{"id":"https://openalex.org/W1565099151","doi":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","title":"Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady\u2010state conditions in type 1 diabetes","display_name":"Insulin degludec: four times lower pharmacodynamic variability than insulin glargine under steady\u2010state conditions in type 1 diabetes","publication_year":2012,"publication_date":"2012-05-17","ids":{"openalex":"https://openalex.org/W1565099151","doi":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","mag":"1565099151","pmid":"https://pubmed.ncbi.nlm.nih.gov/22594461"},"language":"en","primary_location":{"id":"doi:10.1111/j.1463-1326.2012.01627.x","doi":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1463-1326.2012.01627.x","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1463-1326.2012.01627.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065775242","display_name":"Tim Heise","orcid":"https://orcid.org/0000-0002-8346-2037","observed_orcids":["https://orcid.org/0000-0002-8346-2037"]},"institutions":[{"id":"https://openalex.org/I4210165534","display_name":"Profil Institute for Metabolic Research","ror":"https://ror.org/05krxy197","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165534"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"T. Heise","raw_affiliation_strings":["Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany","institution_ids":["https://openalex.org/I4210165534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025454681","display_name":"Lidia Hermanski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165534","display_name":"Profil Institute for Metabolic Research","ror":"https://ror.org/05krxy197","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165534"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Hermanski","raw_affiliation_strings":["Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany","institution_ids":["https://openalex.org/I4210165534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054068635","display_name":"Leszek Nosek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165534","display_name":"Profil Institute for Metabolic Research","ror":"https://ror.org/05krxy197","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165534"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Nosek","raw_affiliation_strings":["Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany","institution_ids":["https://openalex.org/I4210165534"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Feldman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165534","display_name":"Profil Institute for Metabolic Research","ror":"https://ror.org/05krxy197","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210165534"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Feldman","raw_affiliation_strings":["Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Profil Institut f\u00fcr Stoffwechselforschung GmbH  Neuss Germany","institution_ids":["https://openalex.org/I4210165534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110231477","display_name":"S\u00f8ren Rasmussen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S. Rasmussen","raw_affiliation_strings":["Biostatistics Novo Nordisk A/S  S\u00f8borg Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Novo Nordisk A/S  S\u00f8borg Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084566354","display_name":"Hanne L. Haahr","orcid":"https://orcid.org/0000-0002-6980-8230","observed_orcids":["https://orcid.org/0000-0002-6980-8230"]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H. Haahr","raw_affiliation_strings":["Insulin Clinical Pharmacology Novo Nordisk A/S  S\u00f8borg Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insulin Clinical Pharmacology Novo Nordisk A/S  S\u00f8borg Denmark","institution_ids":["https://openalex.org/I189090001"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065775242"],"corresponding_institution_ids":["https://openalex.org/I4210165534"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":32.1279,"has_fulltext":true,"cited_by_count":395,"citation_normalized_percentile":{"value":0.99863909,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"9","first_page":"859","last_page":"864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degludec","display_name":"insulin degludec","score":1.0},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.878000020980835},{"id":"https://openalex.org/keywords/basal-insulin","display_name":"basal insulin","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pharmacodynamic-variability","display_name":"pharmacodynamic variability","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glucose-lowering-effect","display_name":"glucose-lowering effect","score":0.7940000295639038},{"id":"https://openalex.org/keywords/glucose-infusion-rate","display_name":"glucose infusion rate","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ultra-long-acting-insulin","display_name":"ultra-long-acting insulin","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2775927303","wikidata":"https://www.wikidata.org/wiki/Q16252338","display_name":"Insulin