{"id":"https://openalex.org/W155832285","doi":null,"title":"The phenotype of human placental macrophages and its variation with gestational age.","display_name":"The phenotype of human placental macrophages and its variation with gestational age.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W155832285","mag":"155832285","pmid":"https://pubmed.ncbi.nlm.nih.gov/3264459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1880826"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1880826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1880826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1880826","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006429721","display_name":"Jed Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124227911","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982","country_code":"IL","type":"education","lineage":["https://openalex.org/I124227911"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"J Goldstein","raw_affiliation_strings":["Ben-Gurion University of the Negev, Faculty of the Health Sciences, Beer-Sheba, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben-Gurion University of the Negev, Faculty of the Health Sciences, Beer-Sheba, Israel","institution_ids":["https://openalex.org/I124227911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053420290","display_name":"Muriel Braverman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Braverman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027528511","display_name":"C.M. Salafia","orcid":"https://orcid.org/0009-0004-0478-6124","observed_orcids":["https://orcid.org/0009-0004-0478-6124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Salafia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078097574","display_name":"Patrick J. Buckley","orcid":"https://orcid.org/0000-0003-0650-929X","observed_orcids":["https://orcid.org/0000-0003-0650-929X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Buckley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0667,"has_fulltext":false,"cited_by_count":108,"citation_normalized_percentile":{"value":0.91842834,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"133","issue":"3","first_page":"648","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/placental-macrophages","display_name":"placental macrophages","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gestational-age","display_name":"gestational age","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cell-surface-antigens","display_name":"cell surface antigens","score":0.6940000057220459},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hla-dp","display_name":"HLA-DP","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd1-antigen","display_name":"CD1 antigen","score":0.878000020980835},{"id":"https://openalex.org/keywords/cd4-antigen","display_name":"CD4 antigen","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hofbauer-cells","display_name":"Hofbauer cells","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hiv-reservoir","display_name":"HIV reservoir","score":0.5690000057220459},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.5130000114440918},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6591720581054688},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6553060412406921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6524071097373962},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6349512338638306},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.6251545548439026},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5375897884368896},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5274736285209656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4587460160255432},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.42628103494644165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4013131260871887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3737414479255676},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2948110103607178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15259209275245667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13370510935783386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12348189949989319},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.10567453503608704},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07489567995071411}],"mesh":[{"descriptor_ui":"D000940","descriptor_name":"Antigenic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006681","descriptor_name":"HLA-D Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011951","descriptor_name":"Receptors, Complement","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011991","descriptor_name":"Receptors, Virus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015728","descriptor_name":"Receptors, HIV","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1880826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1880826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:3264459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3264459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:155832285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3264459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1880826","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1880826","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W59545532","https://openalex.org/W107727691","https://openalex.org/W116160248","https://openalex.org/W131386058","https://openalex.org/W135854549","https://openalex.org/W174646939","https://openalex.org/W176653346","https://openalex.org/W314104006","https://openalex.org/W1426352533","https://openalex.org/W1483035379","https://openalex.org/W1496