{"id":"https://openalex.org/W155624569","doi":null,"title":"Assessing Mitochondrial Activity in Embryos from Heat-Stressed Ova","display_name":"Assessing Mitochondrial Activity in Embryos from Heat-Stressed Ova","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W155624569","mag":"155624569"},"language":"en","primary_location":{"id":"mag:155624569","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/cgi/viewcontent.cgi?article=2171&context=utk_gradthes","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110546527","display_name":"Kimberly Ann Nagle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kimberly Ann Nagle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110546527"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.065700002014637,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12365","display_name":"Effects of Environmental Stressors on Livestock","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heat-stress","display_name":"heat stress","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.9710000157356262},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.859000027179718},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cumulus-cells","display_name":"cumulus cells","score":0.7110000252723694},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.753000020980835},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ihh","display_name":"Ihh","score":0.5820000171661377},{"id":"https://openalex.org/keywords/oocyte-developmental-competence","display_name":"oocyte developmental competence","score":0.7699999809265137},{"id":"https://openalex.org/keywords/high-ambient-temperature","display_name":"high ambient temperature","score":0.6629999876022339},{"id":"https://openalex.org/keywords/bovine-oocytes","display_name":"bovine oocytes","score":0.6370000243186951},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cleavage-stage-embryos","display_name":"cleavage-stage embryos","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.7336717844009399},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7065328359603882},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.6733106374740601},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6601207852363586},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.6508516073226929},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5950727462768555},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5578413009643555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5410356521606445},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.5402647256851196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5291730761528015},{"id":"https://openalex.org/C2987418964","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Heat stress","level":2,"score":0.4511156380176544},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.44353029131889343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2810998558998108},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.24542924761772156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17891788482666016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09753972291946411},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.08313122391700745}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:155624569","doi":null,"is_oa":false,"landing_page_url":"https://trace.tennessee.edu/cgi/viewcontent.cgi?article=2171&context=utk_gradthes","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":127,"referenced_works":["https://openalex.org/W42618","https://openalex.org/W64840984","https://openalex.org/W96437668","https://openalex.org/W1563889499","https://openalex.org/W1572456387","https://openalex.org/W1649435104","https://openalex.org/W1831444480","https://openalex.org/W1838909952","https://openalex.org/W1946814377","https://openalex.org/W1964776244","https://openalex.org/W1965479136","https://openalex.org/W1967100195","https://openalex.org/W1968197570","https://openalex.org/W1969134338","https://openalex.org/W1970885001","https://openalex.org/W1973509614","https://openalex.org/W1973973780","https://openalex.org/W1977349476","https://openalex.org/W1979676518","https://openalex.org/W1982158632","https://openalex.org/W1985749966","https://openalex.org/W1986066892","https://openalex.org/W1986140299","https://openalex.org/W1986906979","https://openalex.org/W1990286763","https://openalex.org/W1990614593","https://openalex.org/W1990835089","https://openalex.org/W1992865528","https://openalex.org/W1997587953","https://openalex.org/W1998714840","https://openalex.org/W2003791029","https://openalex.org/W2004211635","https://openalex.org/W2004248973","https://openalex.org/W2004873484","https://openalex.org/W2005289306","https://openalex.org/W2005764940","https://openalex.org/W2006006507","https://openalex.org/W2007829773","https://openalex.org/W2008644745","https://openalex.org/W2015897815","https://openalex.org/W2016106800","https://openalex.org/W2018196861","https://openalex.org/W2021140451","https://openalex.org/W2022176169","https://openalex.org/W2022436116","https://openalex.org/W2025884210","https://openalex.org/W2030508372","https://openalex.org/W2030709712","https://openalex.org/W2036926581","https://openalex.org/W2042847464","https://openalex.org/W2043382556","https://openalex.org/W2044037816","https://openalex.org/W2045894564","https://openalex.org/W2047229450","https://openalex.org/W2047295125","https://openalex.org/W2051038137","https://openalex.org/W2053137609","https://openalex.org/W2053829558","https://openalex.org/W2063389375","https://openalex.org/W2063882006","https://openalex.org/W2065246627","https://openalex.org/W2068048197","https://openalex.org/W2069215557","https://openalex.org/W2069240619","https://openalex.org/W2070681399","https://openalex.org/W2071002924","https://openalex.org/W2074682657","https://openalex.org/W2074688515","https://openalex.org/W2077362576","https://openalex.org/W2082795476","https://openalex.org/W2083205981","https