{"id":"https://openalex.org/W1556669800","doi":null,"title":"Regulation of Normal and Neoplastic Steroidogenic Cell Differentiation in the Adrenal Gland and Ovary","display_name":"Regulation of Normal and Neoplastic Steroidogenic Cell Differentiation in the Adrenal Gland and Ovary","publication_year":2014,"publication_date":"2014-12-12","ids":{"openalex":"https://openalex.org/W1556669800","mag":"1556669800"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/136450","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/136450","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/136450","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022204510","display_name":"Marjut Pihlajoki","orcid":"https://orcid.org/0000-0002-9869-5706","observed_orcids":["https://orcid.org/0000-0002-9869-5706"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marjut Pihlajoki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9869-5706","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022204510"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.1688999980688095,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.15479999780654907,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenal-cortex-development","display_name":"adrenal cortex development","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gata6","display_name":"GATA6","score":0.8999999761581421},{"id":"https://openalex.org/keywords/foxl2","display_name":"FOXL2","score":0.7120000123977661},{"id":"https://openalex.org/keywords/granulosa-cell-tumor","display_name":"granulosa cell tumor","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":0.765999972820282},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":1.0},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.5860000252723694},{"id":"https://openalex.org/keywords/x-zone","display_name":"X-zone","score":0.6740000247955322},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.859000027179718},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.3160000145435333},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.44600000977516174},{"id":"https://openalex.org/keywords/sex-cord-stromal-tumors","display_name":"sex cord-stromal tumors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.3930000066757202},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.6215348243713379},{"id":"https://openalex.org/C2780694816","wikidata":"https://www.wikidata.org/wiki/Q712294","display_name":"Adrenal gland","level":2,"score":0.49461695551872253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49168258905410767},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4765748977661133},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43947646021842957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43542954325675964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21202212572097778}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/136450","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/136450","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1556669800","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/136450/1/regulati.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/136450","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/136450","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":225,"referenced_works":["https://openalex.org/W92307352","https://openalex.org/W1484771785","https://openalex.org/W1498970130","https://openalex.org/W1537712767","https://openalex.org/W1540418377","https://openalex.org/W1554144288","https://openalex.org/W1810584464","https://openalex.org/W1958920937","https://openalex.org/W1961869750","https://openalex.org/W1964143773","https://openalex.org/W1964657454","https://openalex.org/W1964940531","https://openalex.org/W1966249598","https://openalex.org/W1967199332","https://openalex.org/W1968747163","https://openalex.org/W1968975770","https://openalex.org/W1969328947","https://openalex.org/W1969689856","https://openalex.org/W1970856815","https://openalex.org/W1971599917","https://openalex.org/W1973158357","https://openalex.org/W1973773749","https://openalex.org/W1976678205","https://openalex.org/W1976722903","https://openalex.org/W1978162225","https://openalex.org/W1978478526","https://openalex.org/W1979053455","https://openalex.org/W1979134116","https://openalex.org/W1980427996","https://openalex.org/W1981065455","https://openalex.org/W1983102462","https://openalex.org/W1984261567","https://openalex.org/W1984863553","https://openalex.org/W1986212270","https://openalex.org/W1986414520","https://openalex.org/W1987991173","https://openalex.org/W1990624032","https://openalex.org/W1991046191","https://openalex.org/W1993198178","https://openalex.org/W1993932453","https://openalex.org/W1994893992","https://openalex.org/W1995183635","https://openalex.org/W1998106693","https://openalex.org/W1998234777","https://openalex.org/W1998970590","https://openalex.org/W1999276992","https://openalex.org/W1999343359","https://openalex.org/W2000286028","https://openalex.org/W2000292756","https://openalex.org/W2001021583","https://openalex.org/W2001282311","https://openalex.org/W2001403404","https://openalex.org/W2002809240","https://openalex.org/W2003456330","https://openalex.org/W2003668368","https://openalex.org/W2003967044","https://openalex.org/W2005607945","https://openalex.org/W2005821186","https://openalex.org/W2013216633","https://openalex.org/W2013877353","https://openalex.org/W2013881488","https://openalex.org/W2015533701","https://openalex.org/W2016791091","https://openalex.org/W2016800963","https://openalex.org/W2017008764","https://openalex.org/W2019038132","https://openalex.org/W2020584778","https://openalex.org/W2021544762","https://openalex.org/W2023531352","https://openalex.org/W2024147232","https://openalex.org/W2024805700","https://openalex.org/W2025351096","https://openalex.org/W2026250050","https://openalex.org/W2029872286","https://openalex.org/W2031714657","https://openalex.org/W2032457040","https://openalex.org/W2035066075","https://openalex.org/W2035207372","https://openalex.org/W2036177369","https://openalex.org/W2038988941","https://openalex.org/W2040525542","https://openalex.org/W2040972148","https://openalex.org/W2041372147","https://openalex.org/W2042183080","https://openalex.org/W2043914264","https://openalex.org/W2044221542","https://openalex.org/W2044693854","https://openalex.org/W2045247659","https://openalex.org/W2046318151","https://openalex.org/W2046516822","https://openalex.org/W2046619493","https://openalex.org/W2048327621","https://openalex.org/W2048659659","https://openalex.org/W2049004724","https://openalex.org/W2049442901","https://openalex.org/W2050478791","https://openalex.org/W2052846984","https://openalex.org/W2052857449","https://openalex.org/W2053865741","https://openalex.org/W2056616628","https://openalex.org/W2057805027","https://openalex.org/W2059173412","https://openalex.org/W2060172591","https://openalex.org/W2060889469","https://openalex.org/W2061564388","https://openalex.org/W2061904534","https://openalex.org/W2062626814","https://openalex.org/W2062840422","https://openalex.org/W2063398727","https://openalex.org/W2064686852","https://openalex.org/W2066639629","https://openalex.org/W2066773152","https://openalex.org/W2066801022","https://openalex.org/W2068049794","https://openalex.org/W2068707743","https://openalex.org/W2070466664","https://openalex.org/W2070692423","https://openalex.org/W2072698217","https://openalex.org/W2072781709","https://openalex.org/W2074435588","https://openalex.org/W2076606336","https://openalex.org/W2077070289","https://openalex.org/W2077732361","https://openalex.org/W2077790055","https://openalex.org/W2079463756","https://openalex.org/W2082775864","https://openalex.org/W2083397112","https://openalex.org/W2084506573","https://openalex.org/W2084815510","https://openalex.org/W2087209804","https://openalex.org/W2088974591","https://openalex.org/W2089893928","https://openalex.org/W2090008450","https://openalex.org/W2090396315","https://openalex.org/W2091965888","https://openalex.org/W2092224562","https://openalex.org/W2092351713","https://openalex.org/W2092407833","https://openalex.org/W2092508425","https://openalex.org/W2093170574","https://openalex.org/W2093498435","https://openalex.org/W2093943347","https://openalex.org/W2094836511","https://openalex.org/W2096736856","https://openalex.org/W2098728140","https://openalex.org/W2098763049","https://openalex.org/W2099711527","https://openalex.org/W2100689001","https://openalex.org/W2100859941","https://openalex.org/W2101169432","https://openalex.org/W2102629299","https://openalex.org/W2103693642","https://openalex.org/W2104759721","https://openalex.org/W2105583547","https://openalex.org/W2107577013","https://openalex.org/W2108259939","https://openalex.org/W2110698122","https://openalex.org/W2110969580","https://openalex.org/W2110985070","https://openalex.org/W2111391096","https://openalex.org/W2111652072","https://openalex.org/W2112986981","https://openalex.org/W2113505777","https://openalex.org/W2114012800","https://openalex.org/W2116393840","https://openalex.org/W2116533563","https://openalex.org/W2118912793","https://openalex.org/W2121466247","https://openalex.org/W2121875134","https://openalex.org/W2123037811","https://openalex.org/W2124126928","https://openalex.org/W2125016845","https://openalex.org/W2126844737","https://openalex.org/W2127860778","https://openalex.org/W2129072528","https://openalex.org/W2130453712","https://openalex.org/W2131118910","https://openalex.org/W2131352876","https://openalex.org/W2133795954","https://openalex.org/W2133834560","https://openalex.org/W2136527972","https://openalex.org/W2138158343","https://openalex.org/W2138493972","https://openalex.org/W2139618255","https://openalex.org/W2140253494","https://openalex.org/W2140745387","https://openalex.org/W2141197851","https://openalex.org/W2142330433","https://openalex.org/W2142790993","https://openalex.org/W2144641360","https://openalex.org/W2145870562","https://openalex.org/W2146913091","https://openalex.org/W2147982925","https://openalex.org/W2148070806","https://openalex.org/W2148321928","https://openalex.org/W2148839199","https://openalex.org/W2150001956","https://openalex.org/W2153751284","https://openalex.org/W2154500801","https://openalex.org/W2156028272","https://openalex.org/W2156352518","https://openalex.org/W2157610967","https://openalex.org/W2157634837","https://openalex.org/W2158701974","https://openalex.org/W2158771177","https://openalex.org/W2160507736","https://openalex.org/W2161693710","https://openalex.org/W2162233013","https://openalex.org/W2162514244","https://openalex.org/W2164760878","https://openalex.org/W2166045505","https://openalex.org/W2166329690","https://openalex.org/W2167200046","https://openalex.org/W2167862718","https://openalex.org/W2169327129","https://openalex.org/W2171319840","https://openalex.org/W2171321223","https://openalex.org/W2171539702","https://openalex.org/W2172100709","https://openalex.org/W2273383057","https://openalex.org/W2292193643","https://openalex.org/W2324583721","https://openalex.org/W2334476405","https://openalex.org/W2410162266","https://openalex.org/W2615946525"],"related_works":["https://openalex.org/W1976717257","https://openalex.org/W1542668158","https://openalex.org/W1979204710","https://openalex.org/W2033674005","https://openalex.org/W2023531352","https://openalex.org/W2079792742","https://openalex.org/W2292193643","https://openalex.org/W2164198570","https://openalex.org/W1557099976","https://openalex.org/W2044789020"],"abstract_inverted_index":{"The":[0,323],"main":[1],"steroidogenic":[2,76,109,146],"organs,":[3],"adrenal":[4,37,80,116],"cortex":[5,38],"and":[6,26,39,48,93,131,201,234,244,249,261,264,277,285,314,332,377,386,407,410,415],"ovary,":[7],"arise":[8],"from":[9,290],"a":[10,87,99,114,195,427],"common":[11,158],"pool":[12],"of":[13,28,35,45,51,74,90,126,145,190,203,226,232,325,374,396],"progenitors":[14,147],"in":[15,30,63,78,95,102,108,162,180,187,198,239,252,316,358,393,435],"the":[16,23,36,72,79,143,156,199,223,230,297,310,347,371,416,436],"developing":[17],"embryo.":[18],"Similar":[19],"signaling":[20,390],"pathways":[21,434],"regulate":[22],"differentiation,":[24],"growth,":[25],"survival":[27],"cells":[29,289,360,381,403],"these":[31,52,257,432],"tissues.":[32],"Proper":[33],"development":[34,92,200],"ovary":[40],"requires":[41],"precise":[42],"spatiotemporal":[43],"control":[44],"gene":[46,247],"expression":[47,73,248],"apoptosis;":[49],"disruption":[50],"processes":[53],"may":[54],"lead":[55],"to":[56,166,320,355],"congenital":[57],"disorders":[58],"or":[59,327],"malignant":[60,321,359],"transformation.":[61,322],"Earlier":[62],"vitro":[64],"studies":[65],"demonstrated":[66,282],"that":[67,84,118,140,256,262,283,306,401,411],"transcription":[68,181],"factor":[69,182,368],"GATA6":[70,85,141],"regulates":[71,142],"multiple":[75],"genes":[77],"cortex.":[81],"To":[82,221],"show":[83],"is":[86,105,185,218,272,330,353,370],"crucial":[88],"regulator":[89,373],"adrenocortical":[91,149],"function":[94,202],"vivo,":[96],"we":[97,228,281],"generated":[98],"mouse":[100],"model":[101],"which":[103,271],"Gata6":[104],"conditionally":[106],"deleted":[107],"cells.":[110,150,206,364,398],"These":[111,135,303,424],"mice":[112],"exhibited":[113],"complex":[115],"phenotype":[117],"includes":[119],"cortical":[120],"thinning,":[121],"blunted":[122],"aldosterone":[123],"production,":[124],"lack":[125],"an":[127,387],"X-zone,":[128],"impaired":[129],"apoptosis,":[130,214],"subcapsular":[132],"cell":[133,153,172,213,241,250,422],"hyperplasia.":[134],"results":[136],"offer":[137],"genetic":[138],"proof":[139],"differentiation":[144],"into":[148],"Ovarian":[151],"granulosa":[152,171,205,240,317],"tumors":[154,161],"(GCTs),":[155],"most":[157],"sex-cord":[159],"stromal":[160],"women,":[163],"are":[164,337],"thought":[165],"be":[167],"caused":[168],"by":[169,274,300],"aberrant":[170],"apoptosis":[173,294,298,315,342,357],"during":[174],"folliculogenesis.":[175],"A":[176],"somatic":[177],"missense":[178],"mutation":[179],"FOXL2":[183,193,210,217,233,292,308],"(402C\u2192G)":[184],"present":[186],"vast":[188],"majority":[189],"human":[191],"GCTs.":[192,253],"plays":[194],"key":[196,372],"role":[197],"normal":[204,363],"Wild":[207],"type":[208],"(wt)":[209],"induces":[211],"GCT":[212,288,402,421,437],"while":[215],"mutated":[216,278,301,307],"less":[219],"effective.":[220],"clarify":[222],"molecular":[224],"pathogenesis":[225],"GCTs,":[227],"investigated":[229],"impact":[231],"two":[235,433],"other":[236],"factors":[237,258],"implicated":[238],"function,":[242],"GATA4":[243,263,284],"SMAD3,":[245],"on":[246],"viability":[251],"We":[254,399],"found":[255,400],"physically":[259],"interact":[260],"SMAD3":[265,286],"synergistically":[266],"induce":[267,356,420],"CCND2":[268],"promoter":[269],"transactivation,":[270],"reduced":[273],"both":[275,375],"wt":[276,291],"FOXL2.":[279,302],"Finally,":[280],"protect":[287],"induced":[293,299],"without":[295,361],"affecting":[296,362],"findings":[304,425],"suggest":[305],"disrupts":[309],"balance":[311],"between":[312],"growth":[313,367],"cells,":[318],"leading":[319],"treatment":[324,335,412],"recurrent":[326],"metastatic":[328],"GCTs":[329],"challenging,":[331],"biologically":[333],"targeted":[334],"modalities":[336],"needed.":[338],"Tumor":[339],"necrosis":[340],"factor-related":[341],"inducing":[343],"ligand":[344],"(TRAIL)":[345],"activates":[346],"extrinsic":[348],"apoptotic":[349],"pathway.":[350],"Interestingly,":[351],"TRAIL":[352,406,414],"able":[354],"Vascular":[365],"endothelial":[366],"(VEGF)":[369],"physiological":[376],"pathological":[378],"angiogenesis.":[379],"Cancer":[380],"often":[382],"express":[383,404],"VEGF":[384,408],"receptor,":[385],"autocrine":[388],"VEGF/VEGFR":[389],"loop":[391],"exists":[392],"several":[394],"types":[395],"cancer":[397],"functional":[405],"receptors,":[409],"with":[413],"VEGF-binding":[417],"antibody":[418],"(bevacizumab)":[419],"apoptosis.":[423],"establish":[426],"preclinical":[428],"basis":[429],"for":[430],"targeting":[431],"treatment.":[438]},"counts_by_year":[],"updated_date":"2026-08-18T07:49:30.821534","created_date":"2016-06-24T00:00:00"}
