{"id":"https://openalex.org/W156357843","doi":"https://doi.org/10.1007/978-1-59259-297-5_8","title":"Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases","display_name":"Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W156357843","doi":"https://doi.org/10.1007/978-1-59259-297-5_8","mag":"156357843"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-297-5_8","doi":"https://doi.org/10.1007/978-1-59259-297-5_8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-297-5_8","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinflammation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4406311601","display_name":"Neuroinflammation"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-1-59259-297-5_8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321252","display_name":"Robert A. Floyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Floyd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111718974","display_name":"Kenneth Hensley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth Hensley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7374,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70066519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"171","last_page":"186"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/neurotoxins","display_name":"neurotoxins","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.527999997138977},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6060000061988831},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.5730000138282776},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8059999942779541},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.859000027179718},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nitrones","display_name":"nitrones","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9745265245437622},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6950209736824036},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.5711815357208252},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5499274134635925},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5448163151741028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5155327320098877},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49237358570098877},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4337083399295807},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.42529404163360596},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2150522768497467},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20060080289840698},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-59259-297-5_8","doi":"https://doi.org/10.1007/978-1-59259-297-5_8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-297-5_8","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinflammation","raw_type":"book-chapter"},{"id":"doi:10.1385/1-59259-297-x:171","doi":"https://doi.org/10.1385/1-59259-297-x:171","is_oa":false,"landing_page_url":"http://doi.org/10.1385/1-59259-297-x:171","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinflammation","raw_type":"book-chapter"},{"id":"mag:156357843","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/chapter/10.1007/978-1-59259-297-5_8","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1007/978-1-59259-297-5_8","doi":"https://doi.org/10.1007/978-1-59259-297-5_8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-1-59259-297-5_8","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroinflammation","raw_type":"book-chapter"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W86072502","https://openalex.org/W102674785","https://openalex.org/W179936679","https://openalex.org/W226259664","https://openalex.org/W566270593","https://openalex.org/W600438260","https://openalex.org/W627720834","https://openalex.org/W1428148397","https://openalex.org/W1480587960","https://openalex.org/W1593692115","https://openalex.org/W1599922015","https://openalex.org/W1621971853","https://openalex.org/W1667686291","https://openalex.org/W1668344921","https://openalex.org/W1693283493","https://openalex.org/W1745925983","https://openalex.org/W1862355269","https://openalex.org/W1964413344","https://openalex.org/W1965179669","https://openalex.org/W1965417918","https://openalex.org/W1965823299","https://openalex.org/W1966227204","https://openalex.org/W1967674023","https://openalex.org/W1974198922","https://openalex.org/W1979108885","https://openalex.org/W1980565738","https://openalex.org/W1982054375","https://openalex.org/W1983407561","https://openalex.org/W1985788035","https://openalex.org/W1994258654