://openalex.org/W2084991309","https://openalex.org/W2085386879","https://openalex.org/W2087173922","https://openalex.org/W2088472987","https://openalex.org/W2091173216","https://openalex.org/W2093909178","https://openalex.org/W2094602033","https://openalex.org/W2097968907","https://openalex.org/W2101861123","https://openalex.org/W2104107865","https://openalex.org/W2104256886","https://openalex.org/W2104672587","https://openalex.org/W2108051889","https://openalex.org/W2110795667","https://openalex.org/W2113045439","https://openalex.org/W2113190784","https://openalex.org/W2114750869","https://openalex.org/W2115240951","https://openalex.org/W2117674538","https://openalex.org/W2123480171","https://openalex.org/W2124838379","https://openalex.org/W2126868334","https://openalex.org/W2128017454","https://openalex.org/W2129538822","https://openalex.org/W2131009459","https://openalex.org/W2131112712","https://openalex.org/W2131754758","https://openalex.org/W2133184958","https://openalex.org/W2139588608","https://openalex.org/W2141528919","https://openalex.org/W2146047318","https://openalex.org/W2146883159","https://openalex.org/W2148049163","https://openalex.org/W2155329548","https://openalex.org/W2158723358","https://openalex.org/W2159467731","https://openalex.org/W2159474920","https://openalex.org/W2159491581","https://openalex.org/W2160273500","https://openalex.org/W2160483433","https://openalex.org/W2160878899","https://openalex.org/W2161682861","https://openalex.org/W2162362753","https://openalex.org/W2162756794","https://openalex.org/W2165268250","https://openalex.org/W2167243619","https://openalex.org/W2168420558","https://openalex.org/W2172282886","https://openalex.org/W2252785585","https://openalex.org/W2268957067","https://openalex.org/W2289579068","https://openalex.org/W2405123243","https://openalex.org/W2418556469","https://openalex.org/W2426474556","https://openalex.org/W2546782222","https://openalex.org/W2937529423"],"related_works":["https://openalex.org/W2789752363","https://openalex.org/W2181679224","https://openalex.org/W2182325403","https://openalex.org/W2785877806","https://openalex.org/W4409034962","https://openalex.org/W7166717372","https://openalex.org/W2418161947","https://openalex.org/W2074279757","https://openalex.org/W1992865528","https://openalex.org/W2172112459"],"abstract_inverted_index":{"Elevated":[0],"ambient":[1],"temperatures":[2],"negatively":[3],"impacts":[4],"pregnancy":[5],"rates":[6],"in":[7,23,80,87,92,138,141,152,185,188,208,222,261,271,298,308,325,337],"agriculturally":[8],"important":[9,27],"females.":[10],"An":[11],"oocyte":[12,263,327],"undergoing":[13],"meiotic":[14,54],"maturation":[15,55],"exposed":[16],"to":[17,45,109,232,246],"a":[18,182,233],"physiologically-relevant":[19],"heat":[20,46,217],"stress":[21,47,218],"results":[22],"alterations":[24,91,137],"of":[25,40,53,63,95,118,128,196,237,267,288,303,314,340],"developmentally":[26],"processes":[28],"and":[29,65,72,121,177,195,259,264,293,300,330],"reportedly":[30],"decreases":[31,287],"subsequent":[32,142],"developmental":[33,235,338],"potential":[34,236],"after":[35,43,144],"fertilization.":[36],"To":[37,131],"address":[38],"problems":[39],"reduced":[41,234],"competence":[42,339],"exposure":[44],"for":[48,157,162,170,334],"the":[49,60,77,81,146,163,171,262,268,272,279,322,326],"first":[50,164],"12":[51,165,173],"h":[52,159,166],"(hIVM),":[56],"Payton":[57],"(2009)":[58],"assessed":[59],"transcriptome":[61],"profiles":[62],"oocytes":[64,97,153,191,223,299],"associated":[66],"cumulus":[67,274,309],"cells":[68],"by":[69,168],"microarray":[70,248,281],"analysis":[71],"reported":[73],"heat-induced":[74,126,136,286,301,319],"perturbations":[75,127,320],"at":[76,105,155,321],"molecular":[78,323],"level":[79,324],"oocyte.":[82],"Specifically,":[83],"20":[84],"transcripts":[85,120],"involved":[86],"mitochondrial":[88,129,220],"function":[89,221],"exhibited":[90],"relative":[93],"abundance":[94],"heat-stressed":[96,189,240],"which":[98,224,228],"coincided":[99],"with":[100,278],"significantly":[101],"more":[102],"ATP":[103,123,150,186],"content":[104,151,187],"24":[106,158],"hIVM":[107],"compared":[108],"non-heat-stressed":[110],"controls":[111],"(Payton":[112],"et":[113],"al.,":[114],"unpublished).":[115],"These":[116],"findings":[117,249,316],"altered":[119],"elevated":[122],"production":[124],"suggest":[125],"function.":[130],"further":[132],"discern":[133],"whether":[134],"these":[135,315],"mitochondria":[139],"persists":[140,225],"embryos":[143,203,238],"fertilization,":[145,227],"present":[147],"study":[148],"measured":[149],"matured":[154,190],"38.5\u00b0C":[156,169],"or":[160],"41\u00b0C":[161],"followed":[167],"remaining":[172],"h,":[174],"resultant":[175,197,341],"cleavage,":[176],"blastocyst-stage":[178],"embryos.":[179,211,342],"Results":[180,276],"demonstrated":[181],"significant":[183],"increase":[184],"(P":[192,199,290,295,305],"=":[193,200,296,306],"0.0148)":[194],"8-to-16-cell":[198],"0.0323)":[201],"stage":[202,210],"but":[204],"was":[205,245],"not":[206],"evident":[207,329],"blastocyst":[209],"Here":[212],"we":[213],"provide":[214,332],"information":[215],"that":[216],"alters":[219],"following":[226],"may":[229,331],"ultimately":[230],"contribute":[231],"from":[239],"oocytes.":[241],"A":[242],"second":[243],"objective":[244],"validate":[247],"via":[250],"qPCR":[251],"of:":[252],"1)":[253],"electron":[254],"transport":[255],"chain":[256],"transcripts,":[257],"COQ3":[258,294],"NDUFC2,":[260],"2)":[265],"IHH":[266,304],"Hedgehog":[269],"Pathway":[270],"surrounding":[273],"cells.":[275,310],"agreed":[277],"previous":[280],"data":[282],"(Payton,":[283],"2009)":[284],"reporting":[285],"NDUFC2":[289],"\u2264":[291],"0.002)":[292],"0.02)":[297],"increases":[302],"0.007)":[307],"While":[311],"functional":[312],"significance":[313],"remains":[317],"unclear,":[318],"are":[328],"explanation":[333],"reductions":[335],"seen":[336]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
