{"id":"https://openalex.org/W1560460331","doi":null,"title":"Lysis of fresh natural killer-resistant tumor cells by lectin-activated syngeneic and allogeneic murine splenocytes.","display_name":"Lysis of fresh natural killer-resistant tumor cells by lectin-activated syngeneic and allogeneic murine splenocytes.","publication_year":1983,"publication_date":"1983-12-01","ids":{"openalex":"https://openalex.org/W1560460331","mag":"1560460331","pmid":"https://pubmed.ncbi.nlm.nih.gov/6640524"},"language":"en","primary_location":{"id":"pmid:6640524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6640524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105356995","display_name":"Amitabha Mazumder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Mazumder","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110077099","display_name":"Maury Rosenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Rosenstein","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072133376","display_name":"Steven A. Rosenberg","orcid":"https://orcid.org/0000-0002-8939-8910","observed_orcids":["https://orcid.org/0000-0002-8939-8910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6419,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.66048092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"12 Pt 1","first_page":"5729","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04039999842643738,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/concanavalin-a","display_name":"concanavalin A","score":0.9279999732971191},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tumor-cell-lysis","display_name":"tumor cell lysis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/syngeneic-tumor-cells","display_name":"syngeneic tumor cells","score":0.7450000047683716},{"id":"https://openalex.org/keywords/allogeneic-tumor-cells","display_name":"allogeneic tumor cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.7680000066757202},{"id":"https://openalex.org/keywords/alpha-methyl-mannoside","display_name":"alpha-methyl-D-mannoside","score":0.8579999804496765},{"id":"https://openalex.org/keywords/thy-1-cells","display_name":"Thy-1+ cells","score":0.6179999709129333},{"id":"https://openalex.org/keywords/p815-mastocytoma-cells","display_name":"P815 mastocytoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.4519999921321869},{"id":"https://openalex.org/keywords/adhesion","display_name":"adhesion","score":0.37400001287460327},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.6580551266670227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6120238900184631},{"id":"https://openalex.org/C19869320","wikidata":"https://www.wikidata.org/wiki/Q419277","display_name":"Concanavalin A","level":3,"score":0.58661949634552},{"id":"https://openalex.org/C2778930412","wikidata":"https://www.wikidata.org/wiki/Q6785569","display_name":"Mastocytoma","level":3,"score":0.5202909111976624},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.5084089636802673},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.49157652258872986},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4796091318130493},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4581716060638428},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.44507890939712524},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4209282696247101},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.414650022983551},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2977462708950043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27379941940307617},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.27230602502822876},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.20199209451675415},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.18740466237068176},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18732962012290955},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.06878849864006042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06393444538116455}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010954","descriptor_name":"Plasmacytoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012513","descriptor_name":"Sarcoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6640524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6640524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:1560460331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6640524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1484285187","https://openalex.org/W1486428023","https://openalex.org/W1561440286","https://openalex.org/W1594111463","https://openalex.org/W1633669131","https://openalex.org/W1758768634","https://openalex.org/W1779202196","https://openalex.org/W1783973309","https://openalex.org/W1906112488","https://openalex.org/W1936744554","https://openalex.org/W1980843757","https://openalex.org/W2000787210","https://openalex.org/W2012231676","https://openalex.org/W2013701131","https://openalex.org/W2036275492","https://openalex.org/W2063267366","https://openalex.org/W2102251060","https://openalex.org/W2111711939","https://openalex.org/W2144931720","https://openalex.org/W2152181181","https://openalex.org/W2412519231"],"related_works":["https://openalex.org/W1893785002","https://openalex.org/W1633669131","https://openalex.org/W1576552529","https://openalex.org/W2043849755","https://openalex.org/W2064550332","https://openalex.org/W2076288847","https://openalex.org/W1525786945","https://openalex.org/W1605632064","https://openalex.org/W2119737712","https://openalex.org/W2043621456"],"abstract_inverted_index":{"This":[0],"paper":[1],"demonstrates":[2],"that":[3],"lectin-activated":[4],"lymphocytes":[5],"of":[6,106,135,168,181,205],"selected":[7],"mouse":[8,183],"strains":[9,184],"can":[10],"lyse":[11],"fresh":[12,21,43,53,73],"autologous":[13],"or":[14,91],"allogeneic":[15,54,88],"tumor":[16,40,218],"cells":[17,23,41,64,71,80,93,126,129,171,191,207],"but":[18,120],"not":[19,82,95,121],"the":[20,83,98,117,133,179],"normal":[22],"tested":[24],"in":[25,65,72,116,122,212],"short-term":[26],"51Cr":[27],"release":[28,67],"assays.":[29,68],"Murine":[30],"splenocytes,":[31],"incubated":[32],"with":[33,193],"concanavalin":[34,99,109],"A":[35,110],"for":[36,132],"3":[37],"days,":[38],"lysed":[39,77,96],"from":[42],"syngeneic":[44,214],"P815":[45],"mastocytoma,":[46],"102":[47],"methylcholanthrene":[48],"sarcoma,":[49],"and":[50,58,61,81,87,127,145,149,178,202,216],"FBL3":[51],"lymphoma;":[52],"3LL":[55],"lung":[56],"carcinoma":[57],"MethA":[59],"sarcoma;":[60],"tissue-cultured":[62,78],"YAK":[63,79],"18-hr51Cr":[66],"Natural":[69],"killer":[70,101],"splenocyte":[74],"preparations":[75],"only":[76],"other":[84],"targets.":[85],"Syngeneic":[86],"lymphoblasts,":[89],"lung,":[90],"liver":[92],"were":[94,130,142],"by":[97,108,114,158,161],"A-activated":[100],"(CAK)":[102],"cells.":[103,137],"The":[104,138,152,200],"induction":[105],"cytotoxicity":[107,123],"incubation":[111],"was":[112],"abrogated":[113],"alpha-methylmannoside":[115],"3-day":[118],"incubation,":[119],"assay.":[124],"Radiosensitive":[125],"adherent":[128],"necessary":[131],"generation":[134],"CAK":[136,139,153,176,190],"effectors":[140],"themselves":[141],"radioresistant,":[143],"nonadherent,":[144],"mostly":[146],"Thy":[147],"1+":[148,164,170],"Ly":[150,163,169],"2+.":[151],"phenomenon":[154],"may":[155],"be":[156],"mediated":[157],"lymphokine":[159],"production":[160],"an":[162],"cell,":[165],"since":[166],"depletion":[167],"prior":[172],"to":[173,188,196],"activation":[174],"abrogates":[175],"induction,":[177],"ability":[180,195],"numerous":[182],"(and":[185],"nude":[186],"mice)":[187],"generate":[189],"correlated":[192],"their":[194],"produce":[197],"Interleukin":[198],"2.":[199],"biological":[201],"therapeutic":[203],"role":[204],"these":[206],"is":[208],"currently":[209],"being":[210],"investigated":[211],"murine":[213],"primary":[215],"metastatic":[217],"models.":[219]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}