{"id":"https://openalex.org/W1564093355","doi":null,"title":"Herpes Simplex Virus Infection, Pathological Pain and Recurrent Lymphocytic Meningitis","display_name":"Herpes Simplex Virus Infection, Pathological Pain and Recurrent Lymphocytic Meningitis","publication_year":2009,"publication_date":"2009-12-04","ids":{"openalex":"https://openalex.org/W1564093355","mag":"1564093355"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22678","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22678","pdf_url":"http://hdl.handle.net/10138/22678","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/22678","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080325601","display_name":"Katariina Kallio-Laine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katariina Kallio-Laine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080325601"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9279999732971191},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/widespread-pain","display_name":"widespread pain","score":0.6449999809265137},{"id":"https://openalex.org/keywords/igg1-subclass","display_name":"IgG1 subclass","score":0.6819999814033508},{"id":"https://openalex.org/keywords/hla-drb1-01","display_name":"HLA-DRB1*01","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hla-b27","display_name":"HLA-B27","score":1.0},{"id":"https://openalex.org/keywords/mbl2","display_name":"MBL2","score":0.6759999990463257},{"id":"https://openalex.org/keywords/complement-c4","display_name":"complement C4","score":0.5680000185966492},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.503000020980835},{"id":"https://openalex.org/keywords/brain-pain-processing","display_name":"brain pain processing","score":0.7400000095367432},{"id":"https://openalex.org/keywords/insular-cortex","display_name":"insula","score":0.8100000023841858},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":0.9850000143051147},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6495729684829712},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5602300763130188},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5401941537857056},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.5313190817832947},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49768736958503723},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4463636875152588},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.42137882113456726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2706972658634186},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.15763986110687256}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/22678","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22678","pdf_url":"http://hdl.handle.net/10138/22678","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1564093355","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/22678/1/herpessi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22678","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22678","pdf_url":"http://hdl.handle.net/10138/22678","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320310467","display_name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","ror":"https://ror.org/020cpqb94"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1564093355.pdf","grobid_xml":"https://content.openalex.org/works/W1564093355.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W121687570","https://openalex.org/W191173172","https://openalex.org/W315197452","https://openalex.org/W1558813989","https://openalex.org/W1625625073","https://openalex.org/W1927461748","https://openalex.org/W1936135068","https://openalex.org/W1950677051","https://openalex.org/W1964522214","https://openalex.org/W1966359408","https://openalex.org/W1967551020","https://openalex.org/W1968370892","https://openalex.org/W1968402792","https://openalex.org/W1969882672","https://openalex.org/W1973571641","https://openalex.org/W1976219259","https://openalex.org/W1976933908","https://openalex.org/W1977713879","https://openalex.org/W1978035202","https://openalex.org/W1979413573","https://openalex.org/W1982249239","https://openalex.org/W1983079867","https://openalex.org/W1985138866","https://openalex.org/W1987089470","https://openalex.org/W1988116741","https://openalex.org/W1989871310","https://openalex.org/W1991140142","https://openalex.org/W1992643654","https://openalex.org/W1993571469","https://openalex.org/W1995282498","https://openalex.org/W1996914503","https://openalex.org/W1997283068","https://openalex.org/W1997426681","https://openalex.org/W1998913607","https://openalex.org/W2000319686","https://openalex.org/W2003083222","https://openalex.org/W2003210625","https://openalex.org/W2003360699","https://openalex.org/W2004219505","https://openalex.org/W2004323875","https://openalex.org/W2004555632","https://openalex.org/W2006785548","https://openalex.org/W2007147818","https://openalex.org/W2007520476","https://openalex.org/W2009812771","https://openalex.org/W2015356286","https://openalex.org/W2015894956","https://openalex.org/W2016124588","https://openalex.org/W2016748877","https://openalex.org/W2017966466","https://openalex.org/W2018515402","https://openalex.org/W2019990398","https://openalex.org/W2020939052","https://openalex.org/W2023044521","https://openalex.org/W2023453521","https://openalex.org/W2024052406","https://openalex.org/W2025577666","https://openalex.org/W2025988857","https://openalex.org/W2028194634","https://openalex.org/W2031098953","https://openalex.org/W2032071790","https://openalex.org/W2032480075","https://openalex.org/W2036923488","https://openalex.org/W2037667533","https://openalex.org/W2041515205","https://openalex.org/W2042293679","https://openalex.org/W2043217368","https://openalex.org/W2044862329","https://openalex.org/W2045120834","https://openalex.org/W2045432647","https://openalex.org/W2047670385","https://openalex.org/W2047912148","https://openalex.org/W2049832188","https://openalex.org/W2050504180","https://openalex.org/W2052851214","https://openalex.org/W2054077496","https://openalex.org/W2058350963","https://openalex.org/W2064647226","https://openalex.org/W2064851589","https://openalex.org/W2064927709","https://openalex.org/W2069302399","https://openalex.org/W2070158337","https://openalex.org/W2071978760","https://openalex.org/W2073772220","https://openalex.org/W2073939477","https://openalex.org/W2076446969","https://openalex.org/W2077885131","https://openalex.org/W2083261157","https://openalex.org/W2084676166","https://openalex.org/W2086827933","https://openalex.org/W2087340224","https://openalex.org/W2088132969","https://openalex.org/W2090056166","https://openalex.org/W2091015977","https://openalex.org/W2091320827","https://openalex.org/W2093374250","https://openalex.org/W2094795912","https://openalex.org/W2095901107","https://openalex.org/W2096130477","https://openalex.org/W2097639794","https://openalex.org/W2098396931","https://openalex.org/W2098813714","https://openalex.org/W2100837670","https://openalex.org/W2101369755","https://openalex.org/W2102023851","https://openalex.org/W2103168705","https://openalex.org/W2105614022","https://openalex.org/W2105951868","https://openalex.org/W2110840292","https://openalex.org/W2113617025","https://openalex.org/W2114977310","https://openalex.org/W2119848633","https://openalex.org/W2121463325","https://openalex.org/W2123569370","https://openalex.org/W2127152798","https://openalex.org/W2129646517","https://openalex.org/W2131165483","https://openalex.org/W2132309748","https://openalex.org/W2134025933","https://openalex.org/W2134582169","https://openalex.org/W2136484280","https://openalex.org/W2136779819","https://openalex.org/W2137532415","https://openalex.org/W2139096982","https://openalex.org/W2142305564","https://openalex.org/W2142875688","https://openalex.org/W2143639723","https://openalex.org/W2143869492","https://openalex.org/W2146481987","https://openalex.org/W2151149731","https://openalex.org/W2156364336","https://openalex.org/W2156667707","https://openalex.org/W2160779124","https://openalex.org/W2160821394","https://openalex.org/W2162398269","https://openalex.org/W2162730620","https://openalex.org/W2164513741","https://openalex.org/W2167204693","https://openalex.org/W2168602546","https://openalex.org/W2169501595","https://openalex.org/W2169875026","https://openalex.org/W2170019750","https://openalex.org/W2171064865","https://openalex.org/W2171927817","https://openalex.org/W2186245672","https://openalex.org/W2342308685","https://openalex.org/W2395525