{"id":"https://openalex.org/W155750408","doi":null,"title":"Optimal Treatment of the \u2018High-Risk\u2019 Patient with Carotid Artery Stenosis","display_name":"Optimal Treatment of the \u2018High-Risk\u2019 Patient with Carotid Artery Stenosis","publication_year":2013,"publication_date":"2013-11-28","ids":{"openalex":"https://openalex.org/W155750408","mag":"155750408"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/287129","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/287129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/287129","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048044178","display_name":"Talje M. Fokkema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Talje M. Fokkema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048044178"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotid-stenosis","display_name":"carotid artery stenosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/carotid-endarterectomy","display_name":"carotid endarterectomy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/carotid-artery-stenting","display_name":"carotid artery stenting","score":0.996999979019165},{"id":"https://openalex.org/keywords/high-risk-patients","display_name":"high-risk patients","score":0.8429999947547913},{"id":"https://openalex.org/keywords/risk-benefit-assessment","display_name":"risk-benefit assessment","score":0.5770000219345093},{"id":"https://openalex.org/keywords/postoperative-stroke","display_name":"postoperative stroke","score":0.6909999847412109},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.8309999704360962},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9390000104904175},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/symptomatic-carotid-stenosis","display_name":"symptomatic carotid stenosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8972125053405762},{"id":"https://openalex.org/C2781068581","wikidata":"https://www.wikidata.org/wiki/Q5045544","display_name":"Carotid endarterectomy","level":3,"score":0.7528904676437378},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.5816131830215454},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5465036630630493},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.535700261592865},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5327890515327454},{"id":"https://openalex.org/C2776184368","wikidata":"https://www.wikidata.org/wiki/Q1576205","display_name":"Carotid artery disease","level":4,"score":0.4883515536785126},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.4800727963447571},{"id":"https://openalex.org/C2779745121","wikidata":"https://www.wikidata.org/wiki/Q81476","display_name":"Endarterectomy","level":3,"score":0.4593207836151123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4466702938079834},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.391345739364624},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35362720489501953},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/287129","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/287129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/287129","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/287129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/287129","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/287129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:155750408","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/287129/1/fokkema.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/287129","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/287129","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W90252285","https://openalex.org/W121592306","https://openalex.org/W127266610","https://openalex.org/W1605370691","https://openalex.org/W1691057582","https://openalex.org/W1740376762","https://openalex.org/W1939126639","https://openalex.org/W1950146087","https://openalex.org/W1965229539","https://openalex.org/W1965489704","https://openalex.org/W1965652425","https://openalex.org/W1968013204","https://openalex.org/W1968416911","https://openalex.org/W1970379077","https://openalex.org/W1970719996","https://openalex.org/W1971830254","https://openalex.org/W1973691167","https://openalex.org/W1975607240","https://openalex.org/W1977037755","https://openalex.org/W1978134938","https://openalex.org/W1979865485","https://openalex.org/W1981211431","https://openalex.org/W1982085645","https://openalex.org/W1983499948","https://openalex.org/W1984294672","https://openalex.org/W1985518655","https://openalex.org/W1986437260","https://openalex.org/W1987527124","https://openalex.org/W1988345193","https://openalex.org/W1988695491","https://openalex.org/W1989369072","https://openalex.org/W1989722759","https://openalex.org/W1992081803","https://openalex.org/W1993135672","https://openalex.org/W1993894169","https://openalex.org/W1994147148","https://openalex.org/W1994617252","https://openalex.org/W1994634877","https://openalex.org/W1995267748","https://openalex.org/W1996188275","https://openalex.org/W1997663201","https://openalex.org/W1998003306","https://openalex.org/W1999617086","https://openalex.org/W2000238972","https://openalex.org/W2001965531","https://openalex.org/W2002229304","https://openalex.org/W2003251304","https://openalex.org/W2003336913","https://openalex.org/W2007883168","https://openalex.org/W2008188706","https://openalex.org/W2010617617","https://openalex.org/W2011290673","https://openalex.org/W2011721412","https://openalex.org/W2012739938","https://openalex.org/W2015228258","https://openalex.org/W2016552328","https://openalex.org/W2016911638","https://openalex.org/W2016912625","https://openalex.org/W2017182381","https://openalex.org/W2017337401","https://openalex.org/W2017913356","https://openalex.org/W2017981183","https://openalex.org/W2018175431","https://openalex.org/W2020467721","https://openalex.org/W2021079664","https://openalex.org/W2022549623","https://openalex.org/W2023344865","https://openalex.org/W2024015279","https://openalex.org/W2024839530","https://openalex.org/W2026856116","https://openalex.org/W2027033507","https://openalex.org/W2028006266","https://openalex.org/W2028884087","https://openalex.org/W2030156041","https://openalex.org/W2033815773","https://openalex.org/W2036397809","https://openalex.org/W2036878202","https://openalex.org/W2038169486","https://openalex.org/W2038361419","https://openalex.org/W2039666458","https://openalex.org/W2040181956","https://openalex.org/W2041730141","https://openalex.org/W2043942046","https://openalex.org/W2045504627","https://openalex.org/W2046334265","https://openalex.org/W2046338065","https://openalex.org/W2046922870","https://openalex.org/W2047872799","https://openalex.org/W2048546040","https://openalex.org/W2049554088","https://openalex.org/W2050516433","https://openalex.org/W2055593034","https://openalex.org/W2058036166","https://openalex.org/W2060990622","https://openalex.org/W2065700756","https://openalex.org/W2065740147","https://openalex.org/W2066684995","https://openalex.org/W2067964239","https://openalex.org/W2068256004","https://openalex.org/W2069396906","https://openalex.org/W2070011829","https://openalex.org/W2078455767","https://openalex.org/W2078938202","https://openalex.org/W2079526838","https://openalex.org/W2083222165","https://openalex.org/W2084349461","https://openalex.org/W2085884432","https://openalex.org/W2086930440","https://openalex.org/W2087046046","https://openalex.org/W2087175050","https://openalex.org/W2089354764","https://openalex.org/W2090522898","https://openalex.org/W2090715808","https://openalex.org/W2091789730","https://openalex.org/W2092379959","https://openalex.org/W2092983794","https://openalex.org/W2093837272","https://openalex.org/W2094030464","https://openalex.org/W2096428391","https://openalex.org/W2096654040","https://openalex.org/W2097030777","https://openalex.org/W2097349400","https://openalex.org/W2097367062","https://openalex.org/W2099729338","https://openalex.org/W2100194095","https://openalex.org/W2100858319","https://openalex.org/W2102526607","https://openalex.org/W2104071895","https://openalex.org/W2105719445","https://openalex.org/W2106151737","https://openalex.org/W2107715463","https://openalex.org/W2109790016","https://openalex.org/W2111703698","https://openalex.org/W2111714587","https://openalex.org/W2114940019","https://openalex.org/W2115098571","https://openalex.org/W2118332543","https://openalex.org/W2120562258","https://openalex.org/W2122528416","https://openalex.org/W2123898975","https://openalex.org/W2124247204","https://openalex.org/W2124820341","https://openalex.org/W2127101162","https://openalex.org/W2128041583","https://openalex.org/W2130525374","https://openalex.org/W2