{"id":"https://openalex.org/W1557520752","doi":"https://doi.org/10.1002/term.1525","title":"Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application","display_name":"Tantalum trabecular metal - addition of human skeletal cells to enhance bone implant interface strength and clinical application","publication_year":2012,"publication_date":"2012-06-04","ids":{"openalex":"https://openalex.org/W1557520752","doi":"https://doi.org/10.1002/term.1525","mag":"1557520752","pmid":"https://pubmed.ncbi.nlm.nih.gov/22674820"},"language":"en","primary_location":{"id":"doi:10.1002/term.1525","doi":"https://doi.org/10.1002/term.1525","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.1525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.1525","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.1525","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003693772","display_name":"James O. Smith","orcid":"https://orcid.org/0000-0001-8132-6659","observed_orcids":["https://orcid.org/0000-0001-8132-6659"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. O. Smith","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026365000","display_name":"Bram G. Sengers","orcid":"https://orcid.org/0000-0001-5859-6984","observed_orcids":["https://orcid.org/0000-0001-5859-6984"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. G. Sengers","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112270499","display_name":"Alexander Aarvold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Aarvold","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104131250","display_name":"Edward R. Tayton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E. R. Tayton","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079529359","display_name":"D. Dunlop","orcid":"https://orcid.org/0000-0002-2331-0330","observed_orcids":["https://orcid.org/0000-0002-2331-0330"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. G. Dunlop","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050887535","display_name":"Richard O. C. Oreffo","orcid":"https://orcid.org/0000-0001-5995-6726","observed_orcids":["https://orcid.org/0000-0001-5995-6726"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]},{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB","SA"],"is_corresponding":true,"raw_author_name":"R. O. C. Oreffo","raw_affiliation_strings":["Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","Stem Cell Unit, Department of Anatomy, College of Medicine; King Saud University; Riyadh Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences; University Hospital Southampton; UK","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I43439940"]},{"raw_affiliation_string":"Stem Cell Unit, Department of Anatomy, College of Medicine; King Saud University; Riyadh Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050887535"],"corresponding_institution_ids":["https://openalex.org/I28022161","https://openalex.org/I2802965805","https://openalex.org/I43439940"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":0.6471,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.65067772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"4","first_page":"304","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10359","display_name":"Dental Implant Techniques and Outcomes","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-bone-marrow-stromal-cells","display_name":"human bone marrow stromal cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bone-allografts","display_name":"bone allografts","score":0.7369999885559082},{"id":"https://openalex.org/keywords/autograft","display_name":"autograft","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.37599998712539673},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tensile-properties","display_name":"tensile properties","score":0.6869999766349792},{"id":"https://openalex.org/keywords/bone-implant-interface","display_name":"bone-implant interface","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bone-graft-substitutes","display_name":"bone graft substitutes","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6656279563903809},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6281969547271729},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6028767824172974},{"id":"https://openalex.org/C2993373878","wikidata":"https://www.wikidata.org/wiki/Q9621","display_name":"Human bone","level":3,"score":0.4493095874786377},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.416642963886261},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3822488486766815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3662540912628174},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2754225432872772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25884342193603516},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1716345250606537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013635","descriptor_name":"Tantalum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/term.1525","doi":"https://doi.org/10.1002/term.1525","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.1525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.1525","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},{"id":"pmid:22674820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22674820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of tissue engineering and regenerative medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.soton.ac.uk:345798","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/345798/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/term.1525","doi":"https://doi.org/10.1002/term.1525","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.1525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.1525","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1999724742","display_name":"Device for Enrichment of Skeletal Stem Cells for Orthopaedic Applications","funder_award_id":"TS/G001650/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G6960593786","display_name":null,"funder_award_id":"BB/GO10579","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7340167743","display_name":null,"funder_award_id":"G0802397","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320312043","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1557520752.pdf","grobid_xml":"https://content.openalex.org/works/W1557520752.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W125852739","https://openalex.org/W1978778471","https://openalex.org/W1980959628","https://openalex.org/W1988881359","https://openalex.org/W1990502529","https://openalex.org/W1994172589","https://openalex.org/W1999242671","https://openalex.org/W2015979204","https://openalex.org/W2016341421","https://openalex.org/W2027156617","https://openalex.org/W2027403719","https://openalex.org/W2033869562","https://openalex.org/W2034025018","https://openalex.org/W2038134163","https://openalex.org/W2044727638","https://openalex.org/W2045499212","https://openalex.org/W2061754982","https://openalex.org/W2063736731","https://openalex.org/W2065860366","https://openalex.org/W2067196811","https://openalex.org/W2068106634","https://openalex.org/W2069400823","https://openalex.org/W2074534529","https://openalex.org/W2081554679","https://openalex.org/W2086695938","https://openalex.org/W2102247975","https://openalex.org/W2103106557","https://openalex.org/W2108824316","https://openalex.org/W2112269425","https://openalex.org/W2114451063","https://openalex.org/W2118414106","https://openalex.org/W2132131875","https://openalex.org/W2137452172","https://openalex.org/W2141981680","https://openalex.org/W2143228580","https://openalex.org/W2144015007","https://openalex.org/W2163083466","https://openalex.org/W2287012127","https://openalex.org/W2407434876"],"related_works":["https://openalex.org/W2530363941","https://openalex.org/W2531091298","https://openalex.org/W2311218402","https://openalex.org/W2266694607","https://openalex.org/W4390147158","https://openalex.org/W1984614174","https://openalex.org/W1979780940","https://openalex.org/W2751081027","https://openalex.org/W1846428048","https://openalex.org/W2118414106"],"abstract_inverted_index":{"The":[0,72],"osteo-regenerative":[1,81,239],"properties":[2],"of":[3,11,23,29,74,83,100,139,191,201,219],"allograft":[4,24,92,102,237],"have":[5,25],"recently":[6],"been":[7],"enhanced":[8,205],"by":[9,150],"addition":[10],"autogenous":[12],"human":[13,91],"bone":[14,62],"marrow":[15],"stromal":[16],"cells":[17,166],"(HBMSCs).":[18],"Limitations":[19],"in":[20,41,46,59,87,105,189],"the":[21,27,80,136,140,217],"use":[22],"prompted":[26],"investigation":[28],"tantalum":[30],"trabecular":[31],"metal":[32],"(TTM)":[33],"as":[34,245],"a":[35,246],"potential":[36,82],"alternative.":[37],"TTM":[38,56,84,178,220,232],"is":[39,50,57],"already":[40],"widespread":[42],"orthopaedic":[43],"use,":[44],"although":[45,182],"applications":[47,244],"where":[48],"there":[49],"poor":[51],"initial":[52,64],"stability,":[53],"or":[54,103],"when":[55],"used":[58,122,133],"conjunction":[60],"with":[61,85,154,168,177],"grafting,":[63],"implant":[65],"loading":[66],"may":[67],"need":[68],"to":[69,78,90,123,134,165,196,211,221,229,236],"be":[70],"limited.":[71],"aim":[73],"this":[75],"study":[76],"was":[77,132],"evaluate":[79],"HBMSCs,":[86],"direct":[88],"comparison":[89],"and":[93,107,113,118,128,145,152,158,225],"autograft.":[94],"HBMSCs":[95,142],"were":[96,121],"cultured":[97,167],"on":[98],"blocks":[99],"TTM,":[101,148],"autograft":[104],"basal":[106],"osteogenic":[108,192,226],"media.":[109],"Molecular":[110],"profiling,":[111],"confocal":[112],"scanning":[114],"electron":[115],"microscopy":[116],"(SEM)":[117],"biochemical":[119],"assays":[120,172],"characterize":[124],"cell":[125,170],"adherence,":[126],"proliferation":[127,146,171],"phenotype.":[129],"Mechanical":[130],"testing":[131,200],"define":[135],"tensile":[137,206],"characteristics":[138],"constructs.":[141,213],"displayed":[143],"adherence":[144],"throughout":[147],"evidenced":[149],"immunocytochemistry":[151],"SEM,":[153],"significant":[155,187],"cellular":[156],"ingrowth":[157],"matrix":[159],"production":[160],"through":[161],"TTM.":[162],"In":[163,194],"contrast":[164,195],"allograft,":[169],"showed":[173,204],"significantly":[174],"higher":[175],"activity":[176],"(p":[179],"<":[180],"0.001),":[181],"molecular":[183],"profiling":[184],"confirmed":[185],"no":[186],"difference":[188],"expression":[190],"genes.":[193],"acellular":[197],"constructs,":[198],"mechanical":[199],"cell-TTM":[202],"constructs":[203],"characteristics,":[207],"which":[208],"compared":[209],"favourably":[210],"cell-allograft":[212],"These":[214],"studies":[215],"demonstrated":[216],"ability":[218],"support":[222],"HBMSC":[223],"growth":[224],"differentiation":[227],"comparable":[228],"allograft.":[230,249],"Thus,":[231],"represents":[233],"an":[234],"alternative":[235],"for":[238,248],"strategies,":[240],"extending":[241],"its":[242],"clinical":[243],"substitute":[247]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}