{"id":"https://openalex.org/W1564556885","doi":null,"title":"Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells.","display_name":"Flavopiridol, a cyclin-dependent kinase inhibitor, prevents spindle inhibitor-induced endoreduplication in human cancer cells.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1564556885","mag":"1564556885","pmid":"https://pubmed.ncbi.nlm.nih.gov/10741717"},"language":"en","primary_location":{"id":"pmid:10741717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042853916","display_name":"Mona Motwani","orcid":"https://orcid.org/0000-0003-0912-5478","observed_orcids":["https://orcid.org/0000-0003-0912-5478"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Motwani","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369478","display_name":"Xiaoling Li","orcid":"https://orcid.org/0000-0001-5920-7784","observed_orcids":["https://orcid.org/0000-0001-5920-7784","https://orcid.org/0009-0007-8397-6592","https://orcid.org/0000-0002-5597-7375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006913373","display_name":"Gary K. Schwartz","orcid":"https://orcid.org/0000-0003-1813-5061","observed_orcids":["https://orcid.org/0000-0003-1813-5061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G K Schwartz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.671,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.80835381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"3","first_page":"924","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavopiridol","display_name":"flavopiridol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/endoreduplication","display_name":"endoreduplication","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/g1-s-checkpoint","display_name":"G1/S checkpoint","score":0.8830000162124634},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6039999723434448},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyclin-e-cdk2","display_name":"cyclin E/CDK2","score":0.9070000052452087},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7919999957084656},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9739999771118164},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.843999981880188},{"id":"https://openalex.org/keywords/nocodazole","display_name":"nocodazole","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.972000002861023},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C145226528","wikidata":"https://www.wikidata.org/wiki/Q1340781","display_name":"Endoreduplication","level":4,"score":0.6565606594085693},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.615423321723938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5968552231788635},{"id":"https://openalex.org/C9743823","wikidata":"https://www.wikidata.org/wiki/Q5198264","display_name":"Cyclin B","level":5,"score":0.5689786076545715},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5042377710342407},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4978652000427246},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.488779753446579},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.46475091576576233},{"id":"https://openalex.org/C16438837","wikidata":"https://www.wikidata.org/wiki/Q5198260","display_name":"Cyclin A","level":5,"score":0.463530570268631},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.4434038996696472},{"id":"https://openalex.org/C94561458","wikidata":"https://www.wikidata.org/wiki/Q24724860","display_name":"Cyclin E","level":5,"score":0.43727970123291016},{"id":"https://openalex.org/C2778437423","wikidata":"https://www.wikidata.org/wiki/Q5198265","display_name":"Cyclin B1","level":5,"score":0.42528772354125977},{"id":"https://openalex.org/C11882975","wikidata":"https://www.wikidata.org/wiki/Q24781041","display_name":"Cyclin D","level":5,"score":0.4239940941333771},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4001085162162781},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.3941763639450073},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3751407265663147},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.32765382528305054},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.314557820558548},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.28872713446617126},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19049495458602905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13485780358314514},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.1301957368850708}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016193","descriptor_name":"G1 Phase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019926","descriptor_name":"Cyclin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019927","descriptor_name":"Cyclin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042846","descriptor_name":"CDC2-CDC28 Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056744","descriptor_name":"Cyclin B1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10741717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1564556885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7205842776","display_name":"Clinical Trials of Flavopiridol with