743250","https://openalex.org/W1504829946","https://openalex.org/W1506410773","https://openalex.org/W1528252721","https://openalex.org/W1529893227","https://openalex.org/W1552730840","https://openalex.org/W1554739819","https://openalex.org/W1575397990","https://openalex.org/W1584545803","https://openalex.org/W1586050515","https://openalex.org/W1588659221","https://openalex.org/W1590407189","https://openalex.org/W1591113877","https://openalex.org/W1595872169","https://openalex.org/W1603440519","https://openalex.org/W1762530211","https://openalex.org/W1912163190","https://openalex.org/W1917162722","https://openalex.org/W1925232228","https://openalex.org/W1926345004","https://openalex.org/W1953021129","https://openalex.org/W1969783034","https://openalex.org/W1972866849","https://openalex.org/W1973433176","https://openalex.org/W1976565632","https://openalex.org/W1984952188","https://openalex.org/W2002475242","https://openalex.org/W2002594142","https://openalex.org/W2009811622","https://openalex.org/W2014828698","https://openalex.org/W2017324008","https://openalex.org/W2027621324","https://openalex.org/W2038879439","https://openalex.org/W2045417135","https://openalex.org/W2047505474","https://openalex.org/W2049403521","https://openalex.org/W2061109731","https://openalex.org/W2066121768","https://openalex.org/W2068675018","https://openalex.org/W2076618633","https://openalex.org/W2077520023","https://openalex.org/W2079029118","https://openalex.org/W2088991693","https://openalex.org/W2095739565","https://openalex.org/W2096428903","https://openalex.org/W2096747204","https://openalex.org/W2098643663","https://openalex.org/W2105074038","https://openalex.org/W2106762722","https://openalex.org/W2108639204","https://openalex.org/W2117636530","https://openalex.org/W2134284956","https://openalex.org/W2147237655","https://openalex.org/W2199203165","https://openalex.org/W2317667918","https://openalex.org/W2321860441","https://openalex.org/W2328139329","https://openalex.org/W2401116114","https://openalex.org/W2410113986","https://openalex.org/W2414554120","https://openalex.org/W2418241239"],"related_works":["https://openalex.org/W2027590597","https://openalex.org/W142050114","https://openalex.org/W2070731695","https://openalex.org/W116160248","https://openalex.org/W2420982222","https://openalex.org/W2157384292","https://openalex.org/W2030509660","https://openalex.org/W110518993","https://openalex.org/W59545532","https://openalex.org/W2003677779"],"abstract_inverted_index":{"The":[0,34,61,190],"antigenic":[1],"phenotype":[2,56],"of":[3,23,36,53,129,145,212,227,242,245,293,303],"human":[4,281],"villous":[5,65,162,205,232],"stromal":[6,66,102],"macrophages":[7],"(M":[8],"phi":[9,43,55,79,104,123,164,172,207,234,256],"s)":[10],"from":[11,90,121],"first":[12,180],"and":[13,77,81,115,131,154,166,199,236,260],"third":[14,187],"trimester":[15,181,188],"placentas":[16,133],"was":[17,39,158,176,202,252],"analyzed":[18],"using":[19],"a":[20,48,243,291],"large":[21],"number":[22,244],"monoclonal":[24],"antibodies":[25],"(MAbs)":[26],"to":[27,40,46,94,270],"monocyte":[28],"(Mo)/M":[29],"phi-associated":[30],"cell":[31,71,110,247],"membrane":[32],"determinants.":[33],"purpose":[35],"this":[37,113,220,298],"study":[38],"investigate":[41],"M":[42,54,78,103,122,163,171,206,233,255],"phenotypic":[44,119],"heterogeneity":[45],"create":[47],"database":[49],"for":[50,279,297],"the":[51,107,179,213,240,271,277,280,301],"correlation":[52],"with":[57,97,139,224,266],"specific":[58],"immunologic":[59],"functions.":[60],"results":[62],"showed":[63,230],"that":[64,82,231,254,274,286],"mononuclear":[67],"cells":[68,93,96,185,198,238,288],"express":[69],"many":[70],"surface":[72,248],"antigens":[73],"found":[74,194],"on":[75,160,169,184,195,204,219],"Mo":[76],"s":[80,105,124,165,173,208,235,257],"they":[83],"are":[84],"morphologically":[85],"diverse,":[86],"ranging":[87],"in":[88,112,125,136,143,178,186,258,300],"appearance":[89],"classic":[91],"Hofbauer":[92],"spindle-shaped":[95],"long":[98],"cytoplasmic":[99],"processes.":[100],"Villous":[101],"were":[106],"numerically":[108],"dominant":[109],"type":[111],"structure":[114],"exhibited":[116],"some":[117],"major":[118,148],"differences":[120],"other":[126,246],"tissues.":[127],"Comparison":[128],"first-":[130,259],"third-trimester":[132,170,261],"revealed":[134],"variation":[135],"antigen":[137,156,273],"expression":[138,241],"increasing":[140],"gestational":[141],"age,":[142],"particular":[144],"class":[146],"II":[147],"histocompatibility":[149],"complex":[150],"(MHC)":[151],"determinants:":[152],"HLA-DR":[153],"HLA-DP":[155],"density":[157],"low":[159],"first-trimester":[161],"much":[167],"higher":[168],"while":[174],"HLA-DQ":[175],"undetectable":[177],"but":[182],"present":[183],"placentas.":[189],"CD1":[191],"(T6)":[192],"antigen,":[193],"Langerhans":[196],"(LH)":[197],"cortical":[200],"thymocytes,":[201],"detected":[203],"by":[209],"two":[210],"thirds":[211],"MAbs":[214,267],"directed":[215],"against":[216],"different":[217],"epitopes":[218],"determinant.":[221],"Furthermore,":[222],"comparison":[223],"similar":[225],"studies":[226],"lymphoid":[228],"tissues":[229],"dendritic":[237],"share":[239],"antigens.":[249],"Finally,":[250],"it":[251],"shown":[253],"villi":[262],"exhibit":[263],"strong":[264],"reactivity":[265],"(Leu":[268],"3a,b)":[269],"CD4":[272],"serves":[275],"as":[276],"receptor":[278],"immunodeficiency":[282],"virus":[283,299],"(HIV),":[284],"suggesting":[285],"these":[287],"may":[289],"be":[290],"portal":[292],"entry":[294],"or":[295],"reservoir":[296],"fetuses":[302],"pregnant,":[304],"HIV+":[305],"women.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}