{"id":"https://openalex.org/W1557516508","doi":null,"title":"DEVELOPMENTAL AND CELLULAR FUNCTIONS OF DELTA-CATENIN","display_name":"DEVELOPMENTAL AND CELLULAR FUNCTIONS OF DELTA-CATENIN","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1557516508","mag":"1557516508"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1140","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/114","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062440253","display_name":"Dongmin Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongmin Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062440253"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.39719998836517334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delta-catenin","display_name":"\u03b4-catenin","score":0.7710000276565552},{"id":"https://openalex.org/keywords/p120-catenin","display_name":"p120 catenin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/armadillo-domain","display_name":"armadillo domain","score":0.7440000176429749},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.8109999895095825},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.753000020980835},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-3-cleavage","display_name":"caspase-3 cleavage","score":0.8560000061988831},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.382999986410141},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.6140000224113464},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.6039999723434448},{"id":"https://openalex.org/keywords/morpholino-antisense","display_name":"morpholino antisense","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.4251343607902527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3410681486129761},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13701629638671875},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1140","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/114","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations & Theses (Open Access)","raw_type":"text"},{"id":"mag:1557516508","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=1140&context=utgsbs_dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":180,"referenced_works":["https://openalex.org/W15380068","https://openalex.org/W154439523","https://openalex.org/W205138462","https://openalex.org/W1515978409","https://openalex.org/W1583843945","https://openalex.org/W1591151241","https://openalex.org/W1612221740","https://openalex.org/W1807490936","https://openalex.org/W1828512827","https://openalex.org/W1841730068","https://openalex.org/W1910650341","https://openalex.org/W1964212105","https://openalex.org/W1964242395","https://openalex.org/W1965820314","https://openalex.org/W1965950604","https://openalex.org/W1966958204","https://openalex.org/W1967784918","https://openalex.org/W1969009583","https://openalex.org/W1969204556","https://openalex.org/W1970671298","https://openalex.org/W1971041575","https://openalex.org/W1972666776","https://openalex.org/W1974093434","https://openalex.org/W1974258845","https://openalex.org/W1974712344","https://openalex.org/W1974764190","https://openalex.org/W1977067307","https://openalex.org/W1977125048","https://openalex.org/W1977286350","https://openalex.org/W1978820767","https://openalex.org/W1980061153","https://openalex.org/W1980331623","https://openalex.org/W1983113969","https://openalex.org/W1984682553","https://openalex.org/W1984970029","https://openalex.org/W1989038231","https://openalex.org/W1989170923","https://openalex.org/W1989334647","https://openalex.org/W1991108446","https://openalex.org/W1993933453","https://openalex.org/W1994507795","https://openalex.org/W1994510778","https://openalex.org/W1995737930","https://openalex.org/W1996345468","https://openalex.org/W1998849358","https://openalex.org/W2000407232","https://openalex.org/W2001784209","https://openalex.org/W2004280410","https://openalex.org/W2004962670","https://openalex.org/W2005261405","https://openalex.org/W2006340329","https://openalex.org/W2008763684","https://openalex.org/W2009244738","https://openalex.org/W2010776189","https://openalex.org/W2010854221","https://openalex.org/W2012793556","https://openalex.org/W2016730049","https://openalex.org/W2016770813","https://openalex.org/W2017938741","https://openalex.org/W2019512652","https://openalex.org/W2020934262","https://openalex.org/W2021845810","https://openalex.org/W2022207101","https://openalex.org/W2024548275","https://openalex.org/W2024733032","https://openalex.org/W2027785585","https://openalex.org/W2028802056","https://openalex.org/W2032914985","https://openalex.org/W2032930150","https://openalex.org/W2034191509","https://openalex.org/W2035331118","https://openalex.org/W2035950592","https://openalex.org/W2036999913","https://openalex.org/W2039179672","https://openalex.org/W2040210675","https://openalex.org/W2041677910","https://openalex.org/W2043371776","https://openalex.org/W2045603099","https://openalex.org/W2047393288","https