{"id":"https://openalex.org/W1556965950","doi":"https://doi.org/10.1161/circ.130.suppl_2.19483","title":"Abstract 19483: Assessment of Outcome in Patients With Acute Minor Ischemic Stroke Treated With Intravenous TPA","display_name":"Abstract 19483: Assessment of Outcome in Patients With Acute Minor Ischemic Stroke Treated With Intravenous TPA","publication_year":2014,"publication_date":"2014-11-25","ids":{"openalex":"https://openalex.org/W1556965950","doi":"https://doi.org/10.1161/circ.130.suppl_2.19483","mag":"1556965950"},"language":"en","primary_location":{"id":"doi:10.1161/circ.130.suppl_2.19483","doi":"https://doi.org/10.1161/circ.130.suppl_2.19483","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.19483","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000746403","display_name":"Sameer Sharma","orcid":"https://orcid.org/0000-0002-2415-4333","observed_orcids":["https://orcid.org/0000-0002-2415-4333"]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameer Sharma","raw_affiliation_strings":["Neurology, Upstate Univ Hosp, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, Upstate Univ Hosp, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061275982","display_name":"Umair Afzal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umair Afzal","raw_affiliation_strings":["Neurology, upstate university hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, upstate university hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052679068","display_name":"Mubashir Pervez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mubashir Pervez","raw_affiliation_strings":["Neurology, upstate university hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, upstate university hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007594442","display_name":"Rochele Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rochele Clark","raw_affiliation_strings":["Neurology, upstate university hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, upstate university hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394146","display_name":"Julius Gene Latorre","orcid":"https://orcid.org/0000-0002-2998-8732","observed_orcids":["https://orcid.org/0000-0002-2998-8732"]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius G Latorre","raw_affiliation_strings":["Neurology, upstate university hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, upstate university hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078383002","display_name":"Ziad El-Zammar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziad El-Zammar","raw_affiliation_strings":["Neurology, upstate university hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology, upstate university hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210106223"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"suppl_2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minor-stroke","display_name":"minor stroke","score":0.8309999704360962},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9470000267028809},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.6740000247955322},{"id":"https://openalex.org/keywords/functional-outcome","display_name":"functional outcome","score":0.8519999980926514},{"id":"https://openalex.org/keywords/modified-rankin-scale","display_name":"modified Rankin Scale","score":0.968999981880188},{"id":"https://openalex.org/keywords/nihss","display_name":"NIHSS","score":0.9129999876022339},{"id":"https://openalex.org/keywords/stroke-severity","display_name":"stroke severity","score":0.3840000033378601},{"id":"https://openalex.org/keywords/hemorrhagic-transformation","display_name":"hemorrhagic transformation","score":0.4390000104904175},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.39500001072883606},{"id":"https://openalex.org/keywords/stroke-subtypes","display_name":"stroke subtypes","score":0.4490000009536743},{"id":"https://openalex.org/keywords/lacunar-stroke","display_name":"lacunar stroke","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cardioembolic-stroke","display_name":"cardioembolic stroke","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cryptogenic-stroke","display_name":"cryptogenic