{"id":"https://openalex.org/W1563660110","doi":"https://doi.org/10.1002/mc.22298","title":"Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation","display_name":"Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation","publication_year":2015,"publication_date":"2015-03-19","ids":{"openalex":"https://openalex.org/W1563660110","doi":"https://doi.org/10.1002/mc.22298","mag":"1563660110","pmid":"https://pubmed.ncbi.nlm.nih.gov/25789966"},"language":"en","primary_location":{"id":"doi:10.1002/mc.22298","doi":"https://doi.org/10.1002/mc.22298","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.22298","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chen Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Miao","raw_affiliation_strings":["Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103149500","display_name":"Yan Ren","orcid":"https://orcid.org/0000-0003-3985-9755","observed_orcids":["https://orcid.org/0000-0003-3985-9755"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Ren","raw_affiliation_strings":["Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357856","display_name":"Meng Chen","orcid":"https://orcid.org/0000-0002-2449-5904","observed_orcids":["https://orcid.org/0000-0002-2449-5904","https://orcid.org/0000-0002-2812-2750"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng Chen","raw_affiliation_strings":["Department of laboratory Medicine; The University of Texas M. D. Anderson Cancer Center; Houston Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of laboratory Medicine; The University of Texas M. D. Anderson Cancer Center; Houston Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100665318","display_name":"Zhen Wang","orcid":"https://orcid.org/0000-0002-6401-4968","observed_orcids":["https://orcid.org/0000-0002-6401-4968"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Wang","raw_affiliation_strings":["Department of Pathology; First Affiliated Hospital of Nanjing Medical University; Nanjing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology; First Affiliated Hospital of Nanjing Medical University; Nanjing China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ting Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, School of Basic MedicalSciences, Nanjing MedicalUniversity, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":1.0851,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.72305134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"5","first_page":"514","last_page":"524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10236","display_name":"Aquatic Ecosystems and Phytoplankton Dynamics","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microcystin-lr","display_name":"microcystin-LR","score":0.9959999918937683},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9210000038146973},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8539999723434448},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.906000018119812},{"id":"https://openalex.org/keywords/cyanotoxins","display_name":"cyanotoxins","score":0.7839999794960022},{"id":"https://openalex.org/keywords/environmental-carcinogens","display_name":"environmental carcinogens","score":0.9049999713897705},{"id":"https://openalex.org/keywords/dld-1-cells","display_name":"DLD-1 cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6819999814033508},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9316568374633789},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.7933075428009033},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6353119611740112},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5717474222183228},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5227434635162354},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.48917534947395325},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1607685089111328}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008387","descriptor_name":"Marine Toxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052998","descriptor_name":"Microcystins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D052998","descriptor_name":"Microcystins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mc.22298","doi":"https://doi.org/10.1002/mc.22298","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mc.22298","pdf_url":null,"source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:25789966","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25789966","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4405965720","display_name":"\u5fae\u56ca\u85fb\u6bd2\u7d20-LR\u4fc3\u8fdb\u80bf\u7624\u8f6c\u79fb\u7684\u4f5c\u7528\u53ca\u5176\u5206\u5b50\u673a\u5236\u7814\u7a76","funder_award_id":"21177062","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1971035624","https://openalex.org/W1980505218","https://openalex.org/W1993002855","https://openalex.org/W2007080891","https://openalex.org/W2013752282","https://openalex.org/W2038083756","https://openalex.org/W2060964204","https://openalex.org/W2064248967","https://openalex.org/W2064505857","https://openalex.org/W2073750933","https://openalex.org/W2074712268","https://openalex.org/W2077466352","https://openalex.org/W2081010886","https://openalex.org/W2082189908","https://openalex.org/W2088535777","https://openalex.org/W2089894687","https://openalex.org/W2092110872","https://openalex.org/W2092180337","https://openalex.org/W2099117662","https://openalex.org/W2112874194","https://openalex.org/W2112965326","https://openalex.org/W2113586978","https://openalex.org/W2115511355","https://openalex.org/W2121276791","https://openalex.org/W2122224873","https://openalex.org/W2123424871","https://openalex.org/W2130987314","https://openalex.org/W2134792037","https://openalex.org/W2147843797","https://openalex.org/W2150286564","https://openalex.org/W2165322824","https://openalex.org/W2167094540","https://openalex.org/W2319709814","https://openalex.org/W2324495167","https://openalex.org/W2326765751","https://openalex.org/W6679716126","https://openalex.org/W6701684025"],"related_works":["https://openalex.org/W2897072199","https://openalex.org/W4382133428","https://openalex.org/W2769599326","https://openalex.org/W2324495167","https://openalex.org/W4310532679","https://openalex.org/W2326765751","https://openalex.org/W2550681015","https://openalex.org/W4400934692","https://openalex.org/W2513718941","https://openalex.org/W2055648020"],"abstract_inverted_index":{"Microcystin-LR":[0],"(MC-LR)":[1],"is":[2,30,155],"an":[3],"environmental":[4,20],"toxin":[5],"from":[6],"blooms":[7],"of":[8,18,25,56,84,95,112,175,207,221,239],"cyanobacteria":[9],"and":[10,41,71,93,98,101,109,120,128,142,145,151,168,181,192,194,219,224],"it":[11],"has":[12],"been":[13],"shown":[14],"to":[15,62,216],"be":[16],"one":[17],"the":[19,23,44,106,156,182,205,217,234],"carcinogens":[21],"for":[22],"progression":[24],"colorectal":[26,38,165,236],"carcinoma.":[27],"However,":[28],"there":[29],"no":[31],"direct":[32],"evidence":[33],"that":[34,88,173,204],"MC-LR":[35,58,89,132,139,210],"can":[36,163],"induce":[37,63],"cancer":[39,166,237],"migration":[40,92,141,191,218],"invasion.":[42],"In":[43,134],"present":[45],"study,":[46],"0.04":[47],"or":[48],"40":[49],"\u00b5g/kg/d":[50],"(human":[51],"tolerable":[52],"daily":[53],"intake":[54],"value":[55],"MC-LR)":[57],"treatment":[59,90],"was":[60],"observed":[61],"Matrix":[64],"Metalloproteinase-13":[65],"(MMP-13)":[66],"expression":[67,162],"in":[68,74,125,148,178,212],"tumor":[69],"tissues":[70],"local":[72],"invasion":[73,94,143,167,193,220],"DLD-1":[75,126,149,222],"xenograft":[76],"model.":[77],"The":[78,227],"results":[79,211],"are":[80,102],"consistent":[81],"with":[82,105],"those":[83],"cell":[85],"test":[86],"showing":[87],"enhanced":[91],"DLD-1,":[96],"HT-29,":[97],"SW480":[99],"cells":[100,127,130,150,223],"also":[103],"correlated":[104],"increased":[107,177],"mRNA":[108],"protein":[110],"levels":[111],"MMP-13":[113,136,146,161,195,213],"by":[114,209],"Quantitative":[115],"real-time":[116],"PCR,":[117],"Luciferase":[118],"assay,":[119],"Western":[121],"blot":[122],"assay":[123],"respectively":[124],"HT-29":[129,152,225],"after":[131],"exposure.":[133],"addition,":[135],"siRNA":[137],"inhibited":[138],"induced":[140],"enhancement":[144],"over-expression":[147],"cells.":[153,226],"This":[154],"first":[157],"paper":[158],"confirming":[159],"MC-LR-induced":[160],"promote":[164],"migration.":[169],"Further":[170],"investigation":[171],"revealed":[172],"phosphorylation":[174],"AKT":[176],"MC-LR-treated":[179],"cells,":[180],"phosphatidylinositol":[183],"3-kinase/Akt.":[184],"(PI3-K/AKT)":[185],"inhibitor":[186],"LY294002":[187],"effectively":[188],"abolished":[189],"MC-LR-enhanced":[190],"expression.":[196],"Therefore,":[197],"based":[198],"on":[199],"these":[200],"observations,":[201],"we":[202],"concluded":[203],"activation":[206],"PI3K/AKT":[208],"expression,":[214],"leading":[215],"study":[228],"provides":[229],"a":[230],"mechanistic":[231],"insight":[232],"into":[233],"promoting":[235],"functions":[238],"MC-LR.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}