054","https://openalex.org/W2524749754"],"related_works":["https://openalex.org/W2071757332","https://openalex.org/W2017966466","https://openalex.org/W7097232721","https://openalex.org/W2160821394","https://openalex.org/W2150040171","https://openalex.org/W2117665876","https://openalex.org/W2156869368","https://openalex.org/W1993116849","https://openalex.org/W2086074150","https://openalex.org/W2417597290"],"abstract_inverted_index":{"Background:":[0],"Aims":[1],"of":[2,41,68,77,86,141,262,300,323],"the":[3,9,33,56,61,66,139,153,168,173,181,186,193,196,203,206,212,272,277,294,303],"study":[4],"were:":[5],"(i)":[6],"to":[7,31,257],"characterise":[8],"clinical":[10,35,269],"picture,":[11],"immunological":[12,38,264],"features":[13],"and":[14,19,27,29,37,52,64,81,83,93,103,108,110,124,149,162,191,195,208,223,229,238,244,335],"changes":[15,164],"in":[16,21,48,138,167,172,180,185,192,202,205,293,302],"brain":[17,169,304,312],"morphology":[18],"function":[20],"patients":[22,154],"with":[23,344],"widespread":[24,286],"unilateral":[25],"pain":[26,144,232,287,340],"HSV-infections,":[28],"(ii)":[30],"analyse":[32],"prevalence,":[34],"symptoms":[36],"predisposing":[39,249,327],"factors":[40,250,328],"HSV-2":[42,316,324],"induced":[43,317],"recurrent":[44,258],"lymphocytic":[45],"meningitis":[46,213,240],"(RLM)":[47],"Southern":[49],"Finland.":[50],"Patients":[51,54,254],"methods:":[53],"for":[55,156,251],"studies":[57,214],"were":[58,89,114,129,165],"recruited":[59],"from":[60,65],"Pain":[62],"Clinic,":[63],"Department":[67],"Neurology,":[69],"at":[70],"Helsinki":[71],"University":[72],"Central":[73],"Hospital.":[74],"Plasma":[75],"concentrations":[76,85],"IgM,":[78],"IgA,":[79],"IgG,":[80],"IgG1-4,":[82],"serum":[84,147],"C3,":[87],"C4":[88,99],"measured.":[90],"Serological":[91],"anti-HSV-1":[92],"-2":[94],"antibody":[95],"status":[96],"was":[97,200,216],"tested.":[98],"genotyping,":[100,107],"HLA-A,":[101],"HLA-B":[102],"HLA-DRB1":[104],"typing,":[105],"MBL2":[106],"IgG1":[109,148,246,331],"IgG3":[111,150],"allotyping":[112],"(Gm)":[113],"performed.":[115,131],"Clinical":[116],"neurological":[117],"examination,":[118],"quantitative":[119],"sensory":[120],"testing,":[121],"skin":[122],"biopsy,":[123],"functional":[125,161,311],"magnetic":[126],"resonance":[127],"imaging":[128,313],"also":[130],"Results:":[132],"HSV":[133,158,259,266],"probably":[134,288],"has":[135],"a":[136,142,320],"role":[137],"generation":[140],"pathological":[143,285],"state.":[145],"Low":[146],"levels,":[151,333],"made":[152],"vulnerable":[155,256],"recurring":[157],"infections.":[159],"Both":[160],"structural":[163],"observed":[166],"pain-processing":[170,305],"areas":[171,306],"patients:":[174],"they":[175],"had":[176],"less":[177,224],"pain-related":[178],"activity":[179],"insular":[182],"cortices":[183],"bilaterally,":[184],"anterior":[187],"cingular":[188],"cortex":[189],"(ACC),":[190],"thalamus,":[194],"gray":[197],"matter":[198],"density":[199],"lower":[201],"ACC,":[204],"frontal":[207],"prefrontal":[209],"cortices.":[210],"In":[211,296],"it":[215],"shown":[217],"that":[218,230],"RLM":[219,318],"is":[220,233,319,341],"more":[221],"common":[222],"benign":[225],"than":[226],"previously":[227],"reported,":[228],"neuropathic":[231],"frequently":[234,342],"present":[235],"both":[236],"during":[237],"after":[239],"episodes.":[241],"HLA-DRB1*01,":[242],"HLA-B*27,":[243],"low":[245,330],"levels":[247],"are":[248,255],"RLM.":[252,345],"Conclusions:":[253],"infections":[260],"because":[261],"subtle":[263],"abnormalities.":[265],"causes":[267],"diverse":[268],"manifestations.":[270],"First,":[271],"herpes":[273],"simplex":[274],"virus,":[275],"or":[276],"inflammatory":[278],"process":[279],"triggered":[280],"by":[281,289,310],"it,":[282],"may":[283],"cause":[284],"activating":[290],"glial":[291],"cells":[292],"CNS.":[295],"these":[297],"patients,":[298],"signs":[299],"alterations":[301],"can":[307],"be":[308],"demonstrated":[309],"methods.":[314],"Secondly,":[315],"rare":[321],"complication":[322],"virus.":[325],"The":[326],"include":[329],"subclass":[332],"HLA-DRB1*01":[334],"HLA":[336],"\u2013B*27":[337],"genotypes.":[338],"Neuropathic":[339],"associated":[343]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}