{"id":"https://openalex.org/W1563532858","doi":null,"title":"Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.","display_name":"Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W1563532858","mag":"1563532858","pmid":"https://pubmed.ncbi.nlm.nih.gov/8203459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887468"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019494412","display_name":"Annapurna Poduri","orcid":"https://orcid.org/0000-0002-7350-5136","observed_orcids":["https://orcid.org/0000-0002-7350-5136"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Poduri","raw_affiliation_strings":["Neurology Service, Massachusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Massachusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063529297","display_name":"Marla Gearing","orcid":"https://orcid.org/0000-0002-1959-7412","observed_orcids":["https://orcid.org/0000-0002-1959-7412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gearing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082978510","display_name":"George William Rebeck","orcid":"https://orcid.org/0000-0001-6276-248X","observed_orcids":["https://orcid.org/0000-0001-6276-248X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G W Rebeck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062983762","display_name":"Suzanne Samuels Mirra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Mirra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006383313","display_name":"Johannes Tigges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Tigges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068688487","display_name":"Bradley T. Hyman","orcid":"https://orcid.org/0000-0002-7959-9401","observed_orcids":["https://orcid.org/0000-0002-7959-9401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B T Hyman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0304,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.95567495,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"144","issue":"6","first_page":"1183","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9760000109672546},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.9330000281333923},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cerebral-vasculature","display_name":"cerebral vasculature","score":0.953000009059906},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.41200000047683716},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cross-species-homology","display_name":"cross-species homology","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.8477622270584106},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.7664928436279297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6533148288726807},{"id":"https://openalex.org/C2779594886","wikidata":"https://www.wikidata.org/wiki/Q159429","display_name":"Baboon","level":2,"score":0.5435438752174377},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5400840044021606},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4986076354980469},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4481002986431122},{"id":"https://openalex.org/C2777790613","wikidata":"https://www.wikidata.org/wiki/Q191562","display_name":"Cerebral amyloid angiopathy","level":4,"score":0.4139212965965271},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2634727954864502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17027246952056885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16321763396263123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15405869483947754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15378618240356445},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0629110336303711}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002536","descriptor_name":"Cerebral Arteries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002550","descriptor_name":"Cerebral Veins","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002550","descriptor_name":"Cerebral Veins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1887468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8203459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8203459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:1563532858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8203459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1887468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1887468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1054070016","display_name":"EMORY ALZHEIMERS DISEASE CENTER","funder_award_id":"P30AG010130","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7343529753","display_name":"REGULATION OF APP IN ALZHEIMERS AND DOWNS BRAINS","funder_award_id":"F32AG005598","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1489048499","https://openalex.org/W1604834291","https://openalex.org/W1744913051","https://openalex.org/W1957366117","https://openalex.org/W1965496447","https://openalex.org/W1982120496","https://openalex.org/W1999631936","https://openalex.org/W2001688761","https://openalex.org/W2003527151","https://openalex.org/W2020005787","https://openalex.org/W2021181758","https://openalex.org/W2034968148","https://openalex.org/W2036642860","https://openalex.org/W2049550755","https://openalex.org/W2050723290","https://openalex.org/W2060590320","https://openalex.org/W2072682191","https://openalex.org/W2079381569","https://openalex.org/W2091924214","https://openalex.org/W2095091118","https://openalex.org/W2111774300","https://openalex.org/W2134633907","https://openalex.org/W2411467893","https://openalex.org/W4233622592"],"related_works":["https://openalex.org/W2092955056","https://openalex.org/W2020201709","https://openalex.org/W4253931334","https://openalex.org/W2072902382","https://openalex.org/W1963624995","https://openalex.org/W1976722506","https://openalex.org/W1483033914","https://openalex.org/W2009273836","https://openalex.org/W2088004915","https://openalex.org/W2090774331"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"of":[2,17,22,30,59,70,77,99,105,108,117,171],"late":[3],"onset":[4],"familial":[5],"and":[6,28,37,72,88,94,154,163,182,188],"sporadic":[7],"Alzheimer's":[8],"disease":[9],"(AD)":[10],"show":[11],"a":[12,50],"genetic":[13],"disequilibrium":[14],"between":[15],"inheritance":[16],"the":[18,23,57,67,75,97,106,118,128,133,142,147,158,164,169],"epsilon":[19,120,144,160],"4":[20,122,145],"allele":[21,162],"apolipoprotein":[24],"E":[25],"(ApoE)":[26],"gene":[27],"development":[29],"AD.":[31],"beta-Amyloid":[32],"(A":[33],"beta)-positive":[34],"senile":[35,92],"plaques":[36,93],"blood":[38],"vessels":[39,95],"in":[40,52,82,96,127,186],"AD":[41,187],"are":[42],"immunoreactive":[43],"for":[44,178],"ApoE,":[45],"suggesting":[46],"that":[47,132],"ApoE":[48,71,78,87,119],"plays":[49],"role":[51],"amyloid":[53],"deposition.":[54],"We":[55],"examined":[56],"brains":[58,98],"nine":[60],"rhesus":[61,129,134],"monkeys":[62],"(Macaca":[63],"mulatta)":[64],"to":[65,73,86],"determine":[66],"immunohistochemical":[68],"distribution":[69],"investigate":[74],"association":[76,107],"with":[79],"A":[80,89,179],"beta":[81,90,180,184],"this":[83,139],"species.":[84],"Antibodies":[85],"labeled":[91],"aged":[100,172],"monkeys,":[101],"indicating":[102],"cross-species":[103],"homogeneity":[104],"these":[109],"two":[110],"proteins.":[111],"Polymerase":[112],"chain":[113],"reaction/restriction":[114],"enzyme":[115],"analysis":[116],"3/epsilon":[121],"allelic":[123],"site":[124,140],"(residue":[125],"112)":[126],"monkey":[130],"revealed":[131],"has":[135],"an":[136],"arginine":[137],"at":[138],"like":[141],"human":[143,159],"allele,":[146],"cynomolgus":[148],"monkey,":[149],"baboon,":[150],"cow,":[151],"pig,":[152],"mouse,":[153],"rat":[155],"but":[156],"unlike":[157],"3":[161],"rabbit.":[165],"These":[166],"results":[167],"emphasize":[168],"value":[170],"nonhuman":[173],"primates":[174],"as":[175],"animal":[176],"models":[177],"deposition":[181],"ApoE4-A":[183],"interactions":[185],"aging.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
