{"id":"https://openalex.org/W1565836638","doi":null,"title":"Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus","display_name":"Analysis of the central and peripheral mechanisms underlying the analgesic effects of the extracts of Phyllanthus amarus and Phyllanthus fraternus","publication_year":2013,"publication_date":"2013-03-28","ids":{"openalex":"https://openalex.org/W1565836638","mag":"1565836638"},"language":"en","primary_location":{"id":"mag:1565836638","doi":null,"is_oa":false,"landing_page_url":"https://www.indianjournals.com/ijor.aspx?target=ijor:ajpr&volume=3&issue=1&article=004&type=pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764524052","display_name":"Asian Journal of Pharmaceutical Research","issn_l":"2231-5683","issn":["2231-5683","2231-5691"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Pharmaceutical Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039472131","display_name":"Atul R. Chopade","orcid":"https://orcid.org/0000-0002-4557-9322","observed_orcids":["https://orcid.org/0000-0002-4557-9322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atul R. Chopade","raw_affiliation_strings":["Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, Dist. Satara. 415124"],"raw_orcid":"https://orcid.org/0000-0002-4557-9322","affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, Dist. Satara. 415124","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114004977","display_name":"Fahim J. Sayyad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fahim Sayyad","raw_affiliation_strings":["Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, Dist. Satara. 415124"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology and Pharmacognosy, Government College of Pharmacy, Karad, Dist. Satara. 415124","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4343,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58458704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"1","first_page":"10","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phyllanthus-amarus","display_name":"Phyllanthus amarus","score":1.0},{"id":"https://openalex.org/keywords/phyllanthus-fraternus","display_name":"Phyllanthus fraternus","score":1.0},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.9100000262260437},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6830000281333923},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2776718122","wikidata":"https://www.wikidata.org/wiki/Q310927","display_name":"Phyllanthus","level":2,"score":0.7481124401092529},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.6363937258720398},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.599152147769928},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5785198211669922},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4817762076854706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35385414958000183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34235680103302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.341158390045166},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20961201190948486}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1565836638","doi":null,"is_oa":false,"landing_page_url":"https://www.indianjournals.com/ijor.aspx?target=ijor:ajpr&volume=3&issue=1&article=004&type=pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764524052","display_name":"Asian Journal of Pharmaceutical Research","issn_l":"2231-5683","issn":["2231-5683","2231-5691"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Pharmaceutical Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1771441866","https://openalex.org/W1965406171","https://openalex.org/W1998436631","https://openalex.org/W2011717482","https://openalex.org/W2014965141","https://openalex.org/W2020613944","https://openalex.org/W2028812611","https://openalex.org/W2058742288","https://openalex.org/W2071000712","https://openalex.org/W2085881767","https://openalex.org/W2108006450","https://openalex.org/W2122560536","https://openalex.org/W2229863986","https://openalex.org/W2278365557","https://openalex.org/W2310962972"],"related_works":["https://openalex.org/W4406918427","https://openalex.org/W2400418802","https://openalex.org/W4220894103","https://openalex.org/W2328771432","https://openalex.org/W2028812611","https://openalex.org/W1979523129","https://openalex.org/W1986510237","https://openalex.org/W2228096037","https://openalex.org/W1965406171","https://openalex.org/W2315595098"],"abstract_inverted_index":{"Ethnopharmacological":[0],"relevance:":[1],"A":[2],"great":[3],"number":[4,90],"of":[5,21,23,33,47,50,79,91,109,127,158,197,206,213],"preclinical":[6],"and":[7,40,53,63,69,88,112,129,141,161,193,216],"clinical":[8],"studies":[9],"have":[10,15],"not":[11],"only":[12],"confirmed":[13],"but":[14],"also":[16],"extended":[17],"the":[18,24,34,38,44,48,59,89,107,123,135,147,156,179,207,211],"medicinal":[19],"uses":[20],"species":[22],"genus":[25],"Phyllanthus":[26,51,54,110,113,159,162,184],"mentioned":[27],"in":[28,56,172,174,189],"traditional":[29],"medicine.":[30],"Aim":[32],"study:":[35],"To":[36],"evaluate":[37],"central":[39,217],"peripheral":[41,215],"mechanisms":[42],"underlying":[43],"analgesic":[45],"effects":[46],"extracts":[49,108,157,185],"amarus":[52,111,160],"fraternus":[55,163],"mice":[57,173],"using":[58],"acetic":[60,81,100,169,198],"acid-induced":[61,170],"writhing":[62,171],"hot":[64,148,180],"plate":[65,149,181],"tests.":[66],"Materials":[68],"methods:":[70],"a)":[72],"Writhing":[73],"was":[74,119,134],"induced":[75,200],"by":[76],"intraperitoneal":[77],"injection":[78,102],"0.6%":[80],"acid":[82,101,199],"(v/v)":[83],"(80":[84],"mg/kg":[85],"body":[86],"wt.)":[87],"muscular":[92],"contractions":[93],"were":[94],"counted":[95],"for":[96,138],"30":[97],"min":[98],"following":[99],"with":[103,106],"animals":[104],"treated":[105],"fraternus.":[114],"B)":[116],"The":[117,131],"assay":[118],"performed":[120],"according":[121],"to":[122,146],"classical":[124],"hot-plate":[125],"technique":[126],"Eddy":[128],"Leimbach.":[130],"parameter":[132],"evaluated":[133],"latency":[136,182],"time":[137,192],"paw":[139],"licking":[140],"jumping":[142],"responses":[143],"after":[144],"exposure":[145],"surface.":[150],"Results:":[152],"Results":[153],"showed":[154,186],"that":[155],"given":[164],"intraperitoneally":[165],"can":[166],"significantly":[167],"attenuate":[168],"a":[175],"dose-dependent":[176],"manner.":[177],"In":[178],"test,":[183],"common":[187],"activity":[188],"prolonging":[190],"duration":[191],"caused":[194],"marked":[195],"inhibition":[196],"pain.":[201],"Conclusions:":[203],"These":[204],"findings":[205],"current":[208],"study":[209],"imply":[210],"involvement":[212],"both":[214],"antinociceptive":[218],"mechanisms.":[219]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}