{"id":"https://openalex.org/W1556056103","doi":"https://doi.org/10.4049/jimmunol.158.1.144","title":"CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation","display_name":"CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1556056103","doi":"https://doi.org/10.4049/jimmunol.158.1.144","mag":"1556056103","pmid":"https://pubmed.ncbi.nlm.nih.gov/8977185"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.158.1.144","doi":"https://doi.org/10.4049/jimmunol.158.1.144","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.1.144","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111812010","display_name":"J. Navarro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J P\u00e9guet-Navarro","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081841730","display_name":"Catherine Dalbiez\u2010Gauthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Dalbiez-Gauthier","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043641935","display_name":"Corinne Moulon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C Moulon","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091552097","display_name":"Odile Berthier\u2010Vergnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"O Berthier","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043620675","display_name":"Alain R\u00e9ano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A R\u00e9ano","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081625214","display_name":"M Gaucherand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Gaucherand","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002962815","display_name":"Jacques Banchereau","orcid":"https://orcid.org/0000-0003-3535-7221","observed_orcids":["https://orcid.org/0000-0003-3535-7221"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J Banchereau","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113757928","display_name":"F Rousset","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"F Rousset","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050720725","display_name":"Daniel Schmitt","orcid":"https://orcid.org/0000-0001-5929-0346","observed_orcids":["https://orcid.org/0000-0001-5929-0346"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"D Schmitt","raw_affiliation_strings":["INSERM Unit 346, Edouard Herriot Hospital , Lyon,","INSERM Unit 346, Edouard Herriot Hospital, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital , Lyon,","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]},{"raw_affiliation_string":"INSERM Unit 346, Edouard Herriot Hospital, Lyon, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210123600"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.8427,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.95363828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"158","issue":"1","first_page":"144","last_page":"152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2685999870300293,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.2685999870300293,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.23659999668598175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.13930000364780426,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9890000224113464},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.984000027179718},{"id":"https://openalex.org/keywords/epidermal-basal-cells","display_name":"epidermal basal cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/profilaggrin","display_name":"profilaggrin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7409999966621399},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/soluble-cd40-ligand","display_name":"soluble CD40 ligand","score":0.871999979019165},{"id":"https://openalex.org/keywords/anti-cd40-antibody","display_name":"anti-CD40 antibody","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.8277445435523987},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.6920565366744995},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6263971328735352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5739696621894836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5667916536331177},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.49774888157844543},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.46168676018714905},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4454939663410187},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43838363885879517},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42292076349258423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36517876386642456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22111424803733826},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20679327845573425},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16932862997055054},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10319784283638},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.10319486260414124},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023201","descriptor_name":"CD40 Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.158.1.144","doi":"https://doi.org/10.4049/jimmunol.158.1.144","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.158.1.144","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:8977185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8977185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00189866v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00189866","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Immunology, 1997, 158 (1), pp.144-52","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073739218","https://openalex.org/W2140621499","https://openalex.org/W1974169539","https://openalex.org/W2016204658","https://openalex.org/W1979532268","https://openalex.org/W1965940751","https://openalex.org/W2006406347","https://openalex.org/W2397222110","https://openalex.org/W1968046151","https://openalex.org/W1604007169"],"abstract_inverted_index":{"While":[0],"CD40-CD40":[1],"ligand":[2,193],"interactions":[3,128],"are":[4],"known":[5,16],"to":[6,76,194],"regulate":[7],"B":[8,78],"cell":[9,25,49,79,249],"proliferation":[10,145,182,202],"and":[11,51,62,118,216,228,235,251],"differentiation,":[12],"much":[13],"less":[14],"is":[15,37,54,73,226],"about":[17],"the":[18,47,77,135,150,195,209],"role":[19,132],"this":[20],"receptor":[21],"plays":[22],"on":[23,46,56,85,154,203,230,237],"other":[24,89],"types,":[26],"especially":[27,45],"those":[28],"of":[29,115,173,181,191,200,208,248,253],"nonhemopoietic":[30],"origin.":[31],"We":[32],"report":[33],"here":[34],"that":[35,52,66,107,126,143,224],"CD40":[36,67,83,108,192,225,240],"expressed":[38,68,227],"in":[39,43,111,133],"normal":[40],"human":[41,231],"epidermis":[42],"situ,":[44],"basal":[48,59,71,123,233],"layer,":[50],"it":[53],"maintained":[55],"cultured":[57,86,121],"epidermal":[58,70,122,232],"cells.":[60,163],"Immunoprecipitation":[61],"SDS-PAGE":[63],"analysis":[64,215],"confirms":[65],"by":[69,120,171,186,213],"cells":[72,103,151,234],"immunologically":[74],"related":[75],"CD40.":[80],"IFN-gamma":[81],"up-regulates":[82],"expression":[84],"keratinocytes,":[87],"whereas":[88],"proinflammatory":[90],"cytokines,":[91],"such":[92],"as":[93,156,211],"IL-1":[94],"or":[95,160],"TNF-alpha,":[96],"have":[97],"little":[98],"effects.":[99],"Using":[100],"CD40-ligand-transfected":[101],"L":[102,162],"(CD40Lc),":[104],"we":[105,141],"demonstrated":[106],"triggering":[109],"results":[110,222],"an":[112],"enhanced":[113],"secretion":[114],"both":[116],"IL-8":[117],"TNF-alpha":[119],"cells,":[124,210,239],"suggesting":[125],"CD40-CD40L":[127],"may":[129,242],"play":[130],"a":[131,188,244],"amplifying":[134],"cutaneous":[136],"inflammatory":[137],"reactions.":[138],"More":[139],"importantly,":[140],"found":[142],"keratinocyte":[144,196,201],"was":[146],"significantly":[147],"inhibited":[148],"when":[149],"were":[152],"grown":[153],"CD40Lc,":[155],"compared":[157],"with":[158,175,206],"CD32-transfected,":[159],"nontransfected,":[161],"This":[164],"inhibitory":[165],"effect":[166],"can":[167],"be":[168,184,243],"reversed":[169],"substantially":[170],"pretreatment":[172],"keratinocytes":[174],"anti-CD40":[176],"mAb.":[177],"In":[178],"addition,":[179],"inhibition":[180,199],"could":[183],"obtained":[185],"adding":[187],"soluble":[189],"form":[190],"cultures.":[197],"Interestingly,":[198],"CD40Lc":[204],"correlates":[205],"differentiation":[207],"assessed":[212],"morphologic":[214],"increased":[217],"profilaggrin":[218],"content.":[219],"Collectively,":[220],"these":[221,238],"demonstrate":[223],"functional":[229],"that,":[236],"ligation":[241],"signal":[245],"for":[246],"limitation":[247],"growth":[250],"induction":[252],"differentiation.":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
