{"id":"https://openalex.org/W1558068440","doi":null,"title":"Regression of an adrenal cortical carcinoma by estradiol treatment.","display_name":"Regression of an adrenal cortical carcinoma by estradiol treatment.","publication_year":1967,"publication_date":"1967-10-01","ids":{"openalex":"https://openalex.org/W1558068440","mag":"1558068440","pmid":"https://pubmed.ncbi.nlm.nih.gov/6064962"},"language":"en","primary_location":{"id":"pmid:6064962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6064962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022648593","display_name":"Mohamed Nabil El-Bolkainy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M N el-Bolkainy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108405541","display_name":"G. Barry Pierce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G B Pierce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"A J French","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J French","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3538,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51111111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"10","first_page":"1846","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.22179999947547913,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9150000214576721},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.968999981880188},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.9269999861717224},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5149999856948853},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cholesterol-accumulation","display_name":"cholesterol accumulation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/hypophysectomy","display_name":"hypophysectomy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/reticulum-cell-sarcoma","display_name":"reticulum cell sarcoma","score":0.8159999847412109},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6913567781448364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6778750419616699},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6050002574920654},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5492425560951233},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5177502036094666},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4954882860183716},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.47470441460609436},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4720666706562042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4469958543777466},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.43730881810188293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23556643724441528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17587178945541382},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007016","descriptor_name":"Hypophysectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6064962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6064962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1967-2085","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1967/1086","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1967","raw_type":"text"},{"id":"mag:1558068440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6064962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W71540919","https://openalex.org/W1589921432","https://openalex.org/W2147842236","https://openalex.org/W2082802597","https://openalex.org/W1761570216","https://openalex.org/W2613024643","https://openalex.org/W1966046965","https://openalex.org/W1862667960","https://openalex.org/W1951614337","https://openalex.org/W2003354462"],"abstract_inverted_index":{"The":[0],"effect":[1,118],"of":[2,23,45,49,57,59,73,78,100,119,134],"estradiol":[3,60,92],"on":[4,66,125],"a":[5,130],"transplantable":[6],"adrenal":[7,127],"cortical":[8],"carcinoma":[9],"was":[10,61,81],"studied":[11],"in":[12,38,53,83,96,103,112,116],"BALB/c":[13,135],"mice.":[14],"Estradiol":[15],"treatment":[16,93],"(10":[17],"\u00b5g":[18],"daily)":[19],"prior":[20],"to":[21,63,122],"inoculation":[22],"the":[24,33,54,79,101,126],"tumors":[25,34,42,80,102],"precluded":[26],"successful":[27],"transplantation":[28],"and,":[29],"when":[30],"started":[31],"after":[32],"were":[35],"palpable,":[36],"resulted":[37],"their":[39,109],"regression.":[40],"Estradiol-treated":[41],"showed":[43],"arrest":[44],"mitoses":[46],"and":[47,51,107],"accumulation":[48],"lipid":[50],"cholesterol":[52],"cytoplasm.\n\nThe":[55],"mode":[56],"action":[58],"considered":[62],"be":[64,123],"direct":[65],"tumor":[67,128],"cells":[68],"rather":[69],"than":[70],"through":[71],"inhibition":[72],"pituitary":[74],"hormones":[75],"because":[76],"regression":[77],"observed":[82],"hypophysectomized,":[84],"pair-fed":[85],"mice":[86,136],"treated":[87,138],"with":[88],"estradiol.":[89],"In":[90],"addition,":[91],"(20":[94],"\u00b5g/ml":[95],"modified":[97],"Eagle's":[98],"medium)":[99],"organ":[104],"culture":[105],"inhibited":[106],"retarded":[108],"subsequent":[110],"growth":[111],"isologous":[113],"hosts.":[114],"This":[115],"vitro":[117],"estrogen":[120],"appeared":[121],"specific":[124],"since":[129],"reticulum":[131],"cell":[132],"sarcoma":[133],"similarly":[137],"did":[139],"not":[140],"show":[141],"this":[142],"behavior.":[143]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}