{"id":"https://openalex.org/W1564406367","doi":"https://doi.org/10.1155/2016/8923860","title":"Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells","display_name":"Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells","publication_year":2015,"publication_date":"2015-11-15","ids":{"openalex":"https://openalex.org/W1564406367","doi":"https://doi.org/10.1155/2016/8923860","mag":"1564406367","pmid":"https://pubmed.ncbi.nlm.nih.gov/26649146","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663008"},"language":"en","primary_location":{"id":"doi:10.1155/2016/8923860","doi":"https://doi.org/10.1155/2016/8923860","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/8923860","pdf_url":"http://downloads.hindawi.com/journals/omcl/2016/8923860.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/omcl/2016/8923860.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110946681","display_name":"Tingting Dou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Dou","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067212887","display_name":"Mengling Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengling Yan","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027238680","display_name":"Xinjin Wang","orcid":"https://orcid.org/0000-0002-7606-388X","observed_orcids":["https://orcid.org/0000-0002-7606-388X"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjin Wang","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103252941","display_name":"Wen Lu","orcid":"https://orcid.org/0000-0002-1398-9933","observed_orcids":["https://orcid.org/0000-0002-1398-9933"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Lu","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":"https://orcid.org/0000-0002-1398-9933","affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035876132","display_name":"Lina Zhao","orcid":"https://orcid.org/0000-0002-9796-0221","observed_orcids":["https://orcid.org/0000-0002-9796-0221","https://orcid.org/0000-0002-5421-6101"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lina Zhao","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069092697","display_name":"Dan Wen Lou","orcid":"https://orcid.org/0000-0002-9269-4737","observed_orcids":["https://orcid.org/0000-0002-9269-4737"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Lou","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101726129","display_name":"Chunhua Wu","orcid":"https://orcid.org/0009-0004-7872-3759","observed_orcids":["https://orcid.org/0009-0004-7872-3759"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhua Wu","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066298687","display_name":"Xiuli Chang","orcid":"https://orcid.org/0000-0002-0281-1523","observed_orcids":["https://orcid.org/0000-0002-0281-1523"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuli Chang","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103029198","display_name":"Zhijun Zhou","orcid":"https://orcid.org/0000-0002-2407-2071","observed_orcids":["https://orcid.org/0000-0002-2407-2071"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhijun Zhou","raw_affiliation_strings":["School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066298687","https://openalex.org/A5103029198"],"corresponding_institution_ids":["https://openalex.org/I24943067"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":1.6152,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.82710107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2016","issue":"1","first_page":"8923860","last_page":"8923860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.17800000309944153,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraquat","display_name":"paraquat","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nrf2-are-signaling-pathway","display_name":"Nrf2/ARE pathway","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-neural-progenitor-cells","display_name":"human neural progenitor cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.796999990940094},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.8399999737739563},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8949999809265137},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.7900000214576721},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9639999866485596},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antioxidant-genes","display_name":"antioxidant genes","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8876613974571228},{"id":"https://openalex.org/C2776527163","wikidata":"https://www.wikidata.org/wiki/Q409669","display_name":"Paraquat","level":2,"score":0.8853878974914551},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7142308950424194},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.600106418132782},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5303738117218018},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5242828726768494},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.48368555307388306},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4419204294681549},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.43086516857147217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34767380356788635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33954310417175293},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3312731385231018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31238847970962524},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18651896715164185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14042529463768005}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010269","descriptor_name":"Paraquat","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016660","descriptor_name":"NAD(P)H Dehydrogenase (Quinone)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2016/8923860","doi":"https://doi.org/10.1155/2016/8923860","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/8923860","pdf_url":"http://downloads.hindawi.com/journals/omcl/2016/8923860.