{"id":"https://openalex.org/W1558197166","doi":null,"title":"CNS DEPRESSANT, SEDATIVE AND ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FRUIT OF PIPER CHABA REVEALED AFTER NEUROPHARMACOLOGICAL SCREENING","display_name":"CNS DEPRESSANT, SEDATIVE AND ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FRUIT OF PIPER CHABA REVEALED AFTER NEUROPHARMACOLOGICAL SCREENING","publication_year":2014,"publication_date":"2014-10-14","ids":{"openalex":"https://openalex.org/W1558197166","mag":"1558197166"},"language":"en","primary_location":{"id":"mag:1558197166","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/2109","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/2109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079182291","display_name":"Sana Ahmed Sarfaraz","orcid":"https://orcid.org/0000-0002-5104-7488","observed_orcids":["https://orcid.org/0000-0002-5104-7488"]},"institutions":[{"id":"https://openalex.org/I18718515","display_name":"Jinnah University for Women","ror":"https://ror.org/056zv5g90","country_code":"PK","type":"education","lineage":["https://openalex.org/I18718515"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sana Sarfaraz","raw_affiliation_strings":["Jinnah University for women"],"raw_orcid":"https://orcid.org/0000-0002-5104-7488","affiliations":[{"raw_affiliation_string":"Jinnah University for women","institution_ids":["https://openalex.org/I18718515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113633897","display_name":"Rahila Najam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rahila Najam","raw_affiliation_strings":["University of karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of karachi","institution_ids":["https://openalex.org/I193670377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032821884","display_name":"Abeer Sarfaraz","orcid":"https://orcid.org/0000-0001-8777-9982","observed_orcids":["https://orcid.org/0000-0001-8777-9982"]},"institutions":[{"id":"https://openalex.org/I1312300495","display_name":"Jinnah Postgraduate Medical Center","ror":"https://ror.org/00952fj37","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I1312300495"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abeer Sarfaraz","raw_affiliation_strings":["Jinnah Post Graduate Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jinnah Post Graduate Medical Center","institution_ids":["https://openalex.org/I1312300495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3902,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.87602931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"11","first_page":"186","last_page":"189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piper-chaba","display_name":"Piper chaba","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ethanolic-fruit-extract","display_name":"ethanolic fruit extract","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cns-depressant-activity","display_name":"CNS depressant activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":1.0},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9120000004768372},{"id":"https://openalex.org/keywords/light-dark-test","display_name":"light/dark test","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2777025580","wikidata":"https://www.wikidata.org/wiki/Q1976211","display_name":"Depressant","level":2,"score":0.8005253076553345},{"id":"https://openalex.org/C2777185600","wikidata":"https://www.wikidata.org/wiki/Q156522","display_name":"Piperaceae","level":3,"score":0.7273179292678833},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.6442137360572815},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.5795500874519348},{"id":"https://openalex.org/C2777155639","wikidata":"https://www.wikidata.org/wiki/Q159536","display_name":"Piper","level":2,"score":0.557379961013794},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.46833372116088867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3786435127258301},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3288876414299011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05921962857246399},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1558197166","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/2109","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"mag:1558197166","doi":null,"is_oa":true,"landing_page_url":"https://innovareacademics.in/journals/index.php/ijpps/article/view/2109","pdf_url":null,"source":{"id":"https://openalex.org/S2764469077","display_name":"International Journal of Pharmacy and Pharmaceutical Sciences","issn_l":"0975-1491","issn":["0975-1491","2656-0097"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697801","host_organization_name":"Innovare Academic Sciences","host_organization_lineage":["https://openalex.org/P4322697801"],"host_organization_lineage_names":["Innovare Academic Sciences"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Pharmacy and Pharmaceutical Sciences","raw_type":null},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W921310561","https://openalex.org/W1495124792","https://openalex.org/W1525799106","https://openalex.org/W1556074533","https://openalex.org/W1963756622","https://openalex.org/W1977118330","https://openalex.org/W1992925143","https://openalex.org/W2002937066","https://openalex.org/W2005480323","https://openalex.org/W2007210172","https://openalex.org/W2013082402","https://openalex.org/W2040050178","https://openalex.org/W2042207765","https://openalex.org/W2044078605","https://openalex.org/W2049746343","https://openalex.org/W2050968528","https://openalex.org/W2059256029","https://openalex.org/W2063360806","https://openalex.org/W2079733845","https://openalex.org/W2083048709","https://openalex.org/W2083650833","https://openalex.org/W2100056256","https://openalex.org/W2116947438","https://openalex.org/W2123409005","https://openalex.org/W2131891832","https://openalex.org/W2153394357","https://openalex.org/W2153592313","https://openalex.org/W2155801027","https://openalex.org/W2171296380","https://openalex.org/W2197078876","https://openalex.org/W2297023285","https://openalex.org/W2589882073","https://openalex.org/W3185207729"],"related_works":["https://openalex.org/W335421502","https://openalex.org/W2155801027","https://openalex.org/W4363625560","https://openalex.org/W1999990858","https://openalex.org/W2550100325","https://openalex.org/W2026824049","https://openalex.org/W7098918956","https://openalex.org/W1544253758","https://openalex.org/W7120582205","https://openalex.org/W4312049119"],"abstract_inverted_index":{"Objective:":[0],"Different":[2],"ailments":[3],"can":[4],"be":[5],"treated":[6],"by":[7],"multiple":[8,32],"approaches.":[9],"Since":[10],"ancient":[11],"civilization":[12],"plant":[13],"material":[14],"have":[15],"been":[16],"used":[17],"successfully":[18],"for":[19,29,79],"treating":[20],"diseases.":[21,33],"Plants":[22],"contain":[23],"active":[24],"ingredients":[25],"which":[26],"are":[27],"beneficial":[28],"treatment":[30],"of":[31,36,45,48,50,77,84,102,145,147],"The":[34,97],"purpose":[35],"the":[37,42],"study":[38],"was":[39,65],"to":[40,75,89],"evaluate":[41,90],"neuropharmacological":[43],"effects":[44],"ethanolic":[46,63,143],"extract":[47,64,144],"fruit":[49,146],"Piper":[52,60,149],"chaba.":[53],"Methods:":[57],"chaba\u2019s":[61],"diluted":[66],"in":[67,116,124],"DMSO":[68],"and":[69,109,120,126,157],"administered":[70],"orally":[71],"at":[72],"300mg/kg":[73],"according":[74],"weight":[76],"mice":[78],"21":[80],"days.":[81],"A":[82],"number":[83,101],"tests":[85],"were":[86],"then":[87],"performed":[88],"CNS":[91,153],"activity.":[92],"Results:":[95],"results":[98,135],"showed":[99],"reduced":[100,113],"cage":[103],"crossing,":[104,112],"head":[105],"dips,":[106],"decreased":[107,121],"central":[108],"peripheral":[110],"square":[111],"struggling":[114],"time":[115,122],"forced":[117],"swim":[118],"test":[119],"spends":[123],"light":[125],"dark":[127],"test.":[128],"Conclusion:":[131],"From":[133],"our":[134],"it":[136],"is":[137],"concluded":[138],"that":[139],"after":[140],"acute":[141],"dosing":[142],"chaba":[150],"possesses":[152],"depressant,":[154],"mild":[155],"anxiolytic":[156],"sedative":[158],"effect.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}