{"id":"https://openalex.org/W156028082","doi":null,"title":"The value of preserving HIV-specific immune responses.","display_name":"The value of preserving HIV-specific immune responses.","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W156028082","mag":"156028082","pmid":"https://pubmed.ncbi.nlm.nih.gov/12840711"},"language":"en","primary_location":{"id":"pmid:12840711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12840711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of HIV therapy","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078444774","display_name":"DE Kaufmann","orcid":"https://orcid.org/0000-0003-4467-136X","observed_orcids":["https://orcid.org/0000-0003-4467-136X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E Kaufmann","raw_affiliation_strings":["Massachusetts General Hospital, Division of Infectious Disease, Gray J 529, 55 Fruit Street, GRJ 529, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Division of Infectious Disease, Gray J 529, 55 Fruit Street, GRJ 529, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082842988","display_name":"Eric\u00a0S. Rosenberg","orcid":"https://orcid.org/0000-0002-8217-5458","observed_orcids":["https://orcid.org/0000-0002-8217-5458","https://orcid.org/0009-0002-3650-7375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric S Rosenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2301,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.47885325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"19","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-helper-cells","display_name":"CD4+ T helper cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/persistent-viraemia","display_name":"persistent viraemia","score":0.7440000176429749},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.8309999704360962},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.968999981880188},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.48899999260902405},{"id":"https://openalex.org/keywords/prophylactic-vaccination","display_name":"prophylactic vaccination","score":0.6859999895095825},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/t-cell-priming","display_name":"T cell priming","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7744529843330383},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7630969285964966},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.70301753282547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6651784181594849},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5540282130241394},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.44680798053741455},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4455283582210541},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.44276896119117737},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.43687283992767334},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4008057117462158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2565106749534607},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C100701293","wikidata":"https://www.wikidata.org/wiki/Q193838","display_name":"Germination","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014766","descriptor_name":"Viremia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12840711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12840711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of HIV therapy","raw_type":"Journal Article"},{"id":"mag:156028082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12840711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118148901","https://openalex.org/W1574561647","https://openalex.org/W2041166864","https://openalex.org/W2437663082","https://openalex.org/W2014730278","https://openalex.org/W2011646391","https://openalex.org/W2022356741","https://openalex.org/W2411635574","https://openalex.org/W2077263857","https://openalex.org/W2412456777"],"abstract_inverted_index":{"HIV-1":[0,63,113],"infection":[1,114,151],"is":[2],"characterised":[3],"by":[4,98,187],"persistent":[5,43],"viraemia":[6,44,117],"and":[7,14,45,50,95,108,131,152,177,184,191],"a":[8,57,84,89,123],"progressive":[9],"decline":[10,46],"in":[11,38,47,83,92,145],"both":[12],"number":[13,49],"function":[15,51],"of":[16,31,52,60,86,120,141,181],"CD4":[17,53,142],"T-helper":[18,143],"lymphocytes.":[19],"The":[20,42],"inability":[21],"to":[22,56,62,67,78,125,129,155,159],"contain":[23],"viral":[24],"replication":[25],"presumably":[26],"results":[27],"from":[28],"the":[29,48,93,138,146,170],"lack":[30],"an":[32],"effective":[33],"HIV-1-specific":[34,103,133],"immune":[35,81,147,157],"response":[36,148],"observed":[37],"most":[39,109],"HIV-infected":[40],"individuals.":[41],"cells":[54,144],"lead":[55],"further":[58],"loss":[59],"immunity":[61,104],"as":[64,66],"well":[65],"opportunistic":[68,99],"pathogens.":[69],"Highly":[70],"active":[71],"antiretroviral":[72],"therapy":[73],"(HARRT)":[74],"has":[75],"been":[76],"shown":[77],"reconstitute":[79],"pathogen-specific":[80],"responses":[82,158],"majority":[85],"subjects,":[87],"with":[88,111,164],"dramatic":[90],"drop":[91],"morbidity":[94],"mortality":[96],"caused":[97],"infections.":[100],"By":[101],"contrast,":[102],"remains":[105],"largely":[106],"ineffective":[107],"people":[110,163],"chronic":[112],"cannot":[115],"control":[116],"after":[118],"interruption":[119],"HARRT,":[121],"indicating":[122],"need":[124],"develop":[126],"new":[127],"strategies":[128],"maintain":[130],"improve":[132],"immunity.":[134],"Here":[135],"we":[136,168],"review":[137],"relative":[139],"role":[140],"against":[149],"HIV":[150],"their":[153],"contribution":[154],"cell-mediated":[156],"other":[160],"pathogens":[161],"infecting":[162],"AIDS.":[165],"In":[166],"addition,":[167],"discuss":[169],"concepts":[171],"of:":[172],"supervised":[173],"treatment":[174],"interruptions,":[175],"therapeutic":[176],"preventive":[178],"vaccination,":[179],"optimisation":[180],"antigen":[182],"presentation":[183],"T-cell":[185],"priming":[186],"ex":[188],"vivo":[189],"stimulated":[190],"expanded":[192],"dendritic":[193],"cells.":[194]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
