{"id":"https://openalex.org/W1564010969","doi":null,"title":"Juvenile systemic lupus erythematosus in Portugal: clinical and immunological patterns of disease expression in a cohort of 56 patients.","display_name":"Juvenile systemic lupus erythematosus in Portugal: clinical and immunological patterns of disease expression in a cohort of 56 patients.","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W1564010969","mag":"1564010969","pmid":"https://pubmed.ncbi.nlm.nih.gov/24435032"},"language":"en","primary_location":{"id":"pmid:24435032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24435032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta reumatologica portuguesa","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10400.17/2031","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Marta Cabral","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Cabral","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Carlos Escobar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Escobar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021729996","display_name":"Marta Conde","orcid":"https://orcid.org/0000-0002-0193-2067","observed_orcids":["https://orcid.org/0000-0002-0193-2067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Conde","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Margarida Ramos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margarida Ramos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010634605","display_name":"J A Melo Gomes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A Melo Gomes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3422,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.78783754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"38","issue":"4","first_page":"274","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-systemic-lupus-erythematosus","display_name":"pediatric lupus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/neuropsychiatric-systemic-lupus-erythematosus","display_name":"neuropsychiatric lupus","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.8759999871253967},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.8059999942779541},{"id":"https://openalex.org/keywords/complement-c3-and-c4","display_name":"complement C3 and C4","score":0.7829999923706055},{"id":"https://openalex.org/keywords/sledai","display_name":"SLEDAI","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.765999972820282},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.30399999022483826},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.5839999914169312},{"id":"https://openalex.org/keywords/long-term-remission","display_name":"long-term remission","score":0.7710000276565552},{"id":"https://openalex.org/keywords/portugal","display_name":"Portugal","score":0.44600000977516174},{"id":"https://openalex.org/keywords/pediatric-rheumatology","display_name":"pediatric rheumatology","score":0.7979999780654907},{"id":"https://openalex.org/keywords/disease-manifestations","display_name":"disease manifestations","score":0.4099999964237213},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9604174494743347},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6675219535827637},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.6506057977676392},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6398736238479614},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.5639209747314453},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.5526323914527893},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.528831422328949},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5038670897483826},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.45875099301338196},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.4574436843395233},{"id":"https://openalex.org/C156662089","wikidata":"https://www.wikidata.org/wiki/Q6931223","display_name":"Mucocutaneous zone","level":3,"score":0.4437016546726227},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3538574278354645},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3155120611190796},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20887067914009094},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.07727083563804626},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011174","descriptor_name":"Portugal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:24435032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24435032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta reumatologica portuguesa","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.chlc.pt:10400.17/2031","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.17/2031","pdf_url":"http://hdl.handle.net/10400.17/2031","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:repositorio.hff.min-saude.pt:10400.10/1302","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.10/1302","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:1564010969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24435032","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.chlc.pt:10400.17/2031","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.17/2031","pdf_url":"http://hdl.handle.net/10400.17/2031","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1564010969.pdf","grobid_xml":"https://content.openalex.org/works/W1564010969.