://openalex.org/W2047772224","https://openalex.org/W2051408959","https://openalex.org/W2052073579","https://openalex.org/W2052374677","https://openalex.org/W2056920813","https://openalex.org/W2059402621","https://openalex.org/W2060056985","https://openalex.org/W2060449956","https://openalex.org/W2060998383","https://openalex.org/W2061260618","https://openalex.org/W2062094940","https://openalex.org/W2063575573","https://openalex.org/W2064147220","https://openalex.org/W2064686935","https://openalex.org/W2067976784","https://openalex.org/W2069580248","https://openalex.org/W2071199281","https://openalex.org/W2072272565","https://openalex.org/W2075073585","https://openalex.org/W2076546994","https://openalex.org/W2077078276","https://openalex.org/W2078006332","https://openalex.org/W2078236511","https://openalex.org/W2079196943","https://openalex.org/W2081657952","https://openalex.org/W2081858053","https://openalex.org/W2083869636","https://openalex.org/W2084421367","https://openalex.org/W2084943069","https://openalex.org/W2085150520","https://openalex.org/W2085179400","https://openalex.org/W2086868488","https://openalex.org/W2086972041","https://openalex.org/W2087367624","https://openalex.org/W2087820146","https://openalex.org/W2091199826","https://openalex.org/W2091793431","https://openalex.org/W2094484000","https://openalex.org/W2095064485","https://openalex.org/W2095230191","https://openalex.org/W2095271002","https://openalex.org/W2095397788","https://openalex.org/W2096791952","https://openalex.org/W2098716084","https://openalex.org/W2099275419","https://openalex.org/W2099353036","https://openalex.org/W2101115544","https://openalex.org/W2101507674","https://openalex.org/W2102591774","https://openalex.org/W2103626309","https://openalex.org/W2104209102","https://openalex.org/W2111022195","https://openalex.org/W2111969540","https://openalex.org/W2113474142","https://openalex.org/W2114355635","https://openalex.org/W2114900293","https://openalex.org/W2115646229","https://openalex.org/W2118644071","https://openalex.org/W2119284420","https://openalex.org/W2120114376","https://openalex.org/W2121621688","https://openalex.org/W2122877719","https://openalex.org/W2124757853","https://openalex.org/W2126032058","https://openalex.org/W2127412428","https://openalex.org/W2127731893","https://openalex.org/W2133548880","https://openalex.org/W2133890761","https://openalex.org/W2134767876","https://openalex.org/W2138687206","https://openalex.org/W2142119280","https://openalex.org/W2142867910","https://openalex.org/W2144040654","https://openalex.org/W2146827844","https://openalex.org/W2148012979","https://openalex.org/W2148934768","https://openalex.org/W2149605222","https://openalex.org/W2150171625","https://openalex.org/W2150589615","https://openalex.org/W2152695708","https://openalex.org/W2154404625","https://openalex.org/W2154861644","https://openalex.org/W2156659788","https://openalex.org/W2157796706","https://openalex.org/W2158682312","https://openalex.org/W2159447630","https://openalex.org/W2161129289","https://openalex.org/W2161968975","https://openalex.org/W2163019872","https://openalex.org/W2163740123","https://openalex.org/W2165250124","https://openalex.org/W2167537931","https://openalex.org/W2171888347","https://openalex.org/W2172051772","https://openalex.org/W2182475970","https://openalex.org/W2334498457","https://openalex.org/W2338127681","https://openalex.org/W2399613612","https://openalex.org/W2412525495","https://openalex.org/W2530397088","https://openalex.org/W4301326813"],"related_works":["https://openalex.org/W2120114376","https://openalex.org/W2091535593","https://openalex.org/W2017070747","https://openalex.org/W1989828854","https://openalex.org/W2122506460","https://openalex.org/W2132273568","https://openalex.org/W7073567850","https://openalex.org/W2028802056","https://openalex.org/W2226357250","https://openalex.org/W7098582170"],"abstract_inverted_index":{"Catenins":[0],"have":[1],"diverse":[2],"and":[3,43,50,69,92,155,168,176,179,184,192,224,242,262,312,336,386,409,434,464,477,493,503,510],"powerful":[4],"roles":[5,214,251,371,473],"in":[6,37,63,85,97,108,115,131,147,150,215,252,273,474,508,519],"embryogenesis,":[7],"homeostasis":[8],"or":[9,198,201,282,521],"disease":[10,522],"progression,":[11],"as":[12,121,238,254,256,275,277,417],"best":[13],"exemplified":[14],"by":[15,432],"the":[16,76,100,245,321,345,457,500],"well-known":[17],"beta-catenin.":[18],"The":[19,286],"less":[20],"studied":[21],"delta-catenin":[22,55,105,144,171,206,237,329,507],"likewise":[23,435],"contains":[24],"a":[25,38,86,289,350,380,418,442],"central":[26,322],"Armadillo-domain.":[27,323],"In":[28,53,166,230],"common":[29],"with":[30,60,218,261,334,391,415],"other":[31,425],"p120":[32,426,453],"sub-class":[33,427],"members,":[34,455],"it":[35,412],"acts":[36],"variety":[39],"of":[40,118,182,244,299,320,328,372,379,452,460,506,512],"intracellular":[41],"compartments":[42],"modulates":[44],"cadherin":[45,174],"stability