degludec","level":5,"score":0.8080000877380371},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.8027262687683105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6476460695266724},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6272368431091309},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6032264828681946},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.5425231456756592},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5312150716781616},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5018448829650879},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.4597243666648865},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.42950111627578735},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.42647743225097656},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4260566532611847},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.41747069358825684},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4117279350757599},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.3706926703453064},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.1745310127735138},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1463-1326.2012.01627.x","doi":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1463-1326.2012.01627.x","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:22594461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22594461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1463-1326.2012.01627.x","doi":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1463-1326.2012.01627.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1463-1326.2012.01627.x","source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1565099151.pdf","grobid_xml":"https://content.openalex.org/works/W1565099151.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W43308025","https://openalex.org/W1986874694","https://openalex.org/W2000532172","https://openalex.org/W2019136020","https://openalex.org/W2024796443","https://openalex.org/W2050756416","https://openalex.org/W2063406949","https://openalex.org/W2065518778","https://openalex.org/W2069824034","https://openalex.org/W2071173797","https://openalex.org/W2082431219","https://openalex.org/W2091030955","https://openalex.org/W2106459655","https://openalex.org/W2109533147","https://openalex.org/W2119060402","https://openalex.org/W2136164787","https://openalex.org/W2139103625","https://openalex.org/W2497721881","https://openalex.org/W2917207274","https://openalex.org/W4253023439"],"related_works":["https://openalex.org/W2603131458","https://openalex.org/W2758044071","https://openalex.org/W2325852125","https://openalex.org/W1952276185","https://openalex.org/W3046959850","https://openalex.org/W2492089331","https://openalex.org/W3035564592","https://openalex.org/W2034327086","https://openalex.org/W7100926821","https://openalex.org/W4281901968"],"abstract_inverted_index":{"AIMS:":[0],"Insulin":[1],"degludec":[2],"(IDeg)":[3],"is":[4],"a":[5,47,75,209],"new-generation":[6],"basal":[7],"insulin":[8,24,129],"with":[9,41,61],"an":[10],"ultra-long":[11],"duration":[12],"of":[13,21,59,64,159,166,180,191],"action.":[14],"We":[15],"compared":[16],"the":[17,53,85,92,97,120,131,141,178],"pharmacodynamic":[18],"(PD)":[19],"variability":[20,32,71,99,139,158,179],"IDeg":[22,65,96,147,160,207],"and":[23,56,118,173,184,198],"glargine":[25],"(IGlar)":[26],"under":[27],"steady-state":[28],"conditions.":[29],"METHODS:":[30],"Day-to-day":[31],"in":[33,38,100,140],"glucose-lowering":[34,101,213],"effect":[35,102,112,143,214],"was":[36,72,103,144,161,182],"investigated":[37],"54":[39],"subjects":[40],"type":[42],"1":[43],"diabetes":[44],"who":[45],"underwent":[46],"24-h":[48],"euglycaemic":[49],"glucose":[50,86],"clamp":[51],"on":[52,79],"6th,":[54],"9th":[55],"12th":[57],"day":[58,216,218],"treatment":[60],"0.4":[62],"U/kg":[63],"or":[66],"IGlar":[67,108,149,181],"once":[68],"daily.":[69],"Within-subject":[70],"estimated":[73],"using":[74],"linear":[76],"mixed":[77],"model":[78],"log-transformed":[80],"PD":[81],"endpoints":[82],"derived":[83],"from":[84,215],"infusion":[87],"rate":[88],"(GIR)":[89],"profiles":[90],"during":[91,130],"clamps.":[93],"RESULTS:":[94],"For":[95],"day-to-day":[98],"four-times":[104],"lower":[105,138,156],"than":[106,219],"for":[107,109,119,146,168,171,175,193,196,200],"total":[110],"metabolic":[111],"(AUC(GIR,0-24h,SS),":[113],"CV":[114,133,151],"20%":[115],"vs.":[116,135,148,153],"82%)":[117],"last":[121],"22":[122],"h":[123,188],"[AUC(GIR,2-24h,SS)":[124],"(not":[125],"influenced":[126],"by":[127],"intravenous":[128],"clamp),":[132],"22%":[134],"92%].":[136],"Furthermore,":[137],"maximum":[142],"observed":[145],"(GIR(max,SS),":[150],"18%":[152],"60%).":[154],"The":[155],"within-subject":[157],"consistent":[162],"over":[163],"time":[164],"(CVs":[165,190],"33%":[167,174],"AUC(GIR,0-2h,SS),":[169,194],"32%":[170],"AUC(GIR,10-12h,SS)":[172,197],"AUC(GIR,22-24h,SS)),":[176],"whereas":[177],"higher":[183],"increased":[185],"substantially":[186],"8":[187],"post-dosing":[189],"60%":[192],"135%":[195],"115%":[199],"AUC(GIR,22-24h,SS)).":[201],"CONCLUSIONS:":[202],"These":[203],"results":[204],"show":[205],"that":[206],"has":[208],"significantly":[210],"more":[211],"predictable":[212],"to":[217],"IGlar.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":51},{"year":2014,"cited_by_count":44},{"year":2013,"cited_by_count":44},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}