{"id":"https://openalex.org/W1556591328","doi":null,"title":"Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products.","display_name":"Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products.","publication_year":1986,"publication_date":"1986-04-01","ids":{"openalex":"https://openalex.org/W1556591328","mag":"1556591328","pmid":"https://pubmed.ncbi.nlm.nih.gov/3948173"},"language":"en","primary_location":{"id":"pmid:3948173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3948173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044143691","display_name":"Nancy E. Davidson","orcid":"https://orcid.org/0000-0003-1520-6442","observed_orcids":["https://orcid.org/0000-0003-1520-6442"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N E Davidson","raw_affiliation_strings":["\u2020Uniformed Services University of the Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Uniformed Services University of the Health Sciences","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057410563","display_name":"Diane A. Bronzert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D A Bronzert","raw_affiliation_strings":["\u2020Uniformed Services University of the Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Uniformed Services University of the Health Sciences","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085761422","display_name":"Pierre Chambon","orcid":"https://orcid.org/0000-0002-7861-6046","observed_orcids":["https://orcid.org/0000-0002-7861-6046"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Chambon","raw_affiliation_strings":["CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090047154","display_name":"E P Gelmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E P Gelmann","raw_affiliation_strings":["\u2020Uniformed Services University of the Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Uniformed Services University of the Health Sciences","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028539104","display_name":"Marc E. Lippman","orcid":"https://orcid.org/0000-0001-5280-4084","observed_orcids":["https://orcid.org/0000-0001-5280-4084"]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M E Lippman","raw_affiliation_strings":["\u2020Uniformed Services University of the Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Uniformed Services University of the Health Sciences","institution_ids":["https://openalex.org/I148314036"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2999,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.96543909,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"46","issue":"4 Pt 2","first_page":"1904","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ps2-gene","display_name":"pS2 gene","score":0.9440000057220459},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.4690000116825104},{"id":"https://openalex.org/keywords/antiestrogen-resistance","display_name":"antiestrogen resistance","score":0.9160000085830688},{"id":"https://openalex.org/keywords/autocrine-growth-stimulation","display_name":"autocrine growth stimulation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.8592586517333984},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.8343377113342285},{"id":"https://openalex.org/C2776067312","wikidata":"https://www.wikidata.org/wiki/Q50429983","display_name":"Antiestrogen","level":5,"score":0.7590938806533813},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7129948139190674},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6501113772392273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5997257828712463},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5206484198570251},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.4939942955970764},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.483464777469635},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46037206053733826},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40358132123947144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40174993872642517},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39130645990371704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38342010974884033},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3196832239627838},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2520042061805725},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.23274299502372742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16040509939193726},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13849112391471863},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.12291795015335083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08753159642219543}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3948173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3948173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1556591328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3948173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2018579779","https://openalex.org/W2029987769","https://openalex.org/W2036903205","https://openalex.org/W2077077811"],"related_works":["https://openalex.org/W2002809517","https://openalex.org/W220880097","https://openalex.org/W1519533002","https://openalex.org/W4236588307","https://openalex.org/W2137246906","https://openalex.org/W1575873090","https://openalex.org/W1498027545","https://openalex.org/W1997168698","https://openalex.org/W1594917281","https://openalex.org/W5512500"],"abstract_inverted_index":{"Two":[0],"variants":[1],"of":[2,17,79,88,119],"the":[3,15,42,47,76,80,86,106,117],"human":[4],"estrogen-responsive":[5],"breast":[6],"cancer":[7],"cell":[8,30,68,126],"line":[9],"MCF-7,":[10],"were":[11,51,100],"utilized":[12],"to":[13,39,75],"study":[14],"expression":[16,94],"an":[18,23],"estrogen-induced":[19,24],"gene,":[20],"pS2,":[21],"and":[22,46,95,109,124],"Mr":[25,48,96,110],"52,000":[26,49,97,111],"protein.":[27],"One":[28],"variant":[29,67,125],"line,":[31,69],"I13,":[32],"is":[33],"growth":[34,61,127],"inhibited":[35,63],"after":[36],"chronic":[37],"exposure":[38],"estrogen.":[40,65],"Both":[41],"pS2":[43,93,107],"gene":[44,108],"product":[45],"protein":[50,98,112],"produced":[52],"at":[53,56],"maximal":[54],"levels":[55],"a":[57],"time":[58],"when":[59],"I13":[60],"was":[62],"by":[64],"The":[66],"LY2,":[70],"selected":[71],"for":[72],"its":[73],"resistance":[74],"growth-inhibitory":[77],"effects":[78],"antiestrogen,":[81],"LY117018,":[82],"grew":[83],"normally":[84],"in":[85],"presence":[87],"this":[89],"drug,":[90],"although":[91],"both":[92],"production":[99],"inhibited.":[101],"These":[102],"results":[103],"confirm":[104],"that":[105,129],"are":[113,131],"estrogen-regulated":[114],"elements,":[115],"but":[116],"lack":[118],"correlation":[120],"between":[121],"their":[122],"activities":[123],"suggests":[128],"they":[130],"not":[132],"major":[133],"autocrine":[134],"growth-stimulatory":[135],"agents.":[136]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}