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W201358863","https://openalex.org/W284116301","https://openalex.org/W1773184831","https://openalex.org/W1831090765","https://openalex.org/W1963970819","https://openalex.org/W1965883352","https://openalex.org/W1976017391","https://openalex.org/W1976219089","https://openalex.org/W1999480158","https://openalex.org/W2010971965","https://openalex.org/W2012592010","https://openalex.org/W2044306362","https://openalex.org/W2045996380","https://openalex.org/W2047722521","https://openalex.org/W2049142512","https://openalex.org/W2054330426","https://openalex.org/W2058983527","https://openalex.org/W2064472094","https://openalex.org/W2064999867","https://openalex.org/W2070436152","https://openalex.org/W2070527591","https://openalex.org/W2073938518","https://openalex.org/W2087785715","https://openalex.org/W2126682268","https://openalex.org/W2126775039","https://openalex.org/W2137703086","https://openalex.org/W2146203649","https://openalex.org/W2157038471","https://openalex.org/W2162054238","https://openalex.org/W2162085609","https://openalex.org/W2411948708","https://openalex.org/W2412239954","https://openalex.org/W2466562945"],"related_works":["https://openalex.org/W3098573084","https://openalex.org/W2910926488","https://openalex.org/W2795300528","https://openalex.org/W3101349471","https://openalex.org/W2771203714","https://openalex.org/W4377939136","https://openalex.org/W2418710618","https://openalex.org/W2078835744","https://openalex.org/W3212320995","https://openalex.org/W2807686857"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"define":[2],"the":[3,39,214,221,225,294,306,328],"pattern":[4],"of":[5,27,41,73,83,98,100,131,135,207,227,296],"disease":[6,36,81,114,211,268,290],"expression":[7],"and":[8,62,66,94,121,133,157,167,178,224,280,291,308],"to":[9,199,213,275,314],"gain":[10],"better":[11],"understanding":[12],"in":[13,22,47,129,138,144,161,173,176,232,266,271,278,283,303,327],"patients":[14,29,75,108,132,175,194,233,257,286,305,319],"with":[15,30,51,76,234,252,260],"juvenile":[16,315],"onset":[17,37,82],"systemic":[18,31,316],"lupus":[19,32,237,317],"erythematosus":[20,33,318],"(SLE)":[21],"Portugal.":[23],"METHODS:":[24],"The":[25,111,217],"features":[26,310],"unselected":[28],"who":[34],"had":[35,195],"before":[38],"age":[40,79],"18":[42],"years":[43,87],"were":[44,68,109,116,152,171,188,229,258,312,334],"retrospectively":[45],"analysed":[46],"three":[48],"Portuguese":[49],"centres":[50],"Pediatric":[52],"Rheumatology":[53],"Clinic":[54],"over":[55],"a":[56,77,95,196,204],"24-year":[57],"period":[58,97],"(1987-2011).":[59],"Demographic,":[60],"clinical":[61,307],"laboratory":[63,309],"manifestations,":[64],"therapy":[65,200,276,333],"outcome":[67,324],"assessed.":[69],"RESULTS:":[70],"A":[71],"cohort":[72],"56":[74],"mean":[78,96],"at":[80,219],"12.6":[84],"\u00b1":[85,89,102],"4.04":[86],"(mean":[88],"1SD)":[90],"(range,":[91],"1.0-17.0":[92],"years)":[93],"follow-up":[99],"5.5":[101],"5.4":[103],"years.":[104],"Forty":[105],"six":[106],"(82.1%)":[107],"female.":[110],"most":[112,174,193],"common":[113],"manifestations":[115,142,282],"musculoskeletal":[117],"(87.5%),":[118,243],"mucocutaneous":[119],"(80.3%)":[120],"haematological":[122],"abnormalities":[123],"(75%).":[124],"Lupus":[125],"nephritis":[126,137],"was":[127,264,269,325],"diagnosed":[128],"46.4%":[130],"consisted":[134],"glomerular":[136],"all":[139],"cases.":[140],"Neuropsychiatric":[141],"occurred":[143,277],"21.4%":[145],"but":[146],"severe":[147,292],"central":[148],"nervous":[149],"system":[150],"complications":[151,228],"uncommon,":[153],"as":[154,181,183,201],"brain":[155,159],"infarcts":[156],"organic":[158],"syndrome":[160],"4":[162],"(7.1%)":[163],"patients.":[164],"Antinuclear":[165],"antibodies":[166],"anti-double":[168],"stranded":[169],"DNA":[170],"positive":[172],"(98.2%":[177],"71.4%":[179],"respectively),":[180],"well":[182],"low":[184],"C3":[185],"and/or":[186,236],"C4":[187],"observed":[189,311],"frequently":[190],"(85.7%).":[191],"Generally,":[192],"good":[197],"response":[198],"demonstrated":[202],"by":[203],"significant":[205],"decreasing":[206],"SLEDAI":[208,218,223],"score":[209],"from":[210,320,332],"presentation":[212],"last":[215],"evaluation.":[216],"diagnosis,":[220],"maximum":[222],"incidence":[226],"significantly":[230],"higher":[231],"neurolupus":[235],"nephritis.":[238],"Therapy":[239],"included":[240],"oral":[241],"steroids":[242],"hydroxychloroquine":[244],"(85.7%),":[245],"azathioprine":[246],"(55.4%),":[247],"IV":[248],"cyclophosphamide":[249],"(28.6%)":[250],"along":[251],"other":[253,321],"drugs.":[254],"Six":[255],"(10.7%)":[256],"treated":[259],"rituximab.":[261],"Long-term":[262],"remission":[263],"achieved":[265],"32%,":[267],"active":[270,289],"68%,":[272],"adverse":[273],"reactions":[274],"53.6%":[279],"complications/severe":[281],"23.2%.":[284],"Two":[285],"died,":[287],"being":[288],"infection":[293],"causes":[295],"death.":[297],"CONCLUSIONS:":[298],"This":[299],"study":[300],"suggests":[301],"that":[302],"our":[304],"similar":[313],"series.":[322],"Clinical":[323],"favourable":[326],"present":[329],"study.":[330],"Complications":[331],"frequent.":[335]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
