{"id":"https://openalex.org/W1561990802","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","title":"The Total Amino Acid Profile of Human Milk is Stable Over the First Year of Lactation and Consistent Across Geographical Populations: a GEHM Study","display_name":"The Total Amino Acid Profile of Human Milk is Stable Over the First Year of Lactation and Consistent Across Geographical Populations: a GEHM Study","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1561990802","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","mag":"1561990802"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.583.6","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034617337","display_name":"Beau Labhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beau Labhart","raw_affiliation_strings":["Pediatric Nutrition Institute Mead Johnson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Nutrition Institute Mead Johnson","institution_ids":["https://openalex.org/I2802050884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040339087","display_name":"Michael A. Gray","orcid":"https://orcid.org/0000-0001-8850-1990","observed_orcids":["https://orcid.org/0000-0001-8850-1990"]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Gray","raw_affiliation_strings":["Pediatric Nutrition Institute Mead Johnson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Nutrition Institute Mead Johnson","institution_ids":["https://openalex.org/I2802050884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035322467","display_name":"Sarah Maria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Maria","raw_affiliation_strings":["Pediatric Nutrition Institute Mead Johnson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Nutrition Institute Mead Johnson","institution_ids":["https://openalex.org/I2802050884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103612120","display_name":"Shay C. Phillips","orcid":"https://orcid.org/0000-0002-5767-014X","observed_orcids":["https://orcid.org/0000-0002-5767-014X"]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shay Phillips","raw_affiliation_strings":["Pediatric Nutrition Institute Mead Johnson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Nutrition Institute Mead Johnson","institution_ids":["https://openalex.org/I2802050884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert McMahon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802050884","display_name":"Mead Johnson (United States)","ror":"https://ror.org/05p4pn188","country_code":"US","type":"company","lineage":["https://openalex.org/I2802050884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert McMahon","raw_affiliation_strings":["Pediatric Nutrition Institute Mead Johnson"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Nutrition Institute Mead Johnson","institution_ids":["https://openalex.org/I2802050884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068350537","display_name":"Barbara S. Davidson","orcid":"https://orcid.org/0000-0001-7016-9424","observed_orcids":["https://orcid.org/0000-0001-7016-9424"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Davidson","raw_affiliation_strings":["Perinatal Institute Cincinnati Children's Hospital Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perinatal Institute Cincinnati Children's Hospital Medical Center","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064415363","display_name":"Ardythe Luxion Morrow","orcid":"https://orcid.org/0000-0002-1126-4525","observed_orcids":["https://orcid.org/0000-0002-1126-4525"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ardythe Morrow","raw_affiliation_strings":["Perinatal Institute Cincinnati Children's Hospital Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perinatal Institute Cincinnati Children's Hospital Medical Center","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10979","display_name":"Breastfeeding Practices and Influences","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13540","display_name":"Animal Diversity and Health Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.9599999785423279},{"id":"https://openalex.org/keywords/amino-acid-composition","display_name":"amino acid composition","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.746999979019165},{"id":"https://openalex.org/keywords/free-amino-acids","display_name":"free amino acids","score":0.875},{"id":"https://openalex.org/keywords/total-amino-acids","display_name":"total amino acids","score":0.9399999976158142},{"id":"https://openalex.org/keywords/threonine","display_name":"threonine","score":0.878000020980835},{"id":"https://openalex.org/keywords/breast-milk-composition","display_name":"breast milk composition","score":0.7110000252723694},{"id":"https://openalex.org/keywords/breastfeeding","display_name":"breastfeeding","score":0.42899999022483826},{"id":"https://openalex.org/keywords/infant-development","display_name":"infant development","score":0.6380000114440918},{"id":"https://openalex.org/keywords/cross-population-comparison","display_name":"cross-population comparison","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.819720983505249},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.7931281328201294},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.7064499855041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4500468373298645},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.35256218910217285},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3248278796672821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30273663997650146},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.12758848071098328},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10946965217590332},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.09428948163986206},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.583.6","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.583.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.5365999937057495,"display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3176464922","https://openalex.org/W2035126854","https://openalex.org/W2511513427","https://openalex.org/W2288284001","https://openalex.org/W2969504751","https://openalex.org/W1941921916","https://openalex.org/W7163219494","https://openalex.org/W2524981069","https://openalex.org/W2891231485","https://openalex.org/W1530926408"],"abstract_inverted_index":{"The":[0],"amino":[1,31,50,115,145,153,167,192,200],"acid":[2,32,51,116,154,168,201],"composition":[3],"of":[4,15,19,23,37,91,110,118,134,208],"human":[5,119,148],"milk":[6,120],"is":[7],"thought":[8],"to":[9,106],"be":[10,195],"critical":[11],"in":[12,30,147,176,190],"the":[13,20,35,108,114,132,151,165,198],"development":[14],"breastfed":[16],"infants.":[17],"Part":[18],"Global":[21],"Exploration":[22],"Human":[24],"Milk":[25],"(GEHM)":[26],"study":[27,87],"examines":[28],"variability":[29,158,207],"profiles":[33,117,155,169],"over":[34],"course":[36],"lactation,":[38],"both":[39],"between":[40],"individual":[41],"mothers":[42],"and":[43,48,76,82,183,213],"across":[44,184],"geographical":[45,139,178],"populations.":[46],"Total":[47],"free":[49,152,211],"profiles,":[52],"determined":[53],"using":[54],"specialized":[55],"ion":[56],"exchange":[57],"chromatography":[58],"followed":[59],"by":[60,197,224],"post":[61],"column":[62],"derivitization,":[63],"are":[64],"reported":[65,123],"for":[66,210,215,219],"longitudinal":[67],"samples":[68,136],"collected":[69],"from":[70,137],"three":[71],"global":[72],"cohorts":[73],"(Mexico,":[74],"China,":[75],"USA)":[77],"at":[78],"4,":[79],"13,":[80],"26,":[81],"52":[83],"weeks":[84],"lactation.":[85,185],"This":[86,186],"focused":[88],"on":[89],"utilization":[90],"rigorously":[92],"controlled":[93],"sample":[94],"collection":[95],"techniques":[96],"as":[97,99,129,131],"well":[98,130],"statistically":[100],"monitored":[101],"process":[102],"control":[103,127],"during":[104],"analysis":[105],"ensure":[107],"accuracy":[109],"generated":[111],"results.":[112],"Although":[113],"have":[121],"been":[122],"previously,":[124],"these":[125,161],"extra":[126],"measures":[128],"integration":[133],"numerous":[135],"different":[138],"populations":[140],"provides":[141],"additional":[142],"insights":[143],"into":[144],"acids":[146],"milk.":[149],"While":[150],"exhibit":[156],"higher":[157],"amongst":[159,180],"individuals,":[160],"findings":[162],"suggest":[163],"that":[164],"total":[166,216],"remain":[170],"remarkably":[171],"consistent":[172],"even":[173],"when":[174],"investigated":[175],"distinct":[177],"locations,":[179],"multiple":[181],"donors,":[182],"characteristic":[187],"pattern,":[188],"observed":[189],"all":[191],"acids,":[193],"can":[194],"illustrated":[196],"essential":[199],"Threonine":[202],"(Thr),":[203],"which":[204],"has":[205],"a":[206],"55%":[209],"Thr":[212],"4%":[214],"Thr.":[217],"Support":[218],"this":[220],"research":[221],"was":[222],"provided":[223],"Mead":[225],"Johnson":[226],"Pediatric":[227],"Nutrition":[228],"Institute.":[229]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}