{"id":"https://openalex.org/W155686744","doi":null,"title":"Differential Impact of Age and Stress on Amygdala Physiology and Function","display_name":"Differential Impact of Age and Stress on Amygdala Physiology and Function","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W155686744","mag":"155686744"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3566591","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3566591","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3566591","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhang, Wei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhang, Wei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.4368000030517578,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repeated-restraint-stress","display_name":"repeated restraint stress","score":0.949999988079071},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.7770000100135803},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.8709999918937683},{"id":"https://openalex.org/keywords/age-dependent-effects","display_name":"age-dependent effects","score":0.5699999928474426},{"id":"https://openalex.org/keywords/fear-conditioning","display_name":"fear conditioning","score":0.7509999871253967},{"id":"https://openalex.org/keywords/fear-extinction","display_name":"fear extinction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gaba-transmission","display_name":"GABA transmission","score":0.8029999732971191},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.8429999947547913},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.890999972820282},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6480000019073486},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.906000018119812},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.4976101219654083},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.47681161761283875},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46115779876708984},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4436194896697998},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43902474641799927},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4287579357624054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3740895092487335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2911227345466614},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.11880448460578918},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.09062176942825317},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3566591","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3566591","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3566591","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2090100345","https://openalex.org/W1990907937","https://openalex.org/W2740539688","https://openalex.org/W2013095929","https://openalex.org/W1984030005","https://openalex.org/W7064802163","https://openalex.org/W2297575002","https://openalex.org/W1993142638","https://openalex.org/W2757219164","https://openalex.org/W595079019"],"abstract_inverted_index":{"Occasional":[0],"stress":[1,13,16,34,45,87,101,117,125,175,207,235,262,278,343],"is":[2,49,79,110],"a":[3,63,128,322,352],"normal":[4],"aspect":[5],"of":[6,25,41,44,56,68,99,115,174,239,303,342,355,358,368],"mammalian":[7],"life.":[8],"However":[9],"repeated":[10,116,124,166,199,233,260,276,293,318],"or":[11,23],"prolonged":[12],"exposure":[14],"dysregulates":[15],"responses":[17],"and":[18,32,54,78,131,140,160,179,186,198,202,299,325,362],"contributes":[19],"to":[20,127,165,351],"the":[21,38,42,66,97,103,113,133,172,264,280,356],"onset":[22],"exacerbation":[24],"affective":[26,47,60,90,138,345,360],"disorders":[27,61,361],"such":[28,141],"as":[29],"anxiety,":[30],"depression":[31],"post-traumatic":[33],"disorder":[35],"(PTSD).":[36],"Understanding":[37],"underlying":[39],"mechanism":[40],"effect":[43,98,173,341],"on":[46,102,176,344],"behaviors":[48],"essential":[50],"for":[51],"effective":[52],"prevention":[53],"treatment":[55,367],"these":[57,230,314,369],"disorders.":[58,370],"All":[59],"share":[62],"deficit":[64],"in":[65,75,136,182,215,224,242,253,272,288,309,321,331],"regulation":[67,77],"emotion.":[69],"The":[70,191,328],"amygdala":[71,94,104,130,134,177,210,332],"plays":[72],"crucial":[73],"role":[74],"this":[76,151,348],"adversely":[80],"affected":[81],"by":[82,92,269,285],"stress.":[83,168],"This":[84],"suggests":[85],"that":[86,123,259,317],"precipitates":[88],"abnormal":[89],"state":[91],"altering":[93],"function.":[95],"While":[96],"acute":[100],"has":[105],"been":[106],"well":[107],"described,":[108],"less":[109],"know":[111],"about":[112],"impact":[114],"nor":[118],"its":[119],"age-dependency.":[120],"We":[121,169],"hypothesized":[122],"leads":[126,350],"hyperactive":[129,324],"impairs":[132],"function":[135],"regulating":[137],"behaviors,":[139],"impacts":[142],"are":[143],"greater":[144],"during":[145,148],"prepubescence":[146],"than":[147],"adulthood.":[149],"In":[150,227,291],"study,":[152],"we":[153],"subjected":[154],"prepubescent":[155,183,216,254,273],"(postnatal":[156],"day,":[157],"PND":[158],"\u223c30)":[159],"adult":[161,187,225,289],"rats":[162,217],"(PND":[163,184,188],"\u223c65)":[164],"restraint":[167,200,206,234,261,277,294,319],"then":[170],"measured":[171],"physiology":[178,333],"amygdala-dependent":[180],"behavior":[181],"\u223c40)":[185],"\u223c75)":[189],"rats.":[190,226,255,274,290],"results":[192,320],"were":[193],"compared":[194],"between":[195],"age-matched":[196],"non-restraint":[197],"groups":[201],"across":[203],"age.":[204],"Repeated":[205],"increased":[208],"basolateral":[209],"(BLA)":[211],"spontaneous":[212],"population":[213],"activity":[214,223],"whereas":[218],"it":[219],"enhanced":[220,236,279,300],"individual":[221],"neuron":[222,267,283],"parallel":[228],"with":[229],"physiological":[231],"changes,":[232],"initial":[237],"expression":[238],"conditioned":[240],"fear":[241,250],"both":[243,310],"age":[244,311],"groups,":[245],"but":[246],"impaired":[247],"within":[248],"session":[249],"extinction":[251],"only":[252],"Further":[256],"studies":[257],"demonstrated":[258],"reduced":[263,295],"BLA":[265,281,306],"projection":[266,282,307],"inhibition":[268],"exogenous":[270,286],"GABA":[271,297],"However,":[275],"excitation":[284,302],"glutamate":[287],"addition,":[292],"basal":[296],"transmission":[298],"mPFC-induced":[301],"spontaneously":[304],"active":[305],"neurons":[308],"groups.":[312],"Together,":[313],"findings":[315],"indicate":[316],"generalized":[323],"hyper-responsive":[326],"amygdala.":[327],"distinct":[329],"changes":[330],"at":[334],"different":[335],"developmental":[336],"stages":[337],"might":[338],"underlie":[339],"age-dependent":[340],"behaviors.":[346],"Overall,":[347],"study":[349],"better":[353],"understanding":[354],"pathophysiology":[357],"stress-related":[359],"provide":[363],"insight":[364],"into":[365],"age-specific":[366]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
