a":[221,238],"16:0":[222],"fatty":[223],"acid":[224],"d18:1":[226],"sphingosine":[227],"long":[230],"chain":[231],"base.":[232],"also":[235],"reacted":[236],"series":[239],"L.":[246],"amazonensis,":[247],"longer":[249],"chains,":[251],"probably":[252],"containing":[253],"identical":[254],"end":[255],"groups":[256],"1-->R.":[261],"Expression":[262],"surface":[264],"may":[266],"render":[267],"more":[270],"than":[272],"invading":[277],"host":[278],"macrophages,":[279],"thus":[280],"enhancing":[281],"infectious":[283],"process.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}