{"id":"https://openalex.org/W1560457939","doi":null,"title":"Protection from adriamycin cytotoxicity in L1210 cells by brefeldin A.","display_name":"Protection from adriamycin cytotoxicity in L1210 cells by brefeldin A.","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W1560457939","mag":"1560457939","pmid":"https://pubmed.ncbi.nlm.nih.gov/8106144"},"language":"en","primary_location":{"id":"pmid:8106144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8106144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054352226","display_name":"Paul Vichi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Vichi","raw_affiliation_strings":["Vermont Cancer Center, Burlington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vermont Cancer Center, Burlington","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112999538","display_name":"T R Tritton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T R Tritton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2178,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.38033846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"53","issue":"21","first_page":"5237","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.43950000405311584,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.2897999882698059,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.09510000050067902,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/brefeldin-a","display_name":"brefeldin A","score":0.9649999737739563},{"id":"https://openalex.org/keywords/l1210-cells","display_name":"L1210 leukemia","score":0.9039999842643738},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5699999928474426},{"id":"https://openalex.org/keywords/vesicular-trafficking","display_name":"vesicle trafficking","score":0.7129999995231628},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibitors","display_name":"topoisomerase II inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.996999979019165},{"id":"https://openalex.org/keywords/amsacrine","display_name":"amsacrine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.8650000095367432},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8399999737739563},{"id":"https://openalex.org/keywords/intracellular-drug-accumulation","display_name":"intracellular drug accumulation","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2781373781","wikidata":"https://www.wikidata.org/wiki/Q168790","display_name":"Brefeldin A","level":4,"score":0.9011507034301758},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7103334665298462},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6356393098831177},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6062605381011963},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.5455044507980347},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5063446760177612},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.49521031975746155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.458219438791275},{"id":"https://openalex.org/C2780017796","wikidata":"https://www.wikidata.org/wiki/Q6456824","display_name":"L1210 cells","level":4,"score":0.43217524886131287},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.417524516582489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41704633831977844},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39618998765945435},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38908129930496216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36149531602859497},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34683698415756226},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.23685356974601746},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13854265213012695},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000677","descriptor_name":"Amsacrine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015739","descriptor_name":"Nocodazole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020126","descriptor_name":"Brefeldin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8106144","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8106144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.326.6825","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.326.6825","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/53/21/5237.full.pdf","raw_type":"text"},{"id":"mag:1560457939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8106144","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4489995814","display_name":"MEMBRANE TARGETS IN CANCER CHEMOTHERAPY","funder_award_id":"R01CA044729","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7795681832","display_name":"CELL SURFACE MECHANISMS OF CYTOTOXICITY","funder_award_id":"R01CA056040","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095504660","https://openalex.org/W2134457596","https://openalex.org/W2151329194","https://openalex.org/W2171219384","https://openalex.org/W1983729184","https://openalex.org/W2059328855","https://openalex.org/W2030921971","https://openalex.org/W2122815075","https://openalex.org/W2492522991","https://openalex.org/W2061831038"],"abstract_inverted_index":{"We":[0,96],"present":[1],"studies":[2],"which":[3,216,252,268,299,307],"suggest":[4,275],"that":[5,99,174,250,276,312],"the":[6,26,30,34,63,71,78,84,143,155,161,181,208,234,277,316],"cytotoxic":[7,60],"action":[8],"of":[9,16,21,74,80,86,169,183,195,210,233,236,242,247,266,303],"Adriamycin":[10],"(ADR)":[11],"may":[12,300,308],"involve":[13,286],"intracellular":[14,170],"pathways":[15],"vesicular":[17],"transport.":[18],"The":[19,120],"movement":[20],"proteins":[22],"or":[23,188,290,296],"lipids":[24],"from":[25,88,114,142],"endoplasmic":[27],"reticulum":[28],"to":[29,118,151,244,264],"plasma":[31],"membrane":[32],"via":[33],"Golgi":[35],"organelle":[36],"and":[37,48,83,148,306],"associated":[38],"compartments":[39],"exhibits":[40],"several":[41],"temperature-sensitive":[42],"steps":[43],"between":[44],"15":[45],"degrees":[46,50,104],"C":[47,105],"20":[49],"C.":[51],"In":[52,192],"this":[53],"same":[54],"temperature":[55,92],"range,":[56],"ADR":[57,81,171,184,271],"loses":[58],"its":[59],"capacity.":[61],"Using":[62],"inhibitor":[64],"brefeldin":[65,282],"A":[66,283],"(BFA),":[67],"we":[68],"have":[69],"investigated":[70],"possible":[72],"role":[73],"intravesicular":[75],"trafficking":[76],"in":[77,93,128,180,185,207,214,229],"loss":[79],"activity":[82],"induction":[85],"protection":[87],"cytotoxicity":[89],"at":[90,102,261],"low":[91],"L1210":[94,136],"cells.":[95],"show":[97],"here":[98],"cells":[100,137,186,215,251,267],"pretreated":[101,219,254],"37":[103],"for":[106,160],"2":[107],"h":[108,246],"with":[109,187,220,255],"BFA":[110,190,221,256],"could":[111,138],"be":[112,140,301],"protected":[113,141],"a":[115,152,226,240],"subsequent":[116],"exposure":[117],"ADR.":[119],"concentration":[121,156],"causing":[122,157],"50%":[123,158],"inhibition,":[124],"determined":[125],"by":[126,200,281],"cloning":[127],"soft":[129],"agar,":[130],"was":[131,176,225],"increased":[132,165],"approximately":[133],"3.5":[134],"fold.":[135],"also":[139],"topoisomerase":[144,317],"II":[145],"inhibitors":[146,163],"etoposide":[147],"amsacrine,":[149],"but":[150,292],"lesser":[153],"extent;":[154],"inhibition":[159],"latter":[162],"were":[164,253],"2-fold.":[166],"Spectrofluorometric":[167],"analysis":[168],"accumulation":[172],"revealed":[173,249],"there":[175,224],"no":[177,204],"significant":[178,205],"difference":[179,206,228],"level":[182,209],"without":[189],"pretreatment.":[191],"addition,":[193],"examination":[194,232],"ADR-induced":[196],"cleavable":[197],"complex":[198,319],"formation":[199],"alkaline":[201],"elution":[202],"showed":[203],"DNA":[211,237,258,288,304],"strand":[212,259],"breaks":[213,260],"had":[217,269],"been":[218,321],"even":[222],"though":[223],"large":[227],"survival.":[230],"Further":[231],"persistence":[235],"damage":[238,305],"after":[239,315],"period":[241],"up":[243],"6":[245],"repair":[248,291],"removed":[257],"rates":[262],"equivalent":[263],"those":[265],"received":[270],"directly.":[272],"These":[273],"results":[274],"protective":[278],"effect":[279],"induced":[280],"does":[284],"not":[285],"uptake,":[287],"damage,":[289],"instead":[293],"implicates":[294],"protein":[295],"lipid":[297],"interactions":[298],"independent":[302],"influence":[309],"critical":[310],"events":[311],"take":[313],"place":[314],"II-DNA":[318],"has":[320],"formed.":[322]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