","https://openalex.org/W1997256771","https://openalex.org/W1999499766","https://openalex.org/W2003815800","https://openalex.org/W2005015191","https://openalex.org/W2007525497","https://openalex.org/W2009688381","https://openalex.org/W2024988932","https://openalex.org/W2027317604","https://openalex.org/W2032085425","https://openalex.org/W2035139640","https://openalex.org/W2043676089","https://openalex.org/W2044682428","https://openalex.org/W2047195787","https://openalex.org/W2049189117","https://openalex.org/W2049192526","https://openalex.org/W2051516838","https://openalex.org/W2052944919","https://openalex.org/W2053232186","https://openalex.org/W2054360287","https://openalex.org/W2054526264","https://openalex.org/W2061503607","https://openalex.org/W2068121825","https://openalex.org/W2070046033","https://openalex.org/W2071304143","https://openalex.org/W2071667213","https://openalex.org/W2074274825","https://openalex.org/W2075757243","https://openalex.org/W2076659607","https://openalex.org/W2077512485","https://openalex.org/W2083556882","https://openalex.org/W2085278496","https://openalex.org/W2092044187","https://openalex.org/W2100853822","https://openalex.org/W2104194752","https://openalex.org/W2105140188","https://openalex.org/W2105215015","https://openalex.org/W2108676263","https://openalex.org/W2111641063","https://openalex.org/W2112373780","https://openalex.org/W2114037027","https://openalex.org/W2122644897","https://openalex.org/W2133149481","https://openalex.org/W2139045040","https://openalex.org/W2142084940","https://openalex.org/W2153945143","https://openalex.org/W2166342281","https://openalex.org/W2202491923","https://openalex.org/W2318236294","https://openalex.org/W2326200998","https://openalex.org/W2407905813","https://openalex.org/W2483744482","https://openalex.org/W2494539325","https://openalex.org/W2735705544","https://openalex.org/W4234604396","https://openalex.org/W4246973877","https://openalex.org/W4254030433","https://openalex.org/W4316093067"],"related_works":["https://openalex.org/W2039518578","https://openalex.org/W1584106444","https://openalex.org/W1506970858","https://openalex.org/W2481289024","https://openalex.org/W1981156441","https://openalex.org/W957240018","https://openalex.org/W3186462241","https://openalex.org/W2047195787","https://openalex.org/W2043290296","https://openalex.org/W4327951435"],"abstract_inverted_index":{"There":[0],"is":[1,26,32,59,93,105,131],"critical":[2],"need":[3],"for":[4,10,169,180],"the":[5,11,17,29,35,46,63,95,114,133,152,161,166],"development":[6],"of":[7,13,38,67,78,97,117,155],"novel":[8,178],"therapeutics":[9,179],"treatment":[12],"neurodegenerative":[14,101,182],"diseases.":[15],"Of":[16],"many":[18],"risk":[19],"factors":[20],"involved":[21],"in":[22,34,45,113,151,192],"their":[23],"etiology,":[24],"age":[25,43,53],"by":[27],"far":[28],"largest.":[30],"This":[31],"seen":[33],"increased":[36],"incidences":[37],"stroke":[39,185],"and":[40,111,127,141,186],"dementia":[41,98],"with":[42,100,107],"even":[44],"optimally":[47],"healthy":[48],"individual.":[49],"The":[50,172],"reason":[51],"why":[52],"plays":[54],"such":[55],"a":[56,82],"large":[57],"role":[58],"probably":[60],"related":[61],"to":[62,69,80],"age-associated":[64,89],"enhanced":[65,76,115],"susceptibility":[66],"brain":[68,79],"insults":[70],"which":[71,159],"cause":[72,96],"oxidative":[73],"damage.":[74],"An":[75],"tendency":[77],"have":[81],"smoldering":[83],"neuroinflammatory":[84],"state":[85],"reflects":[86],"this":[87],"heightened":[88],"risk.":[90],"Exacerbated":[91,103],"neuroinflammation":[92,104,163],"considered":[94,132,191],"associated":[99,106],"conditions.":[102],"localized":[108,153],"glia":[109],"activation":[110],"results":[112],"production":[116],"toxins":[118],"that":[119],"act":[120],"more":[121,193],"selectively":[122],"on":[123],"neurons.":[124],"Nitric":[125],"oxide":[126],"its":[128],"oxidation":[129,143],"products":[130,144],"major":[134],"neurotoxin":[135],"produced,":[136],"however,":[137],"reactive":[138],"oxygen":[139],"species":[140],"lipid":[142],"are":[145,174,190],"also":[146],"produced":[147],"at":[148],"high":[149],"levels":[150],"region":[154],"exacerbated":[156,162],"neuroinflammation.":[157],"Agents,":[158],"quell":[160],"state,":[164],"appear":[165],"most":[167],"promising":[168,176],"future":[170],"therapeutics.":[171],"nitrones":[173],"especially":[175,184],"as":[177],"various":[181],"diseases":[183],"Alzheimer\u2019s":[187],"disease.":[188],"They":[189],"depth.":[194]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
