{"id":"https://openalex.org/W156564022","doi":null,"title":"Hipk: a versatile regulator of multiple signaling networks during Drosophila development","display_name":"Hipk: a versatile regulator of multiple signaling networks during Drosophila development","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W156564022","mag":"156564022"},"language":"en","primary_location":{"id":"pmh:oai:summit.sfu.ca:9405","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9405","pdf_url":"http://summit.sfu.ca/item/9405","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://summit.sfu.ca/item/9405","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083352578","display_name":"Wendy Lee","orcid":"https://orcid.org/0000-0002-8807-0550","observed_orcids":["https://orcid.org/0000-0002-8807-0550"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wendy Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8807-0550","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083352578"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homeodomain-interacting-protein-kinase","display_name":"homeodomain-interacting protein kinase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/drosophila-development","display_name":"Drosophila development","score":0.8849999904632568},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/wingless-signaling","display_name":"Wingless signaling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/eye-development","display_name":"eye development","score":0.5320000052452087},{"id":"https://openalex.org/keywords/wing-development","display_name":"wing development","score":0.9480000138282776},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.8442834615707397},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.6405102610588074},{"id":"https://openalex.org/C3017607883","wikidata":"https://www.wikidata.org/wiki/Q25325354","display_name":"Master regulator","level":4,"score":0.531211256980896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4282616674900055},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42505791783332825},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35871803760528564},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3484073877334595},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1669352948665619},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11073353886604309},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06226909160614014}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:summit.sfu.ca:9405","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9405","pdf_url":"http://summit.sfu.ca/item/9405","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:summit.sfu.ca:node-9405","doi":null,"is_oa":true,"landing_page_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/9405/etd4399.pdf","pdf_url":"https://summit.sfu.ca/_flysystem/fedora/sfu_migrate/9405/etd4399.pdf","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:156564022","doi":null,"is_oa":false,"landing_page_url":"https://summit.sfu.ca/system/files/iritems1/9405/etd4399.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:summit.sfu.ca:9405","doi":null,"is_oa":true,"landing_page_url":"http://summit.sfu.ca/item/9405","pdf_url":"http://summit.sfu.ca/item/9405","source":{"id":"https://openalex.org/S4306400490","display_name":"Summit (Simon Fraser University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I18014758","host_organization_name":"Simon Fraser University","host_organization_lineage":["https://openalex.org/I18014758"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W156564022.pdf","grobid_xml":"https://content.openalex.org/works/W156564022.grobid-xml"},"referenced_works_count":161,"referenced_works":["https://openalex.org/W70790455","https://openalex.org/W125898244","https://openalex.org/W1511545125","https://openalex.org/W1532597512","https://openalex.org/W1588637701","https://openalex.org/W1661341289","https://openalex.org/W1894504172","https://openalex.org/W1901013657","https://openalex.org/W1902879109","https://openalex.org/W1920794749","https://openalex.org/W1920846434","https://openalex.org/W1923350544","https://openalex.org/W1927705215","https://openalex.org/W1938464192","https://openalex.org/W1939368982","https://openalex.org/W1963718127","https://openalex.org/W1965856748","https://openalex.org/W1967192173","https://openalex.org/W1970492716","https://openalex.org/W1972175683","https://openalex.org/W1975378120","https://openalex.org/W1975803734","https://openalex.org/W1976856675","https://openalex.org/W1977238166","https://openalex.org/W1977962361","https://openalex.org/W1978313350","https://openalex.org/W1978544252","https://openalex.org/W1980333298","https://openalex.org/W1980955976","https://openalex.org/W1982124131","https://openalex.org/W1983781145","https://openalex.org/W1985645808","https://openalex.org/W1987599413","https://openalex.org/W1987909503","https://openalex.org/W1988846042","https://openalex.org/W1991631964","https://openalex.org/W1994822723","https://openalex.org/W1995216594","https://openalex.org/W1995741673","https://openalex.org/W1997180986","https://openalex.org/W1997409151","https://openalex.org/W1997955636","https://openalex.org/W2000978157","https://openalex.org/W2003241066","https://openalex.org/W2003927747","https://openalex.org/W2004349194","https://openalex.org/W2004823255","https://openalex.org/W2005865365","https://openalex.org/W2008815241","https://openalex.org/W2008887283","https://openalex.org/W2010281502","https