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4663008","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4663008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"},{"id":"pmid:26649146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26649146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.7596","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.7596","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/35/29/OMCL2016-8923860.PMC4663008.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a230397ebd3d405b8c7ce6ad6ea9907a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a230397ebd3d405b8c7ce6ad6ea9907a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2016/8923860","doi":"https://doi.org/10.1155/2016/8923860","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/8923860","pdf_url":"http://downloads.hindawi.com/journals/omcl/2016/8923860.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3098684858","display_name":null,"funder_award_id":"81472996","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3269761138","display_name":null,"funder_award_id":"81072324","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G5012837358","display_name":null,"funder_award_id":"81472996","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G5835891059","display_name":null,"funder_award_id":"10ZR1401700","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G7196445762","display_name":null,"funder_award_id":"NSFC 81472996","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7666673051","display_name":null,"funder_award_id":"10ZR1401700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8249832897","display_name":null,"funder_award_id":"81072324","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1564406367.pdf","grobid_xml":"https://content.openalex.org/works/W1564406367.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W11374300","https://openalex.org/W50981894","https://openalex.org/W114653260","https://openalex.org/W135439809","https://openalex.org/W1516360318","https://openalex.org/W1578994558","https://openalex.org/W1891967301","https://openalex.org/W1969784891","https://openalex.org/W1971735068","https://openalex.org/W1974138151","https://openalex.org/W1980945431","https://openalex.org/W1982421412","https://openalex.org/W1996236557","https://openalex.org/W1999776176","https://openalex.org/W2000017694","https://openalex.org/W2002940154","https://openalex.org/W2004802466","https://openalex.org/W2008738285","https://openalex.org/W2009329139","https://openalex.org/W2009983872","https://openalex.org/W2019686722","https://openalex.org/W2027139882","https://openalex.org/W2028739456","https://openalex.org/W2029850092","https://openalex.org/W2031869195","https://openalex.org/W2033258576","https://openalex.org/W2043475021","https://openalex.org/W2052770514","https://openalex.org/W2053063855","https://openalex.org/W2054561574","https://openalex.org/W2062454567","https://openalex.org/W2065699023","https://openalex.org/W2065738748","https://openalex.org/W2066037623","https://openalex.org/W2071814308","https://openalex.org/W2076055378","https://openalex.org/W2080671121","https://openalex.org/W2080952734","https://openalex.org/W2081475594","https://openalex.org/W2086140220","https://openalex.org/W2088327864","https://openalex.org/W2095364552","https://openalex.org/W2133390170","https://openalex.org/W2141166374","https://openalex.org/W2141811439","https://openalex.org/W2146883699","https://openalex.org/W2150817988","https://openalex.org/W2154332459","https://openalex.org/W2161194102","https://openalex.org/W2167796670","https://openalex.org/W2282054059","https://openalex.org/W2412722296"],"related_works":["https://openalex.org/W7098252784","https://openalex.org/W1999776176","https://openalex.org/W2018558490","https://openalex.org/W2043990301","https://openalex.org/W2095239764","https://openalex.org/W7009551179","https://openalex.org/W2021766187","https://openalex.org/W2002940154","https://openalex.org/W3111175854","https://openalex.org/W2199311665"],"abstract_inverted_index":{"Compelling":[0],"evidences":[1],"have":[2],"shown":[3],"that":[4,80,171],"diverse":[5],"environmental":[6,35],"insults":[7,36],"arising":[8],"during":[9],"early":[10],"life":[11],"can":[12,82],"either":[13],"directly":[14],"lead":[15],"to":[16,30,178],"a":[17,148],"reduction":[18],"in":[19,147,176,196],"the":[20,45,56,84,97,139,153],"number":[21],"of":[22,48,60,76,86,99,110,143,156,193],"dopaminergic":[23],"neurons":[24,31],"or":[25,37],"cause":[26],"an":[27],"increased":[28,105,162],"susceptibility":[29],"degeneration":[32],"with":[33,38,73],"subsequent":[34],"aging":[39],"alone.":[40],"Oxidative":[41],"stress":[42,58,182],"is":[43,174,184],"considered":[44],"main":[46],"effect":[47,59],"neurotoxins":[49],"exposure.":[50],"In":[51,151],"this":[52],"study,":[53],"we":[54],"investigated":[55],"oxidative":[57,181,199],"Paraquat":[61],"(PQ)":[62],"on":[63],"immortalized":[64],"human":[65],"embryonic":[66],"neural":[67],"progenitor":[68],"cells":[69],"by":[70],"treating":[71],"them":[72],"various":[74],"concentrations":[75],"PQ.":[77],"We":[78],"show":[79],"PQ":[81,111,197],"decrease":[83],"activity":[85,189],"SOD":[87],"and":[88,93,101,145,158,190],"CAT":[89],"but":[90,123],"increase":[91],"MDA":[92],"LDH":[94],"level.":[95],"Furthermore,":[96],"activities":[98],"Cyc":[100],"caspase-9":[102],"were":[103,118,134],"found":[104],"significantly":[106,163],"at":[107,120,126,165],"10":[108,121],"\u03bcM":[109,122],"treatment.":[112],"The":[113,129,168],"cytoplasmic":[114],"Nrf2":[115,131,188],"protein":[116,132],"expressions":[117,133,142],"upregulated":[119,135],"fell":[124],"back":[125],"100":[127],"\u03bcM.":[128,167],"nuclear":[130],"as":[136,138],"well":[137],"downstream":[140],"mRNA":[141],"HO-1":[144],"NQO1":[146],"dose-dependent":[149],"manner.":[150],"addition,":[152],"proteins":[154],"expression":[155,192],"PKC":[157],"CKII":[159],"was":[160],"also":[161],"even":[164],"1":[166],"results":[169],"suggested":[170],"Nrf2/ARE":[172],"pathway":[173],"involved":[175],"mild":[177],"moderate":[179],"PQ-induced":[180],"which":[183],"evident":[185],"from":[186],"dampened":[187],"low":[191],"antioxidant":[194],"genes":[195],"induced":[198],"damage.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}