132619922","https://openalex.org/W2132810176","https://openalex.org/W2133858220","https://openalex.org/W2135353076","https://openalex.org/W2137504775","https://openalex.org/W2140862373","https://openalex.org/W2140993963","https://openalex.org/W2141071968","https://openalex.org/W2141218183","https://openalex.org/W2141945335","https://openalex.org/W2143025307","https://openalex.org/W2143751190","https://openalex.org/W2144088700","https://openalex.org/W2145046920","https://openalex.org/W2147035197","https://openalex.org/W2147746297","https://openalex.org/W2148895634","https://openalex.org/W2149728933","https://openalex.org/W2150393846","https://openalex.org/W2151611719","https://openalex.org/W2151971399","https://openalex.org/W2152097915","https://openalex.org/W2152662337","https://openalex.org/W2154447272","https://openalex.org/W2154645966","https://openalex.org/W2158510941","https://openalex.org/W2164498191","https://openalex.org/W2164918103","https://openalex.org/W2165912096","https://openalex.org/W2167755544","https://openalex.org/W2407059770","https://openalex.org/W2407165296","https://openalex.org/W2410193734","https://openalex.org/W2411897231","https://openalex.org/W2461078236","https://openalex.org/W2582743722","https://openalex.org/W2616016892","https://openalex.org/W2767911074","https://openalex.org/W2916269539","https://openalex.org/W2918041145","https://openalex.org/W3032791538"],"related_works":["https://openalex.org/W1971207720","https://openalex.org/W180722889","https://openalex.org/W2947935859","https://openalex.org/W2060027285","https://openalex.org/W1999918674","https://openalex.org/W2065700756","https://openalex.org/W159738006","https://openalex.org/W3027888139","https://openalex.org/W146081868","https://openalex.org/W2783065741"],"abstract_inverted_index":{"Four":[0],"landmark":[1],"randomized":[2],"trials":[3],"have":[4],"clearly":[5],"validated":[6],"the":[7,14,34,42,56,99,111,153,193],"use":[8],"of":[9,16,36,51,136,189],"carotid":[10,21,37,64],"endarterectomy":[11],"(CEA)":[12],"for":[13,30,61,81,113,121,128,152,172],"management":[15,60],"asymptomatic":[17],"and":[18,41,115],"symptomatic":[19],"significant":[20,187],"artery":[22,38,65],"stenosis.":[23],"However,":[24],"its":[25],"risk-to-benefit":[26],"ratio":[27],"is":[28,90,103],"variable":[29],"different":[31],"patients.":[32],"With":[33],"advent":[35],"stenting":[39],"(CAS)":[40],"recent":[43],"improvements":[44],"in":[45,55,106],"medical":[46,73],"therapy,":[47],"an":[48,94],"added":[49],"degree":[50],"complexity":[52],"has":[53],"emerged":[54],"effort":[57],"to":[58],"optimize":[59],"patients":[62,122,137,168],"with":[63,68,138],"disease.":[66],"Patients":[67],"unfavorable":[69],"anatomical":[70],"features":[71],"or":[72,145,175],"comorbidities":[74],"are":[75],"generally":[76],"considered":[77],"a":[78,186],"\u2018high-risk":[79],"group\u2019":[80],"surgical":[82],"CEA.":[83,129,178],"For":[84,179],"these":[85,107],"patients,":[86,108],"minimal":[87],"invasive":[88],"CAS":[89,102],"often":[91],"proposed":[92],"as":[93],"alternative,":[95],"preferential":[96],"treatment.":[97],"Over":[98],"past":[100],"years,":[101],"increasingly":[104],"performed":[105],"particularly,":[109],"since":[110],"Centers":[112],"Medicare":[114],"Medicaid":[116],"Services":[117],"(CMS)":[118],"approved":[119],"reimbursement":[120],"who":[123],"met":[124],"certain":[125],"high-risk":[126,140,165,194],"criteria":[127,166],"In":[130],"this":[131],"thesis":[132],"we":[133],"investigated":[134],"outcome":[135],"anatomic":[139],"comorbid":[141],"conditions":[142],"undergoing":[143],"CEA":[144],"CAS,":[146],"ultimately":[147],"enabling":[148],"optimal":[149],"decision":[150],"making":[151],"individual":[154],"patient.":[155],"Our":[156],"results":[157],"indicate":[158],"that":[159],"some,":[160],"but":[161],"not":[162],"all,":[163],"CMS":[164],"identified":[167],"at":[169],"increased":[170],"risk":[171],"30-day":[173],"stroke":[174],"death":[176],"after":[177],"both":[180],"treatment":[181],"modalities,":[182],"symptom":[183],"status":[184],"was":[185],"predictor":[188],"adverse":[190],"outcome.":[191],"Of":[192],"criteria,":[195],"congestive":[196],"heart":[197],"failure":[198],"class":[199],"III/IV,":[200],"left":[201],"ventricle":[202],"ejection":[203],"fraction":[204]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}