://openalex.org/W2010413075","https://openalex.org/W2012039807","https://openalex.org/W2014893429","https://openalex.org/W2016213943","https://openalex.org/W2017668082","https://openalex.org/W2022207101","https://openalex.org/W2022808499","https://openalex.org/W2023865101","https://openalex.org/W2028441387","https://openalex.org/W2029469952","https://openalex.org/W2029753792","https://openalex.org/W2031782870","https://openalex.org/W2036864436","https://openalex.org/W2036993884","https://openalex.org/W2038614254","https://openalex.org/W2039252526","https://openalex.org/W2040942754","https://openalex.org/W2049277771","https://openalex.org/W2050010024","https://openalex.org/W2051032088","https://openalex.org/W2051202415","https://openalex.org/W2051882112","https://openalex.org/W2052870426","https://openalex.org/W2053949782","https://openalex.org/W2054311839","https://openalex.org/W2055102377","https://openalex.org/W2056806024","https://openalex.org/W2057008723","https://openalex.org/W2060841490","https://openalex.org/W2063669247","https://openalex.org/W2063822655","https://openalex.org/W2070642667","https://openalex.org/W2073223709","https://openalex.org/W2073476400","https://openalex.org/W2074224340","https://openalex.org/W2074582828","https://openalex.org/W2076073895","https://openalex.org/W2076304265","https://openalex.org/W2076914475","https://openalex.org/W2079494666","https://openalex.org/W2081253307","https://openalex.org/W2081832585","https://openalex.org/W2081985759","https://openalex.org/W2082670705","https://openalex.org/W2083723382","https://openalex.org/W2085204257","https://openalex.org/W2086802510","https://openalex.org/W2089569109","https://openalex.org/W2090218100","https://openalex.org/W2090698995","https://openalex.org/W2098357545","https://openalex.org/W2098565860","https://openalex.org/W2098741226","https://openalex.org/W2100070586","https://openalex.org/W2100860418","https://openalex.org/W2101144251","https://openalex.org/W2107648723","https://openalex.org/W2109183374","https://openalex.org/W2109429524","https://openalex.org/W2109744312","https://openalex.org/W2110643873","https://openalex.org/W2118121244","https://openalex.org/W2118177072","https://openalex.org/W2121784339","https://openalex.org/W2124008135","https://openalex.org/W2126967459","https://openalex.org/W2127292022","https://openalex.org/W2128323213","https://openalex.org/W2132475598","https://openalex.org/W2133139998","https://openalex.org/W2138301962","https://openalex.org/W2139739677","https://openalex.org/W2140899494","https://openalex.org/W2141452193","https://openalex.org/W2142740958","https://openalex.org/W2143366342","https://openalex.org/W2146167376","https://openalex.org/W2152123530","https://openalex.org/W2152170899","https://openalex.org/W2153311182","https://openalex.org/W2153942451","https://openalex.org/W2155365827","https://openalex.org/W2157739471","https://openalex.org/W2159112619","https://openalex.org/W2159935247","https://openalex.org/W2160064773","https://openalex.org/W2160340008","https://openalex.org/W2161597083","https://openalex.org/W2163170981","https://openalex.org/W2164338169","https://openalex.org/W2167166050","https://openalex.org/W2168820955","https://openalex.org/W2168948134","https://openalex.org/W2171775558","https://openalex.org/W2175560053","https://openalex.org/W2183722523","https://openalex.org/W2186370879","https://openalex.org/W2187370769","https://openalex.org/W2188357884","https://openalex.org/W2188603786","https://openalex.org/W2188685799","https://openalex.org/W2409464811","https://openalex.org/W2412932334","https://openalex.org/W2414145493","https://openalex.org/W2417380734","https://openalex.org/W2472955934","https://openalex.org/W3144948038","https://openalex.org/W7074140657","https://openalex.org/W7095734969","https://openalex.org/W7096815554"],"related_works":["https://openalex.org/W1974714162","https://openalex.org/W2036993884","https://openalex.org/W44715794","https://openalex.org/W2784366894","https://openalex.org/W2559284686","https://openalex.org/W1964491152","https://openalex.org/W2050712486","https://openalex.org/W2153769874","https://openalex.org/W2001791127","https://openalex.org/W1503991462"],"abstract_inverted_index":{"Development":[0],"of":[1,15,54,57],"multicellular":[2,31],"organisms":[3],"is":[4],"a":[5,30,52],"dynamic":[6],"process":[7],"that":[8],"requires":[9],"cellcell":[10],"communication":[11],"through":[12],"the":[13,85],"transmission":[14],"signal":[16],"transduction":[17],"pathways.Signaling":[18],"cascades":[19],"elicit":[20],"transcriptional":[21,70],"programs":[22],"to":[23,28,42,72],"synchronize":[24],"discrete":[25],"biological":[26],"processes":[27],"pattern":[29],"organism.These":[32],"signals":[33],"are":[34],"tightly":[35],"regulated":[36],"and":[37,45,77],"their":[38],"deregulation":[39],"can":[40],"lead":[41],"cancer":[43],"onset":[44],"progression.Homeodomain":[46],"interacting":[47],"protein":[48],"kinases":[49],"(Hipks)":[50],"represent":[51],"family":[53],"serine/threonine":[55],"kinases.Members":[56],"this":[58],"group":[59],"(in":[60],"particular":[61],"Hipk2)":[62],"have":[63],"been":[64],"implicated":[65],"as":[66],"important":[67],"factors":[68],"in":[69],"regulation":[71],"control":[73],"cell":[74],"growth,":[75],"apoptosis":[76],"development.These":[78],"studies":[79],"identified":[80],"an":[81],"essential":[82],"requirement":[83],"for":[84],"sole":[86],"v":[87]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}