{"id":"https://openalex.org/W1561254355","doi":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","title":"Mechanisms of Profound Myocardial Norepinephrine Depletion in Parkinson Disease (S37.002)","display_name":"Mechanisms of Profound Myocardial Norepinephrine Depletion in Parkinson Disease (S37.002)","publication_year":2014,"publication_date":"2014-04-08","ids":{"openalex":"https://openalex.org/W1561254355","doi":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","mag":"1561254355"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.82.10_supplement.s37.002","doi":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050003203","display_name":"David S. Goldstein","orcid":"https://orcid.org/0000-0002-5709-9940","observed_orcids":["https://orcid.org/0000-0002-5709-9940"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Goldstein","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112260319","display_name":"Patti Sullivan","orcid":"https://orcid.org/0009-0000-8627-8270","observed_orcids":["https://orcid.org/0009-0000-8627-8270"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patti Sullivan","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057348787","display_name":"Courtney S. Holmes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Courtney Holmes","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069002204","display_name":"Gary W. Miller","orcid":"https://orcid.org/0000-0001-8984-1284","observed_orcids":["https://orcid.org/0000-0001-8984-1284"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Miller","raw_affiliation_strings":["Emory University Atlanta GA United States","2Emory University Atlanta GA United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University Atlanta GA United States","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Emory University Atlanta GA United States","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077449453","display_name":"Yehonatan Sharabi","orcid":"https://orcid.org/0000-0002-7566-988X","observed_orcids":["https://orcid.org/0000-0002-7566-988X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yehonatan Sharabi","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042995179","display_name":"Irwin J. Kopin","orcid":"https://orcid.org/0000-0002-8234-870X","observed_orcids":["https://orcid.org/0000-0002-8234-870X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irwin Kopin","raw_affiliation_strings":["Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"1Clinical Neurocardiology Section CNP/DIR/NINDS/NIH Bethesda MD United States","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06448703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"10_supplement","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/noradrenergic-denervation","display_name":"noradrenergic denervation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/vmat2","display_name":"vesicular monoamine transporter 2","score":0.8539999723434448},{"id":"https://openalex.org/keywords/oxidative-deamination","display_name":"oxidative deamination","score":0.746999979019165},{"id":"https://openalex.org/keywords/dhpg","display_name":"DHPG","score":0.7129999995231628},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9959999918937683},{"id":"https://openalex.org/keywords/catecholamine-metabolites","display_name":"catecholamine metabolites","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cardiac-sympathetic-nerves","display_name":"cardiac sympathetic nerves","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.7427339553833008},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5628598928451538},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4880872964859009},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47232741117477417},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.457284152507782},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4346424341201782},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42073139548301697},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3380197286605835},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.24484354257583618}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1212/wnl.82.10_supplement.s37.002","doi":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.82.10_supplement.s37.002","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2050741999","https://openalex.org/W2060267385","https://openalex.org/W2047243733","https://openalex.org/W2074937643","https://openalex.org/W103420449","https://openalex.org/W1834948783","https://openalex.org/W2271202196","https://openalex.org/W3140283715","https://openalex.org/W2064296980","https://openalex.org/W1988959441"],"abstract_inverted_index":{"BACKGROUND:":[0],"Parkinson":[1],"disease":[2],"(PD)":[3],"entails":[4],"both":[5],"striatal":[6],"dopaminergic":[7],"and":[8,58,73,75,116,123,133,169,193,241],"cardiac":[9,41],"noradrenergic":[10,167],"denervation.":[11],"A":[12],"shift":[13,37,195,206,229],"from":[14,161,196],"vesicular":[15,49,101,173,197,211,216],"sequestration":[16,198],"to":[17,24,67,190,199,208,232],"oxidative":[18,200],"deamination":[19,201,220],"of":[20,52,82,98,154,166,202,224,235],"cytosolic":[21,203],"catecholamines":[22],"contributes":[23],"putamen":[25],"dopamine":[26],"(DA)":[27],"depletion":[28,187],"in":[29,40,92,113,118,128,134,143,149,158,172,175,222,238],"PD.":[30,245],"OBJECTIVE:":[31],"We":[32],"hypothesized":[33],"that":[34,243],"an":[35,162],"analogous":[36],"takes":[38],"place":[39],"sympathetic":[42,191],"nerves.":[43,178],"DESIGN/METHODS:":[44],"If":[45],"there":[46],"were":[47,126,141],"decreased":[48,83,110,215],"uptake,":[50],"concentrations":[51],"the":[53,68,99,176,219,227,233,239],"deaminated":[54],"metabolites":[55],"3,4-dihydroxyphenylglycol":[56],"(DHPG)":[57],"3,4-dihydroxyphenylacetic":[59],"acid":[60],"(DOPAC)":[61],"would":[62,78],"be":[63,79],"elevated":[64,80],"with":[65,94],"respect":[66],"parent":[69],"amines,":[70],"norepinephrine":[71],"(NE)":[72],"DA,":[74],"DOPAC:DHPG":[76,139],"ratios":[77,125,140],"because":[81],"intra-vesicular":[84],"NE":[85,108,156,184],"synthesis.":[86],"The":[87,152,186,205],"neurochemical":[88],"approach":[89],"was":[90,109,160],"validated":[91],"mice":[93,136,145],"very":[95],"low":[96],"activity":[97],"type-2":[100],"monoamine":[102],"transporter":[103],"(VMAT2-Lo).":[104],"RESULTS:":[105],"Post-mortem":[106],"myocardial":[107,155,183],"by":[111],"98%":[112],"PD":[114,129,150,159,180],"patients":[115,130],"96%":[117],"VMAT2-Lo":[119,135,144],"mice.":[120],"Tissue":[121],"DHPG:NE":[122],"DOPAC:DA":[124],"increased":[127,142],"(p<0.0001,":[131],"p=0.0004)":[132],"(p<0.0001":[137],"each).":[138],"(p<0.0001)":[146],"but":[147],"not":[148],"patients.":[151],"reduction":[153],"content":[157],"estimated":[163],"89%":[164],"loss":[165],"innervation":[168],"84%":[170],"decrease":[171],"storage":[174],"residual":[177],"CONCLUSIONS:":[179],"involves":[181],"drastic":[182],"depletion.":[185],"is":[188],"due":[189],"denervation":[192],"a":[194],"catecholamines.":[204],"seems":[207],"reflect":[209],"augmented":[210],"permeability":[212],"rather":[213],"than":[214],"uptake.":[217],"Since":[218],"results":[221],"formation":[223],"toxic":[225],"catecholaldehydes,":[226],"vesicular-deamination":[228],"may":[230],"contribute":[231],"losses":[234],"catecholaminergic":[236],"neurons":[237],"brain":[240],"heart":[242],"characterize":[244]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}