{"id":"https://openalex.org/W1556418643","doi":"https://doi.org/10.1002/9783527614998.ch7","title":"Assessment of Distribution\u2010pH Profiles","display_name":"Assessment of Distribution\u2010pH Profiles","publication_year":1996,"publication_date":"1996-04-25","ids":{"openalex":"https://openalex.org/W1556418643","doi":"https://doi.org/10.1002/9783527614998.ch7","mag":"1556418643"},"language":"en","primary_location":{"id":"doi:10.1002/9783527614998.ch7","doi":"https://doi.org/10.1002/9783527614998.ch7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527614998.ch7","pdf_url":null,"source":{"id":"https://openalex.org/S4210233354","display_name":"Methods and principles in medicinal chemistry","issn_l":"1432-4636","issn":["1432-4636","1865-0562"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and Principles in Medicinal Chemistry","raw_type":"other"},"volume":{"id":"https://openalex.org/W2766793182","display_name":"Lipophilicity in Drug Action and Toxicology"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078166589","display_name":"Alex Avdeef","orcid":"https://orcid.org/0000-0002-3139-5442","observed_orcids":["https://orcid.org/0000-0002-3139-5442"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"A. Avdeef","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078166589"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"109","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.09709999710321426,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.7260000109672546},{"id":"https://openalex.org/keywords/logd","display_name":"logD","score":0.4860000014305115},{"id":"https://openalex.org/keywords/octanol-water-partition-coefficient","display_name":"octanol-water partition coefficient","score":0.7099999785423279},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.9430000185966492},{"id":"https://openalex.org/keywords/two-phase-titration","display_name":"two-phase titration","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.5046387910842896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3900013267993927},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.34937602281570435},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3448314070701599},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3208984136581421},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27174311876296997},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.07400566339492798}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9783527614998.ch7","doi":"https://doi.org/10.1002/9783527614998.ch7","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9783527614998.ch7","pdf_url":null,"source":{"id":"https://openalex.org/S4210233354","display_name":"Methods and principles in medicinal chemistry","issn_l":"1432-4636","issn":["1432-4636","1865-0562"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and Principles in Medicinal Chemistry","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W118996005","https://openalex.org/W1540368796","https://openalex.org/W1979809448","https://openalex.org/W1980189764","https://openalex.org/W1984454344","https://openalex.org/W1984743075","https://openalex.org/W1987583649","https://openalex.org/W1989669611","https://openalex.org/W1992544116","https://openalex.org/W1994906546","https://openalex.org/W2003512894","https://openalex.org/W2005306661","https://openalex.org/W2010182430","https://openalex.org/W2015972200","https://openalex.org/W2020390895","https://openalex.org/W2026194834","https://openalex.org/W2045619356","https://openalex.org/W2051210752","https://openalex.org/W2058540171","https://openalex.org/W2070968614","https://openalex.org/W2078130861","https://openalex.org/W2079482932","https://openalex.org/W2111896544","https://openalex.org/W2155768336","https://openalex.org/W2156094555","https://openalex.org/W2331256599","https://openalex.org/W2495469377","https://openalex.org/W3003898783","https://openalex.org/W4248596865"],"related_works":["https://openalex.org/W7222773944","https://openalex.org/W1572194247","https://openalex.org/W6995745040","https://openalex.org/W1591962811","https://openalex.org/W1980095524","https://openalex.org/W4377983736","https://openalex.org/W2049288341","https://openalex.org/W1498609695","https://openalex.org/W4387312235","https://openalex.org/W2074147976"],"abstract_inverted_index":{"This":[0],"chapter":[1],"contains":[2],"sections":[3],"titled:":[4],"Introduction":[5],"Partition":[6],"Coefficient,":[7],"log":[8],"P,":[9],"and":[10,18],"the":[11,19],"Dyrssen":[12],"Two-Phase":[13],"Titration":[14],"Distribution":[15],"Function":[16],"(D)":[17],"Lipophilicity":[20],"Profile":[21],"(log":[22],"D":[23],"vs":[24],"pH)":[25],"Outlook":[26]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}