{"id":"https://openalex.org/W1565442","doi":null,"title":"Neuroprotective properties of melissa officinalis L. Extract against ecstasy-induced neurotoxicity.","display_name":"Neuroprotective properties of melissa officinalis L. Extract against ecstasy-induced neurotoxicity.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1565442","mag":"1565442","pmid":"https://pubmed.ncbi.nlm.nih.gov/23671824","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3652537"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3652537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell J","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017437592","display_name":"Gholamreza Hassanzadeh","orcid":"https://orcid.org/0000-0003-0724-6479","observed_orcids":["https://orcid.org/0000-0003-0724-6479","https://orcid.org/0000-0002-5357-8995"]},"institutions":[{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Gholamreza Hassanzadeh","raw_affiliation_strings":["1. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Anatomy Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037173257","display_name":"Parichehr Pasbakhsh","orcid":"https://orcid.org/0000-0002-6772-9889","observed_orcids":["https://orcid.org/0000-0002-6772-9889","https://orcid.org/0009-0009-8659-6442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Parichehr Pasbakhsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammad Akbari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Akbari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006447954","display_name":"Saeed Shokri","orcid":"https://orcid.org/0000-0002-4925-9748","observed_orcids":["https://orcid.org/0000-0002-4925-9748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saeed Shokri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055143909","display_name":"Mohammadhosein Ghahremani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammadhosein Ghahremani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006069019","display_name":"Gholamreza Amin","orcid":"https://orcid.org/0000-0002-2812-3040","observed_orcids":["https://orcid.org/0000-0002-2812-3040","https://orcid.org/0000-0003-4187-5279"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gholamreza Amin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029391853","display_name":"Iraj Ragerdi Kashani","orcid":"https://orcid.org/0000-0003-3842-7950","observed_orcids":["https://orcid.org/0000-0003-3842-7950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iraj Kashani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112624090","display_name":"Abolfazl Azami Tameh","orcid":"https://orcid.org/0000-0002-5359-3298","observed_orcids":["https://orcid.org/0000-0002-5359-3298","https://orcid.org/0000-0001-5872-0463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abolfazl Azami Tameh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9873,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90217146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"25","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.6758000254631042,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.13830000162124634,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melissa-officinalis","display_name":"lemon balm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.921999990940094},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibition","display_name":"monoamine oxidase inhibition","score":0.9639999866485596},{"id":"https://openalex.org/keywords/antioxidant-plants","display_name":"antioxidant plants","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8385181427001953},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7797046899795532},{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.667370617389679},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6610099077224731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6379057765007019},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.55830979347229},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5536983013153076},{"id":"https://openalex.org/C2994321634","wikidata":"https://www.wikidata.org/wiki/Q148396","display_name":"Melissa officinalis","level":2,"score":0.5412840843200684},{"id":"https://openalex.org/C2779488553","wikidata":"https://www.wikidata.org/wiki/Q625143","display_name":"Ecstasy","level":2,"score":0.49469777941703796},{"id":"https://openalex.org/C2780886089","wikidata":"https://www.wikidata.org/wiki/Q7079617","display_name":"Officinalis","level":2,"score":0.4113743305206299},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.35171258449554443},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3188398480415344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2790369987487793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17874756455421448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09540867805480957},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.06527230143547058},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3652537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell J","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2650683","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3652537","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23671824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23671824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.798.3572","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.798.3572","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dc/67/Cell-J-13-25.PMC3652537.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e6e1fe282246499399d1f4c317c7479f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e6e1fe282246499399d1f4c317c7479f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Journal, Vol 13, Iss 1, Pp 25-30 (2011)","raw_type":"article"},{"id":"mag:2282357917","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652537/figure/F3/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:1565442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23671824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3652537","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3652537/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322670","display_name":"Tehran University of Medical Sciences and Health Services","ror":"https://ror.org/01c4pz451"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1565442.pdf","grobid_xml":"https://content.openalex.org/works/W1565442.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W106207772","https://openalex.org/W1884253425","https://openalex.org/W1966532922","https://openalex.org/W1968214137","https://openalex.org/W1977780735","https://openalex.org/W1987700551","https://openalex.org/W1988897041","https://openalex.org/W1992390260","https://openalex.org/W2038293302","https://openalex.org/W2048841731","https://openalex.org/W2052645853","https://openalex.org/W2081145901","https://openalex.org/W2090237116","https://openalex.org/W2092595655","https://openalex.org/W2101861123","https://openalex.org/W2114918609","https://openalex.org/W2142240281","https://openalex.org/W2163443978","https://openalex.org/W2167277601"],"related_works":["https://openalex.org/W7011775680","https://openalex.org/W2052645853","https://openalex.org/W7100555503","https://openalex.org/W2994608257","https://openalex.org/W2948230062","https://openalex.org/W2144215440","https://openalex.org/W7049237767","https://openalex.org/W7030464690","https://openalex.org/W2759159286","https://openalex.org/W2955292807"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1],"aim":[2],"of":[3,13,34,80,124,156],"the":[4,10,35,90,103,125,153],"present":[5],"study":[6],"was":[7,50],"to":[8,52,71,98,118,163],"investigate":[9],"neuroprotective":[11,145],"effects":[12,146],"Melissa":[14,112,141],"officinalis,":[15],"a":[16],"major":[17],"antioxidant":[18],"plant,":[19],"against":[20,132,147],"neuron":[21],"toxicity":[22],"in":[23,106,138,152],"hippocampal":[24,107,157],"primary":[25,154],"culture":[26],"induced":[27,149],"by":[28,150],"3,4-methylenedioxymethamphetamine":[29],"(MDMA)":[30],"or":[31],"ecstasy,":[32],"one":[33],"most":[36],"abused":[37],"drugs,":[38],"which":[39,159],"causes":[40],"neurotoxicity.":[41],"MATERIALS":[42],"AND":[43],"METHODS:":[44],"3-(4,5-dimethyl-2":[45],"thiazoyl)-2,5-diphenyl-tetrazolium":[46],"bromide":[47],"(MTT)":[48],"assay":[49,61],"used":[51],"assess":[53],"mitochondrial":[54,84,134],"activity,":[55],"reflecting":[56],"cell":[57,74],"survival.":[58],"Caspase-3":[59],"activity":[60],"and":[62,93,121,129,136,169],"Hoechst":[63],"/":[64],"propiedium":[65],"iodide":[66],"(PI)":[67],"staining":[68],"were":[69],"done":[70],"show":[72],"apoptotic":[73,95],"death.":[75],"RESULTS:":[76],"A":[77],"high":[78],"dose":[79],"ecstasy":[81],"caused":[82],"profound":[83],"dysfunction,":[85],"around":[86,99,119],"40%":[87],"less":[88],"than":[89,102],"control":[91,104],"value,":[92],"increased":[94],"neuronal":[96,108],"death":[97],"35%":[100],"more":[101],"value":[105],"culture.":[109],"Co-treatment":[110],"with":[111],"officinalis":[113,142],"significantly":[114],"reversed":[115],"these":[116],"damages":[117],"15%":[120],"20%":[122],"respectively":[123],"MDMA":[126,151],"alone":[127],"group,":[128],"provided":[130],"protection":[131],"MDMA-induced":[133],"dysfunction":[135],"apoptosis":[137,148],"neurons.":[139],"CONCLUSION:":[140],"has":[143],"revealed":[144],"neurons":[155],"culture,":[158],"could":[160],"be":[161],"due":[162],"its":[164],"free":[165],"radical":[166],"scavenging":[167],"properties":[168],"monoamine":[170],"oxidase":[171],"(MAO)":[172],"inhibitory":[173],"effects.":[174]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}