stroke","score":0.968999981880188},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9710322618484497},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.7321122884750366},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6494520306587219},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.5257457494735718},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.4586728513240814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41986745595932007},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.41685599088668823},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38955947756767273},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.319607138633728},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.12091481685638428},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.130.suppl_2.19483","doi":"https://doi.org/10.1161/circ.130.suppl_2.19483","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.130.suppl_2.19483","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4328049152","https://openalex.org/W2000709569","https://openalex.org/W2286205333","https://openalex.org/W2158353659","https://openalex.org/W6939900055","https://openalex.org/W2621264299","https://openalex.org/W2742774943","https://openalex.org/W1511556175","https://openalex.org/W1491742958","https://openalex.org/W4200005723"],"abstract_inverted_index":{"Introduction:":[0],"Minor":[1,76,111,125,293,357],"acute":[2,63],"stroke":[3,77,112,126,199,294],"(NIHSS\u22644)":[4],"within":[5,130],"4.5":[6,131],"hours":[7,132],"from":[8,43,57,233],"symptom":[9],"onset":[10],"is":[11,315,344],"a":[12,66,336],"common":[13],"reason":[14],"for":[15,239,243,271,334],"withholding":[16],"intravenous":[17],"(iv)":[18],"Thrombolysis":[19],"(TPA),":[20],"due":[21,317],"to":[22,235,296,318,346],"potential":[23],"risk":[24],"of":[25,39,69,99,107,121,170,225,351],"major":[26],"bleeding":[27],"with":[28,71,124,148,356],"such":[29],"treatment":[30],"and":[31,55,75,90,197,209,245,325],"assumed":[32],"good":[33,246],"outcome":[34,158,247,309],"without":[35],"intervention.":[36],"This":[37],"subgroup":[38],"patients":[40,70,123,141,149,166,254,273,355],"was":[41,137,146,159,180,215,237,250,269,279],"excluded":[42],"the":[44,52,97,183,189,222,226,311,349],"landmark":[45],"NINDS":[46],"iv":[47,108,174,352],"tPA":[48,201,256,275,286],"trial":[49],"as":[50,161],"per":[51],"prespecified":[53],"protocol":[54],"also":[56],"various":[58],"recent":[59,67],"clinical":[60,308],"trials":[61],"involving":[62],"stroke.":[64,358],"In":[65],"study":[68,343],"Rapid":[72],"Improving":[73],"symptoms":[74],"who":[78,142,150],"did":[79,151,300],"not":[80,86,93,114,152,301],"receive":[81,153],"IV":[82,144,155],"tPA,":[83],"28.3%":[84],"could":[85,92],"be":[87,297],"discharged":[88],"home":[89],"28.5%":[91],"ambulate":[94],"independently":[95],"at":[96,248],"time":[98],"discharge":[100,236,249],"(Smith":[101],"et":[102],"al":[103],"2011).":[104],"The":[105,176],"efficacy":[106],"TPA":[109,145,353],"in":[110,140,182,188,200,231,252,255,259,281,285,292,307,335,354],"has":[113],"been":[115],"previously":[116],"studied.":[117],"Method:":[118],"Retrospective":[119],"review":[120],"consecutive":[122],"(NIHSS":[127],"\u22644)":[128],"arriving":[129],"between":[133,221,310],"January":[134],"2009-July":[135],"2013":[136],"done.":[138],"Outcome":[139],"received":[143,173],"compared":[147],"any":[154,303],"tPA.":[156,175],"Good":[157],"defined":[160],"mRS":[162,278],"\u22642.":[163],"Results:":[164],"186":[165],"were":[167],"identified":[168],"out":[169],"which":[171],"20":[172],"baseline":[177,223],"median":[178],"NIHSS":[179,232],"2":[181],"non-intervention":[184],"group":[185,191,202,261,287],"vs":[186,204,207,211,241,257,283],"3":[187],"intervention":[190,291],"(p":[192,262],"=0.001),":[193],"more":[194],"cardioembolic,":[195],"cryptogenic":[196],"lacunar":[198],"(40%":[203],"35.53%,":[205],"20%":[206],"14.46%":[208],"30%":[210],"22.89%":[212],"respectively)":[213],"there":[214],"no":[216],"other":[217,326],"statistically":[218,304],"significant":[219,305],"difference":[220,306],"characteristics":[224],"two":[227,312],"groups.":[228],"Median":[229],"change":[230],"admission":[234],"1":[238,284],"non-tPA":[240,282],"2.5":[242],"tPA(p<0.001)":[244],"seen":[251],"80%":[253],"69.28%":[258],"non-tpa":[260],"=0.321).":[263],"8-12":[264],"week":[265],"follow":[266],"up":[267],"data":[268],"available":[270],"100":[272],"(12":[274],"patients).":[276],"Mean":[277],"1.34":[280],"(p=0.430)":[288],"Conclusion:":[289],"Acute":[290],"appears":[295],"safe.":[298],"We":[299],"find":[302],"groups;":[313],"this":[314],"likely":[316],"small":[319],"sample":[320],"size,":[321],"short":[322],"follow-up":[323],"period,":[324],"confounding":[327],"factors":[328],"that":[329],"we":[330],"cannot":[331],"fully":[332],"account":[333],"retrospective":[337],"study.":[338],"A":[339],"prospective":[340],"randomized":[341],"control":[342],"warranted":[345],"clearly":[347],"delineate":[348],"effect":[350]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}