{"id":"https://openalex.org/W1560897404","doi":"https://doi.org/10.1542/peds.60.5.730","title":"Haemophilus influenzae Type b Capsular Polysaccharide Vaccine in Children: A Double-Blind Field Study of 100,000 Vaccinees 3 Months to 5 Years of Age in Finland","display_name":"Haemophilus influenzae Type b Capsular Polysaccharide Vaccine in Children: A Double-Blind Field Study of 100,000 Vaccinees 3 Months to 5 Years of Age in Finland","publication_year":1977,"publication_date":"1977-11-01","ids":{"openalex":"https://openalex.org/W1560897404","doi":"https://doi.org/10.1542/peds.60.5.730","mag":"1560897404","pmid":"https://pubmed.ncbi.nlm.nih.gov/335348"},"language":"en","primary_location":{"id":"doi:10.1542/peds.60.5.730","doi":"https://doi.org/10.1542/peds.60.5.730","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.60.5.730","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068332954","display_name":"Heikki Peltola","orcid":"https://orcid.org/0000-0003-2145-1460","observed_orcids":["https://orcid.org/0000-0003-2145-1460"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heikki Peltola","raw_affiliation_strings":["Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097452005","display_name":"Helena K\u00e4ythy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Helena Ka\u0308ythy","raw_affiliation_strings":["Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aulikki Sivonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aulikki Sivonen","raw_affiliation_strings":["Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103495829","display_name":"Pirjo Helena M\u00e4kel\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"P. Helena Ma\u0308kela\u0308","raw_affiliation_strings":["Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Public Health Laboratory and the Department of Bacteriology and Immunology, University of Helsinki","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":null,"apc_paid":null,"fwci":8.1558,"has_fulltext":false,"cited_by_count":497,"citation_normalized_percentile":{"value":0.98074128,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"60","issue":"5","first_page":"730","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-b","display_name":"Haemophilus influenzae type b","score":0.9829999804496765},{"id":"https://openalex.org/keywords/capsular-polysaccharide-vaccine","display_name":"capsular polysaccharide vaccine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/childhood-immunization","display_name":"childhood immunization","score":0.5950000286102295},{"id":"https://openalex.org/keywords/serum-antibody-response","display_name":"serum antibody response","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nasopharyngeal-carriage","display_name":"nasopharyngeal carriage","score":0.9210000038146973},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.9190000295639038},{"id":"https://openalex.org/keywords/vaccine-adverse-events","display_name":"vaccine adverse events","score":0.8980000019073486},{"id":"https://openalex.org/keywords/finland","display_name":"Finland","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9253120422363281},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7006093859672546},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.6755422353744507},{"id":"https://openalex.org/C12590561","wikidata":"https://www.wikidata.org/wiki/Q2920497","display_name":"Booster dose","level":4,"score":0.5517293810844421},{"id":"https://openalex.org/C32762888","wikidata":"https://www.wikidata.org/wiki/Q235356","display_name":"Carriage","level":2,"score":0.48698481917381287},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4766189157962799},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.47289764881134033},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4294188618659973},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3603505492210388},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.2869446575641632},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19935458898544312},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1854008138179779},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.07886576652526855},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001428","descriptor_name":"Bacterial Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.60.5.730","doi":"https://doi.org/10.1542/peds.60.5.730","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.60.5.730","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:335348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/335348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2319447143","https://openalex.org/W4300665976","https://openalex.org/W2473429089","https://openalex.org/W2050893840","https://openalex.org/W2045221557","https://openalex.org/W1676631506","https://openalex.org/W2009642872","https://openalex.org/W4298267234","https://openalex.org/W2046218419","https://openalex.org/W2332973819"],"abstract_inverted_index":{"A":[0,29,124],"recently":[1],"developed":[2],"Haemophilus":[3],"influenzae":[4,53,74,116,159,195],"type":[5,54,75,117,160,196],"b":[6,55,76,161],"capsular":[7],"polysaccharide":[8],"vaccine":[9,31,56,185,210],"was":[10,43,129,166,199],"given":[11],"to":[12,17,156],"48,977":[13],"children":[14,26,47,132,169],"3":[15],"months":[16,59,139,172],"5":[18],"years":[19],"of":[20,25,60,68,96,149,173,183,193,208],"age;":[21],"an":[22],"equal":[23],"number":[24],"receiving":[27],"group":[28,95],"meningococcal":[30],"served":[32],"as":[33,37,39],"controls.":[34],"The":[35,152],"protection":[36,128],"well":[38],"serum":[40,153],"antibody":[41,154],"response":[42,155],"strongly":[44],"age-dependent.":[45],"Among":[46],"who":[48,133],"had":[49,134],"received":[50,145],"the":[51,78,84,93,97,105,114,122,150,157,184,190,209],"H.":[52,73,115,158,194],"when":[57,140],"18":[58,138,171],"age":[61,174,204],"or":[62],"older,":[63],"there":[64],"were":[65,90,211],"no":[66],"cases":[67,89,111],"bacteremic":[69],"disease":[70],"caused":[71],"by":[72,164],"in":[77,92,113,121,168,177,202],"first":[79],"year":[80,107],"after":[81,108],"vaccination.":[82],"At":[83],"same":[85,98],"time":[86],"11":[87],"such":[88],"seen":[91,130,188],"control":[94],"age,":[99],"a":[100,146],"highly":[101],"significant":[102],"difference.":[103],"In":[104],"second":[106],"vaccination":[109],"two":[110],"occurred":[112],"b-vaccinated":[118],"group,":[119],"five":[120],"meningococcal-group":[123],"vaccinated":[125],"group.":[126,205],"No":[127,181],"among":[131],"been":[135],"younger":[136],"than":[137],"vaccinated,":[141],"even":[142],"if":[143],"they":[144],"booster":[147],"dose":[148],"vaccine.":[151],"polysaccharide,":[162],"measured":[163],"radioimmunoassay,":[165],"poor":[167],"below":[170],"and":[175],"good":[176],"those":[178],"above":[179],"it.":[180],"effect":[182],"could":[186],"be":[187],"on":[189],"nasopharyngeal":[191],"carriage":[192],"b,":[197],"which":[198],"approximately":[200],"6%":[201],"this":[203],"Adverse":[206],"effects":[207],"mild.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}