{"id":"https://openalex.org/W156194657","doi":null,"title":"A model of radiation-induced myelopoiesis in space.","display_name":"A model of radiation-induced myelopoiesis in space.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W156194657","mag":"156194657","pmid":"https://pubmed.ncbi.nlm.nih.gov/11771552"},"language":"en","primary_location":{"id":"pmid:11771552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11771552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027009269","display_name":"R D Esposito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R D Esposito","raw_affiliation_strings":["Department of Physics, University \"Federico II\", Dipartimento di Scienze Fisiche, Complesso universitario de Monte S. Angelo, Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, University \"Federico II\", Dipartimento di Scienze Fisiche, Complesso universitario de Monte S. Angelo, Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055277438","display_name":"Marco Durante","orcid":"https://orcid.org/0000-0002-4615-553X","observed_orcids":["https://orcid.org/0000-0002-4615-553X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Durante","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035212219","display_name":"G. Gialanella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Gialanella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047631946","display_name":"G. Grossi","orcid":"https://orcid.org/0000-0003-3956-2345","observed_orcids":["https://orcid.org/0000-0003-3956-2345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Grossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011140913","display_name":"Mariagabriella Pugliese","orcid":"https://orcid.org/0000-0003-4489-5048","observed_orcids":["https://orcid.org/0000-0003-4489-5048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Pugliese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052910826","display_name":"P. Scampoli","orcid":"https://orcid.org/0000-0001-7500-2535","observed_orcids":["https://orcid.org/0000-0001-7500-2535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Scampoli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112250091","display_name":"Troyce D. Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T D Jones","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4183,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59436153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"17 Suppl 1","issue":null,"first_page":"181","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.21570000052452087,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/lymphopoiesis","display_name":"lymphocyte development","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cellular-radiosensitivity","display_name":"cellular radiosensitivity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/stem-cell-repopulation","display_name":"stem cell repopulation","score":0.878000020980835},{"id":"https://openalex.org/keywords/stromal-cells","display_name":"stromal cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hze-radiation","display_name":"HZE radiation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/solar-energetic-particle-events","display_name":"solar energetic particle events","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mars-missions","display_name":"Mars missions","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.7764559388160706},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.622453510761261},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.4713563323020935},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43313363194465637},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.4122743308544159},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.40251368284225464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3080204725265503},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.23888501524925232},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.21511119604110718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2108353078365326},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.14320045709609985},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D003359","descriptor_name":"Cosmic Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011835","descriptor_name":"Radiation Protection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018499","descriptor_name":"Linear Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018535","descriptor_name":"Mars","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019445","descriptor_name":"Solar Activity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019891","descriptor_name":"Leukopoiesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11771552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11771552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)","raw_type":"Journal Article"},{"id":"mag:156194657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11771552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092254726","https://openalex.org/W3170661226","https://openalex.org/W2470018017","https://openalex.org/W2094847178","https://openalex.org/W2170261267","https://openalex.org/W2115343410","https://openalex.org/W3204559137","https://openalex.org/W2801059759","https://openalex.org/W2418486424","https://openalex.org/W2401333512"],"abstract_inverted_index":{"Astronauts'":[0],"radiation":[1,18,41,110,121],"exposure":[2],"limits":[3],"are":[4,95],"based":[5],"on":[6,12,70],"experimental":[7],"and":[8,92,129,135,147],"epidemiological":[9],"data":[10],"obtained":[11],"Earth.":[13],"It":[14,43,74],"is":[15,30,44,51,75,80,116],"assumed":[16,76],"that":[17,47,77,144],"sensitivity":[19],"remains":[20],"the":[21,24,33,36,40,48,66,84,108,113,120,137],"same":[22],"in":[23,102,149,155],"extraterrestrial":[25],"space.":[26,156],"However,":[27],"human":[28,153],"radiosensitivity":[29,79,154],"dependent":[31],"upon":[32],"response":[34],"of":[35,61,68,90,100,107],"hematopoietic":[37],"tissue":[38],"to":[39,118,131,136,139],"insult.":[42],"well":[45],"known":[46],"immune":[49],"system":[50],"affected":[52],"by":[53,83],"microgravity.":[54],"We":[55],"have":[56],"developed":[57],"a":[58,98],"mathematical":[59],"model":[60,106],"radiation-induced":[62],"myelopoiesis":[63,146],"which":[64],"includes":[65],"effect":[67],"microgravity":[69,150],"bone":[71],"marrow":[72],"kinetics.":[73],"cellular":[78],"not":[81],"modified":[82],"space":[85,109],"environment,":[86,111],"but":[87],"repopulation":[88],"rates":[89],"stem":[91],"stromal":[93],"cells":[94],"reduced":[96],"as":[97],"function":[99],"time":[101],"weightlessness.":[103],"A":[104,123],"realistic":[105],"including":[112],"HZE":[114],"component,":[115],"used":[117],"simulate":[119],"damage.":[122],"dedicated":[124],"computer":[125],"code":[126],"was":[127],"written":[128],"applied":[130],"solar":[132],"particle":[133],"events":[134],"mission":[138],"Mars.":[140],"The":[141],"results":[142],"suggest":[143],"altered":[145],"lymphopoiesis":[148],"might":[151],"increase":[152]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}