{"id":"https://openalex.org/W1559890486","doi":"https://doi.org/10.1002/pro.2597","title":"Apo E : The role of conserved residues in defining function","display_name":"Apo E : The role of conserved residues in defining function","publication_year":2014,"publication_date":"2014-11-06","ids":{"openalex":"https://openalex.org/W1559890486","doi":"https://doi.org/10.1002/pro.2597","mag":"1559890486","pmid":"https://pubmed.ncbi.nlm.nih.gov/25377861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4282419"},"language":"en","primary_location":{"id":"doi:10.1002/pro.2597","doi":"https://doi.org/10.1002/pro.2597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2597","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043445006","display_name":"Carl Frieden","orcid":"https://orcid.org/0000-0002-4471-2427","observed_orcids":["https://orcid.org/0000-0002-4471-2427"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carl Frieden","raw_affiliation_strings":["Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biophysics Washington University School of Medicine St. Louis Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043445006"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.9788,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.67848115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"138","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":1.0},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8119999766349792},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/conserved-residues","display_name":"conserved residues","score":0.6769999861717224},{"id":"https://openalex.org/keywords/sequence-conservation","display_name":"sequence conservation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.7170000076293945},{"id":"https://openalex.org/keywords/ligand-binding-site","display_name":"ligand binding sites","score":0.9039999842643738},{"id":"https://openalex.org/keywords/protein-structure-function-relationship","display_name":"protein structure-function relationship","score":0.5699999928474426},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.640999972820282},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interspecies-sequence-comparison","display_name":"interspecies sequence comparison","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.7459143400192261},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6668028235435486},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5903841853141785},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5763838291168213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4874844551086426},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.48385751247406006},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.48058390617370605},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4455285966396332},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.4341452121734619},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39727920293807983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3340412378311157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14608696103096008},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.09902149438858032},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.04810458421707153},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011973","descriptor_name":"Receptors, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053318","descriptor_name":"Apolipoprotein E3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053327","descriptor_name":"Apolipoprotein E4","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/pro.2597","doi":"https://doi.org/10.1002/pro.2597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2597","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4282419","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4282419","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Sci","raw_type":"Text"},{"id":"pmid:25377861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25377861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein science : a publication of the Protein Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/pro.2597","doi":"https://doi.org/10.1002/pro.2597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/pro.2597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2597","source":{"id":"https://openalex.org/S156919612","display_name":"Protein Science","issn_l":"0961-8368","issn":["0961-8368","1469-896X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3843076168","display_name":"ALZHEIMER'S DISEASE: DEFINING THE APOE-AMYLOID-BETA INTERACTION","funder_award_id":"RF1AG044331","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1559890486.pdf","grobid_xml":"https://content.openalex.org/works/W1559890486.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W4166267","https://openalex.org/W134453782","https://openalex.org/W1505230657","https://openalex.org/W1546262989","https://openalex.org/W1548248031","https://openalex.org/W1559121591","https://openalex.org/W1576642143","https://openalex.org/W1659662945","https://openalex.org/W1736154854","https://openalex.org/W1990016625","https://openalex.org/W1994543234","https://openalex.org/W2004324219","https://openalex.org/W2008655430","https://openalex.org/W2034724732","https://openalex.org/W2035467780","https://openalex.org/W2036362108","https://openalex.org/W2051394059","https://openalex.org/W2054021905","https://openalex.org/W2062929870","https://openalex.org/W2067160010","https://openalex.org/W2069118296","https://openalex.org/W2070566118","https://openalex.org/W2076775566","https://openalex.org/W2088655169","https://openalex.org/W2089657004","https://openalex.org/W2090843520","https://openalex.org/W2092818456","https://openalex.org/W2092900687","https://openalex.org/W2094007252","https://openalex.org/W2111135465","https://openalex.org/W2111307154","https://openalex.org/W2119291357","https://openalex.org/W2123504934","https://openalex.org/W2124165977","https://openalex.org/W2128317000","https://openalex.org/W2130947702","https://openalex.org/W2138786214","https://openalex.org/W2153274243","https://openalex.org/W2161925307","https://openalex.org/W2331038954"],"related_works":["https://openalex.org/W2034724732","https://openalex.org/W2119291357","https://openalex.org/W2035029099","https://openalex.org/W2022800519","https://openalex.org/W2780241272","https://openalex.org/W2148033380","https://openalex.org/W193047993","https://openalex.org/W2912556111","https://openalex.org/W2618913695","https://openalex.org/W7166123257"],"abstract_inverted_index":{"The":[0,20],"amino":[1,34,59,94],"acid":[2,60],"sequences":[3,21,32],"of":[4,33,45,73,124,134,153],"apolipoprotein":[5],"E":[6],"(apoE)":[7],"from":[8,16,54],"63":[9],"different":[10],"mammalian":[11],"species":[12],"have":[13,98],"been":[14,99],"downloaded":[15],"the":[17,38,43,71,77,106,122,125,135,138,148,154],"protein":[18,107,136],"database.":[19],"were":[22],"compared":[23],"to":[24,27,81,118,131],"human":[25],"apoE4":[26,55],"determine":[28],"conserved":[29,89],"and":[30,84,108,140,150],"non-conserved":[31,144],"acids.":[35],"ApoE4":[36],"is":[37],"major":[39],"risk":[40,69],"factor":[41],"for":[42,70],"development":[44,72],"late":[46],"onset":[47],"Alzheimer's":[48],"disease":[49],"while":[50],"apoE3,":[51],"which":[52],"differs":[53],"by":[56],"a":[57],"single":[58],"change":[61,127],"at":[62,128,147],"position":[63,129],"112,":[64],"poses":[65],"little":[66],"or":[67],"no":[68],"this":[74],"disease.":[75],"Thus,":[76],"two":[78],"proteins":[79],"appear":[80],"be":[82,119],"structurally":[83],"functionally":[85],"different.":[86],"Seven":[87],"highly":[88],"regions,":[90],"representing":[91],"approximately":[92],"47":[93],"acids":[95],"(of":[96],"299)":[97],"found.":[100],"These":[101],"regions":[102,116,133,145],"are":[103,146],"distributed":[104],"throughout":[105],"reflect":[109],"ligand":[110],"binding":[111],"sites":[112],"as":[113,115],"well":[114],"proposed":[117],"involved":[120],"in":[121,137],"propagation":[123],"cysteine-arginine":[126],"112":[130],"distant":[132],"N-":[139,149],"C-terminal":[141,151],"domains.":[142],"Highly":[143],"ends":[152],"apoE":[155],"protein.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
