{"id":"https://openalex.org/W156621086","doi":null,"title":"Meta-analysis of medical and non-medical treatments of the prodromal phase of psychotic illness in at-risk mental states.","display_name":"Meta-analysis of medical and non-medical treatments of the prodromal phase of psychotic illness in at-risk mental states.","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W156621086","mag":"156621086","pmid":"https://pubmed.ncbi.nlm.nih.gov/21057405"},"language":"en","primary_location":{"id":"pmid:21057405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21057405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Comparative Study"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026540467","display_name":"Christopher J. Kelly","orcid":"https://orcid.org/0000-0002-1246-844X","observed_orcids":["https://orcid.org/0000-0002-1246-844X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher Kelly","raw_affiliation_strings":["University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045126053","display_name":"Andreas V. Hadjinicolaou","orcid":"https://orcid.org/0000-0002-6520-443X","observed_orcids":["https://orcid.org/0000-0002-6520-443X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andreas V Hadjinicolaou","raw_affiliation_strings":["University of Cambridge School of Clinical Medicine, Addenbrooke\u2019s Hospital, Hills Road, Cambridge, U"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge School of Clinical Medicine, Addenbrooke\u2019s Hospital, Hills Road, Cambridge, U","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113027537","display_name":"Clare Holt","orcid":"https://orcid.org/0009-0009-8304-4108","observed_orcids":["https://orcid.org/0009-0009-8304-4108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clare Holt","raw_affiliation_strings":["Fundation Programme East Anglian Deanery, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundation Programme East Anglian Deanery, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101428835","display_name":"Mark A Agius","orcid":"https://orcid.org/0000-0002-5929-8580","observed_orcids":["https://orcid.org/0000-0002-5929-8580"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2800933101","display_name":"South Essex Partnership University Foundation NHS Trust","ror":"https://ror.org/05v823t63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800933101"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Agius","raw_affiliation_strings":["South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2800933101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076646790","display_name":"Rashid Zaman","orcid":"https://orcid.org/0000-0003-3111-9437","observed_orcids":["https://orcid.org/0000-0003-3111-9437"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2800933101","display_name":"South Essex Partnership University Foundation NHS Trust","ror":"https://ror.org/05v823t63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800933101"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rashid Zaman","raw_affiliation_strings":["South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South Essex Partnership University Foundation NHS Trust, UK ;Bedfordshire Centre for Mental Health Research in Association with Cambridge University, UK ;Department of Psychiatry, University of Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2800933101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1975,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.15627996,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"22 Suppl 1","issue":null,"first_page":"S56","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-high-risk-for-psychosis","display_name":"clinical high risk for psychosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/psychosis-prodrome","display_name":"prodromal psychosis","score":0.9039999842643738},{"id":"https://openalex.org/keywords/psychosis-prevention","display_name":"psychosis prevention","score":0.6549999713897705},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8209999799728394},{"id":"https://openalex.org/keywords/olanzapine","display_name":"olanzapine","score":0.9259999990463257},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.7139999866485596},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7760000228881836},{"id":"https://openalex.org/keywords/non-medical-interventions","display_name":"non-medical interventions","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2776619155","wikidata":"https://www.wikidata.org/wiki/Q201872","display_name":"Olanzapine","level":3,"score":0.7200657725334167},{"id":"https://openalex.org/C2776674806","wikidata":"https://www.wikidata.org/wiki/Q12135","display_name":"Mental illness","level":3,"score":0.6883957982063293},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.6489855051040649},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.607761800289154},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5622098445892334},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5211032629013062},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5196850895881653},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.45331645011901855},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.25959277153015137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12324896454811096}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012569","descriptor_name":"Schizotypal Personality Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012569","descriptor_name":"Schizotypal Personality Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D012569","descriptor_name":"Schizotypal Personality Disorder","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015525","descriptor_name":"Fatty Acids, Omega-3","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015928","descriptor_name":"Cognitive Behavioral Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21057405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21057405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatria Danubina","raw_type":"Comparative Study"},{"id":"mag:156621086","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21057405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1967224402","https://openalex.org/W1970967099","https://openalex.org/W2002830118","https://openalex.org/W2020819504","https://openalex.org/W2021060992","https://openalex.org/W2057646365","https://openalex.org/W2107878018","https://openalex.org/W2121366540","https://openalex.org/W2130372506","https://openalex.org/W2135392214","https://openalex.org/W2136857547","https://openalex.org/W2155461654","https://openalex.org/W2158929255","https://openalex.org/W2413961739"],"related_works":["https://openalex.org/W2586037053","https://openalex.org/W2156637826","https://openalex.org/W7098335927","https://openalex.org/W2029552007","https://openalex.org/W2985054930","https://openalex.org/W7113446568","https://openalex.org/W3108898825","https://openalex.org/W2587918810","https://openalex.org/W58010879","https://openalex.org/W2936761628"],"abstract_inverted_index":{"INTRODUCTION:":[0],"there":[1],"are":[2,20,31],"now":[3],"many":[4],"existing":[5],"studies":[6,50,79],"which":[7,97,107],"assess":[8],"the":[9,25,49,67,77,84,102],"treatments":[10,41,82,114,140,146],"available":[11,51,78],"for":[12,70,139],"'at":[13,71],"risk":[14,73],"mental":[15],"states',":[16],"as":[17],"patients":[18],"who":[19],"believed":[21],"to":[22,53,62,121,136,143],"be":[23,66,122],"in":[24,108,141,152],"prodromal":[26,85],"phase":[27,86,154],"of":[28,39,48,58,87,129,155],"psychotic":[29,88,156],"illness":[30,89],"referred":[32],"to.":[33],"However,":[34],"concerns":[35],"regarding":[36],"side":[37,150],"effects":[38,151],"possible":[40],"remain.":[42],"We":[43],"here":[44],"conduct":[45],"a":[46,118],"meta-analysis":[47],"up":[52],"October":[54],"2010.":[55],"The":[56],"aim":[57],"this":[59,153],"study":[60,104],"is":[61,134],"decide":[63],"what":[64],"would":[65],"best":[68],"treatment":[69],"high":[72],"patients'.":[74],"RESULTS:":[75],"all":[76,93],"examining":[80],"potential":[81],"during":[83],"were":[90],"collected.":[91],"They":[92],"showed":[94],"comparable":[95],"efficacy,":[96],"reached":[98],"statistical":[99],"significance,":[100],"excluding":[101],"one":[103],"using":[105],"olanzapine,":[106],"fact":[109],"'tended":[110],"towards":[111],"significance'.":[112],"DISCUSSION:":[113],"appear":[115],"promising":[116],"but":[117],"balance":[119],"needs":[120],"kept":[123],"between":[124],"adverse":[125,149],"events":[126],"and":[127],"effectiveness":[128],"preventing":[130],"psychosis.":[131],"CONCLUSION:":[132],"it":[133],"necessary":[135],"search":[137],"further":[138],"order":[142],"identify":[144],"effective":[145],"with":[147],"fewer":[148],"illness.":[157]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}