Chemotherapy","funder_award_id":"R01CA067819","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1483995411","https://openalex.org/W1500403320","https://openalex.org/W1554057952","https://openalex.org/W1616649596","https://openalex.org/W1622642497","https://openalex.org/W1777669545","https://openalex.org/W1905076019","https://openalex.org/W1937375640","https://openalex.org/W1963750681","https://openalex.org/W1977299280","https://openalex.org/W1979669293","https://openalex.org/W1989193912","https://openalex.org/W1991736202","https://openalex.org/W1999275729","https://openalex.org/W1999330214","https://openalex.org/W2004008931","https://openalex.org/W2005472812","https://openalex.org/W2008117987","https://openalex.org/W2016552601","https://openalex.org/W2028988702","https://openalex.org/W2048721919","https://openalex.org/W2055162988","https://openalex.org/W2066848701","https://openalex.org/W2072720547","https://openalex.org/W2084147994","https://openalex.org/W2087200075","https://openalex.org/W2088179903","https://openalex.org/W2089218510","https://openalex.org/W2090303261","https://openalex.org/W2097555718","https://openalex.org/W2099682050","https://openalex.org/W2107020701","https://openalex.org/W2109458089","https://openalex.org/W2113674897","https://openalex.org/W2115276278","https://openalex.org/W2118866877","https://openalex.org/W2139718226","https://openalex.org/W2141513637","https://openalex.org/W2148810752","https://openalex.org/W2152028923","https://openalex.org/W2168757568"],"related_works":["https://openalex.org/W2099682050","https://openalex.org/W2107020701","https://openalex.org/W2006652368","https://openalex.org/W2138278557","https://openalex.org/W1493696144","https://openalex.org/W2029427305","https://openalex.org/W2100039198","https://openalex.org/W2115276278","https://openalex.org/W2139602468","https://openalex.org/W2082169879"],"abstract_inverted_index":{"Defects":[0],"in":[1,26,40,102,107,145,157,214,219,228,234,260],"cell":[2],"cycle":[3],"checkpoints":[4],"can":[5,17,70],"lead":[6],"to":[7,19,42,58,152,296,303],"chromosome":[8],"abnormality,":[9],"aneuploidy,":[10],"and":[11,23,37,54,68,121,125,137,139,155,196,202,224,240,289,291],"genomic":[12,284],"instability,":[13],"all":[14],"of":[15,105,168,179,199,208,217,258,267,307],"which":[16,100],"contribute":[18],"tumorigenesis.":[20],"Recent":[21],"studies":[22,46],"data":[24],"presented":[25],"this":[27,62],"study":[28],"indicate":[29],"that":[30,49,66,186,280],"cells":[31,51,97,106,170,188,193,218,229,268],"with":[32,98,109,118,161,172],"compromised":[33],"G1":[34,108,133,148,222,272],"checkpoint":[35],"endoreduplicate":[36],"become":[38],"polyploid":[39,50],"response":[41],"microtubule":[43,153],"inhibitors.":[44],"Previous":[45],"have":[47],"shown":[48],"are":[52],"unstable":[53],"lose":[55],"chromosomes":[56],"randomly":[57],"give":[59],"aneuploidy.":[60],"In":[61,90,131],"study,":[63],"we":[64,94,278],"show":[65],"endoreduplication":[67,288],"polyploidation":[69],"be":[71,297],"prevented":[72],"by":[73,79,286],"inhibiting":[74],"the":[75,103,146,158,215,220,225,256,265,270,283,294,305],"cyclin-dependent":[76],"kinases":[77],"(Cdks)":[78],"flavopiridol,":[80],"a":[81,300],"synthetic":[82],"flavone":[83],"presently":[84],"undergoing":[85],"phase":[86,160],"II":[87],"clinical":[88],"trials.":[89],"our":[91],"initial":[92],"studies,":[93,277],"treated":[95],"MCF-7":[96],"paclitaxel,":[99],"results":[101,213],"arrest":[104,144,216,266],"4n":[110,162],"DNA":[111,163,174,232],"content":[112,175,233],"(pseudo":[113],"G1).":[114],"This":[115],"was":[116,253],"coincident":[117],"increased":[119],"p53":[120],"p21":[122],"protein":[123],"expression":[124],"decreased":[126],"cyclin":[127,200,203,238,241],"E/Cdk2":[128,201,239],"kinase":[129,205,243],"activity.":[130,206],"contrast,":[132],"checkpoint-compromised":[134],"MDA-MB-468":[135,169,235],"(p53-/-":[136],"pRb-/-)":[138],"p21-/-":[140],"HCT116":[141,262],"do":[142],"not":[143],"pseudo":[147,221,271],"state":[149,223],"after":[150,176,210,247,255],"exposure":[151],"inhibitors":[154],"enter":[156],"S":[159],"content.":[164],"More":[165],"than":[166],"60%":[167],"accumulate":[171],">4n":[173,231],"72":[177],"h":[178],"nocodazole":[180],"treatment.":[181],"The":[182,237],"MPM-2":[183],"labeling":[184],"showed":[185],"8n":[187],"also":[189],"undergo":[190],"mitosis.":[191,250],"These":[192],"display":[194],"deregulated":[195],"persistent":[197],"activation":[198],"B1/cdc2":[204,242],"Administration":[207],"flavopiridol":[209,259,281],"mitotic":[211],"block":[212],"dramatic":[226],"decrease":[227],"containing":[230],"cells.":[236],"activities":[244],"remained":[245],"low":[246],"exit":[248],"from":[249],"Furthermore,":[251],"pRb":[252],"hypophosphorylated":[254],"addition":[257],"p21-deficient":[261],"cells,":[263],"indicating":[264],"at":[269],"state.":[273],"Based":[274],"on":[275],"these":[276],"propose":[279],"preserves":[282],"stability":[285],"preventing":[287],"polyploidy":[290],"thus":[292],"has":[293],"potential":[295],"used":[298],"as":[299],"chemopreventive":[301],"agent":[302],"prevent":[304],"occurrence":[306],"neoplasia.":[308]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}