{"id":"https://openalex.org/W1557658014","doi":null,"title":"Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.","display_name":"Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1557658014","mag":"1557658014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9216734"},"language":"en","primary_location":{"id":"pmid:9216734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9216734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042154909","display_name":"Huaiyuan Jiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Jiao","raw_affiliation_strings":["Department of Cancer Biology, Cleveland Clinic Research Institute, OH 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Cleveland Clinic Research Institute, OH 44195, USA","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071869928","display_name":"Wentian Yang","orcid":"https://orcid.org/0000-0002-2127-6239","observed_orcids":["https://orcid.org/0000-0002-2127-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009838675","display_name":"Karim Berrada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Berrada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016956318","display_name":"Mohammad A. Tabrizi","orcid":"https://orcid.org/0000-0002-2409-2718","observed_orcids":["https://orcid.org/0000-0002-2409-2718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tabrizi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Shultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111287962","display_name":"T Yi","orcid":"https://orcid.org/0000-0002-3295-025X","observed_orcids":["https://orcid.org/0000-0002-3295-025X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.963,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.9186826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"7","first_page":"592","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf-signaling","display_name":"GM-CSF signaling","score":0.8429999947547913},{"id":"https://openalex.org/keywords/macrophage-proliferation","display_name":"macrophage proliferation","score":0.921999990940094},{"id":"https://openalex.org/keywords/macrophage-colony-stimulating-factor","display_name":"macrophage colony-stimulating factor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/jak2","display_name":"JAK2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sh2-domain-proteins","display_name":"SH2 domain proteins","score":0.640999972820282},{"id":"https://openalex.org/keywords/phosphotyrosine-proteins","display_name":"phosphotyrosine proteins","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/macrophage-accumulation","display_name":"macrophage accumulation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6941068768501282},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6246891021728516},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5773636698722839},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5546410083770752},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.5089867115020752},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4853495657444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47012579441070557},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.46778902411460876},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4302121102809906},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.4259689748287201},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3286251723766327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24905946850776672},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.179933100938797},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.11350896954536438},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08546105027198792}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016173","descriptor_name":"Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016187","descriptor_name":"Receptors, Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054593","descriptor_name":"SH2 Domain-Containing Protein Tyrosine Phosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9216734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9216734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb1990_1999-1892","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb1990_1999/893","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 1990 - 1999","raw_type":"text"},{"id":"mag:1557658014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9216734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2267710321","display_name":"IMMUNODEFICIENCY AND TUMORIGENESIS","funder_award_id":"R01CA020408","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1487525751","https://openalex.org/W2406947414","https://openalex.org/W2029139528","https://openalex.org/W2130747337","https://openalex.org/W4242166543","https://openalex.org/W1995573704","https://openalex.org/W2013307072","https://openalex.org/W4390662744","https://openalex.org/W2111713288","https://openalex.org/W1986219903"],"abstract_inverted_index":{"Loss":[0],"of":[1,29,47,93,113],"functional":[2],"hematopoietic":[3,9],"cell":[4],"phosphatase":[5,153],"(HCP)":[6],"underlies":[7],"severe":[8],"and":[10,19,39,55,107,118,167,192],"immunologic":[11],"abnormalities":[12],"in":[13,61,83,110,129,139,189,200],"mice":[14,24],"homozygous":[15],"for":[16,57,165],"the":[17,44,51,89,94,140,152,170],"motheaten":[18,21,48,95,105,141,190],"viable":[20],"mutations.":[22],"These":[23],"die":[25],"from":[26],"pulmonary":[27],"accumulation":[28],"macrophages":[30,49,65,96,106],"that":[31,77,121,149,159,179,193],"are":[32,124],"regulated":[33],"by":[34],"macrophage":[35,180],"colony-stimulating":[36],"factor":[37,188],"(M-CSF)":[38],"granulocyte":[40],"(G)-M-CSF.":[41],"We":[42],"determined":[43],"growth":[45,53,91,172],"response":[46],"to":[50,70,74,97,174,182],"two":[52],"factors":[54],"looked":[56],"potential":[58],"HCP":[59,78,127,164,194],"substrates":[60,128,198],"these":[62,122,160],"cells.":[63],"Motheaten":[64],"showed":[66],"increased":[67],"proliferative":[68],"responses":[69,92,173],"GM-CSF":[71,85,130,183,201],"but":[72],"not":[73,125],"M-CSF,":[75],"demonstrating":[76],"plays":[79],"a":[80,144,186],"critical":[81,199],"role":[82],"downregulating":[84],"mitogenic":[86,202],"signaling.":[87,131,203],"Despite":[88],"heightened":[90,171],"GM-CSF,":[98],"there":[99],"were":[100,137],"no":[101],"marked":[102],"differences":[103],"between":[104],"normal":[108],"controls":[109],"GM-CSF-induced":[111],"phosphorylation":[112],"GM-CSFR":[114],"beta,":[115],"Jak2,":[116],"STAT5":[117],"MAPK,":[119],"indicating":[120],"molecules":[123],"major":[126,187],"Interestingly,":[132],"several":[133],"markedly":[134],"hyperphosphorylated":[135],"proteins":[136,161],"detected":[138],"macrophages,":[142],"including":[143],"novel":[145,197],"126-kDa":[146],"phosphotyrosine":[147],"protein":[148],"associated":[150],"with":[151],"via":[154],"its":[155],"SH2":[156],"domains,":[157],"suggesting":[158],"depend":[162],"on":[163],"dephosphorylation":[166],"may":[168,184,195],"mediate":[169],"GM-CSF.":[175],"Our":[176],"data":[177],"indicate":[178],"hypersensitivity":[181],"be":[185],"pathogenesis":[191],"dephosphorylate":[196]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