,":[46],"small":[47,186,227,342,462,490],"GTPase":[48],"activities":[49,518],"gene":[51,140,504],"transcription.":[52],"mammals,":[54,104],"exhibits":[56],"neural":[57,119,152],"specific":[58,161],"expression,":[59],"its":[61,271,332,338,389,480],"knock-out":[62],"mice":[64],"correspondingly":[65],"producing":[66],"cognitive":[67],"defects":[68,149],"synaptic":[70],"dysfunctions.":[71],"My":[72,402],"work":[73,469],"instead":[74],"employed":[75,135],"amphibian,":[77],"Xenopus":[78,111,216,279,475],"laevis,":[79],"to":[80,138,222,264,340,361,483],"explore":[81],"delta-catenin\u2019s":[82,95,129,212,232,363,471,517],"physiological":[83],"functions":[84],"distinct":[87],"vertebrate":[88],"system.":[89],"Initial":[90],"isolation":[91],"characterization":[93],"indicated":[94],"expression":[96],"Xenopus.":[98],"Unlike":[99],"pattern":[101],"observed":[102],"for":[103,368],"was":[106,266,301],"detected":[107],"most":[109],"adult":[110],"tissues,":[112],"although":[113],"enriched":[114],"embryonic":[116],"structures":[117],"fate":[120],"visualized":[122],"using":[123,268],"RNA":[124],"in-situ":[125],"hybridization.":[126],"To":[127,366],"determine":[128],"requirement":[130],"amphibian":[132],"development,":[133,217,476],"I":[134,235,324,357,374,399,421],"anti-sense":[136],"morpholinos":[137],"knock-down":[139,172],"products,":[141],"finding":[142],"that":[143,159,188,326,356,405,411,424],"depletion":[145],"results":[146,210,403],"developmental":[148],"gastrulation,":[151],"crest":[153],"migration":[154],"kidney":[156],"tubulogenesis,":[157],"phenotypes":[158],"were":[160],"based":[162,448],"upon":[163,449],"rescue":[164],"experiments.":[165],"biochemical":[167],"cellular":[169],"assays,":[170],"reduced":[173],"levels":[175],"cell":[177,284,484],"adhesion,":[178],"impaired":[180],"activation":[181],"RhoA":[183,200],"Rac1,":[185,203],"GTPases":[187,463],"regulate":[189],"actin":[190],"dynamics":[191],"morphogenetic":[193],"movements.":[194],"Indeed,":[195],"exogenous":[196],"C-cadherin,":[197],"dominant-negative":[199],"dominant-active":[202],"significantly":[204],"rescued":[205],"depletion.":[207],"Thus,":[208],"my":[209,468],"indicate":[211,404],"essential":[213,472],"contributing":[219],"functional":[220],"links":[221],"cadherins":[223],"Rho":[225],"family":[226,395],"G":[228,491],"proteins.":[229],"examining":[231],"nuclear":[233,353,364,370,465],"roles,":[234],"identified":[236,302],"an":[239,309,392],"interacting":[240],"partner":[241],"substrate":[243],"caspase-3":[246,265,450],"protease,":[247],"which":[248],"plays":[249],"critical":[250],"apoptotic":[253,280],"well":[255,276],"non-apoptotic":[257],"processes.":[258],"Delta-catenin\u2019s":[259],"interaction":[260,390],"sensitivity":[263],"confirmed":[267],"assays":[269],"involving":[270],"cleavage":[272,287,327,451],"vitro,":[274],"within":[278,296],"extracts":[281],"mammalian":[283],"lines.":[285],"site,":[288],"highly":[290],"conserved":[291,351],"caspase":[292],"consensus":[293],"motif":[294],"(DELD)":[295],"Armadillo-repeat":[297],"6":[298],"delta-catenin,":[300,373],"through":[303],"peptide":[304],"sequencing.":[305],"Cleavage":[306],"thus":[307],"generates":[308],"amino-":[310],"(1-816)":[311],"carboxyl-terminal":[313,346],"(817-1314)":[314,348],"fragment":[315,347],"each":[316],"containing":[317],"about":[318],"half":[319],"found":[325,358],"both":[330],"abolishes":[331],"association":[333],"cadherins,":[335,461],"impairs":[337],"ability":[339],"modulate":[341],"GTPases.":[343],"Interestingly,":[344],"possesses":[349],"putative":[352],"localization":[354],"signal":[355],"is":[359,407],"needed":[360],"facilitate":[362],"targeting.":[365],"probe":[367],"novel":[369,445,481],"performed":[375],"yeast":[376],"two-hybrid":[377],"screening":[378],"mouse":[381],"brain":[382],"cDNA":[383],"library,":[384],"resolving":[385],"then":[387],"validating":[388],"uncharacterized":[393],"KRAB":[394],"zinc":[396],"finger":[397],"protein":[398],"named":[400],"ZIFCAT.":[401,437],"ZIFCAT":[406],"nuclear,":[408],"suggest":[410],"may":[413],"associate":[414],"DNA":[416],"transcriptional":[419],"repressor.":[420],"further":[422],"determined":[423],"catenins":[428],"are":[429],"similarly":[430],"cleaved":[431],"caspase-3,":[433],"bind":[436],"These":[438],"findings":[439],"potentially":[440],"reveal":[441],"simple":[443],"yet":[444],"signaling":[446,514],"pathway":[447],"sub-family":[454],"facilitating":[456],"coordinate":[458],"modulation":[459],"functions.":[466],"Together,":[467],"suggested":[470],"has":[478],"revealed":[479],"contributions":[482],"junctions":[485],"(via":[486,489,495],"cadherins),":[487],"cytoskeleton":[488],"proteins),":[492],"nucleus":[494],"ZIFCAT).":[496],"Future":[497],"questions":[498],"include":[499],"larger":[501],"role":[502],"targets":[505],"nucleus,":[509],"identification":[511],"upstream":[513],"events":[515],"controlling":[516],"development":[520],"progression.":[523]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
